CN1231195A

CN1231195A - Capsule for treating prostate diseases and preparation process

Info

Publication number: CN1231195A
Application number: CN 98113889
Authority: CN
Inventors: 游文新
Original assignee: Individual
Current assignee: Individual
Priority date: 1998-04-06
Filing date: 1998-04-06
Publication date: 1999-10-13
Anticipated expiration: 2018-04-06
Also published as: CN1064547C

Abstract

The capsule for curing prostatosis is prepared from the Chinese medicinal materials of gentian root, rehmmania root, poria, capillaris, bupleurum root, curcuma tuber, houttuynia and hedyotis, etc. through decocting them in water three times respectively for 2 hr and 1 hr, respectively filtering the decoctions, combining them, depressurized concentration to make paste, drying, pulverizing to obtain the medicinal powder, and capsulizing so as to obtain the invented product with the functions of clearing heat away, removing toxic materials, disinhibiting dampness, dispersing swelling, and promoting blood circulation for curing the diseases of acute and chronic prostatis and prostatic hyperplasia, etc. Its effective rate is 90%.

Description

A kind of capsule and manufacture method for the treatment of prostatosis

The present invention relates to a kind of capsule and manufacture method for the treatment of prostatosis.

Prostatosis comprises acute and chronic prostatitis, prostate hyperplasia, acute and chronic seminal vesiculitis etc., is middle-aging male patient's commonly encountered diseases, and the patient is painful, and treatment is also difficult, and Chinese Traditional Medicines at present preferably still are of no curative effect.

The purpose of this invention is to provide prostatic capsule of a kind of employing traditional Chinese medical herbal treatment and manufacture method, this product is evident in efficacy, nontoxic pair of effect, and cheap.

For achieving the above object, technical scheme foot of the present invention: a kind of capsule for the treatment of prostatosis, the various compositions of its making prescription are by weight:

Radix Gentianae: the Radix Rehmanniae: Poria: Herba Artemisiae Scopariae: Radix Bupleuri: Radix Curcumae: Herba Houttuyniae: Herba Hedyotidis Diffusae=(1.0-1.2): (1.5-2.0): (1.5-2.0): (1.2-1.5): (0.8-1.0): (1.0-1.2): (1.0-1.5): (1.5-2.0);

Also can assist in addition and add following composition, be by weight:

SHANZHIZI: Radix Paeoniae Rubra ∶ CAOXIE: Semen Abutili: Radix Glycyrrhizae: Flos Carthami=(1.0-1.2): (1.0-1.2): (1.2-1.5): (0.8-1.0): (0.2-0.3): (0.8-1.0).

Manufacture method: above-mentioned raw materials is added the octuple decocting for the first time boiled 2 hours, leach decocting liquid, add five times of water for the second time, decoct and leached decocting liquid in 1 hour, add water for the 3rd time and decoct for three times and leached decocting liquid in 1 hour, merges three decocting liquids and concentrating under reduced pressure receipts cream, drying and crushing gets powder, incapsulates.

Discrimination method: 1, get capsule 4 grams, pulverize, add methanol 5ml, flooded 4-5 hour, and filtered filtrate and be concentrated into about 2ml, as test liquid, other gets the gentiopicrin reference substance, adds methanol and makes the solution that every 1ml contains 2mg, in contrast product solution, according to the test of broad layer chromatography, draw each 5 μ L of above-mentioned two kinds of solution, put respectively in same be on the silica GF254 lamellae of binding agent with the sodium carboxymethyl cellulose, with ethyl acetate-methanol-water (20: 2: 1) is developing solvent, secondary launches, and takes out, and dries.Put under the ultra-violet lamp and inspect.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.

2, get capsule 4 grams, pulverize, add acetone 10ml, reflux 10 minutes filters, and filtrate evaporate to dryness, residue add glacial acetic acid 1ml makes dissolving, adds 1 in sulphuric acid again, shows pale red, the thin out brown in back.

The present invention has the effect of heat-clearing and toxic substances removing, inducing diuresis and reducing edema, soothing liver-QI for relieving depression, blood circulation promoting and blood stasis dispelling, is used for diseases such as acute and chronic prostatitis, prostate hyperplasia.Through clinical observation in 3 years obvious curative effects is arranged, dysuria be improved significantly, its effective percentage is 90%.

