CN1254289A - Preventive or remedy for kidney diseases - Google Patents
Preventive or remedy for kidney diseases Download PDFInfo
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- CN1254289A CN1254289A CN97182168A CN97182168A CN1254289A CN 1254289 A CN1254289 A CN 1254289A CN 97182168 A CN97182168 A CN 97182168A CN 97182168 A CN97182168 A CN 97182168A CN 1254289 A CN1254289 A CN 1254289A
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- mushroom
- extract
- hydrophilic solvent
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Abstract
A preventive or remedy for kidney diseases containing as the active ingredient a mushroom extract obtained by using a hydrophilic solvent. The mushroom extract is efficaious in remarkably ameliorating or maintaining the renal functions of patients with renal failure, who have not been subjected to dialysis as yet, and can evade or extremely retard the subjection of patients with renal failure at a terminal stage to dialysis, which has been unavoidable heretofore.
Description
Technical field
The present invention relates to the prevention or the therapeutic agent of nephropathy, further detailed saying relates to the extract of mushroom in hydrophilic solvent as the prevention or the therapeutic agent of the carrying out property renal dysfunction of the nephropathy prevention of effective ingredient or therapeutic agent, the patients with renal failure of not dialysing or have the food that improves the renal function effect.
Prior art
Up to the present the absolute effectively medicine that does not also have to make the renal function of patients with renal failure in late period to be maintained or to recover, its present situation be only for the patient Therapeutic Method such as burden and dangerous very big dialysis or renal transplantation be only the method for continuity life.
On the other hand, suppress the effect that indole, methylindole etc. generate in the feces, use (spy opens flat 2-277456 number) so can be used as the smelly food of disappearing of deodorant, particularly feces because the extract of mushroom in hydrophilic solvent has.But, the extract of mushroom in hydrophilic solvent for improve renal dysfunction, particularly do not dialyse patients with renal failure carrying out property renal dysfunction effectively understanding also do not have fully.
Invention is described
The object of the present invention is to provide a kind of prevention or therapeutic agent of nephropathy.
Another object of the present invention is to provide a kind of prevention or therapeutic agent of carrying out property renal dysfunction of the patients with renal failure of not dialysing.
It is a kind of for treating or prevent not dialyse the effective food of carrying out property renal dysfunction of patients with renal failure that another object of the present invention also is to provide.
It is the beginning base therapy means, that can avoid or postpone patients with renal failure kidney dialysis in late period with the dietetic therapy that the present invention also provides a kind of, can play nephropathy prevention or the therapeutic agent, particularly food of relief effect to irreversible renal function forfeiture patient.
The invention provides a kind of is the nephropathy prevention or the therapeutic agent of effective ingredient with the extract of mushroom in hydrophilic solvent.
Another object of the present invention is to provide a kind of prevention or Therapeutic Method of nephropathy.
Another object of the present invention is to provide a kind of prevention or Therapeutic Method of the carrying out property renal dysfunction to the patients with renal failure of not dialysing.
It is the base therapy means with the dietetic therapy that the present invention also provides a kind of, can avoid or postpone the beginning of patients with renal failure kidney dialysis in late period, can play the nephropathy prevention or the Therapeutic Method of relief effect to irreversible renal function forfeiture patient.
The invention provides a kind of is the nephropathy prevention or the therapeutic agent of effective ingredient with the extract of mushroom in hydrophilic solvent.
The present invention also provides the method for a kind of nephropathy prevention or treatment, it is characterized in that being necessary that the patient who carries out nephropathy prevention or treatment throws and the extract of mushroom in hydrophilic solvent.The preferred forms of invention
In order to suppress the development of the renal dysfunction of patients with chronic renal failure in the past, present inventors, use for kreatinin in the intestinal to have adsorbent than high absorption capacity as Primary Care based on the dietetic therapy of low albumen high-energy.Renal function adopts 1/Cr value in the blood (inverse of kreatinin value in the serum, just low more as the low more renal function of this numerical value of index of renal function) to estimate, and generally this numerical value reaches below the 0.1dl/mg, just begins to dialyse.
Present inventors will pester extract in hydrophilic solvent when throwing patients with renal failure to not dialysis, find significantly to improve renal function that trend worsens surprisingly, avoid beginning dialysis therapy, finish the present invention based on these discoveries.
