CN1241569A - Extraction process of artemisia oil from Arteannuine liquid - Google Patents
Extraction process of artemisia oil from Arteannuine liquid Download PDFInfo
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- CN1241569A CN1241569A CN 99114834 CN99114834A CN1241569A CN 1241569 A CN1241569 A CN 1241569A CN 99114834 CN99114834 CN 99114834 CN 99114834 A CN99114834 A CN 99114834A CN 1241569 A CN1241569 A CN 1241569A
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- mother liquor
- artemisinin
- oil
- liquor
- herba artemisiae
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The extraction process includes following technological steps: extraction of Arteannuine and Arteannuine mother liquid from artemisia apiacea; mixing the Arteannuine mother liquid and water in the volume ratio of 1 to 0.8-1, heating to distil in distiller and collecting the 55-99 deg.c fraction; and dewatering the collected component liquid with waterless sodium sulfate to obtain artemisia oil.
Description
The present invention is relevant with the utilization of extracting the remaining mother liquor of Artemisinin institute from the former plant of sweet wormwood, and is especially relevant with the method for extraction Herba Artemisiae Annuae oil from mother liquor.
Sweet wormwood is one of conventional Chinese medicine, and is except that anti-malarial, also effective in cure to the treatment chronic tracheitis.The existing method of extracting Herba Artemisiae Annuae oil from sweet wormwood is to carry out steam distillation after sweet wormwood is pulverized, and the distillation rate is 0.2～0.25%, gets Herba Artemisiae Annuae oil behind anhydrous sodium sulfate dehydration.This kind method is not considered the comprehensive utilization to sweet wormwood, and is big to the waste of resource, the production cost height.And the residue mother liquor that extracts the Artemisinin generation from sweet wormwood is difficult to handle as waste.
The purpose of this invention is to provide a kind of utilize resources synthetically, the extracting method of the Herba Artemisiae Annuae oil that production cost is low.
Another purpose of the present invention provide a kind of from the former plant of sweet wormwood, extract Artemisinin extract the method for Herba Artemisiae Annuae oil in the remaining mother liquor.
The present invention is achieved in that
The method of from the Artemisinin mother liquor, extracting Herba Artemisiae Annuae oil of the present invention, processing step is as follows:
(1) the sweet wormwood crude drug is extracted Artemisinin and extracts the Artemisinin mother liquor.
(2) contain Artemisinin mother liquor and water in the distiller of band refrigerating unit in following ratio:
Artemisinin mother liquor: water=1: 0.8-1, V/V
(3) heat distiller with naked light, collect 55-99 ℃ of boiling range component,
(4) distillating liquid of collecting is obtained Herba Artemisiae Annuae oil with anhydrous sodium sulfate dehydration.
The production method of Artemisinin mother liquor of the present invention is as follows:
(1) the sweet wormwood crude drug is added organic solvent sherwood oil (6
#Oil) lixiviate gets vat liquor,
(2) vat liquor is adsorbed with effective constituent at chromatography column, reclaims effluent liquid,
(3) effluent liquid is reclaimed solvent and gets mother liquor (I),
(4) chromatography column is added eluent (vinyl acetate between to for plastic: 6
#Oil=6: 94V/V) get elutriant,
(5) with the elutriant condensing crystal, crystal solution is filtered to get filtrate and Artemisinin recrystallization product,
(6) filtrate is reclaimed behind the solvent mother liquor (II),
(7) mother liquor (I) and mother liquor (II) mixing are promptly got the Artemisinin mother liquor.
The present invention collects the Artemisinin mother liquor from each procedure of the former plant extract Artemisinin of sweet wormwood, utilize that mother liquor and contained volatile oil thereof and water are mutually insoluble not to chemically react yet, volatile oil can distill the characteristic that is not destroyed with water, adopts common water to heat up in a steamer the steaming method and extract Herba Artemisiae Annuae oil from the Artemisinin mother liquor.The steam stagnation pressure of mother liquor and water resulting mixture equals each component saturation vapour pressure (being dividing potential drop) sum under this temperature.The dividing potential drop of component and molecular weight product are bigger, and then this component is distilled out the more.Altogether during the water distillation, because water and volatile organic matter (Herba Artemisiae Annuae oil) are relatively, molecular weight is much smaller, and therefore, Herba Artemisiae Annuae oil can be lower than the temperature explosive evaporatoin of its boiling point, thereby causes decomposition, the yield height because of high temperature when having avoided Herba Artemisiae Annuae oil to distill separately.Utilize resources synthetically of the present invention is turned waste into wealth, and production cost is low.
Following is accompanying drawing of the present invention.
Fig. 1 is a process flow sheet of the present invention.
Following is embodiments of the invention:
Extract Artemisinin and Artemisinin mother liquor:
From sweet wormwood, extract sweet wormwood and have three kinds of methods
The industrial naptha method, rare pure method and acetone column chromatography
Industrial naptha method main technique step is as follows:
Sweet wormwood crude drug+sherwood oil (No. 6 oil) lixiviate gets vat liquor, and vat liquor enters chromatography column (silica gel) and is adsorbed with effective constituent (Artemisinin and part volatile oil), reclaims the solvent in the effluent liquid, and residual solution is mother liquor I.With chromatography column with eluent (composition: acetic acid second vinegar: No. 6 oil=6: 94V/V) wash-out, the elutriant condensing crystal is got the Artemisinin crystal, residual solution is mother liquor II.
Mother liquor is principal component:
Qinghaosu III, volatilization wet goods composition
Proportion 0.89～0.95
At room temperature be the thickness congealed solid that brownish black has the sweet wormwood peat-reek.
