CN1239671A - Medicine for treating trachitis and asthma and its preparation - Google Patents
Medicine for treating trachitis and asthma and its preparation Download PDFInfo
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Abstract
The medicine is prepared by using Cordate houttuynia, Inula Japanica, Radix Platycodi, Stemora japonica, orange peel and other eight kinds of Chinese medicinal materials. During the preparation, each Chinese medicine material is extracted separately through crushing, steam process or ethanol process based on the different characteristics, and the extracts are ocncentrated, dried, compounded in certain proportion and pelletized into pellet. The present invention has unique recipe and preparation process as well as obvious curative effect.
Description
The present invention relates to a kind of medicine for the treatment of tracheitis, asthma.More particularly relating to the Chinese herbal medicine is the Chinese patent medicine of feedstock production, the invention still further relates to the preparation method of this medicine.
Tracheitis, asthma are a kind of very obstinate chronic disease and commonly encountered diseases, young child is to old old man, and sickness rate is all than higher, some in addition lost work and self care ability, not only bring very big misery, also cause very big burden simultaneously to family to patient.
At present, Western medicine is adopted in the treatment of this disease more both at home and abroad, as aminophylline, disappear and cough peaceful or cut sieve etc., just the clothes curative effect is better, but because tracheitis, asthma are a kind of often repeatedly chronic diseases, patient body is stronger to the Western medicine Drug resistance, so take to strengthen the way disease controlling of dosage clinically, some is because of the Drug resistance reason, both made strengthened dosage also difficulty obtain effect, simultaneously because the toxic and side effects of Western medicine is bigger, complication is many, makes numerous patients be difficult to take.Existing Chinese medicine is little with respect to the Western medicine side effect, a little less than the Drug resistance, but dose is big, onset is too slow, and very little to the asthma curative effect.For this reason, the applicant once proposed No. 97105840.7 patent applications to Patent Office of the People's Republic of China, with in, Western medicine is in conjunction with capsule, pill or the tablet medicine made, but because Western medicine effect duration is short and exist side effect, and the medicine of taking is dust composition, drug loading is little, poor stability, owing to multi-flavor medicine in the prescription contains Saponin bottleneck throat there is stimulation in addition, can promote expectoration, and capsule, tablet and pill are to send into gastric with instant water, and medicine does not have directly with throat and contacts, thereby makes the expectoration effect can not obtain bigger performance.
One of purpose of the present invention provides a kind of good stability, and drug loading is big, and the relieving cough and resolving phlegm effect is the treatment tracheitis of pure Chinese medicine, the therapeutic agent of asthma preferably all.
Another object of the present invention provides the preparation method of the therapeutic agent of this tracheitis, asthma.
Purpose of the present invention can realize by following measure:
Medicine of the present invention is made by following component: (consumption is a weight portion)
Herba Houttuyniae 2～15 Rhizoma Cynanchi Stauntoniis 1～10
Flos Inulae 1～12 Radix Glycyrrhizae 2～15
Radix Platycodonis 0.5～10 Radix Peucedani 3～10
The Radix Stemonae 0.5～10 Gecko 1～10
Pericarpium Citri Reticulatae 1～10 Bulbus Fritillariae Cirrhosae 0.5～10
Flos Farfarae 2～15 Lignum Aquilariae Resinatum 0.3～2
Semen Armeniacae Amarum (parched) 1～10
Formula optimization weight (part) ratio range of preparation medicine of the present invention is:
Herba Houttuyniae 6～10 Rhizoma Cynanchi Stauntoniis 5～8
Flos Inulae 6～10 Radix Glycyrrhizaes 5～8
Radix Platycodonis 2～8 Radix Peucedanis 4～8
The Radix Stemonae 2～8 Geckos 3～6
Pericarpium Citri Reticulatae 3～6 Bulbus Fritillariae Cirrhosaes 3～6
Flos Farfarae 5～8 Lignum Aquilariae Resinatum 0.5～1
Semen Armeniacae Amarum (parched) 3～8
Medicine optimum weight of the present invention (part) proportioning is:
Herba Houttuyniae 8 Rhizoma Cynanchi Stauntoniis 7
Flos Inulae 8 Radix Glycyrrhizaes 7
Radix Platycodonis 7.5 Radix Peucedanis 6
The Radix Stemonae 7.5 Geckos 5
Pericarpium Citri Reticulatae 5 Bulbus Fritillariae Cirrhosae 5
Flos Farfarae 6 Lignum Aquilariae Resinatum 0.8
Semen Armeniacae Amarum (parched) 6
Above-mentioned each component is made medicine production method of the present invention is:
