CN1258377C - Bamboo extract and its preparation method and application - Google Patents

Bamboo extract and its preparation method and application Download PDF

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Publication number
CN1258377C
CN1258377C CN 03117155 CN03117155A CN1258377C CN 1258377 C CN1258377 C CN 1258377C CN 03117155 CN03117155 CN 03117155 CN 03117155 A CN03117155 A CN 03117155A CN 1258377 C CN1258377 C CN 1258377C
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bamboo
preparation
alkali
alcohol
extract
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CN1517118A (en
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莫尚武
谢秀琼
刘宁
杨远友
罗海燕
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Sichuan University
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Abstract

The present invention discloses a bamboo extract and a preparation method and application thereof. The present invention is prepared with the following method: a. bamboo branches or bamboo leaves are taken to be dried and pulverized or cut, each 50g of the bamboo branches or the bamboo leaves are added with soda water of which the ph value is more than 8 or alkali alcohol from 100 ml to 800 ml for 0.5 to 24 hours and then heated to 40 DEG C to 100 DEG C for 0.5 to 24 hours, and then the bamboo branches or the bamboo leaves are filtered; b. the step a can be repeated by 1 to 2 times for residues; c. the filtrate is combined, concentrated and dried. Besides, the bamboo extract can be used for the preparation of a pure natural calcium channel regulation medicine.

