CN1245205C - Chinese medicine for treating alimentary system malignant tumour - Google Patents

Abstract

The present invention belongs to traditional Chinese medicine for curing alimentary system malignant tumours, which mainly contains Chinese gooseberry root, oldenlandia, barbed skullcap herb, dysosma versipellis, coix seed, rhizoma, hawthorn, giant knotweed rhizome, etc. The medicine of the present invention has the advantages of less toxicity, good curative effect, convenient use, low expense and easy popularization.

Description

The Chinese medicine of treatment alimentary system malignant tumour

Technical field

The invention belongs to a kind of Chinese medicine for the treatment of alimentary system malignant tumour, for treatment hepatocarcinoma significant effect is arranged especially.

Background technology

Alimentary system malignant tumour is one of cancer of ecumenicity high incidence, high mortality, is example with primary hepatocarcinoma (abbreviation hepatocarcinoma), global New Development hepatocarcinoma 31.5 ten thousand in 1985, and 13.8 ten thousand in China, accounts for 43.7%.According to nineteen ninety-five Ministry of Public Health statistics, the PLC mortality rate occupies second of mortality of malignant tumors, and China's southeastern coast and the south of the River belong to the district occurred frequently.

The diagnosis of hepatocarcinoma at present is easier to relatively, and treatment does not but have breakthrough.Early stage small liver cancer excision, big hepatocarcinoma dwindle back second phase excision and have all obtained better curative effect, but only accounting for less than 20% of can perform the operation and excise, and recur in still having 60～80% 5 years behind the operative treatment.And the treatment beyond the operation comprises that curative effects such as interventional therapy, freezing, laser vaporization treatment are all undesirable.Liver cancer research institute of Shanghai medical university soup is encouraged formal plan academician report, palliative treatment 346 examples, and survival rate was respectively 17.1%, 9.0%, 4.6% in 3,5,10 years.Recently the boundling of Chu Xianing is huge can the cutter late result wait to observe.And radiotherapy merges the unresectable hepatocarcinoma of treatment by Chinese herbs, and survival rate reached 43% in 5 years, and curative effect is encouraging, so 70% liver cancer patient needs radiotherapy.

The liver cancer patient of China, 85% merges liver cirrhosis, causes liver that the lonizing radiation dosis tolerata is descended.The full liver dosis tolerata of normal liver is 30～35Gy, and the lethal dose of hepatocarcinoma usually needs more than the Dr60Gy, and the curative effect of hepatocarcinoma increases with the increase of radiotherapy dosage, and dosage is when being higher than Dr60Gy, the sickness rate of radiation hepatitis surpasses 48%, this complication has had a strong impact on the curative effect of hepatocarcinoma radiotherapy in case generation must stop radiotherapy.How solving hepatocarcinoma lethal dose height and the low contradiction of liver dosis tolerata, should improve curative effect and reduce again or prevent hepatic injury, is one of global problem of needing to be resolved hurrily of present hepatocarcinoma radiotherapy.

The clinical experimental research of Chinese medicine hepatocarcinoma, previously reported literature is more.Generally set forth one's views with spleen invigorating two aspects from soothing the liver.Facts have proved, the dialectical complexity of most hepatocarcinoma, stagnation of liver-QI and insufficiency of the spleen just two wherein more common aspects also usually are associated with wet (cold-damp or damp and hot), the stasis of blood (blood stasis due to qi deficiency or qi depression to blood stasis etc.), poison (fire-toxin, severe pathogenic cold, warm poison or stasis of blood poison etc.) etc. simultaneously.The marrow of Chinese traditional treatment hepatocarcinoma remains determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, but at present lacks strong single medicine, lacks also that prescription is precise and appropriate, the compound preparation of determined curative effect, safe ready.We think, make a breakthrough from clinical, must (comprise etiology and pathogenesis, rule of treatment method of treatment) theoretically earlier and innovate.

Summary of the invention

The square medicine of treatment alimentary system malignant tumour, particularly treating the liver cancer is constantly explored through clinical empirical summary for many years by my institute, through revising repeatedly and clinical verification, so far forms my the total offense I of institute's training preparation hepatopathy number (the having another name called side of disappearing).This prescription has the effect of invigorating the spleen for eliminating dampness, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, regulating QI to relieve pain.Experiment showed, that Chinese medicines such as Radix Actinidiae Chinensis, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Semen Coicis, Rhizoma Polygoni Cuspidati, Radix Sophorae Flavescentis have the effect of anticancer, Radix Astragali, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Semen Coicis etc. have the effect that improves immunity.Some medicine has effects such as antiviral, antibacterial, hepatoprotective.Through clinical verification, prove definite curative effect, and no side effects.Experimentation according to University Of Nanhua medicine institute of pharmacology proves that the external inhibition effect to hepatocarcinoma HepG2 cell strain of this medicine is better than 5-Fu.Acute toxicity testing LD50＞16ml/20g (16ml medicine natural juice/20g white mice body weight, down together).Have prescription novelty, safety non-toxic, determined curative effect, easy to use, expense is cheap, the advantage that is easy to promote.

