CN1211084C - Technology for producing Dekuiluan lozenge - Google Patents
Technology for producing Dekuiluan lozenge Download PDFInfo
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- CN1211084C CN1211084C CN 03118738 CN03118738A CN1211084C CN 1211084 C CN1211084 C CN 1211084C CN 03118738 CN03118738 CN 03118738 CN 03118738 A CN03118738 A CN 03118738A CN 1211084 C CN1211084 C CN 1211084C
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- production technology
- buccal tablet
- dequalinium chloride
- refining
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Abstract
The present invention relates to a production technology for a dequalinium chloride lozenge preparation, which orderly comprises the following procedures: preparing materials, refining, granulating, drying, mixing, tabletting, examining metal, wrapping foil and packaging. The present invention overcomes the defects of short mouth keeping time, easy pulverization in the mouth, uneven main medicine content, etc. of the existing western medicine lozenge. The present invention can be widely used for producing lozenge preparations using western medicine as main medicine for treating and preventing disease symptoms, such as stomatitis, pharyngolaryngitis, tonsillitis, etc.
Description
Technical field
The present invention relates to a kind of production technology of pharmaceutical preparation, more particularly it is a kind of production technology of dequalinium chloride buccal tablet.
Background technology
The buccal tablet that present domestic pharmaceutical factory produces is to be principal agent with the Chinese patent medicine mostly, make by conventional tablet forming technique (weighing-mixing-granulation-granulate-tabletting-packing), such buccal tablet exists curative effect indeterminate, bitter in the mouth, mouthfeel is poor, dysphagia, tooth has deficiencies such as color phenomenon after patient's medication; Other has a small amount of buccal tablet is principal agent with the Western medicine, make by conventional tablet forming technique (weighing-mixing-granulation-granulate-tabletting-packing), though such buccal tablet curative effect is comparatively clear and definite, but still exist melting time easily broken during short, containing, drug content is inhomogeneous, thereby deficiency such as affect the treatment.
Summary of the invention
The objective of the invention is to overcome the weak point of above common process, and a kind of production technology of dequalinium chloride buccal tablet is provided.Thereby solved the insurmountable preparation defective of common process.Deficiencies such as easily fragmentation during, containing short as melting time, drug content are inhomogeneous.The manufacturing process of preparation of the present invention is applicable to simultaneously with the Western medicine to be principal agent, produces to be used for the treatment of and to prevent the buccal tablet class preparation of diseases such as stomatitis, pharyngolaryngitis, tonsillitis.
The objective of the invention is to realize by following measure, a kind of production technology of dequalinium chloride buccal tablet, it comprises following operation successively:
Doubly loose: principal agent, adjuvant are mixed by the equivalent gradient dilution, solid through solid-mix, solid-liquid mixing, liquid-liquid is mixed to liquid-mixing, and principal agent evenly is diluted to 1: 240 (weight ratio);
Refining is closed: will be doubly diffusing thing join by the ratio of 1: 25 (weight ratio) and place the two slurry mixers of homoiothermic in the refining caster sugar, the constant temperature speed change stirred 30 minutes, temperature is controlled at 40-70 ℃, two slurries are starched speed and are respectively 10-25 rev/min, 15-30 rev/min;
Granulate: the gained mixture is closed in refining place granulator, be cut into graininess and granulate by screen cloth with 4000-6000 rev/min rotating speed, granular size is not less than 20 orders for being not more than 8 orders;
To granulate back gained medicine grain drying, with after spice mixes, through tabletting, pack promptly.
Described refining closes that the temperature preferable range is controlled at 55-60 ℃ in the operation, and two slurry speed preferable range are respectively: 15 rev/mins, 20 rev/mins.
Granulator rotating speed preferable range is in the described granulation process: 5000 rev/mins.
Between described tabletting and the packaging process, also have metal inspection and plastic-aluminum operation.
The production technology of dequalinium chloride buccal tablet of the present invention, the dequalinium chloride buccal tablet of producing has following advantage: (1) is about 5000 rev/mins because of the granulator rotating speed, so tablet hardness is big, and melting time is long.(2) principal agent and accessory drugs are mixed to 1: 6000 by the equivalent gradient dilution, so drug content uniformity height.(3) the granulation granule is not more than 8 orders, is not less than 20 orders, and therefore containing insoluble matter is limited the quantity of.Above advantage has improved the curative effect of dequalinium chloride buccal tablet greatly.
Description of drawings
Fig. 1 is the technological process of production figure of dequalinium chloride buccal tablet of the present invention
The specific embodiment
Describe performance of the present invention in detail below in conjunction with accompanying drawing:
The present invention implements under the normal pressure situation, and does not need catalyst, temperature is not had specific (special) requirements yet.