(1) Radix Glycyrrhizae of getting Pericarpium Citri Reticulatae, herba houttuyniae, Lignum Aquilariae Resinatum and being ground into coarse powder adds entry, water vapour distillation volatile oil;
(2) will decoct with water extraction after the medicinal residues merging behind Radix Peucedani, Radix Platycodonis, Rhizoma Cynanchi Stauntonii, Flos Farfarae, Flos Inulae, Gecko and (1) the middle extraction volatile oil, add Semen Armeniacae Amarum (parched) in the decoction, discard residue, the aqueous solution that extracts in extracting solution and (1) behind the volatile oil merges, after concentrated as clear paste (I);
(3) get Bulbus Fritillariae Cirrhosae, the Radix Stemonae is ground into coarse powder, extracts with Diluted Alcohol solution, discards residue, extracting solution concentrates the back as clear paste (II);
(4) get the volatile oil in (1), add cycloheptaamylose and Diluted Alcohol solution and grind to form pastel, after 40 ℃ of following dryings, processing powder is broken into the fine powder (III) of 120 order fineness;
(5) clear paste (I) and clear paste (II) are merged, behind concentrate drying, be ground into 120 order fineness, add adjuvant and wetting agent and make granule, by adding powder (III) mixing and drying, make granule again.
Method of the present invention also can realize by following measure:
Described decoct with water to extract be divided into twice, add 10～14 times of water gagings for the first time, extracted 90～150 minutes; For the second time add 6～10 times of water gagings, add Semen Armeniacae Amarum (parched) again, extracted 90～150 minutes, then merge extractive liquid.
Foregoing adjuvant is the mixture of Icing Sugar and dextrin, and mixing ratio is controlled to be 1: 1 usually; Described wetting agent is the alcoholic solution that adopts greater than 80%.
Learn by experiment: decocting boils number of times the extraction of enoxolone is had the greatest impact, and secondly is granularity; The decocting time of boiling has the greatest impact to the extraction of amygdalin, prolongs with decocting time, and the extracted amount of amygdalin is gradually few; The Bulbus Fritillariae Cirrhosae and the Radix Stemonae are to the extraction of total alkaloids, and alcohol extracting method is better than water extraction, and percolation is better than circumfluence method, through being better than of pulverizing without pulverizing.In addition, determining alcohol is also bigger to the influence of extracting the result;
Radix Glycyrrhizae is a monarch drug this side, has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, and the effect of expelling phlegm for arresting cough, its antiasthmatic-antitussive and expectorant active component are glycyrrhizic acid (enoxolone).Semen Armeniacae Amarum (parched) has the effect of sending down the abnormal ascending QI relieving cough and asthma, decomposes after its contained amygdalin enters gastrointestinal tract, discharges the hydrocyanic acid of trace, has antitussive action preferably.The total alkaloids of the Bulbus Fritillariae Cirrhosae and the Radix Stemonae has tangible antitussive effect.Radix Platycodonis has lung qi dispersing, sore-throat relieving, expectorant effect, and its active component Saponin class has direct stimulation to oral cavity, bottleneck throat mucosa, promotes expectoration.Pericarpium Citri Reticulatae has the effect of regulating qi-flowing for strengthening spleen drying dampness to eliminate phlegm, and its contained hesperidin has the spasm effect of removing smooth muscle, and contained volatile oil has the zest phlegm-dispelling functions.
The present invention has that dispersing and descending lung-QI, invigorating the spleen for eliminating dampness eliminate the phlegm, the function of the kidney warming improving inspiration by invigorating kidney-QI Dingchuan.Be used for bronchial asthma, chronic bronchitis belongs to insufficiency of the spleen abundant expectoration, suffer from a deficiency of the kidney do not fall due to asthma rale chest distress, dyspnea with rapid respiration and cough and moving then asthma exhale inhale to wait disease less more.Specifically have following advantage:
1, the present invention is a pure Chinese medicinal preparation, and long shelf-life utilizes the comprehensive function of the Chinese medicine of respectively distinguishing the flavor of to treat tracheitis, asthma, can take for a long time, and nontoxic and without any side effects to human body.
2, the present invention has stimulation owing to multi-flavor medicine in the prescription contains Saponin to bottleneck throat, can promote expectoration effectively, drug administration volume of the present invention is big, and is long time of contact with bottleneck throat, with capsule, pill and tablet are compared the effect that more can bring into play medicine.
3, the present invention can replace all and be used for the treatment of such sick Western medicine and other Chinese medicine or Chinese patent medicine.
4, through extracting the granule of forming behind the active component that more can bring into play its therapeutical effect, drug loading is big by the pure Chinese crude drug of 13 flavors for medicine of the present invention, and it is high and rapid-action to take concentration, need not decoct taking convenience, the good stability of medicine.
Instructions of taking: boiled water is taken after mixing it with water.5 grams/time, day clothes 2 times, 10 days is a course of treatment.
The present invention herbal pharmacology experimental center of state approval has carried out drug effect and toxicity test, and the result is as follows: be subjected to the reagent thing: medicine of the present invention---self-control; Antitussive and antiasthmatic syrup---Harbin No.2 Traditional Chinese Pharmacetical Plant makes.
1, medicine antitussive action experimental result of the present invention:
Table 1, medicine of the present invention cause the influence of cough to mice strong aqua ammonia nebulization
| Group | Number of animals (only) | ?EDT?50 | R value % |
| The heavy dose of group of medicine of the present invention (7.4g/kg) medicine small dose group of the present invention (3.7g/kg) positive drug group (4.3g/kg) ordinary water group | ????9 ????10 ????10 ????10 | ??33.03 ??22.59 ??26.76 ??16.44 | ???200.9 ???137.4 ???162.77 |
The result shows: medicine small dose group of the present invention has antitussive action, and heavy dose of group has significant antitussive action, and its effect is better than the positive drug group.
2, medicine antiasthmatic effect result of the test of the present invention
Table 2, medicine of the present invention draw the influence of breathing heavily to the Cavia porcellus acetylcholine
| Group | Number of animals (only) | Translate into the time (S) |
| The heavy dose of group of invention medicine (7.4g/kg) medicine small dose group of the present invention (3.7g/kg) positive drug group ordinary water group | ????8 ????7 ????8 ????8 | ???76.6±15.73 ???66.6±16.83 ???63.6±22.70 ???54.2±19.71 |
The result shows: the heavy dose of group of medicine of the present invention has stronger antiasthmatic effect, has compared significant statistical significance in the ordinary water group.
3, medicine phlegm-dispelling functions result of the test table 3. of the present invention medicine of the present invention is to the influence of rabbit isolated tracheal cilium slime flux operation (x ± S)
| Group | Number of animals (only) | Running time (S) |
| The heavy dose of group of medicine of the present invention (7.4g/kg) medicine small dose group of the present invention (3.7g/kg) positive drug group (4.3g/kg) ordinary water group | ????4 ????5 ????5 ????5 | ????23.00±0.00 ????29.00±15.55 ????37.50±8.20 ????260.00±50.62 |
The result shows: the large and small dosage group of medicine of the present invention is compared the statistical significance that highly significant is arranged with the ordinary water group, P＜0.001.
4, medicine antiinflammatory action result of the test of the present invention
Table 4. medicine of the present invention is to the bullate influence of rat cotton balls bud
| Group | Number of animals (only) | Running time (S) |
| The heavy dose of group of medicine of the present invention (7.4g/kg) medicine small dose group of the present invention (3.7g/kg) positive drug group (4.3g/kg) ordinary water group | ????7 ????7 ????8 ????7 | ??28.26±6.61 ??32.80±6.56 ??35.44±8.45 ??43.17±8.78 |
The result shows: the large and small dosage group of medicine of the present invention all can suppress the generation of cotton balls granulation, and heavy dose of group is compared P＜0.01 with the ordinary water group.
Table 5. medicine of the present invention is to the influence of rat thoracic cavity leukoplania
| Group | Number of animals (only) | Running time (S) |
| The heavy dose of group of medicine of the present invention (7.4g/kg) medicine small dose group of the present invention (3.7g/kg) positive drug group (4.3g/kg) ordinary water group | ????8 ????8 ????9 ????8 | ???19.00±8.98 ???21.58±11.67 ???22.50±12.53 ???47.90±20.90 |
The result shows: the heavy dose of group of medicine of the present invention has been compared significant difference with the normal saline group, P＜0.01.Table 6. medicine of the present invention is to the influence of mouse peritoneal capillary permeability
| Group | Number of animals (only) | Running time (S) |
| The heavy dose of group of medicine of the present invention (7.4g/kg) medicine small dose group of the present invention (3.7g/kg) positive drug group (4.3g/kg) ordinary water group | ????10 ????10 ????9 ????10 | ????0.236±0.071 ????0.242±0.084 ????0.350±0.168 ????0.525±0.197 |
The result shows: the large and small dosage group of medicine of the present invention is compared with the normal saline group, the difference of highly significant is all arranged, P＜0.001; Compare P＜0.05 with the positive drug group.