That is to say that the present invention relates to the extract of mushroom in hydrophilic solvent is the renal dysfunction prevention or the treatment food of effective ingredient.The invention still further relates to the extract of mushroom in hydrophilic solvent is the carrying out property renal dysfunction therapeutic agent of effective ingredient.
Below describe the present invention in detail.
The so-called patients with renal failure of not dialysing refers to the mesangium proliferative glomerulonephritis among the present invention, the hypertrophy membraneous nephritis, membraneous nephritis, lupus nephritis, chronic nephritiss such as diabetic nephropathy (disease) and glomerulosclerosis, nephrotic syndrome, do not accept the patient of dialysis treatment in the patients with renal failure such as renal ischaemia, the degree that mainly is meant carrying out property renal dysfunction is the 1/Cr value (inverse of serum creatinine value, renal function index)=below the above 0.5dl/mg of 0.1dl/mg, or CCr value (creatinine clearance, renal function index)=following patient of the above 70ml/min of 5ml/min.Particularly the above 0.3dl/mg of 1/Cr value=0.1dl/mg patients with renal failure in late period following or that the above 50ml/min of CCr value=5ml/min is following is preferred object.
Above-mentioned state is meant the state of beginning hemodialysis before treating, that is, though if also remaining have renal function to let matters drift will to lose the stage of renal function in a short time.In addition, even the patient in this stage accepts common dietetic therapy, by with extract and the usefulness of mushroom of the present invention in hydrophilic solvent, also can expect to obtain better effect.That is to say that extract direct or indirect kidney had an effect of mushroom in hydrophilic solvent has remarkable improvement or keep the effect of weak renal function.
The extract of mushroom in hydrophilic solvent opened in the flat 2-277456 communique (No. 08/107333, U.S. Patent application, No. the 0381055th, European patent) the spy and is documented.Mushroom itself is exactly a food, and its extract in hydrophilic solvent does not have toxicity.
The sporophore of mushroom is according to the difference at its maturity and position, and composition is also different.In order to obtain extract of the present invention, preferably select the growth time of mushroom fruitbody or according to position selective extraction method.
Reasons such as the mycelium in the compost also contains effective ingredient, and impurity still low owing to its extraction ratio, that brought by compost when extracting is many can not obtain being suitable for material for oral use.
Usually the material that to supply with edible mushroom fruitbody be the cap closure, just growing considers that from problems such as tones the present invention preferably uses the sporophore in this period.As using the position, can use the whole of sporophore, particularly the cap position is more effective.
From mushroom fruitbody effective component extracting the material that is in fresh state of brown stain preferably will not take place or in that period the material after freezing thinly slice, put into the extraction solvent of heat then immediately.Under the effect of oxidation of phenol enzyme, the mushroom that cuts is overstrike at short notice, causes the decomposition of effective ingredient.Soak into or spraying with the organic or inorganic acid solution more than 0.1% for this reason, can effectively prevent brown stain.
On the other hand, if the unfolded ripe mushroom of cap dipping 10 minutes～1 hour in cold water can extract effective ingredient from the mulberry spore that forms and pleat.Extracting solution begins to be darkviolet, if spend the night and will become clarifying liquid by coagulation sedimentation in cold place placement.Because the poor heat stability of this liquid is used behind the preferably freeze drying powdered.
Beyond dewatering, the extraction solvent can also use hydrophilic solvents such as methanol, ethanol, isopropyl alcohol and acetone or its mixed solvent, even for preferred especially water or the ethanol residual also out of question of edibility.The general extraction solvent that adds is preferably 2～10 times (weight ratios) of raw material.Make the occasion of water, more than 30 minutes, proper more than 2 hours in the time of 80 ℃ when extracting temperature and time and be more than 90 ℃.
With independent use alcohol or ketone extract phase ratio, the more preferably mixed solvent of alcohol or ketone and water.
In addition, can in solvent, add organic acid or sugar, at this moment can more effective extraction composition.
Organic acid optimization citric acid, malic acid, acetic acid, ascorbic acid.Preferably the addition with respect to solvent adds 0.05～2 weight %, makes it to reach the scope of pH3.0～5.0.
Sugar can use fructose, glucose, sucrose, maltose etc.Addition is proper at 0.5～5 weight %.At this moment by the effective ingredient of osmotic pressure in can more effective extraction sporophore cell wall.
