CN1219415A - Medicinal composite for curing chronic retraction psychosis - Google Patents
Medicinal composite for curing chronic retraction psychosis Download PDFInfo
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- CN1219415A CN1219415A CN 97125319 CN97125319A CN1219415A CN 1219415 A CN1219415 A CN 1219415A CN 97125319 CN97125319 CN 97125319 CN 97125319 A CN97125319 A CN 97125319A CN 1219415 A CN1219415 A CN 1219415A
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Abstract
A composite medicine (Shenkang No.III) for curing chronic recessive psychosis contains sulpiride (5.66-7.66 wt.%), ethaperazin (0.33-0.63), nimodipine (0.83-1.83), rhubarb powder (28.33-38.33), borneol (3-8) and Chinese medicinal extract (49.13-59.13), and features low dosage, quickly taking its effect, and low toxic by-effect.
Description
The present invention relates to a kind of pharmaceutical composition that is used for the treatment of chronic recession psychosis, specifically a kind of the assistant by the psychotolytic Pharmaceuticals of classics combines with the micro-calcium channel antagonist, is applicable to the refreshing beneficial pharmaceutical composition of chronic recession psychosis.
Chronic recession psychosis often is secondary to acute mental disorder because of losing the treatment good opportunity or treating not thorough, decline residual property syndrome and describe and a group of leaving behind is chronic, the common clinical manifestation of this disease has: apathy, the poverty of thought, dull unsociable and eccentric, hypobulia, life sluggishness, untidy, purplish tongue, tongue is few or no fur or see ecchymosis, deep-rolling pulse or heavy, knot or unable etc.The normal residual abalienation symptom of this type of patient, and be the chronic gradual decay of omnibearing social function, the course of disease twines and prolongs, treatment is quite difficult, even needs lifelong medication.This type of patient accounts for the last 50% that psychosis is always sent out prevalence according to statistics, and increase progressively with annual 6/10000ths accumulations, give patient oneself, family, society brings difficulty, at present clinical when this mattoid of treatment, the common low dosage of selecting for use, height is tired and is had the chemical synthetic drug of antipsycholic action, as perphenazine, fluphenazine, trifluoperazine, haloperidol etc., but its effective dose curve of these medicines and the orthogonal thereto fork of toxicity curve of self, when that is to say the dose when medicine reaches effective control clinical symptoms, its toxicity is (drowsiness as dizziness, cathisophobia, blood pressure drops, tachycardia, constipation, witless expression etc.) also occur thereupon.The course of disease is touching, the characteristics of easy recurrence because psychosis has, the clinical principle that the time must adhere to taking medicine for a long time control again in treatment, and present clinical employed these chemical synthetic drugs, in use for some time, the untoward reaction of its toxic and side effects, make patient be difficult to persevere, do not take medicine and lose control of unusual mental symptom, disturb or roam about in society.Take the medicine of the treatment chronic recession psychosis that toxic and side effects is little in long period so press for a kind of this type of patient of supplying at present clinically.
Purpose of the present invention just provides a kind of curative effect height, and toxic and side effects is little, and the refreshing health medicine of the chronic recession psychosis of taking convenience.
It is modern to the depth research of psychosis at microcirculation, neurotransmitter, biochemistry etc. to pharmacodynamic study, the combination of psychotropic drugs that purpose of the present invention realizes being based on modern pharmacology.Point out as hemorheology: mental patient's ubiquity nail fold microcirculation disturbance, blood viscosity strengthens, and classical psychosis Pharmaceuticals is difficult for being forced to by blood brain barrier rapidly defectives such as the neural loose medicine of high doses applied.At this defective, on classic treatment chronic recession psychosis method basis, assistant has used trace to have the calcium-channel antagonists of certainty, the effect of selectivity expansion of cerebral vascular, carries out organic assembling.And produced the psychotic novel form of a kind of collaborative treatment of Chinese and western medicines chronic retraction.Novel form merges Chinese medicine and western medicine school elite, be presented on the preferred compatibility of each prescription in this medicine, can either reduce the consumption of chemical synthetic drug, its toxic and side effects of antagonism, can on curative effect, produce good synergism again, reaching western medicine and medical practitioners debates disease and controls fast because of, the dialectical purpose of effecting a permanent cure of Chinese medicine.Medicine advantage of the present invention is also being carried out effective form improvement by selected ratio range by modern high tech method with each component, thus become one group have imitate special, inexpensive, dosage is little, taking convenience, toxic and side effects are low, the novel form for the treatment of both the principal and secondary aspects of a disease resultant effect.