The critical process of the production technology of dequalinium chloride buccal tablet of the present invention is: doubly loose, refine and close, granulate.
Doubly loose: principal agent, adjuvant are mixed by the equivalent gradient dilution, solid through solid-mix, Gu solid-liquid mixing, liquid-liquid is mixed to liquid-mixing, this product principal agent evenly is diluted to 1: 240 (weight ratio), meets national statutory standards (Pharmacopoeia of People's Republic of China version in 2000) to guarantee this product principal agent uniformity.
Refining is closed: will be doubly diffusing thing join by the ratio of 1: 25 (weight ratio) and place the two slurry mixers of homoiothermic in the refining caster sugar, the constant temperature speed change stirred 30 minutes, temperature is controlled at about 60 ℃, two slurries are starched speed and are respectively 15 rev/mins, 20 rev/mins;
Granulate: the gained mixture is closed in refining place granulator, be cut into graininess and granulate by screen cloth with 5000 rev/mins rotating speeds, granular size is not less than 20 orders for being not more than 8 orders;
Mix with spice after the back gained medicine grain drying of will granulating, tabletting, packing is promptly.
After the tablet molding, have or not metal fillings, make tablet not contain any metal fillings, the possibility that has unexpected phenomenon such as the position that scratches oral cavity and throat to occur when so just having avoided the patient to take this product fully by the metal detection process inspection.
Need to prove:,, also can make suitable improvement and distortion the present invention under the prerequisite of the principle of the invention for one of ordinary skill in the art.As technology of the present invention is used for other with the Western medicine be principal agent contain blade technolgy etc., this belongs to protection scope of the present invention equally.
Claims (4)
1, a kind of production technology of dequalinium chloride buccal tablet is characterized in that it comprises following operation successively:
Doubly loose: principal agent, adjuvant are mixed by the equivalent gradient dilution, solid through solid-mix, admittedly-after liquid mixing, liquid-liquid are mixed to liquid-mixing, principal agent evenly is diluted to 1: 240 weight ratio;
Refining is closed: will be doubly diffusing thing join by the ratio of 1: 25 weight ratio and place the two slurry mixers of homoiothermic in the caster sugar, the constant temperature speed change stirred 30 minutes, temperature is controlled at 40-70 ℃, two slurries are starched speed and are respectively 10-25 rev/min, 15-30 rev/min;
Granulate: the gained mixture is closed in refining place granulator, be cut into graininess and granulate by screen cloth with 4000-6000 rev/min rotating speed, granular size is not less than 20 orders for being not more than 8 orders;
With granulation gained medicine grain drying, with after spice mixes, through tabletting, packing promptly.
2, the production technology of a kind of dequalinium chloride buccal tablet according to claim 1 is characterized in that described refining closes that temperature range is controlled at 55-60 ℃ in the operation, and two slurry speed are respectively 15 rev/mins, 20 rev/mins.
3, the production technology of a kind of dequalinium chloride buccal tablet according to claim 1 is characterized in that the granulator rotating speed is 5000 rev/mins in the described granulation process.
4, the production technology of a kind of dequalinium chloride buccal tablet according to claim 1 is characterized in that between described tabletting and the packaging process, also has metal inspection and plastic-aluminum operation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03118738 CN1211084C (en) | 2003-03-07 | 2003-03-07 | Technology for producing Dekuiluan lozenge |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03118738 CN1211084C (en) | 2003-03-07 | 2003-03-07 | Technology for producing Dekuiluan lozenge |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1437944A CN1437944A (en) | 2003-08-27 |
| CN1211084C true CN1211084C (en) | 2005-07-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03118738 Expired - Fee Related CN1211084C (en) | 2003-03-07 | 2003-03-07 | Technology for producing Dekuiluan lozenge |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1211084C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105919959A (en) * | 2016-06-16 | 2016-09-07 | 安徽省逸欣铭医药科技有限公司 | Dequalinium vaginal tablets and preparation method thereof |
| CN106727369B (en) * | 2016-11-21 | 2020-01-21 | 珠海同源药业有限公司 | Dequalinium chloride buccal tablet and preparation method thereof |
| CN106632031A (en) * | 2016-12-13 | 2017-05-10 | 珠海同源药业有限公司 | Dequalinium chloride crystal and buccal tablet thereof, and preparation method of buccal tablet |
| CN108635334A (en) * | 2018-07-27 | 2018-10-12 | 安徽恒星制药有限公司 | A kind of novel Dequalinium Chloride lozenge and preparation method thereof |
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2003
- 2003-03-07 CN CN 03118738 patent/CN1211084C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1437944A (en) | 2003-08-27 |
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