CN121028362A - A microtube holder for easy operation under a microscope - Google Patents
A microtube holder for easy operation under a microscopeInfo
- Publication number
- CN121028362A CN121028362A CN202511494478.9A CN202511494478A CN121028362A CN 121028362 A CN121028362 A CN 121028362A CN 202511494478 A CN202511494478 A CN 202511494478A CN 121028362 A CN121028362 A CN 121028362A
- Authority
- CN
- China
- Prior art keywords
- clamping
- permanent magnet
- microtube
- holder
- clamping piece
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Sampling And Sample Adjustment (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
本申请公开了一种方便显微镜下操作的微管夹持器，涉及夹持器技术领域。在能够可靠夹持微管或微丝的前提下，不仅精巧灵活，而且不会遮挡微管或微丝，从而在显微镜下能够看到微管或微丝的下端在操作界面上的所有运动轨迹，进而能够追踪微管或微丝下端的实时位置。该微管夹持器包括第一夹片、第二夹片和多个限位销；第一夹片和第二夹片相对设置；第一夹片的前端设有第一夹持部，后端设有第一连接部，顶部设有连接杆；第二夹片的前端设有第二夹持部，后端设有第二连接部；第一连接部和第二连接部均滑动连接在限位销上；第一连接部内设有第一永磁体，第二连接部内设有第二永磁体，第一永磁体和第二永磁体相互吸引。本申请用于提升微管夹持器的性能。
This application discloses a microtube holder for convenient microscopic operation, relating to the field of holder technology. While reliably holding microtubes or microfilaments, it is not only compact and flexible but also does not obstruct the microtubes or microfilaments, allowing visualization of the entire movement trajectory of the lower end of the microtube or microfilament on the operating interface under a microscope, thus enabling tracking of the real-time position of the lower end of the microtube or microfilament. The microtube holder includes a first clamping plate, a second clamping plate, and multiple limiting pins; the first and second clamping plates are arranged opposite each other; the first clamping plate has a first clamping portion at its front end, a first connecting portion at its rear end, and a connecting rod at its top; the second clamping plate has a second clamping portion at its front end and a second connecting portion at its rear end; both the first and second connecting portions are slidably connected to the limiting pins; a first permanent magnet is disposed within the first connecting portion, and a second permanent magnet is disposed within the second connecting portion, with the first and second permanent magnets attracting each other. This application aims to improve the performance of microtube holders.
Description
Technical Field
The application relates to the technical field of holders, in particular to a microtube holder convenient to operate under a microscope.
Background
In some narrow areas (the narrowest width is only 3 cm), fine stereotactic instruments (space coordinate error 100 μm) are used for placing microtubules (microtubule diameter 100 μm to 400 μm) or microwires (microwire diameter 70 μm to 400 μm), and the minimum horizontal spacing between the microtubules or microwires to be placed is up to 1000 μm. Such operations are highly skilled to the operator and often such fine operations are performed with the aid of a stereomicroscope and stereotactic apparatus and by means of a holder. For example, referring to fig. 1, the existing clamp 01 includes a fixed clamping piece 02, a movable clamping piece 03, an adjusting screw 04 and a connecting rod 05, which can firmly clamp a micro tube or a micro wire, and because the clamping function is realized by the adjusting screw 04, the clamp occupies a large operation interface, so that the sight line in the microscope direction is easily blocked, the operation interface can be observed only from a limited angle and working distance, the real-time position of the lower end of the micro tube or the micro wire cannot be tracked, and thus, the three-dimensional coordinates of the micro tube or the micro wire can be accurately positioned under the limited interface, and the operation is complicated. For example, when a plurality of 100 μm electrode microtubules are implanted in the brain of a mouse on a stereotactic apparatus, the space occupied by the existing holder 01 is large and there is a significant space conflict with the components on the stereotactic apparatus, so that the intended positioning implantation operation cannot be completed. Meanwhile, the space occupied by the two clamping pieces exceeds 2mm, so that the second microtube cannot be placed nearby the first microtube by 2mm in the horizontal direction after the first microtube is implanted.
The operation is fine, so that an instrument for clamping the microtubes or the microwires is required to be exquisite and flexible while being firmly clamped, and is convenient to operate, so that all movement tracks of the lower ends of the microtubes or the microwires on an operation interface can be seen under a microscope.
