CN1212142C - Prepn of medicine for treating male's sterility - Google Patents
Prepn of medicine for treating male's sterility Download PDFInfo
- Publication number
- CN1212142C CN1212142C CN 03112918 CN03112918A CN1212142C CN 1212142 C CN1212142 C CN 1212142C CN 03112918 CN03112918 CN 03112918 CN 03112918 A CN03112918 A CN 03112918A CN 1212142 C CN1212142 C CN 1212142C
- Authority
- CN
- China
- Prior art keywords
- medicine
- fructus
- preparation
- prepared
- male infertility
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a preparation method of a medicine for treating male infertility, which is prepared by extracting effective components of traditional Chinese medicines, such as epimedium herb, glossy privet fruit, desertliving cistanche, common cnidium fruit, sharpleaf galangal fruit, angelica, barbary wolfberry fruit, Chinese magnolivine fruit, peach seed and licorice root. The preparation method of the present invention is carried out by the following steps: A) the weighing of raw medicinal materials by weight parts; B) distillation and extraction; C) coating; D) extraction and condensation; E) pulverization; F) the active components of the medicine of the present invention are prepared by combination, drying and uniform mixing, and then, the oral application medicine for treating male infertility in various forms can be prepared by the mixing with the general auxiliary materials, granulation, tableting, etc. The present invention has the efficiency of nourishing the kidney, strengthening yang, enriching yin, nourishing the blood and stimulating circulation to end stasis, reasonable preparation, etc. with ingenious compounding. The medicine of the present invention becomes a product for industrialized mass production, and the medicine is an oral preparation with obvious effects on treating male infertility.
Description
Technical field:
The present invention relates to a kind of preparation method of Chinese medicine medicine, the particularly a kind of preparation method that can treat the Chinese medicine medicine of male infertility belongs to the medicinal preparation field.
Background technology:
According to market survey, the 10%-15% that accounts for that suffers from sterile (pregnant) disease among the married couple at child-bearing age of China, wherein immune infertility (pregnant) reaches about 25%, the Western medicine of treatment immune infertility (pregnant) mainly is a glucocorticoid at present, but because of its side effect big, untoward reaction shortcoming more rambunctious is arranged, on using, be very limited.A lot of prescriptions are also arranged in the Chinese medicine, and method mostly is traditional decocting method, and extracts active ingredients is incomplete, and drug effect can not well be brought into play; As the patent No.: 99120678.9 treatment immune infertility and infertile Chinese medicine, its crude drug mainly comprises Herba Epimedii, Fructus Ligustri Lucidi, Herba Cistanches, Fructus Cnidii, Fructus Alpiniae Oxyphyllae, Radix Angelicae Sinensis, Fructus Lycii, Fructus Schisandrae Chinensis, Semen Persicae, Chinese medicines such as Radix Glycyrrhizae, but owing to failing further to work out preferred manufacturing procedure, only adopt mixing to decoct and take with its decoction, though certain curative effect is also arranged, but there are many extracts active ingredients incomplete after all, volatile ingredient almost completely loses, fat-soluble effective ingredient also is insoluble in the water, greatly reduce the expection therapeutic effect of this medicine, also can't adapt to the requirement of industrialized great production simultaneously.Even after adopting decocting in water, alcohol extraction, with adjuvant mixing reconcentration, drying and make tablet Chinese medicine, its volatile ingredient such as Fructus Alpiniae Oxyphyllae and Fructus Cnidii volatile oil and Radix Angelicae Sinensis volatile ingredient etc. be almost completely loss also, and supplementary product consumption is big, cause dose too big, even surpass 4 grams/time, effect does not still reach the expection therapeutic effect of this medicine.
Summary of the invention:
The objective of the invention is in order further to improve the curative effect of said medicine, reduce dose, guarantee that this medicine can fully extract the active ingredient in the various crude drug, a kind of a kind of preparation method for the treatment of the medicine of male infertility that can adapt to the requirement of industrialized great production is provided.