This medicine shows that through the acute and sub-acute toxicity test of Jilin Province's Siping City medicine inspecting institute this product toxicity is lower, for clinical drug safety provides reliable basis.

Zoopery is as follows: Kunming kind white mice, body weight 18-22 gram, male and female half and half, rat body weight 80-100 gram, male and female half and half, animal feeding room and observation ward, sunny, temperature, suitable, the well-ventilated of humidity, feedstuff and water all satisfy supply, and feedstuff is provided by Jilin Province animal housing of medicine inspecting institute.

1, acute toxicity testing

Method: get 20 of white mice, fasting (can't help water) was pressed maximal dose 0.5ml/10g after 17 hours, and gastric infusion is 2 times in one day, observed continuously seven days, and poisoning symptom and death toll appear in the record animal.

The result: the poisoning symptom and the phenomena of mortality all do not appear in animal, after all animal vias become celestial, and each main organs no abnormality seen.This dosage is 625 times of 50kg adult consumption, LD ₅₀Greater than 25g/kg.

2, sub-acute toxicity test

Method: get 30 of rat and be divided into 3 groups at random, 10 every group, matched group (the same volume of normal saline), administration group high dose (16g/kg), low dose group (10g/kg) gastric infusion every day once, successive administration 30 days, weighed once every three days, after 24 hours, each organizes equal sacrificed by decapitation in the last administration, checks routine blood test, liver, renal function, measure the content of blood glutamate pyruvate transaminase and non-protein nitrogen, and core, important organs such as liver, lung, spleen, kidney claim weight in wet base, carry out check pathological section.

The result: this capsule in high dose (400 times of people's consumptions), low dosage (250 times of people's consumptions) compare with matched group; Its measurement result: routine blood test (red white corpuscle number, hemoglobin, platelet value), and the content of glutamate pyruvate transaminase in the blood and non-albumen ammonia, with the relatively more equal no significant difference of matched group, mathematical statistics P value is greater than 0.1.Illustrate that this product do not have obvious influence to routine blood test, liver, renal function.Pathological section does not see that important organs such as the heart, liver, lung, spleen, kidney have the pathological change of drug-induced.

From year May in May, 1996 to 1997, successively use this product and treat 150 examples, obtain curative effect preferably, now be summarized as follows:

One, clinical data:

Make in year 25-40 year 35 examples, 41-55 the year 55 examples, above 60 examples of 56-60, made 75 years old in the biggest year.

Two, case is selected:

In 150 examples, acute prostatitis 20 examples, chronic prostatitis 80 examples, prostate hyperplasia 40 examples, seminal vesiculitis 10 examples.

Symptom: dysuria, 150 examples, frequent micturition 150 examples, urgent micturition 135 examples, difficulty in micturition 150 examples, urine back is dripped white, 140 examples, except also have nearly patient of 20 percent that premature ejaculation, seminal emission, symptoms such as hyposexuality are arranged.The course of disease: first quarter moon-2 year does not wait.

Three, Therapeutic Method:

Oral this medicine, every day three times, each 2 grams were taken before sleeping in one hour after meal, and 15 days is a course of treatment, and need 1-2 month the full course of treatment, takes continuously, do not have a rest between each course of treatment.

Four, curative effect determinate standard:

Cure: all symptoms all disappear, and the urine back does not have the white phenomenon of dripping.

Produce effects: symptom disappears substantially, the rare white phenomenon in urine back.

Effectively: partial symptoms disappears or alleviates.

Invalid: all symptoms all do not have improvement.

Five, observation of curative effect:

1, among the 150 routine patients, all obtain promising result through (1-4 the course of treatment) treatment in 1-2 month, effective percentage 100%, cure rate 70.1%, produce effects 24.5% sees Table

Curative effect	The example number	The rate that takes effect %
Curative effect	The example number	The rate that takes effect %	Cure	????110	????70.1
Produce effects	????37	????24.5	Cure	????110	????70.1
Produce effects	????37	????24.5	Effectively	????3	????5.4
Invalid	????0	????0	Effectively	????3	????5.4

2, the relation of the course of treatment and curative effect sees Table 2

The course of treatment	Cure	Produce effects	Effectively	Invalid
The course of treatment	Cure	Produce effects	Effectively	Invalid	????1	????32	????8		????0
????2	????50	????10		????0	????1	????32	????8		????0
????2	????50	????10		????0	????3	????10	????8		????0
????4	????18	????11	????3	????0	????3	????10	????8		????0
????4	????18	????11	????3	????0	Meter	????110	????37	????3	????0

As seen from Table 2: a part of patient can cure through a course of treatment (15 days) treatment, but most patient needs through two more than the course of treatment, but just Miscanthus sacchariflorus (Maxim) Benth et Hook f gets promising result.

