CN1216700A - Coolant powders - Google Patents
Coolant powders Download PDFInfo
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- CN1216700A CN1216700A CN 98117485 CN98117485A CN1216700A CN 1216700 A CN1216700 A CN 1216700A CN 98117485 CN98117485 CN 98117485 CN 98117485 A CN98117485 A CN 98117485A CN 1216700 A CN1216700 A CN 1216700A
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Abstract
The present invention relates to a method for imparting a cool feeling and relieving itching to the skin. The invention further records a composition about the function. More concretely, the invention firstly makes use of the refrigerant without the burning sensation or the harsh odor normally associated with menthol.
Description
The application is required for protection to be that the application number submitted on August 26th, 1997 is the interests of 60/056,975 U.S. Provisional Application, this provisional application at this all with for referencial use.
The present invention relates to make skin to produce comfortable cooling feeling and without burn feeling that has by menthol usually or the compositions of making us niff, and prepare this method for compositions.
High temperature and moist weather can make the people do not feel like oneself immediately.When temperature raises since with the loss of the corresponding heat of evaporation of thermal stress, sweat gland is upset and perspires.Especially summer, can make the people feel to be clamminess, greasy and scratch where it itches.Take a shower and also can only temporarily be loosened, and use have the coolant that the smell is awful contain the menthol powder can stimulate sensitive skin, such as child's skin, described coolant such as menthol, Camphora and other have the reagent of strong cooling effect and abnormal smells from the patient.
Can see the various compositionss that are used for medicine and cosmetic powdery absorbent in the present technique field.In these powdery absorbent, be very general as coolant with menthol.Yet menthol has relative very strong abnormal smells from the patient and to the skin tingle.
As United States Patent (USP) 5,266, described in No. 592, known ketal has cooling characteristics in this area.United States Patent (USP) 5,451 has been put down in writing the coolant composition of the second kind of coolant that comprises ketal and be made up of menthol, hydroxy amide or its mixture for No. 404.
Therefore need provide a kind of nice and cool powder that contains unique coolant, this coolant can make skin produce soft cooling feeling and the overpowering odor that has without coolant well known in the art.Further need a kind of all right itching relieving powder.
The invention provides a kind of compositions that comprises following composition:
A) a kind of powder composition; With
B) a kind ofly be selected from following coolant:
ⅰ) base 2-pyrrolidone-5-carboxylic acid ester ( base PCA);
ⅱ) 5-methyl-2-(1-methyl ethylene)-Hexalin;
ⅲ) 5-methyl-2-(1-Methylethyl)-cyclohexyl-2 hydroxy propanoic acid ester, promptly
Be 1-lactic acid ester, just acid/- ester (lactic acid ester); Or
ⅳ) its mixture.
In another embodiment of the present invention, provide a kind of and be used to make skin to produce the method for cooling feeling, this method comprises the compositions that comprises following composition to dermal administration:
A) a kind of powder composition; With
B) a kind ofly be selected from following coolant:
ⅰ) base 2-pyrrolidone-5-carboxylic acid ester ( base PCA);
ⅱ) 5-methyl-2-(1-methyl ethylene)-Hexalin;
ⅲ) 5-methyl-2-(1-Methylethyl)-cyclohexyl-2 hydroxy propanoic acid ester,
Be 1-lactic acid ester, just acid/- ester (lactic acid ester); Or
ⅳ) its mixture.
The present invention also has a kind of embodiment, and it provides a kind of to skin itching relieving method, and this force method comprises the compositions that comprises following composition to topical application:
A) a kind of powder composition; With
B) a kind ofly be selected from following coolant:
ⅰ) ketal;
ⅱ) base 2-pyrrolidone-5-carboxylic acid ester ( base PCA);
ⅲ) 5-methyl-2-(1-methyl ethylene)-Hexalin;
ⅳ) 5-methyl-2-(1-Methylethyl)-cyclohexyl-2 hydroxy propanoic acid ester,
Be 1-lactic acid ester, just acid/- ester (lactic acid ester); Or
ⅴ) its mixture is if when coolant was ketal, this compositions was substantially free of menthol, Carboxylamide and composition thereof.