The active component of medicine of the present invention, mainly be that effective component extracting is formulated from Chinese medicine Herba Epimedii, Fructus Ligustri Lucidi, Herba Cistanches, Fructus Cnidii, Fructus Alpiniae Oxyphyllae, Radix Angelicae Sinensis, Fructus Lycii, Fructus Schisandrae Chinensis, Semen Persicae, Radix Glycyrrhizae, the preferred for preparation method of medicine activity component of the present invention is as follows:
A) proportioning takes by weighing each crude drug Herba Epimedii, Fructus Ligustri Lucidi, Herba Cistanches, Fructus Cnidii, Fructus Alpiniae Oxyphyllae, Radix Angelicae Sinensis, Fructus Lycii, Fructus Schisandrae Chinensis, Semen Persicae, Radix Glycyrrhizae by weight, and is standby;
B) distillation and extraction: the Fructus Alpiniae Oxyphyllae of described weight proportion is extracted volatile oil with vapor distillation; The Radix Angelicae Sinensis of described weight proportion is extracted volatile oil with carbon dioxide supercritical fluid extraction;
C) enclose: take by weighing an amount of cyclodextrin, after adding water and making saturated aqueous solution, add above-mentioned volatile oil respectively, stir, after enclose is finished, leave standstill, cold preservation filters, after the gained clathrate drying, be ground into fine powder, be Fructus Alpiniae Oxyphyllae oil clathrate and Radix Angelicae Sinensis oil clathrate, standby.
D) extraction concentrates: with Fructus Ligustri Lucidi, Herba Cistanches, the Fructus Schisandrae Chinensis of described weight proportion, and alcohol reflux, extracting solution is concentrated into relative density and is the clear paste I of 1.30-1.32 (80 ℃) after reclaiming ethanol, and is standby; The medicinal residues that the alcohol extraction medicinal residues of the full medicine of the Herba Epimedii of described weight proportion, Fructus Lycii, Semen Persicae, Radix Glycyrrhizae and Fructus Ligustri Lucidi, Herba Cistanches, Fructus Schisandrae Chinensis and Fructus Alpiniae Oxyphyllae, Radix Angelicae Sinensis are extracted behind the volatile oil mix, decoct with water, extracting solution filters, be concentrated into relative density and be the clear paste II of 1.32-1.35 (80 ℃), standby;
E) pulverize: the Fructus Cnidii of described weight proportion is ground into≤superfine powder of 20 μ m, standby;
F) with the superfine powder mix homogeneously of clear paste I, clear paste II and Fructus Cnidii, vacuum drying is pulverized; Add Fructus Alpiniae Oxyphyllae oil clathrate and Radix Angelicae Sinensis oil clathrate, mix evenly, just be prepared into the active component of medicine of the present invention.
The active component of medicine of the present invention can be mixed with adjuvants such as tablet adjuvant commonly used such as lubricant, disintegrating agent, adhesive, tabletting, bag film-coat, can be prepared into the medicine of tablet formula treatment male infertility.
The active component of medicine of the present invention also can mix with granule adjuvant commonly used such as dextrin and sweeting agent etc., granulates, dry, granulate and be distributed into and bag can be prepared into the medicine that the granule formula is treated male infertility.
The active component of medicine of the present invention can also be mixed with capsule adjuvant commonly used such as lubricant, disintegrating agent, adhesive etc., granulated, drying, granulate and incapsulate, and can be prepared into the medicine that capsule-type is treated male infertility.