Description

Bamboo extract and its production and application
Technical field
The present invention relates to a kind of plant extract and its production and application, specifically, the present invention relates to bamboo extract and its production and application.
Background technology
Folium Bambusae is the leaf of the plant phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle Phyllostachys nigra of standing grain section (L-Odd.) Munro var henonis (Mitf) Stapfex Rendle.Mainly be distributed in the Yangtze river basin, the southwest bamboo resource is very abundant.The application beginning of Folium Bambusae in Chinese medicine is stated from " Mingyi Bielu ", Ming Dynasty's Li Shizhen (1518-1593 A.D.) " Compendium of Materia Medica " volume 37, and " bamboo " has a detailed description, and be all on the books in successive dynasties doctor works such as " Treatise on Dietetic Therapy ", " book on Chinese herbal medicine is looked for the truth ", " book on Chinese herbal medicine justice ".Main effect: go up clearing away heart-fire, following diuresis, heat clearing away and restlessness relieving is controlled the calentura coma; GUIXIN, lung, stomach warp.The bamboo heart commonly used among the people (the web-like tender leaf that just goes out) fry in shallow oil water control vexed, generate heat, quench one's thirst etc.Folium Bambusae frequency of utilization in the modern age Chinese medicinal formulae is very low, and only bamboo in the heart or be used as " extra conductant ingredient ".After bamboo was felled, Folium Bambusae (the tiny part of bamboo branch and top that is comprising leaf) was all given it up, and in the intensive area of bamboo grove, Folium Bambusae covers on the ground as carpet, all is all over the mountains and plains.Along with progress of science and technology, people draw attention to the comprehensive exploitation of bamboo resource, and the basic research of relevant Folium Bambusae increases gradually.We combine with biotechnology with nuclear technology, have studied bamboo extract to influence and mechanism dirty, internal organs organ cell calcium channel, find that bamboo extract has new medical value and health care.
Ca in the cell 2+The multiple physiology of human body, bioprocess are played important regulatory role, normal Ca in the cell 2+The destruction of stability of concentration is the early stage and key condition that cell is injured.A large amount of calcium and pigmentation are generally all arranged in the senile cell; Ca in aging dysmnesia and the brain cell synapse 2+Serious overload is relevant; Body is inflamed or lacks O 2All with position, place cell Ca 2+Concentration raises.Intracellular calcium is unbalance to be considered to " co-channel " of the cell injury that a variety of causes causes.Thereby explore novel drugs in order to get rid of unnecessary calcium in the cell, and can make cell recover normal function again, meaningful to the control of multiple diseases such as aging, cancer.
Modern age, pathological study proved, Ca 2+Enter the cardiovascular cell in a large number and cause of coronary heart disease mechanism is closely related, German scholar Fleckestein in 1969 proposes to reduce stream in the calcium with drug block cell membrane calcium channel, makes the treatment of coronary heart disease obtain rapid progress.This class medicine is called as calcium channel blocker (Calcium Channel Blocker is called for short CCB), and the CCB medicine is widely-used clinically at the heart, cerebrovascular disease at present, but all is chemosynthesis at present, lacks highly active natural CCB medicine.
Summary of the invention
The invention provides a kind of bamboo extract, it is prepared by following method:
A. get bamboo branch or Folium Bambusae, drying is pulverized or cutting, and aqueous alkali or alkali alcohol 100ml～800ml that every 50g adds PH＞8 soaked 0.5-24 hour; 40-100 ℃ of heating 0.5-24h filters;
B. but residue repeating step a is 1-2 time;
C. merging filtrate concentrates, dry getting final product.
The preparation method of above-mentioned bamboo extract also is provided, comprises:
A. get bamboo branch or Folium Bambusae, drying is pulverized or cutting, and aqueous alkali or alkali alcohol 100ml～800ml that every 50g adds PH＞8 soaked 0.5-24 hour; 40-100 ℃ of heating 0.5-24h filters;
B. but residue repeating step a is 1-2 time;
C. merging filtrate concentrates, dry getting final product.
Wherein, aqueous alkali among the step a or alkali alcohol are one or more aqueous solution or alcoholic solutions in calcium hydroxide, ammonium hydrogencarbonate, sodium hydroxide, the ammonia.Wherein, the alcohol amount of containing of alkali alcohol is 10%～70%, and the alcohol in the alkali alcohol is ethanol or methanol preferably.
Bamboo extract of the present invention can be used for preparing calcium channel and regulates medicine.Application in preparation calcium channel blocking agent medicine specifically, the preferably application in the medicine of preparation prevention and treatment cardiovascular and cerebrovascular disease, the most preferably application in the medicine of preparation treatment coronary heart disease, arrhythmia, cerebral vasospasm, cerebral infarction, motion sickness.
The specific embodiment:
The preparation of bamboo extract:
Preparation example 1: alkaline extraction
Adopt down Folium Bambusae or bamboo branch, tap water cleans two times, and oven dry is pulverized, claim 500g to add the 8000ml saturated limewater and soaked 1 hour, heating 1h (80～100 ℃), filtered while hot, residue adds 5000ml saturated limewater reheat and extracts 1h, filter, concentrate, pulverize, be sealed in the sample bottle standby.Obtain alkali and carry matter sample one 80g.
Preparation example 2: alkaline extraction
Adopt down Folium Bambusae or bamboo branch, tap water cleans two times, and oven dry is pulverized, claiming 500g to add 8000ml PH is 3 sodium hydroxide ethanol (concentration of alcohol is 50%) solution soaking 1 hour, heating 1h (80～100 ℃), filtered while hot, residue adds 5000ml sodium hydroxide alcoholic solution reheat and extracts 1h, filter, concentrate, pulverize, be sealed in the sample bottle standby.Obtain alkali and carry matter sample two 80g.
Preparation example 3: alcohol extracting method