The present invention still has a kind of embodiment, and it provides a kind of preparation to comprise the method for the powder composition of following composition:
A) a kind of powder composition; With
B) a kind ofly be selected from following coolant:
ⅰ) ketal;
ⅱ) base 2-pyrrolidone-5-carboxylic acid ester ( base PCA);
ⅲ) 5-methyl-2-(1-methyl ethylene)-Hexalin;
ⅳ) 5-methyl-2-(1-Methylethyl)-cyclohexyl-2 hydroxy propanoic acid ester,
Be 1-lactic acid ester, just acid/- ester (lactic acid ester); Or
ⅴ) its mixture.If when coolant was ketal, this compositions was substantially free of menthol, Carboxylamide and composition thereof;
This method may further comprise the steps:
ⅰ) coolant is dissolved in the liquid perfume, and stirs being enough to form under the condition of premix;
ⅱ) premix is sprayed in the powder composition; With
ⅲ) the product of mixing (ⅱ).
Do not using that the smell is awful or having under the prerequisite of composition of twinge effect, the compositions and methods of the invention provide a kind of can make skin produce cooling feeling and/or to skin itching relieving uniqueness, mode easily.
Powder composition preferably talc, starch, cellulose or derivatives thereof or its mixture of the present composition.The powder composition is Talcum, corn starch or its mixture through sterilizing more preferably, and most preferably is the Talcum through sterilization.It is about 100% that the powder composition accounts for about 50%-of composition total weight, and 70%-about 99% more preferably from about." through what sterilize " used herein is meant Talcum handled to control the quantity of microbial contamination wherein through method well known in the art.Although the present invention can use the powder composition of any granular size, preferred particle size distribution is that at least 95% granule can pass through 200 mesh sieves, and most preferred particle size distribution is to pass through 350 mesh sieves.
Second kind of composition of the present composition is coolant.The preferred coolant of the present invention is structurally relevant with menthol, and has the effective skin treating characteristic of menthol thus and can not keep it such as the smell is awful and harmful characteristic of this class of twinge effect.These coolants by with skin in enzyme reaction form menthol and work, and also can use other skin treatment agent under some situation.In addition, it is antipruritic that these coolants can make skin.Below be to be applicable to the suitable coolant in the present composition and the method but to be not special-purpose:
ⅰ) base 2-pyrrolidone-5-carboxylic acid ester ( base PCA), available from Quest International UKLtd., commodity " Questice " by name, its reaction back generates menthol and 2-pyrrolidone-5-carboxylic acid at skin surface;
ⅱ) 5-methyl-2-(1-methyl ethylene)-Hexalin, available from Takasago InternationalCorporation, commodity " Coolact P " by name, its reaction back generates menthol at skin surface;
ⅲ) 5-methyl-2-(1-Methylethyl)-cyclohexyl-2 hydroxy propanoic acid ester, be 1-lactic acid ester, just acid/- ester (lactic acid ester), be called " Frescolat ML " available from Haarmann and Reimer GmbH, commodity, its reaction back generates menthol and lactic acid at skin surface; Or
ⅳ) its mixture.
As United States Patent (USP) 5,266,592 and 5,451, No. 404 (two pieces of documents intactly are incorporated herein by reference) is described, and ketal is also applicable in the method for the present invention.Ketal not only has fabulous itching-relieving action to skin but also has and the similar cooling characteristics of above-mentioned coolant.
The ketal that preferably contains following general formula
Wherein in R generation, have at least 1 but the C of no more than 3 hydroxyls
2-C
6Alkylidene preferably has 1 hydroxyl.These ketals are structurally also relevant with menthol and have the antipruritic characteristic of menthol thus.Most preferred ketal is 6-isopropyl-9-methyl isophthalic acid, 4-dioxo spiro-(4,5)-decane-2-methanol, is 1-WS-3 (menthone glycerol acetal), and its reaction back generates menthol and glycerol at skin surface.
