CN1245169C - Memory and perception improving pure natural composite preparation and its preparing process - Google Patents
Memory and perception improving pure natural composite preparation and its preparing process Download PDFInfo
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Abstract
The present invention discloses a purely natural compound preparation which can enhance memory and improve cognition. The effective components of the present invention are composed of a huperzia serrata extract, a rhodiola rosea rxtract and concentrated fish oil, wherein the effective component of the huperzia serrata extract is huperzine A, and 50 mu g of huperzine A is contained in per unit of the preparation; the effective component of the sachalin hodiola rhizome extract is salidroside, and 1.5 mg of salidroside is contained in per unit of the preparation; the effective component of the concentrated fish oil is unsaturated fatty acid docosahexenoic acid (DHA), and the content of the DHA in per unit of the preparation is 50 mg. The present invention belongs to the field of health food and relevant fields. The present invention has the advantages that optimum compatibility is carried out aiming at a plurality of mechanisms, which is harmonious and consistent, the information transmission of synapsing relation between neurons is enhanced, antianti-hypoxia ability is enhanced, the structures of nerve cells are stabilized, and nutrient substances which are necessary by the normal structures of the nerve cells are provided.
Description
Technical field
The present invention relates to a kind of improving memory, improve cognitive pure natural compound formulation and preparation method thereof, especially refer to a kind of comprehensive cerebral function improvement that has, improve the brain vigor, replenish brain nutrition, improve the preparation method of pure natural compound formulation, its dosage form and this pure natural compound formulation of cognitive function, belong to health food and association area.
Background technology
Improving cognitive level is human constant pursuit.In the modern society, the rapid increase and the renewal of various information, a lot of people face the pressure of the knowledge learning that does not stop, and have the phenomenon of psychentonia, fatigue and brain overwork.Therefore, entire society exists cerebral function improvement, replenishes brain nutrition, improves cognitive requirement.
The source of brain function is the activity of cerebral neuron, and neuronic energy supplies with, the interaction of neurotransmitter between necessary nutrient and the neuron, has determined the vigor and the cognitive level of brain to a great extent.
1) capacity factor: the activity of neurocyte, extremely active, need lot of energy to supply with.Under the normal condition, carry oxygen, supplier soma by erythrocyte in the blood.The brain blood oxygen requirement that accounts for human body total amount 3-4% but accounts for about 20% of the total blood oxygen of human body amount.In some cases, as brain overwork, cause neuron to need lot of energy, the supply of blood oxygen lacks relatively.
2) neuronic trophic factor: neuronic activity also depends on stability of structure own.Wherein, provide neuronic growth and metabolism needed nutrient substance, keeping the stable of cell membrane is the effectively active basis of performance of neuron.
3) neurotransmitter factor: get in touch by synapse between the neuron, and neurotransmitter, be active between synapse " courier ", acetylcholine (ACh) has different types as a kind of neurotransmitter, extensively be present in the central nervous system peripheral nervous system of unifying, presynaptic membrane discharges, and acts on postsynaptic membrane, transmission information, play a part key, loss of activity by acetylcholinesterase (AChE) metabolism of synaptic space.Discover that now nervous system type acetylcholine mediator reduces and to be the key that intelligence reduces, and is the most remarkable with cerebral cortex and hippocampus, the decline of going down with acetylcholine function of nervous system of learning and memory ability has direct relation.A large amount of basic test and clinical observations show that neuronal nicotinic type acetylcholine is relevant with attention, memory, learning capacity and other cognitive process.