Disclosure of Invention
The embodiment of the application provides a microtubule holder which is convenient for operation under a microscope, and on the premise of reliably holding a microtubule or a microfilament, the microtubule holder is exquisite and flexible, is convenient to operate, and does not shade the microtubule or the microfilament, so that all movement tracks of the lower end of the microtubule or the microfilament on an operation interface can be seen under the microscope, and further the real-time position of the lower end of the microtubule or the microfilament can be tracked.
In order to achieve the above object, an embodiment of the present application provides a microtube holder for facilitating operation under a microscope, including a first clip, a second clip, and a plurality of stopper pins; the first clamping piece and the second clamping piece are oppositely arranged; the front end of the first clamping piece is provided with a first clamping part, the rear end of the first clamping piece is provided with a first connecting part, and the top of the first clamping piece is provided with a connecting rod; the front end of the second clamping piece is provided with a second clamping part, the rear end of the second clamping piece is provided with a second connecting part, the first connecting part and the second connecting part are both connected to the limiting pin in a sliding way, a first permanent magnet is arranged in the first connecting part, a second permanent magnet is arranged in the second connecting part, the first permanent magnet and the second permanent magnet are mutually attracted, magnetic force between the first permanent magnet and the second permanent magnet can clamp a micro tube or a micro wire and can manually separate the first clamping piece from the second clamping piece, all movement tracks of the lower end of the micro tube or the micro wire on an operation interface can be seen under a microscope, the real-time position of tracking the lower end of the micro tube or the micro wire is realized, the clamping surface of the first clamping part is provided with a groove extending along the vertical direction, the groove width of the groove is 0.8 times of the diameter of the micro tube or the micro wire and is used for ensuring that the micro tube or the micro wire is in a determined direction when the micro tube is clamped, the thickness of the first clamping part is smaller than the thickness of the first connecting part, the second clamping part is smaller than the first clamping part and the second clamping part is smaller than the first clamping part, the thickness is smaller than the micro tube or the micro wire, the micro wire or the micro wire, the micro tube or the micro wire or micro wire can be successfully clamping device, the micro wire or the micro wire, the micro wire or micro wire, and the micro wire and the micro clamp and the micro and the micro and the and the micro and the micro and the when the and the when and when, real-time position can be determined under a microscope.
Preferably, the top surface of the first connecting part is provided with a first installation cavity with an upward opening, the lower part of the first permanent magnet is embedded into the first installation cavity, the upper part of the first permanent magnet extends out of the first installation cavity and is used for disassembling the first permanent magnet, the top surface of the second connecting part is provided with a second installation cavity with an upward opening, the lower part of the second permanent magnet is embedded into the second installation cavity, and the upper part of the second permanent magnet extends out of the second installation cavity and is used for disassembling the second permanent magnet.
Preferably, the first clamping piece and the second clamping piece are both single-piece clamping mouths, and the two clamping mouths are the same in size, and are the length, the width and the height=20 mm, and the length, the width and the height=5 mm and the length are 4mm.
Preferably, an elastic protection pad is arranged on the clamping surface of the second clamping part.
Preferably, the elastic protection pad is a rubber pad adhered to the second clamping portion, so as to avoid damage to the micro tube or the micro wire due to too large clamping force.
Preferably, the number of the limiting pins is three, and the connecting lines of the end face center points of the three limiting pins are regular triangles, so that the first clamping piece and the second clamping piece are firmly hung in a three-point surface forming mode.
Preferably, the connecting rod is a cylinder, and the length of the connecting rod is 200mm and the diameter of the connecting rod is 6mm, so that the connecting rod is used for saving space and being reliably connected with the stereotactic instrument.
Compared with the prior art, the application has the following beneficial effects:
1. Compared with the technical scheme of clamping the microtubes or the microfilaments by adjusting the screws in the prior art, the microtube clamp provided by the application has the advantages that the structure is simplified, the volume is reduced, and all movement tracks of the lower ends of the microtubes or the microfilaments on an operation interface can be seen under a microscope, so that the real-time positions of the lower ends of the microtubes or the microfilaments are tracked.
2. When the microtubule holder is used for loading microtubules or microfilaments, only two clamping pieces are needed to be manually separated, the microtubules or the microfilaments are loaded and then released, and the magnetic force of the permanent magnets in the two clamping pieces can automatically clamp the microtubules or the microfilaments, so that the microtubules or the microfilaments are reliably clamped and very convenient to operate.