Medicine of the present invention is made up of following raw materials in percentage by weight: sulpiride 5.66～7.66%, perphenazine 0.33%～0.63%, nimodipine 0.83～1.83%, Borneolum Syntheticum 3～8%, Radix Et Rhizoma Rhei powder 28.33～38.33%, this Chinese medical concrete is made by the following weight proportion raw material: 20～30 parts of Cornu Bubalis, 10～20 parts of Pollen Typhaes, 10～20 parts of Oletum Trogopteroris, 10～20 parts of dried Pheretima, 10～20 parts of Rhizoma Chuanxiongs, all gold is 10～20 parts.
The preferred weight proportioning of preparation Chinese medical concrete is: 23～27 parts of Cornu Bubalis, Pollen Typhae 13～17,12～17 parts of Oletum Trogopteroris, 13～17 parts of dried Pheretima, 13～17 parts of Radix Curcumaes.
Each component in the medicine of the present invention all can be bought on medical market.
Medicine of the present invention can be made into tablet, various peroral dosage forms such as capsule or electuary.
The preparation method of capsule of the present invention is:
At first prepare Chinese medical concrete, take by weighing each component of Chinese herbal medicine, chopping by the proportioning in the prescription of the present invention, soaked 2-4 hour, decocted 1～3 hour, filter, after leaving and taking filtrate, add water, repeated to decoct 1-2 hour, filter, twice filtrate merges, filtrate is concentrated into the thick paste shape, dries, is ground into fine powder with vacuum and low temperature, crosses the 80-100 mesh sieve, and is stand-by.
2. include 5.66-7.66 gram sulpiride by per 100 grams medicine of the present invention, 0.33-0.63 restrains perphenazine, and 0.83-1.83 restrains nimodipine, 3-8 restrains Borneolum Syntheticum, and 28.33-38.33 restrains Radix Et Rhizoma Rhei powder, and 49.13-59.13 restrains Chinese medical concrete, take by weighing each component, and it is stirred.
3. aforementioned pharmaceutical compositions is incapsulated: include 0.45 gram medicated powder by every capsules, the capsule of packing into No. 0, make every capsules include sulpiride 25.5～34.5mg, perphenazine 1.5～2.8mg, nimodipine 3.7～8.2mg, Borneolum Syntheticum 13.5mg～36mg, Radix Et Rhizoma Rhei powder 127.4～172.4mg, Chinese medical concrete 196.1～278.4mg, i.e. preparation cost invention medicine (refreshing health III number)
Medication preparation of the present invention becomes capsule at the usage and dosage of treatment chronic recession psychosis to be: each 2～5, every day secondary, 15 of the Shi Keri that is in a bad way clothes, each dosage generally should be from low dosage, be therapeutic dose when dosage is to the symptom basic controlling gradually, after this therapeutic dose need adhere to taking 40～60 days, slowly remove again and reduce to maintenance dose, promptly every day the 3-6 grain, the preceding decoction being taken at a draught of sleeping, treatment cycle was a course of treatment with three months, consolidated medication and was generally 1-5, but do not recur the sign drug withdrawal in 5 years.
