CN1257704A - Submicro emulsion based on sugar fatty ester and sugar fatty ether, and use thereof - Google Patents

Submicro emulsion based on sugar fatty ester and sugar fatty ether, and use thereof Download PDF

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CN1257704A
CN1257704A CN99126145A CN99126145A CN1257704A CN 1257704 A CN1257704 A CN 1257704A CN 99126145 A CN99126145 A CN 99126145A CN 99126145 A CN99126145 A CN 99126145A CN 1257704 A CN1257704 A CN 1257704A
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ultra micro
micro emulsion
oil
weight
ester
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CN1222275C (en
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J·T·西莫内
O·松内维勒
S·勒松雷特
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LOreal SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
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    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/14—Preparations for removing make-up

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Abstract

A nanoemulsion, the oily globules of which have a number-average size of less than 100 nm, comprising a surfactant which is solid at a temperature of less than or equal to 45 DEG C., which surfactant is chosen from esters of a fatty acid and of a sugar and ethers of a fatty alcohol and of a sugar, and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The nanoemulsion may be used for cosmetics and dermatological applications, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an eye lotion for treating the eyes.

Description

Ultra micro emulsion and application thereof based on sugared aliphatic ester and sugared fatty ether
The present invention relates to based on being solid-state surfactant and at least a its molecular weight greater than the ultra micro emulsion of 400 oil being equal to or less than under 45 ℃ the temperature; Described surfactant is selected from the ester of fatty acid and ester and the ether of aliphatic alcohol and the ether of sugar of sugar; Wherein, the weight ratio of the amount of the amount of oil phase and surfactant is 2～10.
The invention still further relates to the preparation method of described ultra micro emulsion and in cosmetic, dermatosis and/or opthalmological Application for Field.This ultra micro emulsion is stable when storing, and can comprise a large amount of oil, keeps the good transparency simultaneously, also has good cosmetic properties.
The ultra micro emulsion is an emulsion oil-in-water, and its oil droplet has very thin granularity, that is to say, the number average size is less than 100nm.They generally are to make by the oil phase with the Mechanical Crushing aqueous phase in the presence of surfactant.Under the situation of ultra micro emulsion, especially different by means of at least once obtaining the oil of unusual small grain size by high-pressure homogenizer.Small grain size makes the ultra micro emulsion have the premium properties that is different from conventional emulsion in cosmetic field: they are transparent and show new feature.They also can more effectively carry active component.
The present known transparent microemulsion of technology.Opposite with the ultra micro emulsion, microemulsion is not an emulsion strictly speaking, and it is by the clear solution of the micelle of oil swell; Described oil is the oil (as: hexane or decane) of very short chain in general, and by means of the common existence of the cosurfactant of a large amount of formation micelles and surfactant and by solubilization.The granularity of swelling micelle is very little, and this is because oil that can solubilization is seldom measured.As the same with the situation of ultra micro emulsion, the granularity that its transparent reason is a micelle is very little.Yet opposite with the ultra micro emulsion, microemulsion is to form naturally by mixing each component under the condition that the mechanical energy except that simple magnetic stirs is not provided.Surfactant is relevant at high proportion with it for the major defect of microemulsion, thereby on being applied to skin the time, causing can't stand and produce the thickness sense.In addition, its formula range is generally very narrow, and its temperature stability is also very limited.
In addition, the known ultra micro emulsion of prior art comprises the amphiphilic lipoid phase that become by phospholipid, water and line of oils.These emulsions show unsettled shortcoming under storage temperature is 0～45 ℃ usually.It causes the compositions jaundice, and produces the foul smell that increases day by day after storing several days.
Also known to the stable ultra micro emulsion of layered liquid crystal coating, it obtains by combining hydrophilic surfactant and lipophilic surfactant.Yet this being combined in the preparation has problems.In addition, gained ultra micro emulsion shows wax sense and film forming sense, and this is very uncomfortable to user.
In addition, documents and materials EP-A-728,460 disclose the ultra micro emulsion based on aqueous non-ionic amphiphilic lipoid.Yet the shortcoming that these ultra micro emulsions show on being used for skin the time is the toughness sense.
So, need not only not have prior art the ultra micro emulsion shortcoming but also do not have the ultra micro emulsion of microemulsion shortcoming.