In addition, also can in water, add cellulase or amylase 0.01～0.1 weight %, under 25 ℃～40 ℃ conditions, make it to react 24 hours, make cell wall or protein decompose the back and extract.In addition, will pester freezing after, if make it to thaw then organize (cell wall) destroyed, thus can high efficiency effective component extracting.
There is no particular limitation for the administering mode of extract of mushroom in hydrophilic solvent, but oral administration is the easiest.Dosage should be according to suitably increase and decrease such as patient's state, age, sex, but generally is 0.01～50g every day, and particularly 0.1～5g is proper, preferably continuous or discontinuous administration when observing the symptoms, and preferably the longest administration is 3 months.
The directly administration of the extract of mushroom in hydrophilic solvent also can be made various food, and for example food such as beverage, chewing gum, confection, tablet, soup, bean sauce soup, medicated porridge absorb.The concentration of the extract of the mushroom in this based food in hydrophilic solvent is not particularly limited, but in order to absorb above-mentioned 1 day intake 0.01～50g, particularly 0.1～5g, preferably is adjusted to suitable concentration.Industrial applicibility
The extract of mushroom of the present invention in hydrophilic solvent has remarkable improvement or keeps the not effect of the patients with renal failure renal function of dialysis, avoids inevitably the renal failure patients with terminal being transferred in the past adopting the dialysis process treatment to such an extent as to can postpone significantly.
Embodiment
The present invention is described by the following examples.
Production Example 1
Add the aqueous solution 20kg of malic acid 1 weight % in new fresh mushroom 10kg, 70 ℃ were extracted 70 minutes down.Extracting solution 20kg is concentrated 10 times, obtain the 2kg concentrated solution.In this 2kg concentrated solution, add dextrin 1.64kg, adopt spray drying method processing, obtain powder 1kg.These concentrate and powder are sold on market with the trade name of " champignon extractum " Champignon Extract (registered trade mark) by Ricom company.
Embodiment 1
The nephropathy prevention or the therapeutic agent that constitute by the extract (concentrate) of Production Example 1.
Embodiment 2
The nephropathy prevention or the therapeutic agent that constitute by the powder of Production Example 1.
Embodiment 3
After powder 1g, the whey calcium 0.2g of Production Example 1, dextrinosan 0.2g, cellulose 0.1g mixed, the health food that the granule packing is made.
Test example 1 (case 1)
The patient is 24 years old male, because mesangial proliferative glomerulonephritis causes chronic renal failure, concurrent hypertension." champignon extractum " when administration begins height be that 170cm, body weight are 65kg, CCr value=13.2ml/min, 1/Cr value=0.29dl/mg, be energy 2200kcal, protein 25 g with its dietary restrictions.
Make the powder of the oral Production Example 1 of this patient, 1g on the 1st, oral 3 months.(dl/mg) is as shown in table 1 for patients serum's CCr value (ml/min), 1/Cr value before and after the administration.
(table 1)
| (measuring day) | 1/Cr value (dl/mg) | CCr value (ml/min) | |
| Before administration begins | 117 days (8/6) | ????0.30 | ????19.6 |
| Before administration begins | 75 days (9/17) | ????0.28 | ????24.1 |
| Before administration begins | 5 days (11/26) | ????0.27 | ????13.0 |
| After administration begins | 23 days (12/24) | ????0.27 | ????13.3 |
| After administration begins | 75 days (2/14) | ????0.30 | ????16.7 |
| After administration begins | 93 days (3/4) | ????0.29 | Undetermined |
Give the extract of mushroom in hydrophilic solvent by throwing, the reduction that can stop the 1/Cr value as shown in table 1 makes the 1/Cr value maintain 0.30 level.Reduction to the CCr value also has improvement trend, preceding 8～12 weeks of administration are reduced to 13.0ml/min from 24.1ml/min, being equivalent to underspeed in every month is 5.5ml/min, rises to 16.7ml/min by 13.3ml/min after the administration, and being equivalent to had the 1.7ml/min of improvement in every month.
Test example 2 (case 2)
The patient is 40 years old women, because mesangial proliferative glomerulonephritis causes chronic renal failure, concurrent hypertension." champignon extractum " when administration begins height be that 161cm, body weight are 50kg, CCr value=6.9ml/min, 1/Cr value=0.19dl/mg, be energy 2100kcal, protein 25 g with its dietary restrictions.