The medicine that the present invention treats male infertility is a natural product, has no side effect, and has effects such as kidney invigorating and YANG supporting, nourishing YIN and benefiting blood, activating blood circulation to dissipate blood stasis, is mainly used in the treatment male infertility, the infertility that is suitable for antisperm antibody to cause especially.The medicine of the treatment male infertility that makes with preparation method provided by the invention can fully extract the fat-soluble and water miscible effective ingredient in the Chinese crude drug; And use cyclodextrin inclusion compound volatile oil, improved the utilization rate and the stability of volatile oil; The employing micropowder is used as medicine, and has both kept its effective ingredient, has reduced supplementary product consumption again.Select rational preparation method for use, make medicine of the present invention become can industrialized great production the effective oral Chinese patent medicine that has no side effect of treatment male infertility.
The specific embodiment:
The present invention is further described and illustrates as follows:
Comprise by weight percentage Chinese medicine Herba Epimedii 8-10%, Fructus Ligustri Lucidi 8-10%, Herba Cistanches 8-10%, Fructus Cnidii 8-10%, Fructus Alpiniae Oxyphyllae 10-15%, Radix Angelicae Sinensis 10-13%, Fructus Lycii 8-10%, Fructus Schisandrae Chinensis 8-10%, Semen Persicae 12-15%, Radix Glycyrrhizae 10-15% in the medicine of the present invention, the crude drug in the aforementioned proportion scope can take following step to extract its effective active composition.
A) proportioning takes by weighing each crude drug Herba Epimedii, Fructus Ligustri Lucidi, Herba Cistanches, Fructus Cnidii, Fructus Alpiniae Oxyphyllae, Radix Angelicae Sinensis, Fructus Lycii, Fructus Schisandrae Chinensis, Semen Persicae, Radix Glycyrrhizae by weight, and is standby;
B) distillation and extraction: the Fructus Alpiniae Oxyphyllae of described weight proportion is extracted volatile oil with vapor distillation; The Radix Angelicae Sinensis of described weight proportion is extracted volatile oil with carbon dioxide supercritical fluid extraction;
C) enclose: take by weighing an amount of cyclodextrin, after adding water and making saturated aqueous solution, add above-mentioned volatile oil respectively, stir, after enclose is finished, leave standstill, cold preservation filters, after the gained clathrate drying, be ground into fine powder, be Fructus Alpiniae Oxyphyllae oil clathrate and Radix Angelicae Sinensis oil clathrate, standby.
D) extraction concentrates: with Fructus Ligustri Lucidi, Herba Cistanches, the Fructus Schisandrae Chinensis of described weight proportion, and alcohol reflux, extracting solution is concentrated into relative density and is the clear paste I of 1.30-1.32 (80 ℃) after reclaiming ethanol, and is standby; The medicinal residues that the alcohol extraction medicinal residues of the full medicine of the Herba Epimedii of described weight proportion, Fructus Lycii, Semen Persicae, Radix Glycyrrhizae and Fructus Ligustri Lucidi, Herba Cistanches, Fructus Schisandrae Chinensis and Fructus Alpiniae Oxyphyllae, Radix Angelicae Sinensis are extracted behind the volatile oil mix, decoct with water, extracting solution filters, be concentrated into relative density and be the clear paste II of 1.32-1.35 (80 ℃), standby;
E) pulverize: the Fructus Cnidii of described weight proportion is ground into≤superfine powder of 20 μ m, standby;
F) with the superfine powder mix homogeneously of clear paste I, clear paste II and Fructus Cnidii, vacuum drying is pulverized; Add Fructus Alpiniae Oxyphyllae oil clathrate and Radix Angelicae Sinensis oil clathrate, mix evenly, just be prepared into the active component of medicine of the present invention.
The active component of medicine of the present invention can be mixed with adjuvants such as tablet adjuvant commonly used such as lubricant, disintegrating agent, adhesive, tabletting, bag film-coat, can be prepared into the medicine of tablet formula treatment male infertility.
The active component of medicine of the present invention also can mix with granule adjuvant commonly used such as dextrin and sweeting agent etc., granulates, dry, granulate and be distributed into and bag can be prepared into the medicine that the granule formula is treated male infertility.
