CN1234010C - Electrophoretic separation analyzing system - Google Patents
Electrophoretic separation analyzing system Download PDFInfo
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- CN1234010C CN1234010C CN 02126362 CN02126362A CN1234010C CN 1234010 C CN1234010 C CN 1234010C CN 02126362 CN02126362 CN 02126362 CN 02126362 A CN02126362 A CN 02126362A CN 1234010 C CN1234010 C CN 1234010C
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- tubing string
- conductive part
- electrophoretic separation
- analyzing system
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Abstract
The present invention relates to an electrophoretic separation analyzing system which is used for detecting samples. The electrophoretic separation analyzing system comprises a host machine, at least one clamping box and a detection device, wherein the host machine is provided with at least one supporting seat for controlling sample detection; the clamping box is arranged in the supporting seat of the host machine by a detachable method and is provided with at least one detection pipe column which is provided with a first end and a second end, when the clamping box is positioned in the supporting seat of the host machine, the first end of the detection pipe column is provided with a first voltage and the second end of the detecting pipe column is provided with a second voltage, the samples are attached on the second end of the detection pipe column, and a voltage difference between the first voltage and the second voltage is used to make the samples move to the first end from the second end in the detection pipe column; the detection device is arranged in the host machine, and is used for detecting the moving state of the samples in the detection pipe column.
Description
Technical field
The present invention relates to a kind of electrophoretic separation analyzing system, particularly a kind of electrophoretic separation analyzing system with separable cartridge.
Background technology
General in utilizing the method for inspection of electrophoretic separation, utilize electrophoretic separation to come electric charge and the ratio of molecular weight or the difference between molecular weight size or the sample structure of analytical control molecule, particularly in molecular biology, often be used to materials such as nucleic acid, protein analytically, and as the strong instrument of checking the genetic fragment molecule.
Basic electrophoresis system mainly is made up of high-voltage power supply supply, separation tubing string or film and control circuit; Existing electrophoresis system 10 as shown in Figure 1, a power supply unit 12 that has a separating tank 11 and electrically connect with separating tank 11; During test, be positioned over the film 13 that sample is housed in the separating tank 11 after, utilize power supply unit 12 to make the two ends of separating tank 11 produce voltage difference because sample is charged, when voltage difference produced, sample can move at film 13, by this characteristic of test sample.
In early days, use flat agar colloid electrophoresis or polypropylene cyanogen film electrophoresis, though it is easy to use, but need a large amount of biological samples when using, and the required time of analytic process surpasses 30 minutes, therefore, though existing electrophoretic analysis equipment is cheap, but lack of resolution needs other pertinent instruments cooperation and analysis time long again; In addition, the user must draw the sample cell that sample is filled to dull and stereotyped film one by one with suction pipe, and after separating need utilize image acquisition system to read the result again, and is very inconvenient, can't meet the demand of quick test and sample traceization in the use.
Along with molecular biological progress is quick, strong further for the electrophoretic analysis technology requirement, and the resolution in the electrophoretic analysis process is also more and more higher, for example, in the research of gene ordering, the past, employed flat electrophoresis tank did not conform to demand, in order to meet the demand that research is now carried out, in the exploitation of relevant electrophoresis products of separated, the invention of classic flat-plate formula electrophoresis appears replacing with the thin electrophoresis of microtriche.
Fig. 2 announces the sectional view of the thin electrophoretic apparatus 20 of microtriche in No. 5560811 for United States Patent (USP), and on an electrophoretic separation plate 21, the one end is provided with several sample wells 22, and the other end is provided with dashpot 23; One first central electrode 25 and the electrode in sample well 22 26 electrically connect, and one second central electrode 27 is that the position is in dashpot 23; Electrocapillary phoresis tubing string 28 is to be installed in the plate 21, when being full of conducting liquid in sample well 22 and the dashpot 23, utilizes electrocapillary phoresis tubing string 28 to make first central electrode 25 and 27 conductings of second central electrode by this; During operation, the electrophoresis that the electric current between two central electrodes makes sample is from sample well 22 to dashpot 23, by this data of test sample.