Applicant company now is surprisingly found out that, use is solid-state sugar ester or the sugar ether surfactant of being selected from being equal to or less than under 45 ℃ the temperature, and use at least a its molecular weight (to that is to say greater than 400,400 gram/moles) oil can make the whole advantages with known ultra micro emulsion and the new ultra micro emulsion that does not have its shortcoming.
Content of the present invention is a kind of ultra micro emulsion that comprises number average particle size oil phase, its oil droplet that is dispersed in aqueous phase less than 100nm, it is characterized in that being included under the temperature that is equal to or less than 45 ℃ is solid-state surfactant and at least a molecular weight greater than 400 oil; Described surfactant is selected from the ester of fatty acid and ester and the ether of aliphatic alcohol and the ether of sugar of sugar; Wherein, the weight ratio of the amount of the amount of oil phase and surfactant is 2～10.
According to ultra micro emulsion of the present invention is transparent to light blue appearance generally.Its transparency is measured by transmission coefficient under the 600nm, and scope is 10～90%, or by turbidimetry, its scope is 60～600NTU, is preferably 70～300NTU, and turbidity adopts Hach Model2100P lightweight scopometer to measure.
The number average particle size of the oil droplet of ultra micro emulsion of the present invention is preferably 20～75nm less than 100nm, more preferably 40～60nm.The reducing of oil droplet granularity can impel active component to skin surface infiltration (carrier effect).
That can in ultra micro emulsion of the present invention, use and be equal to or less than under 45 ℃ be the ether of the solid-state surfactant ester, the aliphatic alcohol that just are selected from the ester of fatty acid and sugar and sugar ether, and composition thereof, this means that ultra micro emulsion of the present invention does not contain any surfactant that removes sugared fatty ester or its aliphatic ether.
Can be as the ester of the fatty acid of the surfactant in the ultra micro emulsion of the present invention and the ester of sugar, be solid being equal to or less than under 45 ℃ the temperature, especially can be selected from C 8～C 22The ester of fatty acid and sucrose, maltose, glucose or fructose or the mixture of ester and C 14～C 22The ester of fatty acid and methyl glucoside or the mixture of ester.
The C of the fat units of the ester that formation can be used in ultra micro emulsion of the present invention 8～C 22Or C 14～C 22Fatty acid comprises the saturated or unsaturated linear alkyl chain that contains 8～22 or 14～22 carbon atoms respectively.The fat units of ester especially can be selected from stearate, behenic acid ester, arachidonate, cetylate, myristinate, laurate, decanoin with and composition thereof.The preferred stearate that uses.
Example as the mixture of the ester of the ester of fatty acid and sucrose, maltose, glucose or fructose or ester, can mention sucrose monostearate, sucrose distearate, sucrose tristearate and composition thereof, for example Croda company is with trade name Crodesta F50, F70, F110 and F160 product sold, and its HLB (hydrophile-lipophile balance value) is respectively 5,7,11 and 16; As the example of the mixture of the ester of fatty acid and methyl glucoside or ester, can mention distearate methyl glucoside and poly-glycerine-3, sell with trade name Tego-care 450 by Goldschmidt company.Can also mention glucose or maltose monoesters, for example, methyl O-hexadecanoyl-6-D-glucoside and methyl O-hexadecanoyl-6-D-maltoside.
Can be as the ether of the aliphatic alcohol of the surfactant in the ultra micro emulsion of the present invention and the ether of sugar, be solid-state being equal to or less than under 45 ℃ the temperature, especially can be selected from C 8～C 22Fat alcohol and glucose, maltose, sucrose or the ether of fructose or the mixture and the C of ether 14～C 22The ether of aliphatic alcohol and methyl glucoside or the mixture of ether.Alkyl polyglucoside particularly.
The C of the fat units of the ether that formation can be used in ultra micro emulsion of the present invention 8～C 22Or C 14～C 22Aliphatic alcohol comprises the saturated or unsaturated linear alkyl chain that contains 8～22 or 14～22 carbon atoms respectively.The fat units of ether especially can be selected from decyl, cetyl, mountain Yu base, Semen arachidis hypogaeae base, stearyl, palmityl, myristyl, lauryl, octyl group or hexadecanoyl unit with and composition thereof, spermaceti aryl (cetearyl) for example.
