CN1237892C

CN1237892C - Production method of health-care food

Info

Publication number: CN1237892C
Application number: CNB011245255A
Authority: CN
Inventors: 吴奕光
Original assignee: 吴奕光
Current assignee: SHENZHEN BRIGHTWAY BIOLOGICAL MATERIAL TECHNOLOGY CO., LTD.
Priority date: 2001-07-31
Filing date: 2001-07-31
Publication date: 2006-01-25
Anticipated expiration: 2021-07-31
Also published as: CN1399906A

Abstract

The present invention discloses a preparation method of a health food, which can prepare beta-chitin to overcome the defects of alpha-chitin. The present invention is characterized in that the raw materials of beta-chitin or squid cartilage are treated by alkali to remove acetyl, and the product of beta-chitin is obtained and is ground, wherein the process for removing the acetyl by alkali treatment comprises: the beta-chitin or the squid cartilage is poured into an alkali solution whose mass percentage concentration is from 10% to 60% to be stirred, and stirring speed is from 50 turn/minute to 3000 turn/minute; temperature is kept between 30 to 150 DEG C; stirring time is from 0.5 to 24 hours; nitrogen gas is filled for protection in the process; the solid-liquid ratio is from 1:5 to 1:50.

Description

A kind of manufacture method of health food

Technical field:

The present invention relates to a kind of manufacture method of health food.

Background technology:

From 19 beginnings of the century France scholar Bu Lake isolated chitin first from mushroom since, the countries in the world scientist had dropped into great amount of manpower and material resources it has been studied, and confirms that finally chitin has very magical characteristic.Chitin has amino and is alkalescent, just can adsorb the fat that has negative electrical charge in the human body, and activating cell is regulated the acid body fluid of human body, strengthens immune function of human body, and the control cholesterol suppresses the growth of tumour cell.Therefore, chitin constantly is used as and improves and the research and development object of promoting the health project.

At present, each large enterprises has developed miscellaneous chitin kind health care food (medicine) product both at home and abroad, " Pan Dakang " as the U.S., " the crust king " of Japan, " only strong precious " of France, " treasured " of China, " life power " etc., these health products all have prevent disease, the rehabilitation sub-health state cooperates effects such as the non-infectious chronic disease of drug therapy.

But the main active major part of these health care food (medicine) product is by the high deacetylized α-chitin (domestic whole employing α-chitins) that extracts preparation in the shrimp and crab shells.High deacetylized α-chitin has higher amino reservation amount, these amino can be under certain condition by protonated and make chitin become the natural polymer of positively charged, participate in anionic compounds such as Adsorption of Heavy Metal Ions, aliphatic acid.But we studies show that, when the deacetylation of α-chitin surpassed 90%, because strand is tending towards regular relatively, degree of crystallinity improved the amino content that causes in solid-state chitin surface and amorphous regions and reduces, and adsorption effect reduces suddenly.Should high deacetylized α-chitin as the main active of natural health food (medicine) product, it is functional not to be unusual ideal.

Since the beginning of the nineties, abroad the scientific research personnel who is representative with Japanese scientist Kurita has carried out a series of research to the preparation of β-chitin, and has formed complete structure of a cover science and performance characterization system.From the mid-90, domestic scientific research personnel begins to extract β-chitin, preparation β-chitin from fly maggot and silkworm chrysalis, and more existing patent reports.But extracting method is generally complicated, productive rate is low, purity is low, cost is high, and structure and rerum natura characterizing method fall behind, and is difficult to realize its suitability for industrialized production and further application study.

Up to the present, only reports such as Chinese Academy of Sciences Lanzhou Chemical Physics research institute, the Shanghai Aquatic Products Univ. 9CN) process conditions that squid cartilage prepares β-chitin of associating are explored.But the product deacetylation is not high, and structure and rerum natura characterize too simple.

Summary of the invention:

Purpose of the present invention is exactly in order to overcome the above problems, and a kind of manufacture method of health food is provided, and it can prepare β-chitin, overcomes the deficiency of α-chitin.

For achieving the above object, the present invention proposes a kind of manufacture method of health food, it is characterized in that: raw material β-chitin or squid cartilage through the alkali treatment deacetylation, are obtained product β-chitin, grind the back; Wherein the process of alkali treatment deacetylation is: β-chitin or squid cartilage are poured in the aqueous slkali that mass percent concentration is 10%～60% concentration and are stirred, and mixing speed is 50 rev/mins～3000 rev/mins; Maintain the temperature between 30 ℃～150 ℃; Mixing time 0.5 hour～24 hours; Charge into nitrogen protection in the process; Solid-to-liquid ratio is 1: 5～1: 50; Can do two step or multistep alkali treatment deacetylations, per step condition is the same; Wherein said raw material β-chitinous manufacture method is: with squid cartilage through washing, dry, the fibrous powder that is ground into 10 μ m～2mm; Earlier take off albumen through alkali treatment then: the raw material after will pulverizing is poured in the aqueous slkali that concentration is 0.5M～10M and is stirred, and mixing speed is 50 rev/mins～3000 rev/mins, maintains the temperature between 30 ℃～150 ℃; Mixing time 0.5 hour～24 hours; Charge into nitrogen protection in the process, solid and liquid volume ratio are between 1: 5～1: 50; Can adopt the multistep alkali treatment, per step condition is the same; Remove inorganic salts through acid treatment again: will pour in the hydrochloric acid solution of 0.5M～10M concentration through alkali treatment and the product of drying and stir, mixing speed is 50 rev/mins～3000 rev/mins; Maintain the temperature between 30 ℃～150 ℃; Mixing time 0.5 hour～24 hours; Charge into nitrogen protection in the process; Wherein, solid and liquid volume ratio is between 1: 5～1: 50; Can adopt the multistep acid treatment, per step condition is the same.

We studies show that: high deacetylized β-chitin has than α-chitin crystal structure of " loose " more, in the aqueous solution, can complete swelling, and degrade at human body Nei Gengyi.In addition, its all amino can both participate in the absorption to anionic compounds such as metal ion, aliphatic acid, and its health-care efficacy is than more than the superior several times of α-chitin.And β-chitin preparation method that the present invention proposes has also overcome the deficiencies in the prior art, and product purity can reach more than 99%, and deacetylation can be up to more than 99%.

Description of drawings:

Fig. 1 is a technical process schematic diagram of the present invention.

The specific embodiment:

Also the present invention is described in further detail in conjunction with the accompanying drawings below by specific embodiment.

The manufacture method of high-grade functional form natural health care is characterized in that: raw material β-chitin or squid cartilage through the alkali treatment deacetylation, obtained product β-chitin, grind the back.

Described raw material β-chitinous manufacture method is: with squid cartilage through washing, dry, the fibrous powder that is ground into 10 μ m～2mm; Earlier take off albumen through alkali treatment then: the raw material after will pulverizing is poured in the aqueous slkali that concentration is 0.5M～10M (NaOH NaOH or potassium hydroxide KOH) and is stirred, mixing speed is 50 rev/mins～3000 rev/mins, maintains the temperature between 30 ℃～150 ℃; Mixing time 0.5 hour～24 hours; Charge into nitrogen protection in the process, solid and liquid volume ratio are between 1: 5～1: 50; Can adopt the multistep alkali treatment, per step condition is the same; Remove inorganic salts through acid treatment again: will pour in the hydrochloric acid solution of 0.5M～10M concentration through alkali treatment and the product of drying and stir, mixing speed is 50 rev/mins～3000 rev/mins; Maintain the temperature between 30 ℃～150 ℃; Mixing time 0.5 hour～24 hours; Charge into nitrogen protection in the process; Wherein, solid and liquid volume ratio is between 1: 5～1: 50; Can adopt the multistep acid treatment, per step condition is the same.