In addition, in the exploitation of the thin electrophoretic separation detection system of microtriche, for example, United States Patent (USP) is announced No. 6132582, United States Patent (USP) and is announced No. 5885430, United States Patent (USP) and announce No. 6118127, United States Patent (USP) and announce No. 5413686, mostly in order to meet gene sorting experiment demand, therefore all need to require more than tens of centimetres and the capillary inner diameter of tens of microns width at capillary pipe length, be used to improve the resolution of electrophoretic separation.
Yet if use microscopic capillary electrophoresis or microscopic capillary electrophoresis chip equipment, though have the high advantage of resolution, instrument is expensive and use complicated operating process, therefore at present need mostly only to be applied to the occasion of rigorous analysis; In addition, its instrument and equipment O﹠M is not had a convenience, and costing an arm and a leg of instrument and consumptive material in general molecular biosciences laboratory, only limits to be applied in the ordering of gene order simultaneously, can't enlarge to be used in general molecular biosciences and to research and analyse.
Summary of the invention
The object of the present invention is to provide a kind of electrophoretic separation analyzing system, it has detachable cartridge, the convenience that can shorten detection time by this, use when improve detecting, and can reduce the detection cost.
Another object of the present invention is to provide a kind of electrophoresis detection cartridge device, wherein the electrophoresis cartridge have the sampling of can directly handing and with after two kinds of main characteristics abandoning, be used to improve the convenience that testing process operates and avoid cross staining between the sample.
For reaching above-mentioned purpose, the present invention system provides a kind of electrophoretic separation analyzing system, is used for test sample, and comprises a main frame, at least one cartridge and a pick-up unit; Main frame has at least one bearing, and is used to control the carrying out of sample detection; Cartridge is arranged in the bearing of main frame in separable mode, and has at least one detection tubing string, wherein detect tubing string and have one first end and one second end, and when cartridge is arranged in the bearing of main frame, first end that detects tubing string has one first voltage, and second end that detects tubing string has one second voltage, and adheres to sample on second end that detects tubing string, utilize the voltage difference between first voltage and second voltage, sample is moved from second end toward first end in detecting tubing string; This cartridge also comprises: a cartridge body, have this detection tubing string, and be used to adhere to this sample; And a base, combine with this cartridge body, have at least one hole, be used to hold the detection tubing string of this cartridge body; Wherein this main frame also comprises: at least one guide channel, be communicated with this bearing, and be used to guide this cartridge and enter this bearing; Pick-up unit is arranged in the main frame, and is used for test sample in the mobile status that detects tubing string.And the analysis result of electrophoretic separation imported in the computing machine in the mode of numerical data, carry out data storing and operational analysis.Shorten the user and carry out subsequent treatment and required time of interpretation, improve efficiency of test for analysis result.
In a preferred embodiment, the cartridge body can be used for hand-held or with the mechanical arm operation, directly contacts adsorption sample.
In another preferred embodiment, main frame also comprises at least one guide channel, and it is communicated with bearing, is used to guide cartridge and enters bearing.
Again, form one the 3rd depressed part in the guide channel, and cartridge has one first teat corresponding with the 3rd depressed part, utilize the 3rd depressed part and first teat, cartridge is moved in guide channel smooth-goingly.
In another preferred embodiment, form one second teat in the bearing, and cartridge has one four depressed part corresponding with second teat, utilize second teat and the 4th depressed part, cartridge is moved in bearing smooth-goingly.
In another preferred embodiment, have one first conductive part, one second conductive part in the bearing, and cartridge has one three conductive part corresponding with first conductive part and one four conductive part corresponding with second conductive part, when cartridge is arranged in bearing, the 3rd conductive part and the conductive part electric connection, and the 4th conductive part and second conductive part electrically connect, and have first voltage and second voltage so that detect tubing string.