The coolant of the preferred present composition comprises 6-isopropyl-9-methyl isophthalic acid, 4-dioxo spiro-(4,5)-decane-2-methanol, be 1-WS-3 (menthone glycerol acetal), 5-methyl-2-(1-methyl ethylene)-Hexalin or its mixture, most preferably 5-methyl-2-(1-methyl ethylene)-Hexalin.
It is about 5% that the amount of the coolant in the present composition preferably accounts for about 0.05%-of composition total weight, and it is about 2% more preferably to account for about 0.1%-, most preferably accounts for about 0.2%-about 0.8%.
The present composition can contain the structure that strengthens powder or the composition of water proofing property arbitrarily.The example of these components has (being not special use): magnesium carbonate, magnesium stearate and composition thereof.It is about 15% that these components can account for about 0%-of composition total weight, preferably about 1%-about 10%.
Other the available composition that is applicable to the present composition includes, but is not limited to: anticaking agent, such as ternary calcium phosphate; Antimicrobial, such as chloroxylenol or-to chloro-3,5-meta-xylene phenol (PCMX) is available from Nipa Laboratories Ltd., commodity " Nipacide PX " by name, spice, menthol, Camphora, Carboxylamide; Vitamin is such as vitamin E and D-panthenol; Filler, such as magnesium carbonate, available from Konoshima Chemical Co., Ltd., commodity " MagnesiumCarbonate Light " by name; And composition thereof.
It is about 10% that the amount of anticaking agent can account for about 0%-of composition total weight, and preferably about 0.3%-about 0.8%.
It is about 5% that the amount of antimicrobial can account for about 0%-of composition total weight, and preferably about 0.3%-about 1%.
It is about 2% that the amount of spice can account for about 0%-of composition total weight, and preferably about 0.2%-about 1%.
In order to strengthen cooling effect, can use the menthol, Camphora and the Carboxylamide that account for the about 0%-of composition total weight about 1.5%, preferably about 0.1%-about 0.5%.When the coolant in the present composition is the ketal of formula I, neither needs menthol also not need Carboxylamide, and thus in these cases, preferably be substantially free of the compositions of menthol, Carboxylamide and its mixture." being substantially free of " as herein described is defined as by its amount of the gross weight of compositions less than about 0.0005%.
It is about 5% that the amount of vitamin can account for about 0%-of composition total weight, and preferably about 0.05%-about 2%.
It is about 15% that the amount of filler can account for about 0%-of composition total weight, and preferably about 1%-about 10%.
Another embodiment of the present invention provides the method for compositions that a kind of preparation comprises powder composition and above-mentioned coolant.At first under room temperature and ambient pressure, coolant is dissolved in the liquid perfume so that form premix.Also compositions of the present invention can be prepared in any mixing arrangement well known in the art, for example be equipped with or be not equipped with the rustless steel or the glass container of mechanical agitator.After premix is sprayed into Talcum, the mixture that obtains is at room temperature stirred to form better homogeneous mixture.
Powder composition of the present invention helps to prolong the pure and fresh sense of " back of just having taken a shower ", and makes user feel very cool and comfortable.Because the present composition mainly only is made up of the coolant of soft abnormal smells from the patient the bad smell that does not contain similar menthol, so also be very safe with the people that it is used to have sensitive skin.Dust composition usefulness of the present invention is covered on the skin area of need with the user of this combination treatment.When user feels that it is effective, when wishing to make skin antipruritic or when making it produce cooling feeling, can use compositions of the present invention.
Under the situation of not using the not disclosed especially composition of any this paper, component or step, also can implement the openly also illustrational the present invention of this paper.Below cited several embodiment be used for further illustrating content of the present invention and embodiment thereof.But should not be considered as concrete qualification of the present invention.EXAMPLE Example 1: the preparation of pure and fresh powder
Under the temperature of ambient pressure and about 20 ℃-Yue 32 ℃, 6-isopropyl-9-methyl isophthalic acid that will about 0.5kg in the rustless steel storehouse of mechanical agitator is housed, 4-dioxo spiro-(4,5)-decane-2-methanol, be that 1-WS-3 (menthone glycerol acetal) (available from Haarmann and Reimer GmbHd, commodity " Frescolat MGA " by name) is dissolved in about 0.22kg spice so that the formation premix.This premix was mixed about 5-about 10 minutes under the about 30 rev/mins speed of about 20-.