Adopt down Folium Bambusae or bamboo branch, tap water cleans two times, and oven dry is pulverized, claim that 500g adds 8000ml 50% alcohol solution dipping 1 hour, heating 1h (80～100 ℃), filtered while hot, residue adds 5000ml 50% alcoholic solution reheat and extracts 1h, filter, concentrate, pulverize, be sealed in the sample bottle standby.Obtain ethanol extract sample one 75g.
Preparation example 4: alcohol extracting method
Adopt down Folium Bambusae or bamboo branch, tap water cleans two times, and oven dry is pulverized, and claims that 500g adds 8000ml 30% methanol solution, soaked 1 hour, heating 1h (80～100 ℃), filtered while hot, residue adds 5000ml 30% methanol solution reheat and extracts 1h, filter, concentrate, pulverize, be sealed in the sample bottle standby.Obtain ethanol extract sample two 77g.
Carry out pharmacological testing with above-mentioned sample:
Experimental technique:
45Ca strides the film measuring method
Material
The Wistar rat, body weight 200+20g, male and female dual-purpose. 45CaCl 2Solution is Britain AmerSham company product, and specific radioactivity 1570MBq/gCa, other medicine are commercially available analytical pure.
Experiment liquid
PSS liquid (m mol/L): NaCl 137, CaCl 21.5, MgCl 21.0, KCl 3.0, HEPES20, C 6H 12O 6H 2O 10, pH=7.4; High potassium PSS liquid (m mol/L): KCl 100, NaCl 40 all the other with PSS liquid, pH=7.4; EGTA liquid (m mol/L): EGTA l0 does not contain CaCl 2, all the other same PSS; The toluene scintillation solution: PPO 5.0g, POPOP 0.4g, ethylene glycol 300ml, naphthalene 60g are settled to 1000ml with toluene.
45Ca strides flow measurement step in the film:
Press document: Williams GT.Cell, 1991,65:1097 and Zhang Tingjie angiocardiology progress, 1995,16 (1): 43 method is also improved.Hit dizzy rat and take out thoracic aorta, the heart, liver, lung, kidney ... Deng, place PSS solution to remove connective tissue gently, be cut into small pieces, place 37 ℃ of insulations of PSS liquid 1h, immigration contains 45CaPSS solution equilibria 10min.Tremulous pulse bar or continue to stay in this solution, or move in norepinephrine (NE) solution or move into and contain 45The high potassium liquid of Ca is handled 10min.Above step all is at 37 ℃ and logical O 2Carry out under the condition.To organize taking-up again, place 0-2 ℃ of no calcium EGTA solution washing 1h, and put into respectively after blotting arterial ring and weigh with filter paper then and measure bottle and add 20%HClO 425 μ L and 30%H 2O 250 μ L digest 20min in 80 ℃ of water-baths, radioactivity dpm is measured after adding the dark 3h of placement of toluene scintillation solution 4ml in the cooling back in liquid scintillation instrument.Ca 2+Interior flow is calculated by following formula:
Measurement data is represented with x ± S.D, and is carried out the t check.
45Ca strides the excessive measuring method of film:
Getting rat tissue's cell → 37 ℃ PSS liquid hatches → contains 45Ca enters ℃ EGTA flush away extracellular, cell → 4 in a large number by the PDC calcium channel 45Make among ℃ PSS of Ca → 37 45Ca is excessive → regularly surveys among the PSS 45The cpm of Ca is residue in excessive speed → survey cell 45Ca → 45The interior flow of Ca subtracts remaining quantity and promptly gets excessive amount.
In excessive process, select PSS liquid, PSS+ epinephrine, the high potassium of PSS for use, represent respectively that promptly stationary stream calcium channel (Leak), receptor calcium channel (ROC) and voltage rely on the excessive of calcium channel (PDC).
Experimental result
Preparation technology's difference, pharmacological action is variant
The ethanol extraction of Folium Bambusae or bamboo branch and alkaline process extract rely on calcium channel (PDC) to rat aorta voltage 45The influence of stream sees Table I, Table II in the Ca.
Table I Folium Bambusae ethanol extract is to PDC 45The influence (n=8) of stream in the Ca
Classification Concentration (mg/ml) Alcohol extraction sample one Alcohol extraction sample two
Contrast ethanol extract contrast ethanol extract 0 0.02 0.10 0.50 193.18±10.48 185.22±24.34 187.92±5.67 182.86±6.47 193.18±10.48 188.92±9.14 158.52±8.01 143.56±11.41
Table II Folium Bambusae alkali is carried thing to PDC 45The influence (n=8) of stream in the Ca
Classification Concentration (mg/ml) The alkali product one that get sample The alkali product two that get sample
Contrast alkali is carried thing contrast alkali and is carried thing 0 0.02 0.10 0.50 185.87±17.13 147.37±15.72 157.37±14.24 128.91±15.92 185.87±17.13 160.37±16.06 154.76±13.36 106.20±9.76
The result of comparison sheet I, Table II finds out, sample one and contrast zero difference, sample two in the ethanol extract 45The stream effect is better than sample one in the Ca.Carry at alkali that the two all is to have shown good effect in the thing.Relatively alkali is put forward the effect of thing and ethanol extract effect, and alkali is carried thing retardance PDC calcium channel, reduces 45The effect of stream is better than ethanol extract in the Ca.Retardation under 0.02mg/ml concentration, just occurs, and the Concentraton gradient effect is arranged.
Bamboo extract, Folium Ginkgo flavone, Verapamil have similar action rule to calcium channel
Bamboo, Folium Ginkgo, Verapamil etc. see Table III to the action characteristic of the rat heart, liver, lung, kidney PDC calcium channel.
The Table III bamboo extract is to the influence (n=8) of internal organs organ PDC calcium channel
Classification Concentration (mg/ml) Tremulous pulse The heart Liver Lung Kidney
Contrast 0 199.32±12.26 753.16±63.63 425.07±60.64 357.86±44.40 438.28±63.90
Bamboo alkali is carried thing 0.5 135.78±10.87 528.02±24.82 413.69±49.24 223.36±46.46 351.08±36.37
The bamboo ethanol extract 0.5 150.27±5.61 549.80±50.30 378.35±38.54 251.36±23.38 330.24±23.80
Folium Ginkgo 0.5 146.96±22.35 642.30±58.1 360.62±32.98 285.43±12.84 371.58±22.65
Verapamil 0.1 110 589.02±49.88 310.27±15.52 319.11±11.43 407.94±17.80
Can find out that from last table bamboo extract all has regulating and controlling effect to the rat aorta heart, liver, lung, kidney.When concentration is 0.5mg/ml, tremulous pulse, the heart, lung action effect are had identical rule with Folium Ginkgo, verapamil, because of verapamil is chemical medicine, purity is higher, drug action under low concentration very just clearly.