Again, main frame also comprises: with the power supply unit that first conductive part, second conductive part electrically connect, be used for providing via first conductive part and the 3rd conductive part and second conductive part and the 4th conductive part and detect tubing string first voltage and second voltage; With the control device that power supply unit electrically connects, the power supply that is used to control power supply unit whether; With the input panel that control device electrically connects, be used to import the data that institute's desire is analyzed; And with the display device that control device electrically connects, be used for the data of display analysis gained.
Will be appreciated that control device, input panel and display device can be replaced by a computing machine.
In another preferred embodiment, electrophoretic separation analyzing system also comprises a mechanical arm, and itself and main frame electrically connect, and are used for both allocations of mobile cartridge to, the robotization of reaching testing process.
In another preferred embodiment, cartridge has a standard tubing string, is used for as the reference standard that detects tubing string.
Will be appreciated that to detect in the tubing string and can add macromolecular material, and macromolecular material can be natural or artificial macromolecular material with the sample separation of making.
Detect in the tubing string and also can add solution, colloid or solid material, and solid material has hole with the sample separation of making again.
In another preferred embodiment, pick-up unit can be a pick-up unit that utilizes optics, and is arranged in the main frame in the mode corresponding with the bearing of main frame.
Again, optical detection apparatus can comprise a photodiode or photomultiplier.
In another preferred embodiment, can be attached with the sign probe on the sample, be used for the auxiliary detection device test sample.
Indicate probe and can be fluorescence molecule, nanoparticle or extinction molecule again.
In another preferred embodiment, detect tubing string and be provided with convex lens, be used for the auxiliary detection device test sample.
For above and other objects of the present invention, feature and advantage can be become apparent, a preferred embodiment cited below particularly, and conjunction with figs. is described in detail below.
Description of drawings
Fig. 1 is the synoptic diagram of existing flat electrophoresis system;
Fig. 2 is the synoptic diagram of existing microscopic capillary formula electrophoresis system;
Fig. 3 a, 3b are the synoptic diagram of electrophoretic separation analyzing system of the present invention;
Fig. 3 c is the part front view of the main frame among Fig. 3 a;
Fig. 3 d is the synoptic diagram of the variation of electrophoretic separation analyzing system of the present invention;
Fig. 4 a is the decomposing schematic representation of the cartridge among Fig. 3 a;
Fig. 4 b is the synoptic diagram of the detection tubing string among Fig. 4 a; And
Fig. 5 a～5d utilizes electrophoretic separation analyzing system of the present invention to carry out the synoptic diagram of sample detection.
Embodiment
With reference to figure 3a, 3b and 3c, electrophoretic separation analyzing system 100 of the present invention can be in general molecular biosciences be analyzed, (for example be used for test sample, nucleic acid fragment, protein molecule etc.) characteristic, it comprises a main frame 110, several cartridges 120 (only showing in Fig. 3 a), a pick-up unit 130 and a mechanical arm 140.
Shown in Fig. 3 a, 3b, 3c, main frame 110 is used to control the carrying out of sample detection, is provided with several bearings 111, several guide channels 112, several first conductive parts 113, several second conductive parts 118, a power supply unit 114, a control device 115, an input panel 116 and a display device 117 therein.
First conductive part 113 and second conductive part 118 are arranged at respectively in the bearing 111, form is arranged in the bearing 111 arbitrarily, strip for example, but be not limited to this, as long as first conductive part 113 and second conductive part 118 can electrically connect with the conductive part in the cartridge 120; In addition, does not limit the position that first conductive part 113 and second conductive part 118 are arranged in the bearing 111 yet, for example, as can be shown in Fig. 3 c, be arranged at the end face and the bottom surface of bearing 111, but also can be arranged at the side of bearing 111, as long as first conductive part 113 and second conductive part 118 can electrically connect with the conductive part in the cartridge 120.