Use 37 SC type Mateer-Burt aerosol apparatus that this premix is sprayed in about 90kg Talcum (available from Guping PIT, the commodity " Chinese Cosmetic Talc-J200 " by name of China) then, this Talcum has placed 37 SC type Mateer-Burt ribbon blenders.Again with about 60 minutes of gained mixture stir about 30-, or be stirred to and obtain till the even powder.
Repeat this embodiment, but with 5-methyl-2-(1-Methylethyl)-cyclohexyl-2 hydroxy propanoic acid ester, be 1-lactic acid ester, acid just/- ester (lactic acid ester) (available from Haarmann and Reimer GmbH, commodity " Frescolat ML " by name) substitutes " Frescolat MGA ", and uses 5-methyl-2-(1-methyl ethylene)-Hexalin (available from Takasago International Corporation, commodity " Coolact P " by name) to substitute " Frescolat MGA " once more.Embodiment 2: the preparation of pure and fresh powder
Repeat the method for embodiment 1, but before adding premix, directly in ribbon blender, add the branch that may be selected to of about 5kg, comprise magnesium stearate and magnesium carbonate.
Repeat the method for embodiment 1, but after adding premix, directly in ribbon blender, add the branch that may be selected to of about 5kg, comprise magnesium stearate and magnesium carbonate.Embodiment 3: the preparation of pure and fresh powder
Under ambient pressure and about 25 ℃-35 ℃ temperature, base 2-pyrrolidone-5-carboxylic acid ester ( base PCA) (available from Quest International UKLtd., commodity " Questice " by name) that will about 0.5kg in the ribbon blender of embodiment 1 mixes with about 7kg Talcum, and mixing is till obtaining uniform mixture under about 20-30 rev/min speed.After adding the Talcum of about 90kg embodiment 1 therein, mixed about 10-15 minute with the talcose mixture of about 20-30 rev/min speed with gained.Aerosol apparatus by embodiment 1 after wherein injecting the spice of about 0.22kg embodiment 1, with gained contain spice mixt be mixed to obtain uniform powder till.Embodiment 4: the preparation of pure and fresh powder
Prepare following compositions according to embodiment 2 described programs:
The chemistry of " Frescolat MGA " is called 6-isopropyl-9-methyl isophthalic acid, and 4-dioxo spiro-(4,5)-decane-2-methanol is equal to: C
13H
24O
3Can be antipruritic when resulting composition is used for skin.Embodiment 5: the preparation of pure and fresh powder
| The trade name of component | The CTFA name of composition | Function | Active % | Active % (w/w) |
| Chinese?Cosmetic Talc-J2oo | Talcum | Absorbent | 100 | About 95-about 99 |
| Frescolat?MGA | Menthone glycerol acetal * | Coolant | 100 | About 0.2-about 0.8 |
| Magnesium stearate (BP level) | Magnesium stearate | Waterproofing agent | 100 | About 1-about 4 |
| Spice | Spice | Aromatic | 100 | About 0.15-about 0.3 |
| Total amount | 100.00 | |||
Prepare following compositions according to embodiment 2 described methods:
The chemistry of " Coolact P " is called 5-methyl-2-(1-methyl ethylene)-Hexalin, is equal to: C
10H
18O (the positive isopulegol of L-) can make skin produce cooling feeling and also can be antipruritic when resulting composition is used for skin.Embodiment 6: the preparation of pure and fresh powder
| The component trade name | Composition CTFA name | Function | Active % | Active % (w/w) |
| Chinese?Cosmetic Talc-J200 | Talcum | Absorbent | 100 | About 95-about 99 |
| Coolact?P | No CTFA name ** | Coolant | 100 | About 0.2-about 0.8 |
| Magnesium stearate (BP level) | Magnesium stearate | Waterproofing agent | 100 | About 1-about 4 |
| Spice | Spice | Aromatic | 100 | About 0.15-about 0.3 |
| Total amount | 100.00 | |||
Prepare following compositions according to embodiment 2 described programs:
The chemistry of " Coolact P " is called 5-methyl-2-(1-methyl ethylene)-Hexalin, is equal to: C
10H
18O (the positive isopulegol of L-) can make skin produce cooling feeling and also can be antipruritic when resulting composition is used for skin.