As the ether of aliphatic alcohol and the example of the ether of sugar, can mention alkyl polyglucoside, for example decyl glucoside and lauryl glucoside, sell with trade name Plantaren 2000 and Plantaren 1200 respectively as Henkel company, cetearyl glucoside, also with the form of the mixture of spermaceti octadecanol, for example, Seppic company is with trade name Montanov 68, Goldschmidt company with trade name Tego-care CG90 and Henkel company with trade name Emulgade KE3302 seller, and Semen arachidis hypogaeae base glucoside, for example, with Semen arachidis hypogaeae with the form of the mixture of behenyl alcohol and Semen arachidis hypogaeae glucoside, by Seppic company with trade name Montanov 202 sellers.
According to specific embodiments of the present invention, more particularly, use sucrose monostearate, sucrose distearate, sucrose tristearate and composition thereof to make surfactant, also have distearate and alkyl polyglucoside methyl glucoside and poly-glycerine-3.
According to the characteristic of surfactant is more hydrophilic or oleophylic more, it can be entered the water or the oil phase of ultra micro emulsion.
The amount of the surfactant in ultra micro emulsion of the present invention can be preferably 1～8% (weight) for for example 0.2～15% (weight) by ultra micro emulsion gross weight.
The weight ratio of the amount of oil phase and the amount of surfactant is 2～10, is preferably 3～6.Term " amount of oil phase " is interpreted as the total amount of this phase component that does not comprise amount of surfactant herein.
Ultra micro emulsion of the present invention comprises at least a molecular weight greater than 400 oil.Molecular weight can be selected from the oil that animal or plant is originated, mineral oil, artificial oil, silicone oil and composition thereof greater than 400 oil.As such oil, can mention for example different cetyl of Palmic acid, Standamul 7061, American Avocado Tree oil or simmondsia oil.
In addition, oil phase also can comprise other oil, and especially molecular weight is less than 400 oil.This class oil also is selected from oil, mineral oil, artificial oil and the silicone oil in animal or plant source.Less than 400 oil, can mention for example Fancol ID, 2-Methylpentadecane, volatile silicone oils, isopropyl myristate, isopropyl palmitate or C as molecular weight 11～C 13Isoparaffin.
Except above-mentioned oil, oil phase also can comprise the aliphatic material, for example, and aliphatic alcohol such as stearyl alcohol, the pure and mild behenyl alcohol of spermaceti; Fatty acid such as stearic acid, Palmic acid He behenic acid; Fluorinated type oil; Wax; Natural gum and composition thereof.
The oil phase amount that ultra micro emulsion of the present invention comprises is preferably 2～40% (weight) by ultra micro emulsion gross weight, 5～30% (weight) more preferably, and molecular weight preferably accounts at least 40% (weight) of oil phase greater than the ratio of 400 oil.
According to specific embodiments of the present invention, ultra micro emulsion of the present invention also comprises one or more ion-type amphiphilic lipoids.
Can be used in ion-type amphiphilic lipoid in the ultra micro emulsion of the present invention preferably from anionic amphiphilic lipoid, cationic amphiphilic lipoid and alkyl sulfonic derivative.
More particularly, the anionic amphiphilic lipoid can be selected from:
The basic salt of-di(2-ethylhexyl)phosphate spermaceti and two myristins;
The basic salt of-sulphuric acid cholesterol ester;
The basic salt of-phosphoric acid cholesterol ester;
The aminoacid of-fat and salt thereof, acyl glutamic acid list-and two sodium for example are as N-stearoyl-L-disodium glutamate salt of being sold with trade name Acylglutamate HS 21 by Ajinomoto company;
The sodium salt of-phosphatidic acid;
-phospholipid.
The alkyl sulfonic derivative more particularly can be selected from the alkyl sulfonic derivative by (I):
Figure A9912614500091
In the formula, the R representative contains alkyl, the especially C of 16～22 carbon atoms 16H 33And C 18H 37Base, getting mixing or independent form and M is alkali metal, for example sodium.
More particularly, the cationic amphiphilic lipoid can be selected from quaternary ammonium salt, fatty amine and salt thereof.