Therefore, how can effectively strengthen neuronic anti-anoxia ability, how can effectively keep the stable of neuron formation itself, how can effectively increase connecting each other between neuron and the neuron, be to keep the vigorous most critical aspect of neuronal function.Health product and medicine that a lot of brain boosting and supplementings has been arranged on the domestic and international market at present, but the overwhelming majority exists curative effect unreliable or act on single defective.Supplementing the brain health product main component in the market can be divided into several big classes: 1) vitamin, microelement kind, and as gold partner,, this series products needs although can replenishing human body to a certain extent, can not play real brain boosting and supplementing effect; 2) replenish brain nutrition class (lecithin, cephalin, bathypelagic fish wet goods), as various fish oil goods etc., act on singlely, effect is little; 3) pure Chinese patent medicine class (gingko leaf preparation, red sage formulation etc.), as ANSHEN BUNAO YE, brain-invigorating capsule, nourishing brain pill etc., composition is single, and effect is limited; 4) (its chemical name is Mei Letongning to the melatonin class, and as melatonin etc., present medical research has very big dispute for the effect of its brain boosting and supplementing; 5) even contain the composition that promotes central nervous excitation in the product that has, eat up and feel very excited, occur the very pure and fresh sensation of brain for the moment, but be not truly " supplementing the brain ".Therefore, this series products generally has certain exaggerative, untrue words, exists science not strong, and sustainable development is poor.
Summary of the invention
The objective of the invention is to utilize the modern medicine new development, suitable compatible combination, collaborative playing a role, provide one can comprehensive additional brain nutrition at a plurality of links, improve brain function, improve the pure natural compound formulation of cognitive function.
Another object of the present invention is to provide the preparation method of this pure natural preparation.
For achieving the above object, the present invention is by the following technical solutions:
A kind of improving memory, the cognitive pure natural compound formulation of improvement, its effective ingredient is made up of Huperziaserrata extract, Radix Rhodiolae extract and fish oil concentrated, wherein:
The per unit dosage form contains Huperziaserrata extract 0.5mg, and effective ingredient is a huperzine A, and content is 50 μ g;
The per unit dosage form contains Radix Rhodiolae extract 150mg, and effective ingredient is a rhodioside, and content is 1.5mg;
The per unit dosage form contains fish oil concentrated 200mg, and effective ingredient is unsaturated fatty acid docosahexenoic acid (DHA), and DHA content is 50mg in the per unit preparation.
Reasonable recipe of the present invention, definite effect, significantly, can cerebral function improvement, improve cognitive competence, existing being explained as follows to each effective ingredient:
1) Huperziaserrata extract: traditional Chinese herbal medicine Herba Lycopodii serrati, be commonly called as Herba Lycopodii serrati, since the eighties, chemistry and the pharmacological action to Herba Lycopodii serrati both at home and abroad studies in great detail, confirms the effective ingredient that extracts from Herba Lycopodii serrati
Huperzine A is a kind of selectivity AChE inhibitor, can suppress to reversibility the nervous system type acetylcholinesterase between the synapse, thereby indirect raising nervous system type levels of acetylcholine, accelerate the contact between the neuron, and long action time, avirulence.If animal experiment shows that huperzine A can significantly improve the study of animal, memory is consolidated and the memory represents effect, reverses anoxia, galvanic shock, eastern Liang the dysmnesia that alkali treatment causes.Clinical trial observe to show (at random, double blinding, placebo), and effect is remarkable, does not have tangible ill effect.
2) Radix Rhodiolae is the wild plant that is grown in highland and severe cold areas.Its growing environment is extremely abominable, has very strong vitality and special adaptability.The dry root or the rhizome of rhodiola Crassulaceae plant Radix Rhodiolae, discovered in recent years has significant resisting fatigue, oxygen lack resistant function.Show that according to modern pharmacological research its rhizome mainly contains rhodioloside and glycoside unit thereof, in addition, also contain compositions such as the protein tertiary alcohol, oxalic acid, citric acid.Oxygen lack resistant function is arranged: have the expert that 34 kinds of medicines are screened, find that its oxygen lack resistant function is the most remarkable, can increase cerebral tissue, avoid occurring a series of injury responses that cell hypoxia causes to anoxybiotic tolerance.Thereby play the effect of neuroprotective unit.Antifatigue effect: rhodiola rosea formulated product has antifatigue effect, can prevent and treat the energy metabolism disorder, makes hypofunction and the depleted original metabolic activity of organized renewing, improves the content of ribonucleic acid and promotes the synthetic of adenosine triphosphate.But Radix Rhodiolae resisting fatigue and activation central nervous system.In addition, the external clinical trial of doing shows, feeling of fatigue alleviates behind the oral Radix Rhodiolae of trial volunteer, impermanent memory power improves, and attention is concentrated.The prompting Radix Rhodiolae truly has brain-strengthening, improves memory impairments.At home and abroad, there is single composition product of multiple Radix Rhodiolae extract to sell.