| The component trade name | Composition CTFA name | Function | Active % | Active % (w/w) |
| Chinese?Cosmetic Talc-J200 | Talcum | Absorbent | 100 | About 95-about 99 |
| Coolact?P | No CFTA name ** | Coolant | 100 | About 0.2-about 0.8 |
| Magnesium Carbonate?Light | Magnesium carbonate | Filler | 100 | About 1-about 5 |
| Menthol | Menthol | Coolant | 100 | About 0.3-about 0.6 |
| Camphora USP | Camphora | Coolant | 100 | About 0.5-about 0.8 |
| Spice | Spice | Aromatic | 100 | About 0.15-about 0.3 |
| Total amount | 100.00 | |||
Claims (31)
1. compositions comprises:
A) a kind of powder composition; With
B) a kind ofly be selected from following coolant:
ⅰ) base 2-pyrrolidone-5-carboxylic acid ester ( base PCA);
ⅱ) 5-methyl-2-(1-methyl ethylene)-Hexalin;
ⅲ) 5-methyl-2-(1-Methylethyl)-cyclohexyl-2 hydroxy propanoic acid ester,
Be 1-lactic acid ester, just acid/- ester (lactic acid ester); Or
ⅳ) its mixture.
2. the compositions of claim 1, wherein the powder composition is Talcum, corn starch, cellulose or derivatives thereof or its mixture.
3. the compositions of claim 1, wherein the granular size of powder composition is less than about 200 sieve meshes.
4. the compositions of claim 1, wherein coolant is 5-methyl-2-(1-methyl ethylene)-Hexalin.
5. the compositions of claim 1, wherein the amount of coolant accounts for about 0.05%-about 5% of composition total weight.
6. the compositions of claim 1, wherein the amount of coolant accounts for about 0.2%-about 0.8% of composition total weight.
7. the compositions of claim 1 further comprises a kind of ketal.
8. the compositions of claim 7, wherein ketal is a menthone glycerol acetal.
9. the compositions of claim 1 further comprises the structure that strengthens powder or the composition of water proofing property.
10. the compositions of claim 9, wherein strengthening the structure of powder or the composition of water proofing property is magnesium carbonate, magnesium stearate or its mixture.
11. the compositions of claim 1 further comprises anticaking agent, antimicrobial, spice, menthol, Camphora, Carboxylamide, vitamin, filler or its mixture.
12. prepare a kind of product of forming by the described compositions of claim 1.
13. the product of claim 12 preparation, wherein this product is a powder.
14. a method that makes skin produce cooling feeling, this method comprises the compositions that comprises following composition to dermal administration:
A) a kind of powder composition; With
B) a kind ofly be selected from following coolant:
ⅰ) the base is given a tongue-lashing pyrrolidone carboxylate ( base PCA);
ⅱ) 5-methyl-2-(1-methyl ethylene)-Hexalin;
ⅲ) 5-methyl-2-(1-Methylethyl)-cyclohexyl-2 hydroxy propanoic acid ester,
Be 1-lactic acid ester, just acid/- ester (lactic acid ester); Or
ⅳ) its mixture.
15. the method for claim 14, wherein the powder composition is Talcum, corn starch, cellulose or derivatives thereof or its mixture.
16. the method for claim 14, wherein the granular size of powder composition is less than about 200 sieve meshes.
17. the method for claim 14, wherein coolant is 5-methyl-2-(1-methyl ethylene)-Hexalin.
18. the method for claim 14, wherein the amount of coolant accounts for about 0.05%-about 5% of composition total weight.