3. The microtube holder has a small structure, can smoothly finish the expected positioning operation of the microtube or the microfilament in a narrow area with the minimum thickness of 30mm, can well expose the lower end of the microtube or the microfilament, and can determine the real-time position under a microscope.
4. The thickness of the clamping part of the microtube clamp is 0.4mm, and two microtubes or microfilaments with the thickness of 0.8mm adjacent to each other in the horizontal direction can be positioned successively and successfully completed.
Drawings
In order to more clearly illustrate the embodiments of the application or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the application, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic perspective view of a prior art holder;
FIG. 2 is a schematic perspective view of a microtube holder for facilitating operation under a microscope according to an embodiment of the present application;
FIG. 3 is a schematic diagram of an exploded view of a microtube holder for facilitating operation under a microscope according to an embodiment of the present application.
Detailed Description
The following description of the embodiments of the present application will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
In the description of the present application, it should be understood that the terms "center," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like indicate orientations or positional relationships based on the orientation or positional relationships shown in the drawings, merely to facilitate describing the present application and simplify the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present application.
In the description of the present application, it should be noted that, unless explicitly stated and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example, and that the specific meaning of the terms in the present application will be understood to those skilled in the art in specific cases.
The terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present application, unless otherwise indicated, the meaning of "a plurality" is two or more.
Embodiments of the present application provide a microtube holder that facilitates operation under a microscope. The microtube holder is compact and small, the length and width of the occupied interface space are only 20mm multiplied by 8mm multiplied by 5mm, and the expected microtube or microfilament positioning operation can be completed smoothly in the narrowest 30mm narrow area.
Referring to fig. 2 and 3, the microtube holder according to the embodiment of the present application for facilitating the operation under a microscope includes a first clip 1, a second clip 2, and a plurality of stopper pins 3. Wherein the first clamping piece 1 and the second clamping piece 2 are oppositely arranged. The front end of the first clamping piece 1 is provided with a first clamping part 11, the rear end is provided with a first connecting part 12, and the top is provided with a connecting rod 4 for connecting a stereotactic instrument. The front end of the second clamping piece 2 is provided with a second clamping part 21, and the rear end is provided with a second connecting part 22. The first connecting portion 12 and the second connecting portion 22 are both slidably connected to the stopper pin 3. The first permanent magnet 13 is arranged in the first connecting part 12, the second permanent magnet 23 is arranged in the second connecting part 22, and the first permanent magnet 13 and the second permanent magnet 23 are attracted to each other. The magnetic force between the first permanent magnet 13 and the second permanent magnet 23 can just clamp the microtube or microwire and can manually separate the first clip 1 from the second clip 2.
Therefore, compared with the technical scheme of clamping the microtubes or the microwires through adjusting screws in the prior art, the microtube clamp provided by the embodiment of the application has the advantages that the structure is simplified, the volume is reduced, the microtubes or the microwires are not blocked, and therefore, all movement tracks of the lower ends of the microtubes or the microwires on an operation interface can be seen under a microscope, and the purpose of tracking the real-time positions of the lower ends of the microtubes or the microwires is further realized.
Meanwhile, when the microtubule holder is used for loading the microtubule or the microfilament, only two clamping pieces are needed to be manually separated, the microtubule or the microfilament is loaded and then released, and the magnetic force of the permanent magnets in the two clamping pieces can automatically clamp the microtubule or the microfilament, so that the microtubule holder is reliable in clamping and very convenient to operate.
Referring to fig. 2, in some embodiments, the top surfaces of the first connection parts 12 are each provided with a first mounting cavity 14 with an opening facing upward, the lower portion of the first permanent magnet 13 is embedded in the first mounting cavity 14, and the upper portion of the first permanent magnet 13 protrudes out of the first mounting cavity 14. The top surface of the second connecting portion 22 is provided with a second installation cavity 24 with an upward opening, the lower portion of the second permanent magnet 23 is embedded into the second installation cavity 24, and the upper portion of the second permanent magnet 23 extends out of the second installation cavity 24. Thereby, the first permanent magnet 13 and the second permanent magnet 23 are easily attached and detached.
