CN1243008A - Tag oral liquor and preparation method - Google Patents

Abstract

The present invention relates to an aconite accessory tuber oral liquor and its preparation method. It includes the following steps: extracting the Chinese medicine aconite accessory tuber for 1-5 hr. at normal pressure by adding 4-8 times 30%-90% ethyl alcohol, filtering the obtained extract, concentrating until its relative density is 1.10-1.20, adding water to dilute until its relative density is 1.01-1.10, heating to above 100 deg.C and retaining its internal pressure 0.01-0.20 MPa, degrading for 0.5-3 hr, concentrating until its relative density is 1.10-1.20, adding ethyl alcohol to make alcohol precipitation and making the alcohol content be 60-80%, standing still, filtering, recovering ethyl alcohol, using distilled water to regulate until its alkaloid content is greater than or equal to 0.35 mg/ml, filling and sterilizing to obtain the invented produt.

Description

Aconite oral liquor and preparation method thereof

The present invention relates to a kind of preparation method of Chinese patent medicine preparation, be specifically related to a kind of preparation method of Radix Aconiti Lateralis Preparata liquid.

Radix Aconiti Lateralis Preparata is the lateral root by Ranunculaceae aconitum plant Aconitum carmichjaelii Debx., concocts through processing to form.Can help heart-yang to promote blood circulation on this medicine, middle warming the spleen is with strong fortune, and following kidney-replenishing is the supporing yang key medicine of warming the interior with the benefit fire.But because the Radix Aconiti Lateralis Preparata tool is very toxic, though commercially available Radix Aconiti Lateralis Preparata still need decoct through long-time before taking through concocting, careless slightly or improper use still can cause poisoning, even dead.With regard to the outstanding problem that clinical use Radix Aconiti Lateralis Preparata exists, Yunan Baiyao Industry Co., Ltd. discloses " a kind of aconite oral liquor and preparation method thereof " (publication number: CN1137402A, open day: on December 11st, 1996) first.It is to be raw material with the Radix Aconiti Lateralis Preparata, decocts through adding water heating pressurization, and extracting solution is through coarse filtration, and essence is filtered, and extracts repeatedly; With the filtrate concentrating under reduced pressure, add ethanol and carry out precipitate with ethanol, leave standstill, to filter, operations such as packing sterilization are made.The chemical constituent that causes poisoning in the Radix Aconiti Lateralis Preparata can be removed effectively, the therapeutic efficiency that Radix Aconiti Lateralis Preparata had can be kept again simultaneously.Can be directly used in clinical decoction prescription, exempt the trouble of simmering medicine and eradicated the hidden danger of poisoning, take safety, convenient, therapeutic effect is obvious.Finding that through after a while production practices this technology also exists some significantly not enough, mainly is during with a large amount of medical material of this PROCESS FOR TREATMENT, needs band to press and extracts, and operating has certain danger; Moreover during with flooding easily with the invalid components in the medical material, for example: materials soluble in water such as starch, saccharide propose together, handle inert matter to subsequent handling and make troubles.At above-mentioned weak point, the scientific research personnel has carried out research and discovery in depth, and prior art is reformed and innovated.

The objective of the invention is to provide a kind of improved aconite oral liquor and preparation method thereof, and it can make technology more reasonable, operates saferly, and can keep the quality of aconite oral liquor and the stability of curative effect effectively.

The object of the present invention is achieved like this:

1. get Radix Aconiti Lateralis Preparata, add 4～8 times 30%～90% ethanol, under normal pressure, extracted 1～5 hour, extracting liquid filtering, being concentrated into relative density is 1.10～1.20;

2. thin up to relative density is 1.01～1.10, is heated to more than 100 ℃, is pressed in the maintenance under 0.01～0.20 MPa condition, degrades 0.5～3 hour;

3. feed liquid is concentrated into relative density 1.10～1.20, adds the ethanol precipitate with ethanol, makes that to contain the alcohol amount be 60～80%, leaves standstill, and filters;

4. clear liquid is adjusted to alkaloid more than or equal to 0.35 mg/ml with distilled water after reclaiming ethanol, sterilizes after packing, promptly gets the aconite oral liquor finished product.

Compared with prior art, the present invention has two outstanding advantages:

1, adopts ethanol effective component extracting under normal pressure, a small amount of extract that will obtain from a large amount of medical materials is degraded under 0.05～0.20 MPa pressure, avoided prior art to a large amount of medical material pressurised extraction, need press the problem of extracting with the bulk container band, can raise labour productivity like this, reduce the danger when producing;

2, adopt ethanol extraction, can fully extract effective alkaloid, when avoiding prior art to adopt flooding materials such as the invalid components starch in the medical material, saccharide are proposed together, reduced the trouble of handling inert matter effectively.

Instructions of taking of the present invention is: oral, and the 10-20 milliliter of being grown up a time, 1-3 time on the one.Application notice: anemia of pregnant woman's forbidding, should not use together with the Rhizoma Pinelliae, Fructus Trichosanthis, Bulbus Fritillariae Uninbracteatae, the Pseudobulbus Bletillae (Rhizoma Bletillae).

The present invention has removed the chemical constituent that causes poisoning in the Radix Aconiti Lateralis Preparata effectively owing to adopted rational processing method, shows through acute toxicity testing and long term toxicity test: with Coming-of-Age Day 200 times of dosage, through the mouse stomach administration, do not see any untoward reaction.Then with low dosage, middle dosage, high dose respectively to the continuous gastric infusion of rat 60 days, sign, outward appearance, behavior, body weight, the heart, liver, spleen, lung, kidney of its test rat there is no untoward reaction.Equal no significant difference between check pathological section administration group (comprising various dose) and the matched group.