3) DHA (docosahexaenoic acid is and omega-2 fatty acid, docosahexenoic acid) belongs to essential fatty acid, owing to itself can not synthesize, need depend on extraneous absorption.DHA is vital for neural growth, be to constitute the neuronal cell film, synapse position particularly, it also is mitochondrial component part, the growth formation of nerve conduction and synapse and function are kept significant, extend, form in the brain cell projection netted, organize density to play crucial effect.DHA lacks performances such as can causing learning difficulty, absent minded, hypomnesis, and therefore, DHA though do not take effect immediately, has comprehensive, long-range, stable effect as functional health food, is the nutrient of needed by human.Existing market has the fish oil micro-capsule raw material to sell, and can be mixed with dosage forms such as capsule, oral liquid, powder.
Cerebral function improvement provided by the invention, the cognitive pure natural compound formulation of improvement add the galenic pharmacy acceptable auxiliary on the basis of above-mentioned effective ingredient, make various peroral dosage forms, for example capsule, oral liquid and tablet etc.
The preparation method of the pure natural compound formulation of a kind of cerebral function improvement, improvement cognition may further comprise the steps: 1) get the raw materials ready: according to above-mentioned ratio each effective ingredient of ormal weight is added the adjuvant (starch, dextrin, cane sugar powder, essence, magnesium carbonate, magnesium stearate etc.) of the described galenic pharmacy acceptance of appropriate amount of auxiliary materials, abundant mixing; 2) granulate; 3) oven dry; 4) sterilization; 5) packing gets final product.
Creativeness of the present invention is the innovation of compatibility, at a plurality of mechanism, and optimum compatibility, harmonious, can be comprehensively from many aspects supplementing the brain, brain-strengthening.Omnibearing provide improve cerebral blood supply, improve anti-anoxia ability, stablize neurocyte structure, the information transmission of the synaptic contact between the necessary nutrient substance of neurocyte normal configuration, the enhancing neuron is provided.Raw material of the present invention all comes from natural extract, utilize the medical science progress in forward position, traditional medicine is carried out new elaboration, scientific strong, basic research and clinical practice confirm not have obvious toxic and side effects, have edible attribute, do not have the taboo of compatibility between each composition, do not have mutual ill effect.
The invention has the beneficial effects as follows: 1) increase getting in touch between neuron and the synapse, thereby can comprehensively improve cognitive function, can improve school grade.2) oxygen lack resistant function can alleviate the neuronic damage under the anoxia condition and improve survival rate.3) have antioxidant action, can prevent and remove the formation of free radical and lipid epoxide.4) Nutrition of brain: replenish the necessary nutrient substance of nervous system development, and stable neurocyte structure.
The invention will be further described below in conjunction with the specific embodiment, and the replacement that is equal to of all this areas of doing according to content disclosed by the invention all belongs to protection scope of the present invention.
The specific embodiment
Embodiment 1, a kind of cerebral function improvement, the cognitive glue of improvement are assisted
To produce 1000 capsule is example, and raw material is commercially available, abides by Chinese Pharmacopoeia standard in 2000 and carries out:
One, preparation method:
Huperziaserrata extract 0.5g (huperzine A content 10%, HPLC method); Radix Rhodiolae extract 150g (rhodioside content is 1%, the HPLC method); Fish oil concentrated 200g (DHA/EPA content is 40%, and its ratio is 2.5: 1), DHA content is 50mg in the per unit preparation; Add the appropriate amount of starch mixing; Granulate; Oven dry; Encapsulated behind the high temperature sterilize.
Two, specification: the per unit dosage form contains effective composition: huperzine A 50 μ g; Rhodioside 1.5mg; Unsaturated fatty acid docosahexenoic acid (DHA) 50mg.
Three, be suitable for the crowd:
This prescription is applicable to brain overwork crowd, learning difficulty crowd and examination crowd.Although (there is no evidence that the present invention has adverse influence for pregnancy period, breast-feeding female, in view of this class crowd is in special period, careful consideration, not exemplary application)
Four, instructions of taking: every day, the 1-2 unit formulation was taken.
Embodiment 2, clinical observation
One, research purpose: observe the present invention and whether have the cognitive level of improvement, improve the brain function, the effect of hypermnesis.
Two, materials and methods
1, subjects: the object of observation has 46 people, comes from certain middle school healthy population, and the age is at 16-19 between year, male 26 people, women 20 people.Purpose to this observation is carried out man-to-man detailed explanation to family members, teacher and student, adopts the principle of voluntariness.
2, include standard in: (1) school grade is relatively poor, is low middling in class.(2) learning difficulty, readme are ready to be unsatisfied with study but understand memory, and attention is disperseed easily.(3) impassivity, mental symptom or sign do not have other various organic, metabolics, toxic encephalopthy and depression.(3) tried the previous moon and do not taken other types brain-strengthening medicine.
3, experimental technique: all objects are by being divided into treatment group and matched group at random, test group 24 people, and matched group 22 people, WMS does not have significant difference (seeing Table 1) between two groups.
This test method is own control research.
4, medication: adopt single at random blind method administration, test group is taken sample (capsule formulation is adopted in this observation), and matched group is taken and sample dosage form, outward appearance, the identical placebo of packing.Usage is every day 1 time, and each 1,30 days courses of treatment.
5, content measurement: (1) adopts WAIS-RC (WAIS-RC) skeleton symbol four unifications of revisions such as the Gong Yao of Hunan Medical University elder generation, is divided into first, second two formulas, and first formula and second formula are adopted in detection respectively before and after the treatment.Mainly comprise linguistic IQ (VIQ), PIQ (PIQ) and total three aspects of IQ (FIQ).(2) (Wechsler memory scale WMS), is divided into first, second two formulas to the Wechsler Memory Scale that adopts the Gong Yao of Hunan Medical University elder generation etc. to revise, and WMS first formula and second formula are adopted in detection respectively before and after the treatment.Mainly comprise long term memory test, short term memory test, immediate memory test.All tests have trained neurosurgeon to finish.
Simultaneously, if uncomfortable reaction has been set up the mode of contact at any time, and has been given itemized record.
6, statistical method: adopt own control and placebo to analyze, all data are all with self paired t-test analysis.
Three, result
Finish experimenter 46 people.Find no untoward reaction.
1. cognitive function evaluation: test before and after test group and matched group WAIS-RC scoring show that test group VIQ, PIQ and total IQ FIQ all are significantly improved.(table 1).Has statistical significance.And matched group VIQ, PIQ, FIQ significantly do not improve.
Table 1: test before and after test group and matched group WAIS-RC scoring comparison (x ± s).
| Project | Before the test | After the test | Difference | The P value | |
| Test group (n=24) | VIQ PIQ | 99.22±8.76 96.19±10.20 | 109.43±10.45 107.35±7.87 | 10.21±9.43 11.16±9.56 | ＜0.01 ＜0.01 |
| FIQ | 98.93±9.57 | 108.42±8.63 | 11.49±9.77 | ＜0.01 | |
| Matched group (n=22) | VIQ | 98.41±9.33 | 99.32±11.54 | 0.91±8.78 | ＞0.05 |
| PIQ | 99.21±11.14 | 100.64±9.32 | 1.43±10.16 | ＞0.05 | |
| FIQ | 99.65±7.12 | 99.42±9.45 | 0.23±7.76 | ＞0.05 |
1, memory function evaluation:
1) test group and each subtest scale score of matched group and memory quotient (MQ) before the test, there are no significant for comparing difference.(table 2) illustrates that respectively to organize memory level be isostatic before the test.