The active component of medicine of the present invention can also be mixed with capsule adjuvant commonly used such as lubricant, disintegrating agent, adhesive etc., granulated, drying, granulate and incapsulate, and can be prepared into the medicine that capsule-type is treated male infertility.
Because Herba Epimedii contains compositions such as chromocor compound such as icariin, precious icariin, arrow icariin and polysaccharide; Fructus Lycii contains compositions such as lycium barbarum polysaccharide, carotene, aminoacid and trace element; Semen Persicae contains the cyanogen glycosides and comprises amygdaloside and compositions such as micro-Virginia prune glucoside, aminoacid, protein and saccharide; Radix Glycyrrhizae contains triterpenes and comprises glycyrrhizin and compositions such as enoxolone, chromocor compound and polysaccharide; The direct water of above-mentioned four Chinese medicine material is carried just can be complete with its extracts active ingredients.
Herba Cistanches contains liposoluble constituent such as 6-methylindole, phenylpropyl alcohol compounds ergosterol and boschnaloside A, B, C, H etc., water soluble ingredient such as N-N-dimethylglycine methyl ester, betanin, cupreol, saccharide etc.; Fructus Ligustri Lucidi contains compositions such as oleanolic acid, acetyloleanolic acid, Fructus Ligustri Lucidi acid, ursolic acid and phospholipid; Fructus Schisandrae Chinensis contains compositions such as schizandrin, deoxyschisandrin, schisandrin, second, organic acid and glycoside; Above-mentioned three flavor medical materials should first alcohol extraction extract its liposoluble constituent, and water extracts its water soluble ingredient again, like this could its extracts active ingredients is complete.
Fructus Alpiniae Oxyphyllae contains volatile oil more than 1.0%, also contains compositions such as flavonoid, aminoacid, saccharide, vitamin; Radix Angelicae Sinensis contains volatile ingredient such as n-butene phthalein lactone, ligustilide etc., also contains compositions such as saccharide, aminoacid, ferulic acid; Therefore above-mentioned two flavor medical materials should adopt steam distillation or carbon dioxide supercritical extraction method to extract volatile oil earlier, and medicinal residues water are again carried to guarantee its extracts active ingredients complete; Volatile oil can directly spray to be added, also can be with adding behind the cyclodextrin inclusion compound, to improve the utilization rate and the stability of volatile oil again; Simultaneously, also can adopt first alcohol extraction again the method carried of water extract its effective ingredient.
Fructus Cnidii contains volatile oil 1.3%, Coumarins comprises compositions such as osthole and bergapten etc., Palmic acid, cupreol, adopts the micropowder of≤20 μ m to be used as medicine, and has both kept its effective ingredient, has reduced supplementary product consumption again, reduces dose greatly; Simultaneously, also can adopt first alcohol extraction again the method carried of water extract its effective ingredient.
Medicine of the present invention can fully extract fat-soluble and water miscible effective ingredient and volatile oil in the above-mentioned raw materials medicine; And use cyclodextrin inclusion compound volatile oil, improved the utilization rate and the stability of volatile oil; The employing micropowder is used as medicine, and has both kept its effective ingredient, has reduced supplementary product consumption again.Compatibility of the present invention is exquisite, has effects such as kidney invigorating and YANG supporting, nourishing YIN and benefiting blood, activating blood circulation to dissipate blood stasis, adds rational preparation method, make medicine of the present invention become can industrialized great production product, be treatment male infertility obvious results oral formulations.Oral during use, each 1 gram, 3 times on the one.
Medicine of the present invention has been finished drug efficacy study on the experimental model basis of the immune infertility of antisperm antibody (AsAb) mediation.The research shows: this medicine can make in the refining, AsAb is cloudy in the serum changes, and sperm number, vigor sport speed are improved, and improves semen quality.Thereby the increase fertility rate reduces abortion ratio.Heavy dose of treatment does not have influence to fetal development.