Quaternary ammonium salt is, for example:
-have following general formula (II) person:
Figure A9912614500092
In the formula, R 1～R 4Base can be identical or different, and representative contains the linearity or the branched aliphatic of 1～30 carbon atom, or such as the aromatic group of aryl or alkylaryl.The fat base can comprise hetero atom, for example, and especially oxygen, nitrogen, sulfur or halogen.Aliphatic group for example is selected from alkyl, alkoxyl, polyoxyization (C 2～C 6) alkene, alkylamidoalkyl, (C 12～C 22) alkylamidoalkyl (C 2～C 6) alkyl, (C 12～C 22) alkyl acetate or contain the hydroxyalkyl of about 1～30 carbon atom; X is selected from halogenide, phosphate radical, acetate lactate, (C 2～C 6) alkyl sulfate or alkyl-or the anion of alkyl aryl sulphonic acid root.Quaternary ammonium salt as general formula (II), it is preferred to be tetra-allkylammonium chloride such as dialkyl dimethyl ammonium or alkyl trimethyl ammonium chloride on the one hand, wherein alkyl comprises about 12～22 carbon atoms, especially Shan Yu base trimethyl ammonium, distearyl Dimethyl Ammonium, cetyl trimethyl ammonium and benzyl dimethyl stearyl ammonium chloride; Perhaps be stearoyl amido propyl-dimethyl (acetic acid myristin) ammonium chloride on the other hand, sell with trade name " Ceraphyl 70 " by VanDyk company.
-imidazoles quaternary ammonium salt for example, is following general formula (III) person:
Figure A9912614500101
In the formula, R 5Representative contains the alkenyl or the alkyl of 8～30 carbon atoms, for example derived from the tallow acid person; R 6Represent hydrogen atom, contain the alkyl of 1～4 carbon atom or contain the alkenyl or the alkyl of 8～30 carbon atoms; R 7Representative contains the alkyl of 1～4 carbon atom; R 8The alkyl and the X that represent hydrogen atom or contain 1～4 carbon atom are aniones, are selected from halogenide, phosphate radical, acetate, lactate, alkyl sulfate or alkyl-or alkyl aryl sulphonic acid root.R 5And R 6Preferred representative contains the alkenyl of 12～21 carbon atoms or the mixture of alkyl, for example, and derived from tallow acid person, R 7Preferred represent methylidene and R 8The preferred hydrogen of representing.This product is for example sold with trade name " Rewoquat W 75 " by Rewo company.
-general formula (IV) season di-ammonium salts:
Figure A9912614500102
In the formula, R 9Representative contains the aliphatic group of about 16～30 carbon atoms; R 10, R 11, R 12, R 13And R 14Be selected from hydrogen or contain the alkyl of 1～4 carbon atom; With X be the anion that is selected from halogenide, acetate, phosphate radical, nitrate anion and methylsulfate.
This, di-ammonium salts especially comprised propane Adeps Bovis seu Bubali diammonium dichloride in class season.
According to the preferred embodiments of the invention, lipoamino acid is used as ion-type amphiphilic lipoid.
Ion-type amphiphilic lipoidis can enter phase or another phase of ultra micro emulsion.When they were present in the ultra micro emulsion of the present invention, its content was preferably 0.01～5% (weight) by ultra micro emulsion gross weight, more preferably 0.25～1% (weight).
Emulsion of the present invention can comprise the additive that improves the prescription transparency.
These additives preferably from:
-contain the lower alcohols of 1～8 carbon atom, more particularly, 2～6 carbon atoms, for example: ethanol;
-glycols, as glycerol, propylene glycol, 1,3 butylene glycol, dipropylene glycol, pentanediol, isoamyl two pure and mild Polyethylene Glycol, it comprises 4～16, preferred 8～12 ethylene oxide units.
-saccharide, for example glucose, fructose, maltose, lactose or sucrose.
These additives can use with the form of mixture.When they were present in the ultra micro emulsion of the present invention, its content was preferably 0.01～3% (weight) by ultra micro emulsion gross weight, more preferably 5～20% (weight).Amount alcohols and/or saccharide is preferably 5～20% (weight) by ultra micro emulsion gross weight, and the amount of glycol is preferably 5～15% (weight) by ultra micro emulsion gross weight.