The Chinese medicine of this treatment alimentary system malignant tumour, its prescription is:

Radix Actinidiae Chinensis 15～100g Herba Hedyotidis Diffusae 15～50g Herba Scutellariae Barbatae 15～50g Radix et Rhizoma Dysosmatis 15～50g

Semen Coicis 3-100g Rhizoma Paridis 10～30g Fructus Crataegi 10～50g Rhizoma Polygoni Cuspidati 10～50g

Attached with:

Rhizoma dioscoreae 3～100g Fructus Aurantii 5～20g Carapax Trionycis 10～30g Radix Astragali 10～100g

Endothelium Corneum Gigeriae Galli 10～30g Radix Curcumae 10～30 Radix Salviae Miltiorrhizaes 10～30g Rhizoma Alismatis 10～30g

Herba Artemisiae Scopariae 15～100g Radix Codonopsis 1～100g Rhizoma Atractylodis Macrocephalae 10～50g Poria 10～50g

Radix Bupleuri 10～30g Radix Paeoniae Alba 10～50g Radix Sophorae Flavescentis 15～30g Radix Glycyrrhizae 5～15g

The optimum formula of this Chinese medicine is:

Radix Actinidiae Chinensis 50g Herba Hedyotidis Diffusae 30g Herba Scutellariae Barbatae 30g Radix et Rhizoma Dysosmatis 15g

Semen Coicis 50g Rhizoma Paridis 15g Fructus Crataegi 15g Rhizoma Polygoni Cuspidati 30g

Rhizoma dioscoreae 30g Fructus Aurantii 10g Carapax Trionycis 20g Radix Astragali 50g

Endothelium Corneum Gigeriae Galli 15g Radix Curcumae 10g Radix Salviae Miltiorrhizae 15g Rhizoma Alismatis 10g

Herba Artemisiae Scopariae 50g Radix Codonopsis 30g Rhizoma Atractylodis Macrocephalae 20g Poria 20g

Radix Bupleuri 10g Radix Paeoniae Alba 30g Radix Sophorae Flavescentis 15g Radix Glycyrrhizae 5g

Manufacturing process technology routinely is formulated.

Heavy dose of Chinese medicine general attack therapy cooperates full liver to move bar radiotherapy advanced primary liver cancer clinical observation situation:

In order to inquire into the efficacy enhancing and toxicity reducing effect of combined radiotherapy treatment hepatocarcinoma of the present invention, do the comparative study of this random packet.All the patient is all through being diagnosed as primary hepatocarcinoma II or III phase.Be divided into the total offense I of radiotherapy+Chinese medicine hepatopathy number group (observation group's 21 examples) at random, matched group radiation alone (20 example), two groups of auxiliary treatment and radiotheraping method are identical, all adopt full liver moving strip iradiation, mid-plane dosage reaches Dr30Gy～40Gy, then or before this local irradiation 10～15Gy makes dose,tumor reach 50～55Gy.The result tentatively shows (observation group and matched group): alleviation fully, part are alleviated, stable 5,8,3 and 2,4,3 examples (P＜0.05) that are respectively, the AFP descender is 17/21 and 9/20 (P＜0.05), and Karnofsky scoring ascensionist is respectively 18/21 and 10/20 (P＜0.05).The annual rate 14/21 and 7/20 (P＜0.05) of depositing.Show that heavy dose of Chinese medicine general attack therapy cooperates radiotherapy can significantly improve patient's life quality, raising curative effect and the annual rate of depositing.

Take passages several routine model cases as follows below:

Example 1: revive certain, the man, the Hui ethnic group, married, 67 years old, Shaoyang City paper mill, Hunan retired worker.Because of abdominal distention, be admitted to hospital in upper abdominal pain June in 1995.6.2 day, leave hospital in 1996.6.27 day.

The patient is diagnosed as primary hepatocarcinoma (lobus sinister) massive type in provincial capital section hospital, and portal vein tumor thrombus is diagnosed as late period, and thinks through the consultation of doctors and only to live three months and come my institute's diagnosis and treatment.Cooperate full liver to move bar radiotherapy through taking this Chinese medicine, lump disappears after three months, follows up a case by regular visits to so far not recurrence, only feels slight abdominal distention, recovers work capacity.

Example 2: Huang, the man, Han nationality, married, 47 years old, Shaodong County, Hunan oxen and horses department coal miner.Because of upper right abdomen distending pain 1 year repeatedly, to be admitted to hospital in 1996.11.20,1997.1.14 day leaves hospital.