Table 2: test group and each subtest scale score of matched group and MQ are relatively before the test.
| Project | Test group (n=24) | Matched group (n=22) | Difference | The P value |
| 1 → 100 re-recognizes vision regeneration associative learning tactile memory understanding memory along several 100 → 1 inverse numeral accumulation pictures memory visions recites digital MQ | 7.11±3.12 11.98±3.33 10.35±2.52 10.51±2.02 9.79±2.56 10.08±2.62 10.78±2.30 10.77±3.50 12.74±3.09 8.77±2.54 92.66±6.51 | 7.70±3.00 12.27±2.80 10.72±2.04 9.82±2.27 9.62±2.68 10.55±2.45 10.98±2.65 10.44±3.51 12.50±3.27 8.63±2.21 92.84±5.98 | 0.59±2.23 0.29±2.45 0.37±1.34 0.69±1.36 0.16±2.09 0.47±2.14 0.20±2.19 0.33±2.11 0.24±1.12 0.13±1.44 0.24±3.48 | ＞0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05 |
2) before and after the test group test each minute meter divide and MQ relatively (seeing Table 3), except that 100-1 inverse and tactile memory and test front and back zero difference, before all the other each subtest tables branches and MQ all were higher than test, statistics had significant difference.Show this test product for the mankind in short-term and the immediate memory effect that all has clear improvement.
Table 3: each subtest scale score and MQ are relatively before and after the test group.n＝24
| Project | Before the test | After the test | Difference | The P value |
| 1 → 100 re-recognizes vision regeneration associative learning tactile memory understanding memory along several 100 → 1 inverse numeral accumulation pictures memory visions recites digital MQ | 7.11±3.12 11.98±3.33 10.35±2.52 10.51±2.02 9.79±2.56 10.08±2.62 10.78±2.30 10.77±3.50 12.74±3.09 8.77±2.54 92.66±6.51 | 10.61±2.77 12.44±2.76 12.82±2.12 13.91±1.27 11.92±2.42 11.45±2.36 12.18±2.02 11.31±2.46 15.37±1.04 10.89±1.82 106.22±7.21 | 3.50±2.32 0.46±2.50 2.47±1.42 3.40±1.18 2.13±2.21 1.37±2.32 1.40±1.62 0.54±2.47 2.63±1.98 2.12±1.50 14.44±4.66 | ＜0.01 ＞0.05 ＜0.01 ＜0.01 ＜0.01 ＜0.01 ＜0.01 ＞0.05 ＜0.01 ＜0.01 ＜0.01 |
3) each subtest scale score and MQ compare (seeing Table 4) before and after the matched group test, except that the picture memory is significantly improved (effect that has transfer learning and psychological hint is arranged), and all the other each subtest scales and the equal zero difference of MQ.
Table 4: each subtest scale score and MQ are relatively before and after the matched group.n＝22
| Project | Before the test | After the test | Difference | The P value |
| 1 → 100 re-recognizes vision regeneration associative learning tactile memory understanding memory along several 100 → 1 inverse numeral accumulation pictures memory visions recites digital MQ | 7.70±3.00 12.27±2.80 10.72±2.04 9.82±2.27 9.62±2.68 10.55±2.45 10.98±2.65 10.44±3.51 12.50±3.27 8.63±2.21 92.84±5.98 | 8.11±2.52 11.98±2.13 10.75±2.20 11.51±2.02 9.79±2.56 10.88±2.62 10.90±2.22 10.77±2.50 12.74±3.09 8.77±2.54 94.79±6.51 | 0.41±2.17 0.29±1.61 0.07±2.18 1.78±1.98 0.17±2.23 0.33±1.98 0.08±2.04 0.33±2.78 0.24±2.18 0.14±1.33 1.95±3.53 | ＞0.05 ＞0.05 ＞0.05 ＜0.01 ＞0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05 |
4) table 5 shows the comparison of test group and treatment of control group each subtest scale score difference of front and back and MQ difference.As can be seen, relatively there were significant differences between most subtests and MQ increment than matched group for test group.