Claims (4)
1. preparation method for the treatment of the medicine of male infertility, comprise crude drug Herba Epimedii, Fructus Ligustri Lucidi, Herba Cistanches, Fructus Cnidii, Fructus Alpiniae Oxyphyllae, Radix Angelicae Sinensis, Fructus Lycii, Fructus Schisandrae Chinensis, Semen Persicae, Radix Glycyrrhizae, it is characterized in that the preparation method of active component comprises the following steps:
A) proportioning takes by weighing each crude drug Herba Epimedii, Fructus Ligustri Lucidi, Herba Cistanches, Fructus Cnidii, Fructus Alpiniae Oxyphyllae, Radix Angelicae Sinensis, Fructus Lycii, Fructus Schisandrae Chinensis, Semen Persicae, Radix Glycyrrhizae by weight, and is standby;
B) distillation and extraction: the Fructus Alpiniae Oxyphyllae of described weight proportion is extracted volatile oil with vapor distillation; The Radix Angelicae Sinensis of described weight proportion is extracted volatile oil with carbon dioxide supercritical fluid extraction;
C) enclose: take by weighing an amount of cyclodextrin, after adding water and making saturated aqueous solution, add volatile oil, stir, after enclose is finished, leave standstill, cold preservation filters, and after the gained clathrate drying, is ground into fine powder, is Fructus Alpiniae Oxyphyllae oil clathrate and Radix Angelicae Sinensis oil clathrate, and is standby.
D) extraction concentrates: with Fructus Ligustri Lucidi, Herba Cistanches, the Fructus Schisandrae Chinensis of described weight proportion, and alcohol reflux, extracting solution is concentrated into relative density and is the clear paste I of 1.30-1.32 (80 ℃) after reclaiming ethanol, and is standby; The medicinal residues that the alcohol extraction medicinal residues of the full medicine of the Herba Epimedii of described weight proportion, Fructus Lycii, Semen Persicae, Radix Glycyrrhizae and Fructus Ligustri Lucidi, Herba Cistanches, Fructus Schisandrae Chinensis and Fructus Alpiniae Oxyphyllae, Radix Angelicae Sinensis are extracted behind the volatile oil mix, decoct with water, extracting solution filters, be concentrated into relative density and be the clear paste II of 1.32-1.35 (80 ℃), standby;
E) pulverize: the Fructus Cnidii of described weight proportion is ground into≤superfine powder of 20 μ m, standby;
F) with the superfine powder mix homogeneously of clear paste I, clear paste II and Fructus Cnidii, vacuum drying is pulverized; Add Fructus Alpiniae Oxyphyllae oil clathrate and Radix Angelicae Sinensis oil clathrate, mixing just has been prepared into the active component of medicine of the present invention.
2. according to the preparation method of the described medicine of claim 1, it is characterized in that the active component that will make is mixed with tablet adjuvant commonly used, tabletting, bag film-coat, can be prepared into the medicine of tablet formula treatment male infertility.
3. according to the preparation method of the described medicine of claim 1, it is characterized in that the active component that will make is mixed with granule adjuvant commonly used, granulated, dry, granulate and be distributed into and bag can be prepared into the medicine that the granule formula is treated male infertility.