Chemical synthetic drug in the drug component of the present invention is partly: the still classical effectively anti-type psychosis medicine of shrinking back of sulpiride, perphenazine, and clinical normal and be used for heightening the effect of a treatment.Nimodipine is 1.4 dihydropyridine calcium channel antagonists, and pharmacology confirms to select expansion of cerebral vascular at optimal dose tool specificity, and the characteristics that combine with the special receptor of nervus centralis.By these characteristics, drive classical neural loose medicine and enter blood brain barrier to greatest extent.Medicine partly goes out " SHIXIAO SAN " still famous blood circulation promoting and blood stasis dispelling prescription from " prescription of peaceful benevolent dispensary " among in the component, and Pollen Typhae, the special blood circulation promoting and blood stasis dispelling of Oletum Trogopterori merit, the stasis of blood are gone refreshing peace and be principal agent in the side; Cornu Bubali, dried Pheretima be the in love animal drugs of flesh and blood still, supplementing the brain, invigorate blood circulation, the logical twelve regular channels, the stasis of blood go not hinder and just be ministerial drug; Rhizoma Chuanxiong, Radix Curcumae vital energy regualting and blood circulation-promoting drive; Borneolum Syntheticum gas fragrance, inducing resuscitation; It is turbid to cleanse the stasis of blood under Radix Et Rhizoma Rhei rushes down; Altogether for making messenger drug.The stasis of blood is gone through beniol, YIN and YANG in a relative equilibrium, brain gas connects, refreshing peace certainly, make the patient under situation about not affecting the treatment by above synergism, obviously reduce the dose of classical psychosis chemical synthetic drug, thereby also just reduced the toxic and side effects of chemical synthetic drug, thereby guaranteed that the patient can adhere to medication for a long time, provide a kind of medicine for the treatment of chronic recession psychosis for clinical, solved for a long time owing to use toxic and side effects due to the chemical synthetic drug treatment psychosis seriously to perplex the thorny problem of clinical application.
Innovation of the present invention also has in chemical synthetic drug and Chinese herbal medicine organically are combined into one, and not only having significant effect aspect protection curative effect, the reduction toxic and side effects, takes but also greatly facilitate the patient.Make the patient when taking multiple medicine, needn't calculate dose more respectively, check the medicine name, thereby also avoided the patient to take the serious consequence that wrong medicine brings.
The consumption proportion scope of each component of medicine of the present invention determines that through prolonged and repeated practice screening it has guaranteed the curative effect height that medicine of the present invention had, the characteristics that toxic and side effects is little.
The optimum ratio scope of the contained Chinese medical concrete of the present invention makes each component have better synergism.
The effect of pharmaceutical composition of the present invention, the system's clinical observation by 100 routine patients has obtained checking.
The verification method of curative effect of medication of the present invention, toxicity is: patient adopts single at random blind method.Select medical history, the state of an illness, age, the chronic retraction mental patient that sex is suitable are divided into experimental group, two groups of matched groups, experimental group is taken medicine of the present invention, institute's dose of taking is according to the psychosis medicine commutation table of tiring, with the sulpiride, the perphenazine that include, to be converted to the chlorpromazine amount be average every day of 300mg.Matched group is taken simple chemical synthetic drug: it is average every day of 600mg that its sulpiride, perphenazine, institute's dosage are converted to the chlorpromazine amount, the results are shown in Table 1.
Table 1 side reaction evaluation therapeutic index
(the CGI scale relatively)
| Group experimental group matched group X 2 | N curative effect general comment (GI) 50 1.70 ± 0.52 50 1.43 ± 0.38 P＞0.05 | Side reaction (TESS) 1.14 ± 0.42 2.80 ± 0.80 P＜0.01 | Therapeutic index (EI) 3.44 ± 1.15 2.45 ± 1.25 P＜0.01 |
Experimental result shows, includes under the low situation with one times of amount of the used chlorpromazine of matched group of tiring of chlorpromazine at experimental group, and the curative effect general comment index of experimental group also is slightly larger than matched group, through X
2Handle its P＞0.05, show its therapeutic equivalence, the side reaction index of experimental group is lower than the side reaction index of matched group, through X
2Handle its P＜0.01, its difference has the significance meaning, thereby the toxic and side effects that shows medicine of the present invention is starkly lower than simple chemical synthetic drug 5 usefulness.