The present invention had both removed the chemical constituent that causes poisoning effectively, the therapeutic efficiency that simultaneously can keep Radix Aconiti Lateralis Preparata well again and had.Prove through pharmacodynamic experiment, medicine of the present invention has tangible positive inotropic action, can obviously strengthen guinea pig in vitro papillary muscles shrinkage factor, obviously strengthen normal anaesthetized guinea pig and heart failure guinea pig left ventricular pressure and ventricular pressure climbing speed, obvious cardiotonic is arranged, and this and the traditional Chinese medical science are used for " recuperating depleted YANG and rescuing the patient from collapse " and coincide mutually.In addition, medicine of the present invention can obviously suppress formaldehyde, rat foot claw swelling due to the Ovum Gallus domesticus album, this with in the arthralgia of medical Radix Aconiti Lateralis Preparata treatment anemofrigid-damp arthralgia conform to.

The clinical use result of the present invention shows, adopts the product of " alcohol extracting method " to have excellent curative equally.

1, Radix Aconiti Lateralis Preparata liquid of the present invention has promoting the flow of QI in the collateral by warming the meridian, recuperating depleted YANG and rescuing the patient from collapse, and it is kidney-yang supporing yang to mend the gate of vitality, the function of the cold-damp of dispeling the wind numbness is used for the YANG-depletion collapse, the cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, diseases such as arthralgia due to cold-dampnes, taking convenience, safety, have no side effect, curative effect is reliable, total effective rate 93%;

2, can be directly used in clinical decoction prescription, exempt the trouble of simmering medicine and eradicated the hidden danger of poisoning, safety, convenient;

3, can take separately, directly be blended in meat soup or the vegetable soup and take.

Embodiment 1:

1. get Radix Aconiti Lateralis Preparata, add 50% ethanol of 4 times of weight, normal pressure extracted 4 hours down, and extracting solution extracts under the similarity condition three times after filtration repeatedly; Be that it is 1.20 that filtrate is concentrated into relative density under 60 ℃ the condition in temperature;

2. add water adjustment dilution relative density to 1.05 in runny plaste, be heated to 100 ℃, pressurization degraded 3 hours is pressed in 0.15 MPa in the maintenance;

3. feed liquid is concentrated into relative density 1.10, adds the ethanol precipitate with ethanol, and making it contain the alcohol amount is 70%, leaves standstill, and filters;

4. after reclaiming ethanol, be adjusted to alkaloid more than or equal to 0.35 mg/ml, after packing, sterilize, promptly get the aconite oral liquor finished product with distilled water.

Embodiment 2:

1. get Radix Aconiti Lateralis Preparata, add 70% ethanol of 6 times of weight, normal pressure extracted 3 hours down, and extracting solution extracts under the similarity condition three times after filtration repeatedly; Be that it is 1.15 that filtrate is concentrated into relative density under 70 ℃ the condition in temperature;

2. add water and adjust relative density to 1.02 in runny plaste, be heated to 105 ℃, pressurization degraded 2 hours is pressed in 0.18 MPa in the maintenance;

3. feed liquid is concentrated into relative density 1.15, adds the ethanol precipitate with ethanol, and making it contain the alcohol amount is 80%, leaves standstill, and filters;

4. after reclaiming ethanol, be adjusted to alkaloid more than or equal to 0.35 mg/ml, after packing, sterilize, promptly get the aconite oral liquor finished product with distilled water.

Embodiment 3:

1. get Radix Aconiti Lateralis Preparata, add 80% ethanol of 8 times of weight, normal pressure extracted 2 hours down, and extracting solution extracts under the similarity condition three times after filtration repeatedly; Be that it is 1.25 that filtrate is concentrated into relative density under 55 ℃ the condition in temperature;

2. thin up is adjusted relative density to 1.10 in runny plaste, is heated to 110 ℃, and pressurization degraded 1 hour is pressed in 0.02 MPa in the maintenance;

3. feed liquid is concentrated into relative density 1.12, adds the ethanol precipitate with ethanol, and making it contain the alcohol amount is 60%, leaves standstill, and filters;

4. after reclaiming ethanol, be adjusted to alkaloid more than or equal to 0.35 mg/ml, after packing, sterilize, promptly get the aconite oral liquor finished product with distilled water.

Claims (1)

1, a kind of simple prescription preparation is characterized in that with the Radix Aconiti Lateralis Preparata being the oral liquid that raw material is made according to following method:

1. get Radix Aconiti Lateralis Preparata, add 4～8 times 30%～90% ethanol, under normal pressure, extracted 1～5 hour, extracting liquid filtering, being concentrated into relative density is 1.10～1.20;

2. thin up to relative density is 1.01～1.10, is heated to more than 100 ℃, is pressed in the maintenance under 0.01～0.20 MPa condition, degrades 0.5～3 hour;

3. feed liquid is concentrated into relative density 1.10～1.20, adds the ethanol precipitate with ethanol, makes that to contain the alcohol amount be 60～80%, leaves standstill, and filters;

4. clear liquid is adjusted to alkaloid more than or equal to 0.35 mg/ml with distilled water after reclaiming ethanol, sterilizes after packing, promptly gets the aconite oral liquor finished product.