CN1220529C - Making process of medical fiber - Google Patents
Making process of medical fiber Download PDFInfo
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- CN1220529C CN1220529C CN 01121345 CN01121345A CN1220529C CN 1220529 C CN1220529 C CN 1220529C CN 01121345 CN01121345 CN 01121345 CN 01121345 A CN01121345 A CN 01121345A CN 1220529 C CN1220529 C CN 1220529C
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Abstract
The present invention relates to a making method of medical fiber. The degradation time of the existing medical fiber used for making operation sutures and medical auxiliary material is short, and the existing medical fiber is not suitable for the therapy of a wound which needs a long time to be healed. The present invention uses beta-hydroxybunatoic acid and beta-hydroxy valeric acid copolymer as raw material. The raw material is dried, melted, squeezed, conveyed, metered, ejected, cooled, solidified, formed, stretched and shaped, and a completed product is made. The degradation time of the medical fiber made according to the method is long. The medical fiber can be used for making operation sutures for treating a wound which is not easily healed and medical auxiliary material.
Description
Technical field
The present invention relates to the manufacture method of a kind of manufacture method of biomaterial fiber, particularly a kind of medical fibre absorbed by the body.
Background technology
It is raw material that the medical fibre that is used to make operation suture thread and medical accessory at present adopts Acetic acid, hydroxy-, bimol. cyclic ester and lactide copolymer or chitin more, makes by doing wet method.With the fiber that this raw material is made, wet strength descends bigger, and degradation time is shorter, and its intensity of the time in a general week promptly descends about 50%.And in operation the healing time difference of different operative sites, at the position that needs the long period to heal, operation suture thread that existing medical fibre is made and medical accessory are just inapplicable.Because of time that need to recover at this place longer, fiber degradation too fast, unfavorable to the healing of wound.
Summary of the invention
Purpose of the present invention just provide a kind ofly have biodegradability, human body can absorb and the degradation time manufacture method of long medical fibre.
According to the present invention: a kind of manufacture method of medical fibre is to be raw material with beta-hydroxy-butanoic acid and beta-hydroxy valeric acid copolymer, employing melt extrudes the method that combines with wet moulding, and concrete steps comprise successively: dry, melt extruded is carried, metering ejection, cooling curing molding, stretching, typing, finished product.
Adopt this kind method, the number-average molecular weight of raw material beta-hydroxy-butanoic acid of selecting for use and beta-hydroxy valeric acid copolymer is 50,000～700,000; Melt temperature is 170 ℃～240 ℃; Spinning speed is 400～4000m/min, and the after-drawing multiple is 1.1～8 times; Setting temperature is 50 ℃～150 ℃, and shaping time is 5 seconds～72 hours.
Adopting the filament number of the finished fiber that this kind method makes is 3～80dtex, and fracture strength is 1.5～5.0cN/dtex, and elongation at break is 10%～200%.
Adopt this kind method to make medical fibre, raw material sources are extensive, and processing is simple; The medical fibre of making stops the basic no change of its intensity of a week in human body, intensity decreases about 40% after three months, is applicable to the treatment that needs the long period healing of wound.
The specific embodiment
It is 240000 beta-hydroxy-butanoic acid and beta-hydroxy valeric acid copolymer (being called for short PHBV) raw material that embodiment 1. selects number-average molecular weight for use, through super-dry, employing melt extrudes the method that combines with wet moulding, the control melt temperature is 182 ℃, spinning PHBV as-spun fibre, spinning speed is 800m/min, as-spun fibre stretches after 4 times, typing is 1 hour in 80 ℃ shaping box, makes the PHBV finished fiber.The fiber number of this finished fiber is 64dtex, and fracture strength is 2.1cN/dtex, and elongation at break is 42%.
It is 700000 beta-hydroxy-butanoic acid and beta-hydroxy valeric acid copolymer (being called for short PHBV) raw material that embodiment 2. selects number-average molecular weight for use, through super-dry, employing melt extrudes the method that combines with wet moulding, the control melt temperature is 240 ℃, spinning PHBV as-spun fibre, spinning speed is 3000m/min, as-spun fibre stretches after 1.95 times, typing is 72 hours in 150 ℃ shaping box, makes the PHBV finished fiber.The fiber number of this finished fiber is 3dtex, and fracture strength is 4.2cN/dtex, and elongation at break is 80%.
It is 50000 beta-hydroxy-butanoic acid and beta-hydroxy valeric acid copolymer (being called for short PHBV) raw material that embodiment 3. selects number-average molecular weight for use, through super-dry, employing melt extrudes the method that combines with wet moulding, the control melt temperature is 170 ℃, spinning PHBV as-spun fibre, spinning speed is 400m/min, as-spun fibre stretches after 8 times, typing is 36 hours in 50 ℃ shaping box, makes the PHBV finished fiber.The fiber number of this finished fiber is 80dtex, and fracture strength is 1.5cN/dtex, and elongation at break is 57%.