4. according to the preparation method of the described medicine of claim 1, it is characterized in that the active component that will make is mixed with capsule adjuvant commonly used, granulated, drying, granulate and incapsulate, can be prepared into the medicine that capsule-type is treated male infertility.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03112918 CN1212142C (en) | 2003-03-05 | 2003-03-05 | Prepn of medicine for treating male's sterility |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03112918 CN1212142C (en) | 2003-03-05 | 2003-03-05 | Prepn of medicine for treating male's sterility |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1436568A CN1436568A (en) | 2003-08-20 |
| CN1212142C true CN1212142C (en) | 2005-07-27 |
Family
ID=27634175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03112918 Expired - Fee Related CN1212142C (en) | 2003-03-05 | 2003-03-05 | Prepn of medicine for treating male's sterility |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1212142C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1326518C (en) * | 2004-03-26 | 2007-07-18 | 石药集团中奇制药技术（石家庄）有限公司 | Xiaoyao soft capsule and its preparation technology |
| CN107362253A (en) * | 2017-06-20 | 2017-11-21 | 苏州市李良济健康产业有限公司 | A kind of preparation method for the health products for improving fecundity |
| CN110279794B (en) * | 2019-06-24 | 2021-08-31 | 石家庄市第四医院 | Traditional Chinese medicine composition for treating oligospermia and preparation method thereof |
-
2003
- 2003-03-05 CN CN 03112918 patent/CN1212142C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1436568A (en) | 2003-08-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU658614B2 (en) | Pharmaceutical compositions for the treatment of skin disorders | |
| US9138449B2 (en) | Medicinal composition for liver diseases | |
| AU2013362431B2 (en) | Pharmaceutical composition for treating headache, and preparation method thereof | |
| WO2006060951A1 (en) | A pharmaceutical composition for the treatment and/or prevention of hyperlipidemia, processes for producing the same and the use thereof | |
| CN101612362B (en) | Complex preparation for regulating lipid and preventing and curing heart cerebrovascular diseases and preparation method thereof | |
| KR100585445B1 (en) | Bone disease drug composition using herb medicines | |
| KR100854442B1 (en) | Composition comprising an extract of Nelumbinis Folium or herb complex for preventing or treating hyperlipidemia and arteriosclerosis | |
| CN1294952C (en) | Traditional Chinese medicine compound preparation for preventing and treating coccidiosis | |
| CN1212142C (en) | Prepn of medicine for treating male's sterility | |
| CN101584759B (en) | Pharmaceutical composition with pure plant origin and application thereof | |
| CN1799582A (en) | Blood sugar- and blood pressure-lowering medicine | |
| CN100355448C (en) | Chinese traditional medicine compound preparation for preventing and curing alcoholic intestinal tract and liver injury | |
| CN1899415B (en) | Chinese medicine compound preparation for treating chronic hepatic disease and its preparing method | |
| CN1954872B (en) | Traditional Chinese medicine composite and its preparation method | |
| CN1250253C (en) | Chinese medicine capsule for treating ischemic cerebral apoplexy | |
| CN1267086C (en) | Medicine for treating diabetes and adjusting blood sugar concentration and its preparation | |
| Liu et al. | A review of the ethnopharmacology, phytochemistry, pharmacology, pharmacokinetics and toxicology of Abri Herba (Ji-Gu-Cao) | |
| GB2402062A (en) | Pharmaceutical composition for the prophylaxis or treatment of osteoporosis | |
| KR20130070871A (en) | Neutraceutical composition comprising extract of dsx showing an inhibitory effect of osteoclastogenesis | |
| CN101919919A (en) | Fukean dispersible tablet and preparation method thereof | |
| CN101744991B (en) | Single extraction method of ginseng, ophiopogon root and shiandra and preparation thereof | |
| CN1990005A (en) | Cathartic and its preparing method | |
| CN1899574A (en) | Chinese medicine composition for preventing and controlling liver cancer and its use | |
| CN1319578C (en) | Prescription of Chinese medicine compound preparation, its preparation method and use | |
| CN1232281C (en) | Chinese medicine for treating osteoporosis and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: NANJING ZHONGSHAN PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: NANJING ZHONGSHAN PHARMACEUTICAL FACTORY Effective date: 20060210 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20060210 Address after: 210012, Shuanglong street, Yuhua District, Jiangsu, Nanjing, 1 Patentee after: Nanjing Zhongshan Pharmaceutical Co., Ltd. Address before: 210012, Shuanglong street, Yuhua District, Jiangsu, Nanjing, 1 Patentee before: Nanjing Zhongshan Pharmaceutical Factory |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20050727 Termination date: 20190305 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |