CN1237315C - 槽板传热装置 - Google Patents

槽板传热装置 Download PDF

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CN1237315C
CN1237315C CNB028004914A CN02800491A CN1237315C CN 1237315 C CN1237315 C CN 1237315C CN B028004914 A CNB028004914 A CN B028004914A CN 02800491 A CN02800491 A CN 02800491A CN 1237315 C CN1237315 C CN 1237315C
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克里斯托弗·L·琼斯
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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
    • F25B21/00—Machines, plants or systems, using electric or magnetic effects
    • F25B21/02—Machines, plants or systems, using electric or magnetic effects using Peltier effect; using Nernst-Ettinghausen effect
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
    • F25B21/00—Machines, plants or systems, using electric or magnetic effects
    • F25B21/02—Machines, plants or systems, using electric or magnetic effects using Peltier effect; using Nernst-Ettinghausen effect
    • F25B21/04—Machines, plants or systems, using electric or magnetic effects using Peltier effect; using Nernst-Ettinghausen effect reversible
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F28—HEAT EXCHANGE IN GENERAL
    • F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
    • F28F3/00—Plate-like or laminated elements; Assemblies of plate-like or laminated elements
    • F28F3/02—Elements or assemblies thereof with means for increasing heat-transfer area, e.g. with fins, with recesses, with corrugations
    • F28F3/022—Elements or assemblies thereof with means for increasing heat-transfer area, e.g. with fins, with recesses, with corrugations the means being wires or pins
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10N—ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10N10/00—Thermoelectric devices comprising a junction of dissimilar materials, i.e. devices exhibiting Seebeck or Peltier effects
    • H10N10/10—Thermoelectric devices comprising a junction of dissimilar materials, i.e. devices exhibiting Seebeck or Peltier effects operating with only the Peltier or Seebeck effects
    • H10N10/13—Thermoelectric devices comprising a junction of dissimilar materials, i.e. devices exhibiting Seebeck or Peltier effects operating with only the Peltier or Seebeck effects characterised by the heat-exchanging means at the junction

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Abstract

一种传热梳(70)包括许多向上延伸接纳在包围槽板(18)的样品贮存槽(28)的和在其间的空间(30)中的销子(74)。帕尔帖效应模块(42)与传热梳(70)的基板(72)接触以便向该梳(70)供热或从该梳(70)去除热。散热器(46)和风扇(56)从或向模块(42)传热。