It is 500000 beta-hydroxy-butanoic acid and beta-hydroxy valeric acid copolymer (being called for short PHBV) raw material that embodiment 4. selects number-average molecular weight for use, through super-dry, employing melt extrudes the method that combines with wet moulding, the control melt temperature is 225 ℃, spinning PHBV as-spun fibre, spinning speed is 4000m/min, as-spun fibre stretches after 1.1 times, typing is 5 seconds in 70 ℃ shaping box, makes the PHBV finished fiber.The fiber number of this finished fiber is 34dtex, and fracture strength is 5.0cN/dtex, and elongation at break is 60%.
It is 160000 beta-hydroxy-butanoic acid and beta-hydroxy valeric acid copolymer (being called for short PHBV) raw material that embodiment 5. selects number-average molecular weight for use, through super-dry, employing melt extrudes the method that combines with wet moulding, the control melt temperature is 175 ℃, spinning PHBV as-spun fibre, spinning speed is 1000m/min, as-spun fibre stretches after 3.5 times, typing is 8 hours in 80 ℃ shaping box, makes the PHBV finished fiber.The fiber number of this finished fiber is 70dtex, and fracture strength is 1.8cN/dtex, and elongation at break is 200%.
The medical fibre degradation time that adopts this kind method to make is long.This kind medical fibre stops the basic no change of its intensity of a week in human body, intensity decreases about 40% after three months, can be used to make operation suture thread and the medical accessory that treatment is difficult to healing of wound.
Claims (6)
1. the manufacture method of a medical fibre, it is characterized in that this method is a raw material with beta-hydroxy-butanoic acid and beta-hydroxy valeric acid copolymer, employing melt extrudes the method that combines with wet moulding, concrete steps: dry, melt extruded is carried, metering ejection, cooling curing molding, stretching, typing, finished product.
2. the manufacture method of a kind of medical fibre as claimed in claim 1 is characterized in that the raw material beta-hydroxy-butanoic acid selected for use and the number-average molecular weight of beta-hydroxy valeric acid copolymer are 50,000～700,000.
3. the manufacture method of a kind of medical fibre as claimed in claim 1 is characterized in that melt temperature is 170 ℃～240 ℃.
4. the manufacture method of a kind of medical fibre as claimed in claim 1 is characterized in that spinning speed is 400～4000m/min, and the after-drawing multiple is 1.1～8 times.
5. the manufacture method of a kind of medical fibre as claimed in claim 1 is characterized in that setting temperature is 50 ℃～150 ℃, and shaping time is 5 seconds～72 hours.
6. the manufacture method of a kind of medical fibre as claimed in claim 1, the filament number that it is characterized in that its finished fiber is 3～80dtex, and fracture strength is 1.5～5.0cN/dtex, and elongation at break is 10%～200%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01121345 CN1220529C (en) | 2001-06-01 | 2001-06-01 | Making process of medical fiber |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01121345 CN1220529C (en) | 2001-06-01 | 2001-06-01 | Making process of medical fiber |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1389270A CN1389270A (en) | 2003-01-08 |
| CN1220529C true CN1220529C (en) | 2005-09-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01121345 Expired - Fee Related CN1220529C (en) | 2001-06-01 | 2001-06-01 | Making process of medical fiber |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1220529C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0113697D0 (en) | 2001-06-06 | 2001-07-25 | Smith & Nephew | Fixation devices for tissue repair |
| CN103230624A (en) * | 2013-05-02 | 2013-08-07 | 复旦大学附属上海市第五人民医院 | Implanted material for minimally invasive catgut implantation therapy |
| CN106400183A (en) * | 2016-09-22 | 2017-02-15 | 江南大学 | Poly-(3-polyhydroxybutyrate-co-3-polyhydroxybutyrate-hydroxyvalerate) multifilament and preparation method thereof |
-
2001
- 2001-06-01 CN CN 01121345 patent/CN1220529C/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN1389270A (en) | 2003-01-08 |
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Owner name: DONGHUA UNIV.; NINGBO TIANAN BIOLOGY MATERIAL CO. Free format text: FORMER OWNER: DONGHUA UNIV.; HANGZHOU TIANAN ECONOMIC DEVELOPMENT CO., LTD. Effective date: 20070413 |
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Owner name: DONGHUA UNIV.; HANGZHOU TIANAN ECONOMIC DEVELOPMEN Free format text: FORMER NAME OR ADDRESS: DONGHUA UNIV.; TIANAN INDUSTRY CO LTD, HANGZHOU |
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Address after: 200051 No. 1882, Shanghai, West Yan'an Road Co-patentee after: Hangzhou Tian An Economic Development Co.,Ltd. Patentee after: DONGHUA University Address before: 200051 No. 1882, Shanghai, West Yan'an Road Co-patentee before: TIANAN INDUSTRY Co.,Ltd. HANGZHO Patentee before: Donghua University |
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Effective date of registration: 20070413 Address after: 200051 No. 1882, Shanghai, West Yan'an Road Co-patentee after: TIANAN BIOLOGIC MATERIAL Co.,Ltd. NINGBO Patentee after: DONGHUA University Address before: 200051 No. 1882, Shanghai, West Yan'an Road Co-patentee before: Hangzhou Tian An Economic Development Co.,Ltd. Patentee before: Donghua University |
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Granted publication date: 20050928 Termination date: 20130601 |