5, medicine bacteriostasis result of the test of the present invention
Table 7. medicine of the present invention is to the bacteriostasis of golden Portugal bacterium
| Group | Concentration g/ml | Gold Portugal bacteria growing amount |
| The heavy dose of group of medicine of the present invention (7.4g/kg) medicine small dose group of the present invention (3.7g/kg) positive drug group (4.3g/kg) ordinary water group | ????0.078 ????0.039 ????0.020 ????0.010 | Do not have a small amount of a large amount of |
The result shows: medicine of the present invention has bacteriostasis to golden Portugal bacterium, and its minimum inhibitory concentration is 0.039g/mL.
Medicine long term toxicity test of the present invention is as follows:
Get 120 of rats, body weight 180 ± 10g divides 4 groups.
Be 50.4g/kg for the heavy dose of group of medicine of the present invention, be equivalent to 68.1 times of the clinical consumption of people;
To dosage group in the medicine of the present invention is 25.2g/kg, is equivalent to 34.0 times of the clinical consumption of people;
Giving medicine small dose group of the present invention is 0.74g/kg, is equivalent to the clinical consumption of people;
Blank group (ordinary water group)
Be 40 days observing time, every morning is irritated stomach once, irritating stomach dosage is the 4ML/200 gram, in administration 20 days, 40 days blood drawing routines respectively, leukocyte differential count is looked into liver, renal function, weighs, finished other inspection in 40 days in administration, the animal of execution 2/3rds, the perusal digestive system, no any unusual, core, liver, lung, kidney, spleen, adrenal gland, stomach, ovary, uterus, testis, brain weigh, design factor is also done the pathology inspection, and important organ is not had obvious influence, and drug withdrawal is after 15 days, repeat above-mentioned internal organs inspection, also all find no unusual.
Preparation method of the present invention comprises extracts active ingredient and preparation of granules: extracting method is divided into three parts, promptly extracts and water extraction with 70% ethanol percolate extraction, volatile oil.Wherein, because Bulbus Fritillariae Cirrhosae is identical with Radix Stemonae extraction conditions, extract with the Diluted Alcohol percolation together so merge; During water extraction, because it is best that Radix Glycyrrhizae need be extracted 3 effects, other medical materials need extract 2 times, be extraction effect and the simplification production technology that guarantees Radix Glycyrrhizae, the spy at first extracts volatile oil with Pericarpium Citri Reticulatae, Herba Houttuyniae, Lignum Aquilariae Resinatum mixing and water adding with Radix Glycyrrhizae, collect volatile oil and extracting solution, medicinal residues together extract 2 times with other medical materials again and get final product, again because the amygdalin in the Semen Armeniacae Amarum is soluble in water, extract and once can obtain effect preferably, therefore, determine that adding Semen Armeniacae Amarum in other mixed medicinal material extract again after once together extracts.
Aspect the preparation of granule, have difficulties with common granule method for making (clear paste adds adjuvant system soft material, makes granule again), the present invention designs and earlier the extracting solution concentrate drying is become dry extract, adds the particulate technology of adjuvant system again.Adjuvant is selected dextrin and Icing Sugar, proportioning with 1: 1 for well, this proportioning can make the pellet hardness that makes moderate, and is both not too hard, can not cause loose yet and fine powder more, and be easy to granulation.In addition, selecting the alcoholic solution greater than 80% is wetting agent, and when determining alcohol was too low, the system soft material was too sticking, is difficult to granulate.
Embodiment:
Take by weighing raw material (kilogram) by following proportioning:
Herba Houttuyniae 6.5 Rhizoma Cynanchi Stauntoniis 2
Flos Inulae 3 Radix Glycyrrhizaes 6.5
Radix Platycodonis 2 Radix Peucedanis 8
The Radix Stemonae 2 a red-spotted lizards 8
Pericarpium Citri Reticulatae 4 Bulbus Fritillariae Cirrhosaes 3
Flos Farfarae 6.5 Lignum Aquilariae Resinatum 1
Semen Armeniacae Amarum (parched) 1.5
Production method is as follows:
Radix Glycyrrhizae, Bulbus Fritillariae Cirrhosae, Radix Stemonae pulverize separately are become 10 order fineness.