In addition, the alcohols that uses content to be equal to or greater than the above-mentioned qualification of 15% (weight) can access the emulsion that does not contain antiseptic.
The above-mentioned ultra micro emulsion that defines can constitute topical application of compositions, especially makes up or the dermatosis compositions.They also can be used as the opthalmological carrier.
So another content of the present invention is a topical application of compositions, its characteristic is that it is made up of the above-mentioned ultra micro emulsion that defines.
Topical application of compositions comprises the physiology acceptable medium, that is to say, the medium compatible with skin, mucosa, scalp, eyes and/or hair.
Another content of the present invention is the opthalmological carrier, it is characterized in that, it is made up of the above-mentioned ultra micro emulsion that defines.
Ultra micro emulsion of the present invention can comprise and has the active water-soluble or liposoluble active component of cosmetic, dermatosis or opthalmological.The liposoluble active component is in the emulsion oil droplet, and the water-soluble active composition is at the emulsion aqueous phase.As the example of active component, can mention vitamin such as vitamin E and derivant thereof, especially its ester; Provitamin is as panthenol; Wetting agent and sunscreen.
As the active component of opthalmological, can mention for example antiglaucoma agent.As betaxolol; Antibiotics is as acyclovir; Anti-allergin; Antiinflammatory, as ibuprofen and salt, diclofenac and salt thereof, or indomethacin; Or antiviral agent.
Ultra micro emulsion of the present invention can provide with the form of lotion, serum, cream, Emulsion or floral water, can also comprise be usually used in making up, the adjuvant in dermatosis, opthalmological field, for example gellant, antiseptic, antioxidant and spice.Especially use for opthalmological, they also can provide with the form of eye wass.
In available gellant, can mention derivant, natural gum and the synthetic polymer of cellulose derivative, algae, as the polymer and the copolymer of carboxy vinyl acid, for example: those that Goodrich company sells with trade name Carbopol.
Another content of the present invention is the method for the above-mentioned ultra micro emulsion that defines of preparation, and this method is included in 10～80 ℃ and adopts vigorous stirring that water and oil phase are mixed down, then preferred 6 * 10 7Pa～18 * 10 7Make mixture homogenization (high pressure homogenize) under the Pa pressure.Preferred shearing scope is 2 * 10 6s -1～5 * 10 8s -1, more preferably 1 * 10 8s -1～3 * 10 8s -1(s -1Represent second -1).
Ultra micro emulsion of the present invention for example can be used in nurses, treats or disguise skin, face and/or scalp.
So another content of the present invention is the cosmetic applications of the above-mentioned ultra micro emulsion that defines, be used for expanding reason, treatment and/or makeup skin, face and/or scalp.
In addition, ultra micro emulsion of the present invention also can be used in hair conditioning and/or treatment hair.It can be deposited on oil on the hair, makes hair more glossy, and easier maintenance style, and can not make its rareness.It also can be used as pretreating agent, to improve Color or to improve waveform typing effect.
So another content of the present invention is the cosmetic applications of the above-mentioned ultra micro emulsion that defines, be used for hair conditioning and/or treatment hair.
Ultra micro emulsion of the present invention is wet skin, mucosa and/or scalp particularly well, is particularly suitable for treating dry skin.
So another content of the present invention is the cosmetic method of nursing and/or wet skin, mucosa and/or scalp, its characteristic is the above-mentioned ultra micro emulsion that defines is applied on skin, mucosa and/or the scalp.
The present invention also relates to ultra micro emulsion of the present invention and be used for the treatment of application in the dermatosis compositions of dry skin in manufacturing.
At last, the present invention also relates to the application of ultra micro emulsion of the present invention in making ophthalmic pharmaceutical compositions.