With continued reference to fig. 2 and 3, in some embodiments, the stop pins 3 are cylindrical pins, and the stop pins 3 are three, and the line connecting the end surface center points of the three stop pins 3 is a regular triangle. Thereby, the first clip 1 and the second clip 2 are hung in a three-point surface-forming manner. It should be noted that the number of the limit pins 3 may be two or four, which is not limited herein.
With continued reference to fig. 3, in order to ensure a fixed vertical direction for preventing the microtubes or microwires from being damaged when they are clamped, in some embodiments, the clamping surface of the first clamping portion 11 is provided with a groove 25 extending in the vertical direction, the groove width of the groove 25 is 0.8 times the diameter of the microtubes or microwires, and the clamping surface of the second clamping portion 21 is provided with an elastic protection pad 5. Specifically, the elastic protection pad 5 is a rubber pad adhered or bound on the second clamping portion 21. Therefore, the microtubule or microfilament can be ensured to have a definite direction when being clamped, and the microtubule or microfilament is prevented from being damaged due to too large clamping force.
In some embodiments, the connecting rod 4 is a cylinder of stainless steel, the connecting rod 4 having a length of 200mm and a diameter of 6mm. Thus, the space is saved and the connection with the stereotactic instrument can be reliably realized.
Referring to fig. 2 and 3, in order to make the first clip 1 and the second clip 2 as small as possible while securing a sufficient clamping force, in some embodiments, the first clip 1 has a length×width×height=20 mm×5mm×4mm, and the second clip 2 has the same size as the first clip 1. The first clamping piece 1 and the second clamping piece 2 are both single-piece clamping mouths, namely, the thickness of the first clamping part 11 is smaller than that of the first connecting part 12, and the thickness of the second clamping part 21 is smaller than that of the second connecting part 22. Specifically, the first clamping portion 11 and the second clamping portion 21 are 6mm in length, 0.4mm in thickness and 1.5mm in width. Therefore, on the premise that the microtubule holder can reliably hold the microtubules or the microfilaments, the microtubules or the microfilaments adjacent to 800 mu m in the horizontal direction can be successfully positioned in daily work, the lower ends of the microtubules or the microfilaments can be well exposed, and the real-time position can be determined under a microscope.
The present application is not limited to the above embodiments, and any changes or substitutions within the technical scope of the present application should be covered by the scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.
Claims (7)
1. The microtube clamp holder is characterized by comprising a first clamping piece, a second clamping piece and a plurality of limiting pins, wherein the first clamping piece and the second clamping piece are oppositely arranged;
The front end of the first clamping piece is provided with a first clamping part, the rear end of the first clamping piece is provided with a first connecting part, and the top of the first clamping piece is provided with a connecting rod;
The front end of the second clamping piece is provided with a second clamping part, and the rear end of the second clamping piece is provided with a second connecting part;
the first connecting part and the second connecting part are both connected to the limiting pin in a sliding way, a first permanent magnet is arranged in the first connecting part, a second permanent magnet is arranged in the second connecting part, the first permanent magnet and the second permanent magnet are attracted mutually, the magnetic force between the first permanent magnet and the second permanent magnet can clamp a micro tube or a micro wire, the first clamping piece and the second clamping piece can be manually separated, all movement tracks of the lower end of the micro tube or the micro wire on an operation interface can be seen under a microscope, and the real-time position of the lower end of the micro tube or the micro wire is tracked;
a groove extending along the vertical direction is arranged on the clamping surface of the first clamping part, and the groove width of the groove is 0.8 times of the diameter of the micro tube or the micro wire and is used for ensuring the determined direction when the micro tube or the micro wire is clamped;
The thickness of the first clamping part is smaller than that of the first connecting part, the thickness of the second clamping part is smaller than that of the second connecting part, the lengths of the first clamping part and the second clamping part are 6mm, the thicknesses of the first clamping part and the second clamping part are 0.4mm, the widths of the first clamping part and the second clamping part are 1.5mm, and on the premise of reliably clamping microtubes or microfilaments, the microtubes or microfilaments adjacent to 800 mu m in the horizontal direction can be successfully positioned successively in daily work, the lower ends of the microtubes or microfilaments are exposed, and real-time positions can be determined under a microscope.