The patient once excised right hepatoncus because of primary hepatocarcinoma in provincial capital section hospital the second phase behind interventional therapy, and section turns out to be primary hepatocarcinoma.Postoperative hepatic region in March severe pain is diagnosed as recurrence in the liver and not treatment once more in former hospital through colored B ultrasonic and CT examination, and through this side for oral administration of my institute and radiotherapy, pain is ended after 1 week; Lump disappears after March, follows up a case by regular visits to and does not see recurrence so far, does not now have any symptom, recovers work capacity fully.

The specific embodiment

Prescription one:

Radix Actinidiae Chinensis 15g Herba Hedyotidis Diffusae 15g Herba Scutellariae Barbatae 15g Radix et Rhizoma Dysosmatis 15g

Semen Coicis 30g Rhizoma Paridis 10g Fructus Crataegi 10g Rhizoma Polygoni Cuspidati 10g

Rhizoma dioscoreae 30g Fructus Aurantii 5g Carapax Trionycis 10g Radix Astragali 10g

Endothelium Corneum Gigeriae Galli 10g Radix Curcumae 10g Radix Salviae Miltiorrhizae 10g Rhizoma Alismatis 10g

Herba Artemisiae Scopariae 15g Radix Codonopsis 10g Rhizoma Atractylodis Macrocephalae 10g Poria 10g

Radix Bupleuri 10g Radix Paeoniae Alba 10g Radix Sophorae Flavescentis 15g Radix Glycyrrhizae 5g

Prescription two:

Radix Actinidiae Chinensis 100g Herba Hedyotidis Diffusae 50g Herba Scutellariae Barbatae 50g Radix et Rhizoma Dysosmatis 50g

Semen Coicis 100g Rhizoma Paridis 30g Fructus Crataegi 50g Rhizoma Polygoni Cuspidati 50g

Rhizoma dioscoreae 100g Fructus Aurantii 20g Carapax Trionycis 30g Radix Astragali 100g

Endothelium Corneum Gigeriae Galli 30g Radix Curcumae 30g Radix Salviae Miltiorrhizae 30g Rhizoma Alismatis 30g

Herba Artemisiae Scopariae 100g Radix Codonopsis 100g Rhizoma Atractylodis Macrocephalae 50g Poria 50g

Radix Bupleuri 30g Radix Paeoniae Alba 50g Radix Sophorae Flavescentis 30g Radix Glycyrrhizae 15g

By prescription one or fill a prescription and two take by weighing above-mentioned Chinese medicine, technology preparation routinely again gives then that the patient is oral to get final product.1 dose/day, obey 2～3 times for every dose.

Claims (2)

1. Chinese medicine for the treatment of alimentary system malignant tumour is characterized in that this Chinese medicine made by following raw material medicaments:

Radix Actinidiae Chinensis 15～100g Herba Hedyotidis Diffusae 15～50g Herba Scutellariae Barbatae 15～50g Radix et Rhizoma Dysosmatis 15～50g

Semen Coicis 30～100g Rhizoma Paridis 10～30g Fructus Crataegi 10～50g Rhizoma Polygoni Cuspidati 10～50g

Rhizoma dioscoreae 30～100g Fructus Aurantii 5～20g Carapax Trionycis 10～30g Radix Astragali 10～100g

Endothelium Corneum Gigeriae Galli 10～30g Radix Curcumae 10～30g Radix Salviae Miltiorrhizae 10～30g Rhizoma Alismatis 10～30g

Herba Artemisiae Scopariae 15～100g Radix Codonopsis 10～100g Rhizoma Atractylodis Macrocephalae 10～50g Poria 10～50g

Radix Bupleuri 10～30g Radix Paeoniae Alba 10～50g Radix Sophorae Flavescentis 15～30g Radix Glycyrrhizae 5～15g.

2. the Chinese medicine of treatment alimentary system malignant tumour according to claim 1 is characterized in that this Chinese medicine made by following raw material:

Radix Actinidiae Chinensis 50g Herba Hedyotidis Diffusae 30g Herba Scutellariae Barbatae 30g Radix et Rhizoma Dysosmatis 15g

Semen Coicis 50g Rhizoma Paridis 15g Fructus Crataegi 15g Rhizoma Polygoni Cuspidati 30g

Rhizoma dioscoreae 30g Fructus Aurantii 10g Carapax Trionycis 20g Radix Astragali 50g

Endothelium Corneum Gigeriae Galli 15g Radix Curcumae 10g Radix Salviae Miltiorrhizae 15g Rhizoma Alismatis 10g

Herba Artemisiae Scopariae 50g Radix Codonopsis 30g Rhizoma Atractylodis Macrocephalae 20g Poria 20g

Radix Bupleuri 10g Radix Paeoniae Alba 30g Radix Sophorae Flavescentis 15g Radix Glycyrrhizae 5g.