Six, model case:

The patient poplar * *, the man, 60 years old, examined in July, 1996, and ill 2 years of patient's readme does not have positive effect through how tame hospitalize, and symptom has frequent micturition, urgent micturition, dysuria, and difficulty in micturition is very painful.Check: have tangible urine back to drip white phenomenon, white mucus is looked under 20 of leukocyte/every mirror: erythrocyte (-) palpation.Prostate hyperplasia, touch painful.Diagnosis: prostate hyperplasia, chronic prostatitis.Relieving capsule took an evident turn for the better after 2 courses of treatment through the clothes prostatitis, cured substantially after 4 courses of treatment, and the patient is very satisfied.

Embodiment 1

A kind of capsule for the treatment of prostatosis, it is made to fill a prescription and is: (unit: Kg)

Radix Gentianae 1.2 Radix Rehmanniae 2.0 Poria 2.0 Herba Artemisiae Scopariaes 1.5 Radix Bupleuri 1.0 Radix Curcumaes 1.2 Herba Houttuyniae 1.5 Herba Hedyotidis Diffusaes 2.0 SHANZHIZI 1.2 Radix Paeoniae Rubra 1.2 CAOXIE 1.5 Semen Abutilis 1.0 Radix Glycyrrhizaes 0.3 Flos Carthami 1.0;

Embodiment 2

Radix Gentianae 1.2 Radix Rehmanniae 2.0 Poria 2.0 Herba Artemisiae Scopariaes 1.5 Radix Bupleuri 1.0 Radix Curcumaes 1.2 Herba Houttuyniae 1.5 Herba Hedyotidis Diffusaes 2.0

Manufacture method is with embodiment 1.

Embodiment 3

Radix Gentianae 1.2 Radix Rehmanniae 2.0 Poria 2.0 Herba Artemisiae Scopariaes 1.5 Radix Bupleuri 1.0 Radix Curcumaes 1.2 Herba Houttuyniae 1.5 Herba Hedyotidis Diffusaes 2.0 SHANZHIZI 1.0 Radix Paeoniae Rubra 1.0 CAOXIE 1.2 Semen Abutilis 0.8 Radix Glycyrrhizae 0.2 Flos Carthami 0.8.

Manufacture method is with embodiment 1.

Claims

1, a kind of capsule for the treatment of prostatosis is characterized in that: the various compositions of its making prescription are by weight:

Radix Gentianae: the Radix Rehmanniae: Poria: Herba Artemisiae Scopariae: Radix Bupleuri: Radix Curcumae: Herba Houttuyniae: Herba Hedyotidis Diffusae=(1.0-1.2): (1.5-2.0): (1.5-2.0): (1.2-1.5): (0.8-1.0): (1.0-1.2): (1.0-1.5): (1.5-2.0).

2, a kind of capsule for the treatment of prostatosis according to claim 1 is characterized in that: the various compositions of its making prescription are by weight:

Radix Gentianae: the Radix Rehmanniae: Poria: Herba Artemisiae Scopariae: Radix Bupleuri: Radix Curcumae: Herba Houttuyniae: Herba Hedyotidis Diffusae: SHANZHIZI: Radix Paeoniae Rubra ∶ CAOXIE: Semen Abutili: Radix Glycyrrhizae: Flos Carthami=(1.0-1.2): (1.5-2.0): (1.5-2.0): (1.2-1.5): (0.8-1.0): (1.0-1.2): (1.0-1.5): (1.5-2.0): (1.0-1.2): (1.0-1.2): (1.2-1.5): (0.8-1.0): (0.2-0.3): (0.8-1.0).

3, a kind of capsular manufacture method for the treatment of prostatosis, it is characterized in that: raw material is added the octuple decocting for the first time boiled 2 hours, leach decocting liquid, add for the second time five times of water, decoct and leached decocting liquid in 1 hour, add water for the 3rd time and decoct for three times and leached decocting liquid in 1 hour, merges three decocting liquids and concentrating under reduced pressure receipts cream, drying and crushing gets powder, incapsulates.