Description

槽板传热装置
技术领域
本发明涉及冷却或加热贮存在槽板的槽中的样品的槽板传热装置。
背景技术
在制药、基因、蛋白质研究与药物研发实验室中，以及其它生物技术应用中，自动液体处理器用于在各种实验程序中处理实验室样品。例如，液体处理器用于生物技术和制药的液体分析过程，样品准备，化合物配置等等。典型地采用具有一系列多个样品贮存容器或槽的样品贮存槽板。例如，一种广泛采用的样品贮存槽板具有在一个8×12槽型板中的96个深槽的X-Y序列，已知具有样品槽的不同序列的其它槽板。典型的板具有模制的整体塑料形态带有周边裙壁、上顶壁和许多单独的与相邻槽隔开的且从顶壁间下悬挂的样品贮存槽。
对某些应用中希望在样品贮存槽中在降低的温度或升高的温度下保存样品。采用帕尔帖效应的装置已被用来向槽板中的样品供热或从槽板中的样品除去热。
利用帕尔帖效应在两种金属的连结处产生或吸收热以响应电流的通过。在已知的装置中，槽板放置在由一或多个帕尔帖效应模块加热或冷却的导热块或板的上面。槽板可以由一隔热罩覆盖或者放置在由一个或多个帕尔帖效应模块加热或冷却的第二导热块或板的下面。
这些已知的系统已经不能够有效和持久地冷却或加热槽板中的样品。槽板的塑料不是良好的热导体。因此，在槽板顶和/或底部的加热或冷却板或块与板槽中的样品不是一种良好的传热关系。初始热在垂直方向传导。深的槽板具有深度大约3.81cm的槽，这就造成在贮存的样品和热源或排放口板之上或以下之间较大的垂直距离。如果槽板与周围的温度高度隔离，已知的系统能够最终使样品或保持十分恒定的温度，但是由于不良的热传导这就需要较长的时间。这是一个严重的缺点因为延迟妨碍高的过程产量同时能导致为分析而准备的样品的变质或改变。
发明内容
本发明的主要目的是提供一种改进的传热到或从槽板的槽中的样品传热的装置。其它目的是提供一种以高的均匀度和比较短的时间能加热或冷却样品槽的槽板热传导装置；提供一种在横向或水平方向而不是在垂直方向传热到或从样品槽传热的热传导装置；以及提供克服过去使用的那些缺点的槽板热传导装置。
简言之，根据本发明提供了一种槽板传热装置，该所述的槽板具有多个垂直延伸的、成预定的围绕槽的空间型式阵列的分隔开的样品贮存槽，所述传热装置包括一个传热梳，该传热梳包括一基板以及多个垂直延伸的传热销子；其特征在于：所述的传热销子可拆卸地安装到所述基板上，与所述的基板成传热连接，其中所述销子被安排成与预定的围绕样品贮存槽板的样品贮存槽的空间型式相对应；一个提供或吸收热的源，所述源与所述传热梳是传热邻接的。
附图说明
从下列表示在附图中的本发明的优选实施例的详细描述可以最好地理解本发明以及上述和其它目的与优点，附图中：
图1是根据本发明构造的并用于冷却或加热样品贮存槽板中样品的传热装置的轴测视图；
图2是图1的传热装置的元件在缩小比例下的分解轴测视图；
图3是传热装置热组件的分解轴测视图；
图4是热组件传热梳的分解轴测视图；
图5是热组件的隔热外套的轴测视图；以及
图6是具有深槽样品板在适当位置，并去除槽板的一部分以揭示传热梳的传热梳的部分轴测视图。
具体实施方式
现参照附图，并首先参照图1和2，所示为一般以10表示的并根据本发明的原则构造的传热装置。该装置10包括围成槽板腔16的基壳12和配合的盖14，该腔16用于保存一对96个槽的深槽微滴定度板18(图6)，该微滴定度板由装在壳12内的热组件(总的示为20)冷却或加热。
图6中可见一槽板18。它是模制的整体塑料结构并包括顶壁22和带下边缘26的周边侧面或裙壁24。多个敞开顶端的样品贮存槽28挂在顶壁。每个槽28具有一圆柱侧壁和一封闭底壁。槽28呈有规则排列，每个槽与其相邻的槽均匀分隔开。在所示的装置中，传热装置10容纳具有大约3.81cm深度的槽的2个槽板18，同时槽28设成8×12槽型的96个槽的X-Y排列。本发明的原则能应用于其它更多或更少的板的结构，同时板可以是不同的结构，例如具有更多或更少的槽28。每个槽28被4个垂直延伸的敞开空间30所包围并与它们侧面相接。槽板18和空间30的每一个是敞开到底部。在所示的8×12槽型中，空间30是9×13的型式。
热组件20(图3)包括一般为扁平、平面的、具有周边凸缘34的热隔离外套32。一对模块插座36在外套32的上和下面38和40之间延伸。电导体44将模块42与电源互联，该电源选择地操纵模块以便在向上或向下的方向在模块42的顶部与底部之间传热。
散热器46具有平的上表面48，该表面处在外套32的下表面38之下在传热时与帕尔帖效应模块42的底部接触。散热片50从上表面48向下延伸以增加表面面积和散热器46的热扩散功能。
风扇组件52包括带对准风扇56的中央开口的架子或罩盖54。风扇50被接纳在壳12里面的架子54中。壳12包括底壁58、端壁60和侧壁62。当风扇56工作时，空气通过端壁60中的流动开口64、通过架子54及通过端壁60和侧壁62中的通风开口66和68运动。流动开口64对准风扇50(图1)的端部，和空气流过风扇50的表面以便从散热器46排除热或向散热器供热。
根据本发明传热梳70向槽28或从槽28传热。该梳70包括一个通常平的基板72和许多直立的销子74。基板72被接纳在上表面38的上面和在外套32的周边凸缘34内以及与帕尔帖效应模块42的上表面接触。销子74与基板72是良好的传热接触。如图4所见，基板72包括一系列孔76，同时在优选的装置中销子74以过盈配合压配在孔76中。
当操作模块42以便从模块的顶部移去热时，包括销子74的梳子70被冷却到明显比环境温度低的温度。热被散热器46及被风扇56移动的空气所排除。当操作模块42以便向模块顶部移动热时，包括销子74的梳子70加热到明显比环境温度高的温度。热由散热器46和由被风扇56移动的空气供给。
传热梳70的销子74排列得快速和有效地向着或从样品贮存槽28的每一个传热。销子74的排列与空间30的排列相同。当槽板18被放入槽板腔室16中时，一个销子74向上延伸到空间30的每一个。每个槽28被4个销子74侧面相接并包围，同时销子垂直地延伸基本上贯穿槽28的整个垂直深度。
贮存在槽28中的样品的每一部分紧密邻近4个包围的销子74，同时热在每个样品槽28中的内含物与其包围的销子74之间的短距离上水平地传递。短的和低干扰水平的传热路径确保贮存样品的快速和均匀的冷却或加热。
外套32包括一衬垫部分，该衬垫夹持一个与传热梳70的基板72接触的温度传感器。传感器能够提供用于，例如，监控传热装置10的工作的信号。
盖14放置在腔室16中的槽板18的上面以减少热从腔室16逸散或进入腔室16，并有助于槽28中的样品的冷却或加热。盖14具有对准样品槽28的敞开顶部的多个孔80。孔80提供到槽28的入口，例如到自动液体处理器的探头或到手动操作的管子的末端。
尽管已经参考附图所示本发明实施例的细节描述了本发明，但这些细节不是用来限制所附权利要求提出的本发明的保护范围。