Get Pericarpium Citri Reticulatae, Herba Houttuyniae, Lignum Aquilariae Resinatum, Radix Glycyrrhizae and add water, steam distillation extracted 4 hours, volatile oil and extract volatile oil after aqueous solution; Medicinal residues behind the extraction volatile oil and Radix Peucedani, Radix Platycodonis, Rhizoma Cynanchi Stauntonii, Flos Farfarae, Flos Inulae, Gecko merge and add 12 times of water gagings, water boiling and extraction 2 hours, and then add 8 times of water gagings and Semen Armeniacae Amarum (parched), water boiling and extraction 2 hours, merge extractive liquid, also merges with the aqueous solution that extracts behind the volatile oil, and being evaporated to relative density is the clear paste (I) of 1.35 (55 ℃).Get Bulbus Fritillariae Cirrhosae then, the Radix Stemonae adds 70% alcoholic solution, the percolation of pressing in the nineteen ninety-five version pharmacopeia appendix extracts, dip time is 12 hours, percolation speed is 0.75ml/min, the amount of accepting percolate is the 1750ML of medical material amount (volume and a weight ratio), the percolate decompression recycling ethanol, and be concentrated into the clear paste (II) that relative density is 1.35 (55 ℃).Get volatile oil again, add the cycloheptaamylose of 10 times of amounts and 20% ethanol liquid of 2～4 times of amounts, on colloid mill, ground 20 minutes, collect pastel, colloid mill washes with low amounts of water, flushing thing and pastel merge, with dry under 30 ℃ of temperature regimes, then pulverize the fine powder (III) of 120 order fineness, at last clear paste (I) and clear paste (II) are merged, mixing, drying under reduced pressure also is ground into 120 purpose fine powders, add adjuvant that 1: 1 an amount of Icing Sugar and dextrin mix and 90% alcoholic solution again, make granule, add fine powder (III) mixing and drying at last, make granule of the present invention.
Claims (6)
1, a kind of medicine for the treatment of tracheitis, asthma is characterized in that it is the granule of being made by the following weight proportion raw material
Herba Houttuyniae 2～15 Rhizoma Cynanchi Stauntoniis 1～10
Flos Inulae 1～12 Radix Glycyrrhizae 2～15
Radix Platycodonis 0.5～10 Radix Peucedani 3～10
The Radix Stemonae 0.5～10 Gecko 1～10
Pericarpium Citri Reticulatae 1～10 Bulbus Fritillariae Cirrhosae 0.5～10
Flos Farfarae 2～15 Lignum Aquilariae Resinatum 0.3～2
Semen Armeniacae Amarum (parched) 1～10
2, the medicine of treatment tracheitis according to claim 1, asthma, wherein the weight proportion of each raw material is
Herba Houttuyniae 6～10 Rhizoma Cynanchi Stauntoniis 5～8
Flos Inulae 6～10 Radix Glycyrrhizaes 5～8
Radix Platycodonis 2～8 Radix Peucedanis 4～8
The Radix Stemonae 2～8 Geckos 3～6
Pericarpium Citri Reticulatae 3～6 Bulbus Fritillariae Cirrhosaes 3～6
Flos Farfarae 5～8 Lignum Aquilariae Resinatum 0.5～1
Semen Armeniacae Amarum (parched) 3～8
3, the medicine of treatment tracheitis according to claim 1, asthma, wherein the weight proportion of each raw material is
Herba Houttuyniae 8 Rhizoma Cynanchi Stauntoniis 7
Flos Inulae 8 Radix Glycyrrhizaes 7
Radix Platycodonis 7.5 Radix Peucedanis 6
The Radix Stemonae 7.5 Geckos 5
Pericarpium Citri Reticulatae 5 Bulbus Fritillariae Cirrhosaes 5
Flos Farfarae 6 Lignum Aquilariae Resinatum 0.8
Semen Armeniacae Amarum (parched) 6
4, the preparation method of the medicine of the described treatment tracheitis of claim 1, asthma is characterized in that:
(1) gets Pericarpium Citri Reticulatae, Herba Houttuyniae, Lignum Aquilariae Resinatum and be ground into the Radix Glycyrrhizae of coarse powder, add entry, water vapour distillation volatile oil;
(2) will decoct with water extraction after the medicinal residues merging behind Radix Peucedani, Radix Platycodonis, Rhizoma Cynanchi Stauntonii, Flos Farfarae, Flos Inulae, Gecko and (1) the middle extraction volatile oil, add Semen Armeniacae Amarum (parched) in the decoction, discard residue, the aqueous solution that extracts in extracting solution and (1) behind the volatile oil merges, after concentrated as clear paste (I);
(3) get Bulbus Fritillariae Cirrhosae, the Radix Stemonae is ground into coarse powder, extracts with Diluted Alcohol solution, discards residue, extracting solution concentrates the back as clear paste (II);
(4) get the volatile oil in (1), add cycloheptaamylose and Diluted Alcohol solution and grind to form pastel, after 40 ℃ of following dryings, being ground into fineness is 120 order fine powders (III);
(5) clear paste (I) and clear paste (II) are merged, behind concentrate drying, be ground into 120 order fineness, add adjuvant and wetting agent, make granule, by adding fine powder (III) mixing and drying, make granule again.