Power supply unit 114 can electrically connect with the conductive part 113 and second conductive part 118, to provide the cartridge that is positioned in the bearing 111 120 required voltages via first conductive part 113 and second conductive part 118; Control device 115 electrically connects with power supply unit 114, and the power supply that is used to control power supply unit 114 whether; Input panel 116 electrically connects with control device 115, is used to import the data that institute's desire is analyzed; Display device 117 also electrically connects with control device 115, is used for the data of display analysis gained.
Refer again to Fig. 3 a, cartridge 120 is arranged in the bearing 111 of main frame 110 in separable mode, and shown in Fig. 4 a, has several and detect tubing string 121, a cartridge body 122, a base 123, one the 3rd conductive part 125 and one the 4th conductive part 127.
Detect the sample that tubing string 121 absorption desires are analyzed, shown in Fig. 4 b, have one first end 1211 and one second end 1212, and on first end 1211, can be provided with convex lens 1213, be used for auxiliary detection device 130 test sample, the mode that then can be used for directly contact on second end 1212 is adsorbed the sample that desire is analyzed.
The 3rd conductive part 125 is corresponding with first conductive part 113 of main frame 110, the 4th conductive part 127 then second conductive part 118 with main frame 110 is corresponding, it can be set at the end face and the bottom surface of cartridge 120 respectively, but be not restricted to this, if the 3rd conductive part 125 and the 4th conductive part 127 can be respectively with main frame 110 in first conductive part 113, second conductive part 118 electrically connect.Thereby when cartridge 120 is arranged in the bearing 111 of main frame 110, the 3rd conductive part 125 of cartridge 120 can electrically connect with first conductive part 113 of main frame 110, and the 4th conductive part 127 of cartridge 120 can electrically connect with second conductive part 118 of main frame 110, power supply unit 114 in the main frame 110 can make first end 1211 of the detection tubing string 121 in the cartridge 120 have one first voltage, and make second end 1212 of the detection tubing string 121 in the cartridge 120 have one second voltage, utilize the voltage difference between first voltage and second voltage, sample can be moved from second end toward first end in detecting tubing string 121.
Again, cartridge 120 can have one first teat 1232 corresponding with the 3rd depressed part 1121 of main frame 110, utilizes the 3rd depressed part 1121 and first teat 1232, and cartridge 120 can be moved in the guide channel 112 of main frame 110 smooth-goingly; In addition, cartridge 120 can have one four depressed part 124 corresponding with second teat 1111 of main frame 110, utilizes second teat 1111 and the 4th depressed part 124, and cartridge 120 is moved in the bearing 111 of main frame 110 smooth-goingly.
The formation that it should be noted above-mentioned depressed part and teat can be moved in main frame 110 in order to make cartridge 120 smooth-goingly, and its kenel is not restricted to this, for example, can exchange by the teat that depressed part is corresponding with it, or utilizes other arrangement for guiding.
Again,, can have a standard tubing string 126 in the cartridge 120, be used for, but this standard tubing string 126 and nonessential for example, can be stored in reference standard in the main frame 110 in advance as the reference standard that detects tubing string 121 with reference to figure 4a.
Detect in the tubing string 121 and can add macromolecular material, and macromolecular material can be natural or artificial macromolecular material with the sample separation of making.
Detect in the tubing string 121 and also can add solution, colloid or solid material, and solid material has hole with the sample separation of making again.
Pick-up unit 130 is arranged in the main frame 110 shown in Fig. 3 c, and can be provided with respectively several detection components corresponding with bearing 111, is used for the mobile status of test sample at the detection tubing string 121 of cartridge 120; Again, pick-up unit 130 can be a pick-up unit that utilizes optics, for example, and photodiode (photodiode array) or photomultiplier (PMT).
In addition, can be attached with on the sample and indicate probe (labeling probe), be used for auxiliary detection device 130 test sample, can be fluorescence molecule, nanoparticle or extinction molecule and indicate probe.