Claims (14)

1.一种槽板传热装置，该所述的槽板具有多个垂直延伸的、成预定的围绕槽的空间型式阵列的分隔开的样品贮存槽，所述传热装置包括
一个传热梳，该传热梳包括一基板以及多个垂直延伸的传热销子；其特征在于：所述的传热销子可拆卸地安装到所述基板上，与所述的基板成传热连接；
其中所述销子被安排成与预定的围绕样品贮存槽板的样品贮存槽的空间型式相对应；
还包括一个提供或吸收热的源，所述源与所述传热梳是传热邻接的。
2.如权利要求1所述的传热装置，其特征在于所述的槽板具有直线的排和列X-Y的槽阵列，其中每个X排有n个槽，和每个Y列中有m个槽，所述销子为直线排和列的阵列，每X排具有至少n+1个销子和每Y列具有至少m+1个销子。
3.如权利要求2所述的传热装置，其特征在于所述销子是呈每X排n+1个销子和每Y列m+1个销子的阵列。
4.如前面任一权利要求所述的传热装置，其特征在于所述的源包括与所述基板的下侧接触的帕尔帖效应模块。
5.如权利要求4所述的传热装置，其特征在于还包括与所述帕尔帖效应模块的下侧接触的散热器。
6.如权利要求5所述的传热装置，其特征在于还包括移动空气经过所述散热器的风扇。
7.如权利要求1-3之一所述的传热装置，其特征在于所述基板具有一定孔的排列型式，所述销子被接纳在所述孔中。
8.如权利要求7所述的传热装置，其特征在于所述销子压入所述孔中。
9.如权利要求1所述的传热装置，其特征在于所述的提供和吸收热的源包括：
一包含一对模块插座的热隔离外套；
座落在所述插座中并具有暴露在所述外套的顶和底部的上和下表面的帕尔帖效应模块；
在所述外套的下表面或上表面的散热器，所述的散热器与所述模块的所述下表面或上表面成传热接触；
传热梳的基板与所述模块的所述上表面成传热关系地支承在所述外套的顶部。
10.如权利要求9所述的传热装置，其特征在于还包括封闭所述传热梳的隔热盖。
11.如权利要求10所述的传热装置，其特征在于所述盖具有槽进入孔，所述的槽进入孔与槽板的槽相对齐。
12.如权利要求9所述的传热装置，其特征在于所述的传热装置还包括包围所述散热器的基壳，和为移动空气通过所述基壳并跨越所述散热器的风扇。
13.如权利要求9所述的传热装置，其特征在于所述的传热装置还包括在所述的热隔离外套中的衬垫部分，所述的衬垫部分可夹持一个温度传感器。
14.如权利要求13所述的传热装置，其特征在于所述的温度传感器与所述的传热梳成传热邻接。
CNB028004914A 2001-03-03 2002-02-22 槽板传热装置 Expired - Fee Related CN1237315C (zh)

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US09/798,886 US6341490B1 (en) 2001-03-03 2001-03-03 Heat transfer apparatus for sample containing well plates
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