19. the method for claim 14, wherein the amount of coolant accounts for about 0.2%-about 0.8% of composition total weight.
20. the method for claim 14 further comprises a kind of ketal.
21. one kind to skin itching relieving method, comprises the compositions that comprises following composition to topical application:
A) a kind of powder composition; With
B) a kind ofly be selected from following coolant:
ⅰ) ketal;
ⅱ) base 2-pyrrolidone-5-carboxylic acid ester ( base PCA);
ⅲ) 5-methyl-2-(1-methyl ethylene)-Hexalin;
ⅳ) 5-methyl-2-(1-Methylethyl)-cyclohexyl-2 hydroxy propanoic acid ester,
Be 1-lactic acid ester, just acid/- ester (lactic acid ester); Or
ⅴ) its mixture is if when coolant was ketal, this compositions was substantially free of menthol, Carboxylamide and composition thereof.
22. the method for claim 21, wherein the powder composition is Talcum, corn starch, cellulose or derivatives thereof or its mixture.
23. the method for claim 21, wherein the granular size of powder composition is less than about 200 sieve meshes.
24. the method for claim 21, wherein ketal is a menthone glycerol acetal.
25. the method for claim 21, wherein coolant is 5-methyl-2-(1-methyl ethylene)-Hexalin.
26. the method for claim 21, wherein the amount of coolant accounts for about 0.05%-about 5%.
27. the method for claim 21, wherein the amount of coolant accounts for about 0.2%-about 0.8%.
28. method for preparing the powder composition that comprises following composition:
A) a kind of powder composition; With
B) a kind ofly be selected from following coolant:
ⅰ) ketal;
ⅱ) base 2-pyrrolidone-5-carboxylic acid ester ( base PCA);
ⅲ) 5-methyl-2-(1-methyl ethylene)-Hexalin;
ⅳ) 5-methyl-2-(1-Methylethyl)-cyclohexyl-2 hydroxy propanoic acid ester,
Be 1-lactic acid ester, just acid/- ester (lactic acid ester); Or
ⅴ) its mixture.If when coolant was ketal, this compositions was substantially free of menthol, Carboxylamide and composition thereof,
Described method is made up of following steps:
ⅰ) coolant is dissolved in the liquid perfume, and stirs being enough to form under the condition of premix;
ⅱ) premix is sprayed in the powder composition; With
ⅲ) the product of mixing (ⅱ).
29. the described method of claim 28, wherein the powder composition is Talcum, corn starch, cellulose or derivatives thereof or its mixture.
30. the method for claim 28, wherein the granular size of powder composition is less than about 200 sieve meshes.
31. the method for claim 28, wherein coolant is 5-methyl-2-(1-methyl ethylene)-Hexalin, menthone glycerol acetal or its mixture.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5697597P | 1997-08-26 | 1997-08-26 | |
| US056975 | 1997-08-26 | ||
| US13052698A | 1998-08-04 | 1998-08-04 | |
| US130526 | 1998-08-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1216700A true CN1216700A (en) | 1999-05-19 |
Family
ID=26735917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 98117485 Pending CN1216700A (en) | 1997-08-26 | 1998-08-25 | Coolant powders |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN1216700A (en) |
| CO (1) | CO4970727A1 (en) |
| ID (1) | ID20884A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9180506B2 (en) | 2013-03-15 | 2015-11-10 | Novelis Inc. | Manufacturing methods and apparatus for targeted cooling in hot metal rolling |
-
1998
- 1998-08-25 ID IDP981165A patent/ID20884A/en unknown
- 1998-08-25 CN CN 98117485 patent/CN1216700A/en active Pending
- 1998-08-26 CO CO98048822A patent/CO4970727A1/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9180506B2 (en) | 2013-03-15 | 2015-11-10 | Novelis Inc. | Manufacturing methods and apparatus for targeted cooling in hot metal rolling |
Also Published As
| Publication number | Publication date |
|---|---|
| CO4970727A1 (en) | 2000-11-07 |
| ID20884A (en) | 1999-03-18 |
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