Show in the tracking situation that the 128 routine chronic recession psychosis patient situations of taking medicine of taking medicine of the present invention are carried out, wherein 110 patients abide by doctor's advice and adhere to having taken half a year-2 year, not because of being impatient at its toxic and side effects drug withdrawal, 18 patients that its interruption is taken medicine are also because other is former thereby discontinue medication.
Embodiment 1:
(1) the preparation Chinese medical concrete takes by weighing 25 kilograms of Cornu Bubalis, 15 kilograms of Pollen Typhaes, 15 kilograms of Oletum Trogopteroris, 1,000 kilograms of Pheretimas, 15 kilograms of Rhizoma Chuanxiongs, 15 kilograms of Radix Curcumaes.
Cornu Bubali powder is broken into granule, and other medicated powder is broken into fritter, adds water to submerge respectively to soak 4 hours, Cornu Bubali was decocted 3 hours, and other medicine decocted 2 hours, filtered, filtrate merges, and is stand-by, and medicinal residues merge and add water, decocted 1 hour, and filtered, merge filtrate twice, vacuum low-pressure is concentrated into the thick paste shape, after the oven dry, is ground into powder, cross 80 mesh sieves, stand-by.
(2) precision takes by weighing sulpiride 66.6 grams, perphenazine 5.3 grams, nimodipine 13.3 grams, Borneolum Syntheticum 40 grams, Radix Et Rhizoma Rhei powder 333.3 grams, Chinese medical concrete 541.5 grams, fully mixing.
(3) incapsulate by every 0.45 gram weight.
Below 4 embodiment, preparation method is all with embodiment 1, just each set of dispense is than consumption difference.
Following table is the proportional quantity of preparation Chinese medical concrete among the embodiment 2-5.
Contained group component among the embodiment 2-5
The medicine of forming according to above prescription of the present invention has good effect, and toxic and side effects is low, the characteristics of taking convenience.
Claims (2)
1. refreshing beneficial pharmaceutical composition for the treatment of chronic recession psychosis, it is characterized in that it comprises the following raw materials in percentage by weight composition: sulpiride 5.66～7.66%, perphenazine 0.33～0.63%, nimodipine 0.83～1.83%, Borneolum Syntheticum 3～8%, Radix Et Rhizoma Rhei powder 28.33～38.33%, Chinese medical concrete 49.13～59.13%.Its Chinese medical concrete is made by the following weight proportion raw material: 20～30 parts of Cornu Bubalis, 10～20 parts of Pollen Typhaes, 10～20 parts of Oletum Trogopteroris, 10～20 parts of dried Pheretima, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Radix Curcumaes.
2. according to the refreshing beneficial pharmaceutical composition of the described treatment chronic recession psychosis of claim (1), it is characterized in that said Chinese herbal medicine extractum made by the following weight proportion raw material:
23～27 parts of Cornu Bubalis, 13～17 parts of Pollen Typhaes, 13～17 parts of Oletum Trogopteroris, 13～17 parts of dried Pheretima, 13～17 parts of Rhizoma Chuanxiongs, Radix Curcumae 13-17 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97125319 CN1219415A (en) | 1997-12-12 | 1997-12-12 | Medicinal composite for curing chronic retraction psychosis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97125319 CN1219415A (en) | 1997-12-12 | 1997-12-12 | Medicinal composite for curing chronic retraction psychosis |
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| CN1219415A true CN1219415A (en) | 1999-06-16 |
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| CN 97125319 Pending CN1219415A (en) | 1997-12-12 | 1997-12-12 | Medicinal composite for curing chronic retraction psychosis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11962995B2 (en) | 2018-11-01 | 2024-04-16 | South China University Of Technology | Virtual playback method for surround-sound in multi-channel three-dimensional space |
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1997
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11962995B2 (en) | 2018-11-01 | 2024-04-16 | South China University Of Technology | Virtual playback method for surround-sound in multi-channel three-dimensional space |
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