Bamboo extract is to the internal organs organ 45The excessive influence of Ca sees Table IV
The Table IV Folium Bambosae extract is right 45The influence (n=87) that Ca is excessive
Classification Concentration Tremulous pulse The heart Liver Lung Kidney
Contrast 0 57.08±1.19 316.40±22.46 211.45±4.71 165.80±10.90 331.40±11.80
Folium Bambusae alkali is carried thing 0.4 36.60±3.76 271.53±28.28 220.46±29.82 160.56±16.11 340.18±32.65
Bamboo skill alkali is carried thing 0.4 41.70±4.7 285.16±30.60 174.42±25.22 154.69±30.40 262.86±33.61
Folium Ginkgo 0.4 42.90±9.51 271.45±42.51 185.89±25.96 142.11±25.33 239.89±28.80
As seen from Table 4, Folium Bambusae, bamboo skill, Folium Ginkgo, alkali are carried thing can impel Ca in the heart, liver, lung, kidney, the arterial cell under 0.4mg/ml concentration 2+To excessive, to reduce Ca in the cell 2+The injury that the overload pair cell causes.Wherein relatively consistent to tremulous pulse, heart action rule, to lung, liver, kidney not clearly.
From above-mentioned experiment as can be seen, bamboo extract both can promote unnecessary Ca in the cell 2+Excessive, can stop extracellular Ca again 2+Interior stream, it is to multiple organ cell's film calcium channel regulating action, be of value to the stability of keeping intracellular calcium concentration, thereby to cardiovascular and cerebrovascular disease have the treatment and health care function, drug action and Folium Ginkgo have comparability, except that can raw material as preparation CCB (calcium channel blocker) medicine, can also be to keeping normal Ca in the cell 2+Concentration plays regulating action.Normal Ca in the cell 2+The destruction of stability of concentration is the early stage and key condition that cell is injured.A large amount of calcium and pigmentation are generally all arranged in the senile cell; Ca in aging dysmnesia and the brain cell synapse 2+Serious overload is relevant; Body is inflamed or lacks O 2All with position, place cell Ca 2+Concentration raises.Intracellular calcium is unbalance to be considered to " co-channel " of the cell injury that a variety of causes causes.Thereby extract of the present invention makes cell recover normal function again for getting rid of unnecessary calcium in the cell, provides new way for preventing and treating multiple diseases such as aging, cancer.
The invention will be further described below by embodiment, but be not limitation of the present invention.
Embodiment one
The preparation of bamboo extract:
Adopt down Folium Bambusae or bamboo branch, tap water cleans two times, and oven dry is pulverized, claim 500g to add 8000ml saturated limewater (pH14) and soaked 1 hour, heating 1h (80～100 ℃), filtered while hot, residue adds 5000ml saturated limewater reheat and extracts 1h, filter, concentrate, pulverize, be sealed in the sample bottle standby.Obtain extract 80g.
Embodiment two
The preparation of bamboo extract:
Folium Bambusae or bamboo branch are cut into the 1-3cm segment with chopper, dry or directly extract, add 10% sodium bicarbonate (containing 1% Borax) by solid-to-liquid ratio at 1: 16 with the aquatic foods product, soak 2h and do not have heated and boiled 1h, filtered while hot, residue is by adding sodium bicarbonate (containing 1% Borax) at 1: 8, boiled 1 hour again, and filtered, twice filtrate merges, concentrate, oven dry is pulverized, and it is standby to bottle.Obtaining extract is 18% of raw material (dry product).
With the pharmacological experimental method of front, measure it to retardance extracellular Ca 2+Ca in interior stream and the promotion cell 2+Excessive influence, unanimity as a result.
Embodiment three
The preparation of bamboo extract:
Adopt down Folium Bambusae or bamboo branch, tap water cleans two times, oven dry, chopping, title 500g adds alcoholic solution (pH10 contains alcohol 30%) the immersion half an hour that 8000ml contains sodium hydroxide, heating 1h (80～100 ℃), filtered while hot, residue adds the above-mentioned alkali alcohol of 5000ml liquid reheat and extracts 1h, filters, and concentrates, pulverize, be sealed in the sample bottle standby.Obtain extract 74g.
With the pharmacological experimental method of front, measure it to retardance extracellular Ca 2+Ca in interior stream and the promotion cell 2+Excessive influence, unanimity as a result.
Embodiment four
Get the bamboo extract 100g of embodiment one or two or three method preparation, add starch, each 10g of dextrin, mixing is granulated, drying, and granulate in the special-purpose bag of the bagged steeping drug of packing into, is teabag.
Embodiment five
Get the bamboo extract 100g of embodiment one or two or three method preparation, add starch, each 10g of dextrin, mixing is granulated, drying, and granulate in the hard capsule of packing into, is capsule.
Embodiment six
Get the bamboo extract 100g of embodiment one or two or three method preparation, add starch, each 10g of dextrin, mixing is granulated, drying, and granulate adds magnesium stearate 2g, and tabletting is conventional tablet.
Embodiment seven
Get the bamboo extract 100g of embodiment one or two or three method preparation, add smart in a subtle way cellulose 40g, cross-linked pvp 40g, lactose 10g, mixing is granulated, drying, and granulate adds magnesium stearate 2g, and tabletting is dispersible tablet.
Embodiment eight
Get the bamboo extract 100g of embodiment one or two or three method preparation, add starch, each 10g of dextrin or do not add, general system micropill, drying, the bag extended release coatings is slow releasing pill.This ball incapsulates, and is slow releasing capsule.
Embodiment nine
Get the bamboo extract 100g of embodiment one or two or three method preparation, add hydroxypropyl methylcellulose 20g, ethyl cellulose 40g etc., mixing is granulated, and is sustained-release granular formulation.This granule incapsulates, and is slow releasing capsule.This granule tabletting is slow releasing tablet.
Embodiment ten
Get the bamboo extract 100g of embodiment one or two or three method preparation, add hawthorn extract 30g or Fructus Crataegi micropowder 50g, protein sugar 0.3g, be dissolved in or be suspended in the aqueous solution, be health beverage.