Refer again to Fig. 3 b, mechanical arm 140 can electrically connect with main frame 110, is used for both allocations of mobile cartridge 120 to, certainly mechanical arm 140 is comparatively suitable in needing the occasion of macromethod, when a small amount of the analysis, can artificial mobile cartridge 120, and mechanical arm 140 need be set.
The formation of electrophoretic separation analyzing system 100 of the present invention utilizes electrophoretic separation analyzing system of the present invention to carry out the flow process of sample detection below with reference to Fig. 5 a, 5b, 5c, 5d explanation as mentioned above.
At first, shown in Fig. 5 a, behind the guide channel 112 with cartridge 120 aligning main frames 110, cartridge 120 is pushed in the guide channel 112 of main frame 110, shown in Fig. 5 b; Then, the cartridge body 122 of cartridge 120 is separated with base 123, so that base 123 is stayed in the guide channel 112, and second end 1212 that utilizes the detection tubing string 121 in the cartridge body 122 directly picks sample to sample cell 150; To speckle with the cartridge body 122 and base 123 recombination of sample at last, and will in conjunction with after cartridge 120 push in the bearing 111 of main frame 110, shown in Fig. 5 d, start the power supply unit 114 of main frame 110, and utilize pick-up unit 130 to begin to analyze, after analysis is finished, cartridge 120 is withdrawed from, and cartridge body 122 is abandoned together with base 123.
As mentioned above, because detection tubing string of the present invention is arranged on the separable cartridge of abandoning, utilize cartridge is connected in the bearing of main frame, user's easy operating, and the restriction that not furnished by main frame make things convenient for user's direct sample, and express-analysis; System must be filled to sample cell with sample with suction pipe thereby the present invention has simplified the conventional electrophoretic compartment analysis, or needs to rely on the shortcoming of automatic sampling device filling sample.
Again, be arranged on the separable cartridge of abandoning, can change immediately after being suitable for, reduce the chance of sample room cross staining owing to detect tubing string system.
In addition, in detecting tubing string, can be according to the characteristic of desiring the compartment analysis sample, the macromolecular material filling material that filling in advance is fit to makes things convenient for the user to use.
Again, will be built in the pick-up unit in the main frame, pick-up unit is directly located, need not additionally adjust.
Again, in needing the occasion of macromethod, can mechanical arm substitute user's arm, carry out automated analysis.
Though the present invention is open by preferred embodiment; so it is not to be used to limit the present invention, any those of ordinary skill in the art, without departing from the spirit and scope of the present invention; change when doing some equivalences, thus protection scope of the present invention with claim the person of being defined be as the criterion.
Claims (18)
1. an electrophoretic separation analyzing system is used for test sample, it is characterized in that, this system comprises:
One main frame has at least one bearing, is used to control the carrying out of this sample detection;
At least one cartridge, be arranged in separable mode in the bearing of this main frame, has at least one detection tubing string, wherein this detection tubing string has one first end and one second end, when this cartridge is arranged in the bearing of this main frame, first end of this detection tubing string has one first voltage, second end of this detection tubing string has one second voltage, on second end of this detection tubing string, adhere to this sample, utilize the voltage difference between this first voltage and this second voltage, this sample is moved from this second end toward this first end in this detection tubing string; This cartridge also comprises: a cartridge body, have this detection tubing string, and be used to adhere to this sample; And a base, combine with this cartridge body, have at least one hole, be used to hold the detection tubing string of this cartridge body; Wherein this main frame also comprises: at least one guide channel, be communicated with this bearing, and be used to guide this cartridge and enter this bearing; And
One pick-up unit is arranged in this main frame, is used for detecting the mobile status of this sample at this detection tubing string.
2. electrophoretic separation analyzing system as claimed in claim 1, it is characterized in that, form one the 3rd depressed part in this guide channel, and this cartridge has one first teat corresponding with the 3rd depressed part, utilize the 3rd depressed part and this first teat, this cartridge is moved in this guide channel smooth-goingly.