Embodiment 1:
The extraction of Herba Artemisiae Annuae oil
Take by weighing Artemisinin mother liquor (Herba Artemisiae annuae has been extracted the resistates behind the Artemisinin) 0.5kg, put into the 2000ml side-tube flask, add 500ml water afterwards, add several φ 5～8mm glass spheres again, insert 0～150 ℃ of mercurythermometer, load onto water cooler, and open condensation cycle water.
The electric furnace heating treats that a bottle interior mixture becomes mixing liquid at a certain warm area, after the boiling, collects 55～99 ℃ boiling range product, through anhydrous sodium sulfate dehydration.
Receive 150ml (Artemisinin mother liquor Herba Artemisiae Annuae oil)
Proportion (d
20 20) 0.872
Refractive index (n
20 D) 1.3923
Embodiment 2:
Take by weighing Artemisinin mother liquor 450g and put into the side-tube flask that 2000ml is with water cooler, add water 600ml, press embodiment 1 operation.
Receive the 135ml Herba Artemisiae Annuae oil, recovery rate is 30%
Refractive index (D
20 D) 1.4232
Claims (2)
1, a kind of method of extracting Herba Artemisiae Annuae oil from the Artemisinin mother liquor, processing step is as follows: V/V
(1) the sweet wormwood crude drug is extracted Artemisinin and extracts the Artemisinin mother liquor.
(2) contain Artemisinin mother liquor and water in the distiller of band refrigerating unit in following ratio:
The Artemisinin mother liquor: water=1: 0.8-1,
(3) heat distiller with naked light, collect 55-99 ℃ of boiling range component,
(4) distillating liquid of collecting is obtained Herba Artemisiae Annuae oil with anhydrous sodium sulfate dehydration.
2, method according to claim 1 is characterized in that the extracting method of Artemisinin mother liquor is as follows:
(1) the sweet wormwood crude drug is added the lixiviate of organic solvent sherwood oil and gets vat liquor,
(2) vat liquor is adsorbed with effective constituent at chromatography column (silicic acid), reclaims effluent liquid,
(3) effluent liquid is reclaimed solvent and gets mother liquor (I),
(4) chromatography column is added eluent (vinyl acetic monomer: 6
#Oil=6: 94V/V) get elutriant,
(5) with the elutriant condensing crystal, crystal solution is filtered to get filtrate and Artemisinin recrystallization product,
(6) filtrate is reclaimed behind the solvent mother liquor (II),
(7) mother liquor (I) and mother liquor (II) mixing are promptly got the Artemisinin mother liquor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99114834 CN1241569A (en) | 1999-04-30 | 1999-04-30 | Extraction process of artemisia oil from Arteannuine liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99114834 CN1241569A (en) | 1999-04-30 | 1999-04-30 | Extraction process of artemisia oil from Arteannuine liquid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1241569A true CN1241569A (en) | 2000-01-19 |
Family
ID=5277870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 99114834 Pending CN1241569A (en) | 1999-04-30 | 1999-04-30 | Extraction process of artemisia oil from Arteannuine liquid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1241569A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006051987A1 (en) * | 2004-11-15 | 2006-05-18 | Periodock, Co., Ltd. | Novel drug for inhibiting estrogen-dependent diseases, prostaglandin d (pgd)-dependent gynecological diseases, immunological diseases, cancer and angiogenesis |
| CN102517152A (en) * | 2011-11-14 | 2012-06-27 | 牛江林 | Method for extracting artemisia annua oil and artemisia annua dew from artemisia annua |
| CN102702220A (en) * | 2012-07-10 | 2012-10-03 | 刘志强 | Method for extracting arteannuic acid from artemisinin crystallization mother liquor |
| CN105886166A (en) * | 2016-04-22 | 2016-08-24 | 四川蓝伯特生物科技有限责任公司 | Artemisia annua wax handmade soap and production method thereof |
| CN113304180A (en) * | 2021-05-28 | 2021-08-27 | 禹州市天源生物科技有限公司 | Artemisia oil pet antibacterial spray and preparation method thereof |
-
1999
- 1999-04-30 CN CN 99114834 patent/CN1241569A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006051987A1 (en) * | 2004-11-15 | 2006-05-18 | Periodock, Co., Ltd. | Novel drug for inhibiting estrogen-dependent diseases, prostaglandin d (pgd)-dependent gynecological diseases, immunological diseases, cancer and angiogenesis |
| JPWO2006051987A1 (en) * | 2004-11-15 | 2008-05-29 | 株式会社ピリオドック | Estrogen-dependent diseases, prostaglandin D (PGD) -dependent gynecological diseases, immune diseases, cancer, and novel pharmaceuticals for inhibiting angiogenesis |
| CN102517152A (en) * | 2011-11-14 | 2012-06-27 | 牛江林 | Method for extracting artemisia annua oil and artemisia annua dew from artemisia annua |
| CN102702220A (en) * | 2012-07-10 | 2012-10-03 | 刘志强 | Method for extracting arteannuic acid from artemisinin crystallization mother liquor |
| CN102702220B (en) * | 2012-07-10 | 2013-07-31 | 刘志强 | Method for extracting arteannuic acid from artemisinin crystallization mother liquor |
| CN105886166A (en) * | 2016-04-22 | 2016-08-24 | 四川蓝伯特生物科技有限责任公司 | Artemisia annua wax handmade soap and production method thereof |
| CN105886166B (en) * | 2016-04-22 | 2019-05-07 | 四川蓝伯特生物科技股份有限公司 | A kind of sweet wormwood wax Manual perfumed soap and preparation method thereof |
| CN113304180A (en) * | 2021-05-28 | 2021-08-27 | 禹州市天源生物科技有限公司 | Artemisia oil pet antibacterial spray and preparation method thereof |
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