5, the preparation method of the medicine of treatment tracheitis according to claim 4, asthma, it is characterized in that decocting with water extraction and be divided into twice, add 10～14 times of water gagings for the first time, add 6～10 times of water gagings for the second time, and the adding Semen Armeniacae Amarum (parched), extracted respectively 90～150 minutes.
6, the preparation method of the medicine of treatment tracheitis according to claim 4, asthma is characterized in that adjuvant is Icing Sugar and the dextrin mixture by 1: 1 proportioning, and wetting agent is the alcoholic solution greater than 80%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99112228A CN1073439C (en) | 1999-05-21 | 1999-05-21 | Medicine for treating trachitis and asthma and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99112228A CN1073439C (en) | 1999-05-21 | 1999-05-21 | Medicine for treating trachitis and asthma and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1239671A true CN1239671A (en) | 1999-12-29 |
| CN1073439C CN1073439C (en) | 2001-10-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99112228A Expired - Fee Related CN1073439C (en) | 1999-05-21 | 1999-05-21 | Medicine for treating trachitis and asthma and its preparation |
Country Status (1)
| Country | Link |
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| CN (1) | CN1073439C (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1900373A1 (en) * | 2006-09-15 | 2008-03-19 | Luay Rashan | Composition for treating asthma |
| CN102688376A (en) * | 2012-06-06 | 2012-09-26 | 黄金花 | Traditional Chinese medicine composition for treating chronic bronchitis |
| CN105106792A (en) * | 2015-09-23 | 2015-12-02 | 谢桂斌 | Medicine for treating senile chronic bronchitis |
| CN106692822A (en) * | 2015-08-03 | 2017-05-24 | 曾正 | Traditional Chinese medicine pills for treating tracheobronchitis |
| CN110404028A (en) * | 2019-09-03 | 2019-11-05 | 河北巨龙药业有限责任公司 | A kind of children's clearing lung-heat particle and preparation method thereof |
| CN111157633A (en) * | 2018-11-07 | 2020-05-15 | 中日友好医院 | Detection method of traditional Chinese medicine composition preparation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08100447A (en) * | 1994-09-30 | 1996-04-16 | Samsung Heavy Ind Co Ltd | Bucket line recovering apparatus of heavy equipment |
| CN1181251A (en) * | 1996-10-29 | 1998-05-13 | 涂兴顺 | Navel drops for treating tracheitis and its prepn. tech. |
| CN1069206C (en) * | 1997-05-09 | 2001-08-08 | 李跃国 | External-use medicine composition for treatment of tracheitis and asthma |
| CN1210724A (en) * | 1997-09-08 | 1999-03-17 | 陈德铭 | Chinese herbal medicine powder for curing asthma |
-
1999
- 1999-05-21 CN CN99112228A patent/CN1073439C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1900373A1 (en) * | 2006-09-15 | 2008-03-19 | Luay Rashan | Composition for treating asthma |
| CN102688376A (en) * | 2012-06-06 | 2012-09-26 | 黄金花 | Traditional Chinese medicine composition for treating chronic bronchitis |
| CN106692822A (en) * | 2015-08-03 | 2017-05-24 | 曾正 | Traditional Chinese medicine pills for treating tracheobronchitis |
| CN105106792A (en) * | 2015-09-23 | 2015-12-02 | 谢桂斌 | Medicine for treating senile chronic bronchitis |
| CN111157633A (en) * | 2018-11-07 | 2020-05-15 | 中日友好医院 | Detection method of traditional Chinese medicine composition preparation |
| CN110404028A (en) * | 2019-09-03 | 2019-11-05 | 河北巨龙药业有限责任公司 | A kind of children's clearing lung-heat particle and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1073439C (en) | 2001-10-24 |
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