Following example can be understood the present invention better, yet and non-limiting.Shown in amount be % (weight).Example 1: liquid cosmetic detergent oil phase: the disodium salt of-Tego-Care 450 (Goldschmidt company) 4.5%-N-stearoyl-L-glutamic acid
(Acylglutamate HS21 is by Ajinomoto
Company produces) 0.5%-Standamul 7061 (M.W=508) 10%-isopropyl myristate (M.W=270) 5% water :-glycerol 5%-dipropylene glycol 10%-water 65% makes transparent ultra micro emulsion, its oil droplet granularity is 49nm, and turbidity is 218NTU.Example 2: make up and clean the gel oil phase: the disodium salt of-Crodesta F50 (Croda company) 4.5%-N-stearoyl-L-glutamic acid
(Acylglutamate HS21 is by Ajinomoto
Company produces) 0.5%-Standamul 7061 (M.W=508) 20%-C 11～C 13Isoparaffin (M.W=170) 2.5%-2-Methylpentadecane (MW=226) 2.5% water :-glycerol 5%-dipropylene glycol 10%-water 55% makes the transparent ultra micro emulsion of gel state, its oil droplet granularity is 45nm, and turbidity is 260NTU.Example 3: perfume oil phase: the disodium salt 0.5% of-Crodesta F70 (Croda company) 4.5%-N-stearoyl-L-glutamic acid
(Acylglutamate HS21 is by Ajinomoto company
Produce)-soya-bean oil (M.W about 900) 6%-volatile silicone oils (M.W=106) 2%-spices 3%-vitamin e acetate 0.5%-ethanol 10% water :-glycerine 5%-water 68.5
% makes transparent ultra micro emulsion, and its oil droplet granularity is 39nm, and turbidity is 96NTU.Example 4: liquid cosmetic detergent oil phase: the disodium salt of-Tego-Care CG90 (Goldschmidt company) 4.5%-N-stearoyl-L-glutamic acid
(Acylglutamate HS21 is by Ajinomoto
Company produces) 0.5%-Standamul 7061 10%-isopropyl myristate 5% water :-glycerol 5%-dipropylene glycol 10%-water 65% makes transparent ultra micro emulsion, its oil droplet granularity is 43nm, and turbidity is 145NTU.The disodium salt of example 5: nursing gel oil phase :-Montanov 68 (Seppic company) 4.5%-N-stearoyl-L-glutamic acid
(Acylglutamate HS21 is by Ajinomoto
Company produces) 0.5%-Oleum Glycines (MW is about 900) 9%-American Avocado Tree oil (MW is about 900) 9%-volatile silicone oils (M.W=106) 6% water :-glycerol 5%-dipropylene glycol 10%-water 56% makes the transparent ultra micro emulsion of gel, its oil droplet granularity is 46nm, and turbidity is 240NTU.

Claims (26)

1. ultra micro emulsion, it comprises the oil phase that is dispersed in aqueous phase, and this oil droplet number average particle size is characterized in that less than 100nm, and being included under the temperature that is equal to or less than 45 ℃ is solid-state surfactant and at least a molecular weight greater than 400 oil; Described surfactant is selected from the ester of fatty acid and ester and the ether of aliphatic alcohol and the ether of sugar of sugar; Wherein, the weight ratio of the amount of the amount of oil phase and surfactant is 2～10.
2. according to the ultra micro emulsion of claim 1, it is characterized in that turbidity is 60～600NTU.
3. according to the ultra micro emulsion of claim 1 or 2, it is characterized in that the amount of surfactant is counted 0.2～15% (weight) by ultra micro emulsion gross weight, be preferably 1～8% (weight).
4. according to any one ultra micro emulsion in the aforementioned claim, it is characterized in that the weight ratio of the amount of oil phase and the amount of surfactant is 3～6.
5. according to any one ultra micro emulsion in the aforementioned claim, it is characterized in that the oil droplet particle mean size is 20～75nm.
6. according to any one ultra micro emulsion in the aforementioned claim, it is characterized in that surfactant is selected from C 8～C 22The ester of fatty acid and sucrose, maltose, glucose or fructose or the mixture of ester, C 14～C 22The ester of fatty acid and methyl glucoside or the mixture of ester, C 8～C 22Fat alcohol and glucose, maltose, sucrose or the ether of fructose or the mixture and the C of ether 14～C 22The ether of aliphatic alcohol and methyl glucoside or the mixture of ether.
7. according to any one ultra micro emulsion in the aforementioned claim, it is characterized in that surfactant is selected from sucrose monostearate, the two stearates of sucrose, sucrose tristearate and composition thereof; Distearate methyl glucoside and poly-glycerine-3, and alkyl polyglucoside.