3. electrophoretic separation analyzing system as claimed in claim 1, it is characterized in that form one second teat in this bearing, and this cartridge having one four depressed part corresponding with this second teat, utilize this second teat and the 4th depressed part, this cartridge is moved in this bearing smooth-goingly.
4. electrophoretic separation analyzing system as claimed in claim 1, it is characterized in that, have one first conductive part, one second conductive part in this bearing, and this cartridge has one three conductive part corresponding with this first conductive part and one four conductive part corresponding with this second conductive part, when this cartridge is arranged in this bearing, the 3rd conductive part and this first conductive part electrically connect, and the 4th conductive part and this second conductive part electrically connect, so that this detection tubing string has this first voltage and this second voltage.
5. electrophoretic separation analyzing system as claimed in claim 4 is characterized in that, this main frame also comprises:
One power supply unit electrically connects with this first conductive part, this second conductive part, and being used for provides this first voltage of this detection tubing string and this second voltage via this first conductive part and the 3rd conductive part and this second conductive part and the 4th conductive part; And
One control device electrically connects with this power supply unit, is used to control this power supply unit and whether powers.
6. electrophoretic separation analyzing system as claimed in claim 5 is characterized in that, this main frame also comprises:
One input panel electrically connects with this control device, is used to import the data that institute's desire is analyzed; And
One display device electrically connects with this control device, is used for the data of display analysis gained.
7. electrophoretic separation analyzing system as claimed in claim 6 is characterized in that, this control device, this input panel and this display device are replaced by a computing machine.
8. electrophoretic separation analyzing system as claimed in claim 1 is characterized in that, also comprises: a mechanical arm, electrically connect with this main frame, and be used for moving both allocations of this cartridge to one.
9. electrophoretic separation analyzing system as claimed in claim 1 is characterized in that, this cartridge has a standard tubing string, is used for the reference standard as this detection tubing string.
10. electrophoretic separation analyzing system as claimed in claim 1 is characterized in that, adds in this detection tubing string to have macromolecular material, solution or the colloid that makes this sample separation.
11. electrophoretic separation analyzing system as claimed in claim 10 is characterized in that, this macromolecular material is natural or artificial macromolecular material.
12. electrophoretic separation analyzing system as claimed in claim 1 is characterized in that, add in this detection tubing string to have the solid material that makes this sample separation, and this solid material has hole.
13. electrophoretic separation analyzing system as claimed in claim 1 is characterized in that, this pick-up unit is the pick-up unit that utilizes optics.
14. electrophoretic separation analyzing system as claimed in claim 13 is characterized in that, this pick-up unit comprises at least one photodiode, and is arranged in this main frame in the mode corresponding with the bearing of this main frame.
15. electrophoretic separation analyzing system as claimed in claim 13 is characterized in that, this optical detection apparatus comprises a photomultiplier, and is arranged in this main frame in the mode corresponding with the bearing of this main frame.
16. electrophoretic separation analyzing system as claimed in claim 1 is characterized in that, is attached with the sign probe on this sample, is used for auxiliary this pick-up unit and detects this sample.
17. electrophoretic separation analyzing system as claimed in claim 16 is characterized in that, this sign probe is fluorescence molecule, nanoparticle or extinction molecule.
18. electrophoretic separation analyzing system as claimed in claim 1 is characterized in that, this detection tubing string is provided with convex lens, is used for auxiliary this pick-up unit and detects this sample.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02126362 CN1234010C (en) | 2002-07-19 | 2002-07-19 | Electrophoretic separation analyzing system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02126362 CN1234010C (en) | 2002-07-19 | 2002-07-19 | Electrophoretic separation analyzing system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1469119A CN1469119A (en) | 2004-01-21 |
| CN1234010C true CN1234010C (en) | 2005-12-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02126362 Expired - Fee Related CN1234010C (en) | 2002-07-19 | 2002-07-19 | Electrophoretic separation analyzing system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1234010C (en) |
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2002
- 2002-07-19 CN CN 02126362 patent/CN1234010C/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN1469119A (en) | 2004-01-21 |
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