Table 5: the MQ increment relatively before and after test group and the matched group test
| Project | Test group (n=24) | Matched group (n=22) | Difference | The P value |
| 1 → 100 re-recognizes vision regeneration associative learning tactile memory understanding memory along several 100 → 1 inverse numeral accumulation pictures memory visions recites digital MQ | 3.50±2.32 0.46±2.50 2.47±1.42 3.40±1.18 2.13±2.21 1.37±2.32 1.40±1.62 0.54±2.47 2.63±1.98 2.12±1.50 14.44±4.66 | 0.41±2.17 0.29±1.61 0.07±2.18 1.78±1.98 0.17±2.23 0.33±1.98 0.08±2.04 0.33±2.78 0.24±2.18 0.14±1.33 1.95±3.53 | 3.09±2.16 0.17±1.73 2.40±1.44 1.62±1.41 1.96±2.18 1.04±2.02 1.32±1.74 1.41±2.05 2.39±1.64 1.98±1.07 12.49±4.14 | ＜0.01 ＞0.05 ＜0.01 ＜0.01 ＜0.01 ＜0.01 ＜0.01 ＞0.05 ＜0.01 ＜0.01 ＜0.01 |
Four, discuss:
Cognitive function is the topmost Premium Features of brain, WAIS-RC (WAIS-RC) can comprehensively be measured cognitive function, being with Webster memory capacitance (WMS) is classical instrument in the world, table reliability, validity is satisfied, has obtained using widely in clinical position.General international standard is adopted in this test, and intelligence scale and memory scale are measured simultaneously, are used for estimating overall cognitive function and memory, and be with a high credibility.
The present invention is a compound preparation that comprises natural components such as Huperziaserrata extract, Radix Rhodiolae extract and DHA, because each composition has reliably and the mechanism through confirming, wherein, the extract of Herba Lycopodii serrati, huperzine A can improve the synaptic contact between the neuron; Radix Rhodiolae extract is brought into play significant resisting fatigue, oxygen lack resistant function; DHA can replenish the crucial nutrition of nervous system development.Show that by result of the test in the human trial level, test group can be improved cognitive function, improving memory significantly; And safe, there is not untoward reaction.
Therefore, the present invention confirms rational compatibility in clinical level, at a plurality of links, breaks through the effect limitation of each single composition, can play a role comprehensively and effectively, plays a kind of improving memory, improves cognitive brain boosting and supplementing effect.
Claims (4)
1, a kind of improving memory, the cognitive pure natural compound formulation of improvement, it is characterized in that: its effective ingredient is made up of Huperziaserrata extract, Radix Rhodiolae extract and fish oil concentrated, wherein:
The per unit dosage form contains Huperziaserrata extract 0.5mg, and effective ingredient is a huperzine A, and content is 50 μ g;
The per unit dosage form contains Radix Rhodiolae extract 150mg, and effective ingredient is a rhodioside, and content is 1.5mg;
The per unit dosage form contains fish oil concentrated 200mg, and effective ingredient is the unsaturated fatty acid docosahexenoic acid, and content is 50mg in the per unit preparation.
2, a kind of improving memory according to claim 1, the cognitive pure natural compound formulation of improvement, it is characterized in that: described preparation is a peroral dosage form, comprises capsule, oral liquid and tablet.
3, the preparation method of the pure natural compound formulation of a kind of improving memory, improvement cognition is characterized in that this method comprises the steps:
1) gets the raw materials ready: according to the described prescription of claim 1 each composition of ormal weight is added the adjuvant that an amount of galenic pharmacy is accepted, fully mixing;
2) granulate; 3) oven dry; 4) sterilization; 5) packing gets final product.
4, the preparation method of the pure natural compound formulation of a kind of improving memory according to claim 3, improvement cognition, it is characterized in that: the adjuvant that described galenic pharmacy is accepted comprises one or more in starch, dextrin, cane sugar powder, essence, magnesium carbonate, the magnesium stearate.
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