2. The microtube holder as claimed in claim 1, wherein,
The top surface of the first connecting part is provided with a first installation cavity with an upward opening, the lower part of the first permanent magnet is embedded into the first installation cavity, and the upper part of the first permanent magnet extends out of the first installation cavity and is used for disassembling and assembling the first permanent magnet;
the top surface of second connecting portion all is equipped with the second installation cavity that the opening up, second permanent magnet lower part embedding the second installation intracavity, the upper portion of second permanent magnet stretches out the second installation cavity is used for the dismouting the second permanent magnet.
3. The microtube holder as claimed in claim 1 wherein the first and second jaws are monolithic jaws, the same dimensions being length x width x height = 20mm x 5mm x 4mm.
4. The microtube holder as claimed in claim 1, wherein the clamping surface of the second clamping section is provided with a resilient protective pad.
5. The holder for a microtube as claimed in claim 4, wherein the elastic protection pad is a rubber pad attached to the second holding portion for preventing damage to the microtube or microwire due to excessive holding force.
6. The microtube holder as claimed in claim 1, wherein the number of the limit pins is three, and the connection line of the end face center points of the three limit pins is a regular triangle for hanging the first clip and the second clip in a three-point surface mode.
7. The microtube holder as claimed in claim 1 wherein the connecting rod is cylindrical and has a length of 200mm and a diameter of 6mm for space saving and reliable connection to a stereotactic apparatus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202511494478.9A CN121028362A (en) | 2021-10-20 | 2021-10-20 | A microtube holder for easy operation under a microscope |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202511494478.9A CN121028362A (en) | 2021-10-20 | 2021-10-20 | A microtube holder for easy operation under a microscope |
| CN202111219819.3A CN113866976A (en) | 2021-10-20 | 2021-10-20 | Microtubule holder convenient for operation under microscope |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111219819.3A Division CN113866976A (en) | 2021-10-20 | 2021-10-20 | Microtubule holder convenient for operation under microscope |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN121028362A true CN121028362A (en) | 2025-11-28 |
Family
ID=78996662
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202511494478.9A Pending CN121028362A (en) | 2021-10-20 | 2021-10-20 | A microtube holder for easy operation under a microscope |
| CN202111219819.3A Pending CN113866976A (en) | 2021-10-20 | 2021-10-20 | Microtubule holder convenient for operation under microscope |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111219819.3A Pending CN113866976A (en) | 2021-10-20 | 2021-10-20 | Microtubule holder convenient for operation under microscope |
Country Status (2)
| Country | Link |
|---|---|
| CN (2) | CN121028362A (en) |
| WO (1) | WO2023065524A1 (en) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107139204A (en) * | 2017-07-05 | 2017-09-08 | 威海新北洋正棋机器人股份有限公司 | Robot clamping jaw, gripper method and robot |
| CN107877195A (en) * | 2017-12-11 | 2018-04-06 | 新昌县卓能电子有限公司 | A kind of Multifunctional grip device |
| CN208163179U (en) * | 2018-05-18 | 2018-11-30 | 哈尔滨理工大学 | A kind of magnetic holding device for clamping difference dimension workpiece |
| US10899558B2 (en) * | 2018-11-08 | 2021-01-26 | Federal Mfg. Llc | Bottle neck gripper |
| CN110301910B (en) * | 2019-07-23 | 2020-12-04 | 中国科学院深圳先进技术研究院 | An electrode fixing holder |
| CN211466116U (en) * | 2020-01-06 | 2020-09-11 | 科斗（苏州）脑机科技有限公司 | An electrode holder and locator |
| CN212311869U (en) * | 2020-04-17 | 2021-01-08 | 中船黄埔文冲船舶有限公司 | Spanner |
| CN112828860A (en) * | 2020-12-31 | 2021-05-25 | 苏州大学 | An electromagnetically actuated micro-gripper based on a flexible wrist structure |
| CN216083261U (en) * | 2021-10-20 | 2022-03-18 | 深圳市妇幼保健院 | Microtubule holder convenient for operation under microscope |
-
2021
- 2021-10-20 CN CN202511494478.9A patent/CN121028362A/en active Pending
- 2021-10-20 CN CN202111219819.3A patent/CN113866976A/en active Pending
- 2021-12-23 WO PCT/CN2021/140800 patent/WO2023065524A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN113866976A (en) | 2021-12-31 |
| WO2023065524A1 (en) | 2023-04-27 |
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