8. according to any one ultra micro emulsion in the aforementioned claim, it is characterized in that, molecular weight greater than 400 grease separation from the oil, mineral oil, artificial oil and the silicone oil that are derived from animal or plant, with and composition thereof.
9. according to any one ultra micro emulsion in the aforementioned claim, it is characterized in that oil phase also comprises at least a molecular weight less than 400 oil.
10. according to any one ultra micro emulsion in the aforementioned claim, it is characterized in that oil phase comprises by 40% (weight) molecular weight of oil phase gross weight greater than 400 oil at least.
11., it is characterized in that the amount of oil phase is counted 2～40% (weight) by ultra micro emulsion gross weight according to any one ultra micro emulsion in aforementioned extremely sharp the requirement.
12. according to any one ultra micro emulsion in the aforementioned claim, it is characterized in that it also comprises at least a ion-type amphiphilic lipoid, it is selected from anionic amphiphilic lipoid, cationic amphiphilic lipoid and alkyl sulfonic derivative.
13. the ultra micro emulsion according to claim 12 is characterized in that, ion-type amphiphilic lipoid is selected from:
The basic salt of-di(2-ethylhexyl)phosphate spermaceti and two myristins,
The basic salt of-sulphuric acid cholesterol ester;
The basic salt of-phosphoric acid cholesterol ester;
The amino acid whose salt of-fat;
The sodium salt of-phosphatidic acid;
-phospholipid;
The alkyl sulfonic derivative of-general formula (I): In the formula, R represents C 16～C 22Alkyl is got and is mixed or independent form, and M is an alkali metal;
-quaternary ammonium salt, fatty amine and its salt;
And their mixture.
14. the ultra micro emulsion according to claim 12 or 13 is characterized in that: the amount of ion-type amphiphilic lipoid is counted 0.01～5% (weight) by ultra micro emulsion gross weight.
15., it is characterized in that it comprises the additive that is selected from lower alcohol, glycol, sugar and composition thereof that can improve transparency according to any one ultra micro emulsion in the aforementioned claim.
16. the ultra micro emulsion according to claim 15 is characterized in that: existing content of additive is counted 5～20% (weight) by ultra micro emulsion gross weight.
17., it is characterized in that it comprises cosmetic, dermatosis or opthalmological active component according to any one ultra micro emulsion in the aforementioned claim.
18. a topical application of compositions is characterized in that, it is by forming according to the ultra micro emulsion of any one in the claim 1～17.
19. an opthalmological carrier is characterized in that, it is by forming according to the ultra micro emulsion of any one in the claim 1～17.
20. according to any one ultra micro emulsion in the claim 1～17 in nursing, treatment and/or the cosmetic applications of makeup in skin, face and/or the scalp.
21. according to any one ultra micro emulsion in the claim 1～17 at hair conditioning and/or be the cosmetic applications of treatment in the hair.
22. the cosmetic method of a nursing and/or wet skin, mucosa and/or scalp is characterized in that, will be applied on skin, mucosa and/or the scalp according to the ultra micro emulsion of claim 1～17.
23. will be used for the treatment of application in the dermatosis compositions of dry skin in manufacturing according to the ultra micro emulsion of any one in the claim 1～17.
24. will be according to any one the application of ultra micro emulsion in making ophthalmic pharmaceutical compositions in the claim 1～17.
25. a method for preparing according to the ultra micro emulsion of any one in the claim 1～17, it comprises: with vigorous stirring water and oil phase are mixed under 10～80 ℃ of ambient temperatures, then 6 * 10 7Pa～18 * 10 7Make mixture homogenization under the pressure of Pa.
26. a method that requires according to aforesaid right is characterized in that the shearing scope is 2 * 10 6s -1～5 * 10 8s -1
CNB991261453A 1998-12-14 1999-12-13 Submicro emulsion based on sugar fatty ester and sugar fatty ether, and use thereof Expired - Lifetime CN1222275C (en)

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FR98/15765 1998-12-14

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EP1010413B1 (en) 2002-11-20
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ATE227967T1 (en) 2002-12-15
FR2787027B1 (en) 2001-01-12
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ES2188115T5 (en) 2011-03-10
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CN1222275C (en) 2005-10-12
EP1010413B2 (en) 2010-12-29

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