Make the powder of the oral Production Example 1 of this patient, 1g on the 1st, oral 3 months.(dl/mg) is as shown in table 2 for patients serum's CCr value (ml/min), 1/Cr value before and after the administration.
(table 2)
| (measuring day) | 1/Cr value (dl/mg) | CCr value (ml/min) | |
| Before administration begins | 5 days (12/19) | ????0.19 | ????6.9 |
| Administration begins day | 0 day (12/24) | Undetermined | Undetermined |
| After administration begins | 16 days (1/9) | ????0.18 | ????7.5 |
| After administration begins | 28 days (2/6) | ????0.18 | ????7.9 |
| After administration begins | 56 days (3/6) | ????0.19 | Undetermined |
Give the extract of mushroom in hydrophilic solvent by throwing, after 1/Cr value as shown in table 2 maintains 0.18, rise to 0.19.The CCr value also rises to 7.9ml/min slightly.
Test example 3 (case 3)
The patient is 67 years old male, because nephrosclerosis causes chronic renal failure, concurrent hypertension." champignon extractum " when administration begins height be that 158cm, body weight are 54kg, CCr value=37.1ml/min, 1/Cr value=0.5dl/mg, be energy 2200kcal, albumen 50g with its dietary restrictions.
Make the powder of the oral Production Example 1 of this patient, 1g on the 1st, oral 3 months.(dl/mg) is as shown in table 3 for patients serum's CCr value (ml/min), 1/Cr value before and after the administration.
(table 3)
| (measuring day) | 1/Cr value (dl/mg) | CCr value (ml/min) | |
| Before administration begins | 116 days (8/24) | ????0.55 | Undetermined |
| Before administration begins | 74 days (11/7) | ????0.51 | ????30.9 |
| Administration begins day | 0 day (12/19) | ????0.52 | ????37.1 |
| After administration begins | 35 days (1/23) | ????0.59 | ????53.5 |
| After administration begins | 49 days (2/6) | ????0.58 | ????57.5 |
Give the extract of mushroom in hydrophilic solvent by throwing, after 1/Cr value as shown in table 3 rises to 0.59, maintain par.The CCr value significantly rose to 57.5ml/min after 49 days.
Suppress the reason of serum creatinine value rising and it is generally acknowledged two: (1) is by improving renal function, strengthen the discharge capacity of kreatinin, (2) minimizing by muscle, thereby reduce the growing amount of kreatinin, therebetween, because body weight does not reduce, can not think has muscle to reduce, so thereby can judge because the improvement of renal function has suppressed the rising of serum creatinine.
Claims (5)
1, with the extract of mushroom in hydrophilic solvent is the nephropathy prevention or the therapeutic agent of effective ingredient.
2, with the extract of mushroom in hydrophilic solvent be the prevention or the therapeutic agent of carrying out property renal dysfunction of the patients with renal failure of not dialysing of effective ingredient.
3, with the extract of mushroom in hydrophilic solvent be the nephropathy prevention or the treatment food of effective ingredient.
4, with the extract of mushroom in hydrophilic solvent be the prevention or the treatment food of carrying out property renal dysfunction of the patients with renal failure of not dialysing of effective ingredient.
5, be the food with renal function improvement effect of effective ingredient with the extract of mushroom in hydrophilic solvent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB971821682A CN1157222C (en) | 1997-04-04 | 1998-04-04 | Preventive or remedy for kidney diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB971821682A CN1157222C (en) | 1997-04-04 | 1998-04-04 | Preventive or remedy for kidney diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1254289A true CN1254289A (en) | 2000-05-24 |
| CN1157222C CN1157222C (en) | 2004-07-14 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB971821682A Expired - Lifetime CN1157222C (en) | 1997-04-04 | 1998-04-04 | Preventive or remedy for kidney diseases |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1157222C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1330671C (en) * | 2002-10-08 | 2007-08-08 | 株式会社利根 | Chitosan-containing polysaccharide, method for preparing the same and use thereof |
-
1998
- 1998-04-04 CN CNB971821682A patent/CN1157222C/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1330671C (en) * | 2002-10-08 | 2007-08-08 | 株式会社利根 | Chitosan-containing polysaccharide, method for preparing the same and use thereof |
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| Publication number | Publication date |
|---|---|
| CN1157222C (en) | 2004-07-14 |
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