The process of described alkali treatment deacetylation is: pour β-chitin or squid cartilage in the aqueous slkali that mass percent concentration is 10%～60% concentration (NaOH NaOH or potassium hydroxide KOH) stirring, mixing speed is 50 rev/mins～3000 rev/mins; Maintain the temperature between 30 ℃～150 ℃; Mixing time 0.5 hour～24 hours; Charge into nitrogen protection in the process; Solid-to-liquid ratio is 1: 5～1: 50.Can do two step or multistep alkali treatments, per step condition is the same.The alkali treatment number of times can be controlled the deacetylation degree, designs number of times as requested.

After obtaining β-chitin, can pack through grinding, to obtain powder or capsule product, β-chitin content should be more than 60% in the manufactured goods, can composite fructose, the vitamin composition.

For example: β-chitin powder (about 100 μ m) poured in 30% the NaOH solution (solid-to-liquid ratio is 1: 20), stirred 10 hours down in nitrogen protection, during maintain the temperature at 100 ℃, speed of agitator is 1000 rev/mins.After stirring end, filter, spend deionised water to neutral, oven dry.So mode is handled three times, and product purity is up to 99%, and deacetylation is also up to 99%.When making raw material, also can use above-mentioned same condition and technology with squid cartilage.

For the difference of reaction condition, the difference as a result that is produced.Its difference is the requirement difference of end-product.Division is as follows:

1. the influence of granular size, particle is little, sufficient reacting, production efficiency height, product purity height; But the separation process difficulty causes product to contain impurity.

2. the influence of reaction temperature, the temperature height can make the product deacetylation improve, on the contrary the deacetylation deficiency; But the color burn that may cause product, decolouring then makes complex manufacturing again.

3. the influence of acid base concentration, the concentration height, the deacetylation height, but product may cause unnecessary degradation reaction, and influence product purity.

4. the influence of rotating speed, rotating speed improves, and reaction efficiency is improved, and but causes the power degraded easily.

5, the influence of N2 in the production process, charges into N2 and can avoid the product degradation that oxidation reaction causes and the intensification of product color.

Claims

1, a kind of manufacture method of health food is characterized in that: raw material β-chitin or squid cartilage through the alkali treatment deacetylation, are obtained product β-chitin, grind the back; Wherein the process of alkali treatment deacetylation is: it is to stir in 10%～60% the aqueous slkali that β-chitin or squid cartilage are poured mass percent concentration into, and mixing speed is 50 rev/mins～3000 rev/mins; Maintain the temperature between 30 ℃～150 ℃; Mixing time 0.5 hour～24 hours; Charge into nitrogen protection in the process; Solid-to-liquid ratio is 1: 5～1: 50; Can do two step or multistep alkali treatment deacetylations, per step condition is the same; Wherein

Described raw material β-chitinous manufacture method is: with squid cartilage through washing, dry, the fibrous powder that is ground into 10 μ m～2mm; Earlier take off albumen then: the raw material after will pulverizing through alkali treatment

Pour in the aqueous slkali that concentration is 0.5M～10M and stir, mixing speed is 50 rev/mins～3000 rev/mins, maintains the temperature between 30 ℃～150 ℃; Mixing time 0.5 hour～24 hours; Charge into nitrogen protection in the process, solid and liquid volume ratio are between 1: 5～1: 50; Can adopt the multistep alkali treatment, per step condition is the same; Remove inorganic salts through acid treatment again: will pour in the hydrochloric acid solution of 0.5M～10M concentration through alkali treatment and the product of drying and stir, mixing speed is 50 rev/mins～3000 rev/mins; Maintain the temperature between 30 ℃～150 ℃; Mixing time 0.5 hour～24 hours; Charge into nitrogen protection in the process; Wherein, solid and liquid volume ratio is between 1: 5～1: 50; Can adopt the multistep acid treatment, per step condition is the same.

2, the manufacture method of health food as claimed in claim 1 is characterized in that: keep β-chitin content under the prerequisite more than 60%, composite fructose, vitamin composition.