Claims (6)

1, a kind of bamboo extract is characterized in that: it is following method preparation:
A, get bamboo branch or Folium Bambusae, drying is pulverized or cutting, and aqueous alkali or alkali alcohol 100ml～800ml that every 50g adds PH＞8 soaked 0.5-24 hour; Containing the alcohol amount in the alkali alcohol is 10%～70%; 40-100 ℃ of heating 0.5-24h filters;
But b, residue repeating step a1-2 time;
C, merging filtrate concentrate, dry getting final product.
2, the preparation method of the described bamboo extract of claim 1 is characterized in that:
A, get bamboo branch or Folium Bambusae, drying is pulverized or cutting, and aqueous alkali or alkali alcohol 100ml～800ml that every 50g adds PH＞8 soaked 0.5-24 hour; Containing the alcohol amount in the alkali alcohol is 10%～70%; 40-100 ℃ of heating 0.5-24h filters;
But b, residue repeating step a1-2 time;
C, merging filtrate concentrate, dry getting final product.
3, preparation method according to claim 2 is characterized in that: aqueous alkali among the step a or alkali alcohol are: the aqueous solution of one or more in calcium hydroxide, ammonium hydrogencarbonate, sodium hydroxide, the ammonia or alcoholic solution.
4, according to claim 2 or 3 described preparation methoies, it is characterized in that: the alcohol in the alkali alcohol is ethanol or methanol.
5, the application of the described bamboo extract of claim 1 in preparation calcium channel adjusting medicine.
6, the application of the described bamboo extract of claim 5 in preparation calcium channel blocking agent medicine.
CN 03117155 2003-01-14 2003-01-14 Bamboo extract and its preparation method and application Expired - Fee Related CN1258377C (en)

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Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100473408C (en) * 2005-01-21 2009-04-01 四川奥邦药业有限公司 Heat-clearing and phlegm-resolving medicine composition, preparation and use thereof
CN101531904B (en) * 2009-05-05 2012-06-20 国际竹藤网络中心 Bamboo leaves extract, preparing method and purpose thereof
CN102277009B (en) * 2011-07-27 2013-09-04 晨光生物科技集团股份有限公司 Method for extracting and purifying cottonseed brown pigment from cottonseed hulls
CN114831032A (en) * 2022-05-25 2022-08-02 广州多美丝互联网科技有限公司 Bamboo powder cat litter

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