CN1210056C - Method for preparing Chinese medicinal tablet by ultramicropulverization technology - Google Patents
Method for preparing Chinese medicinal tablet by ultramicropulverization technology Download PDFInfo
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- CN1210056C CN1210056C CN 03143206 CN03143206A CN1210056C CN 1210056 C CN1210056 C CN 1210056C CN 03143206 CN03143206 CN 03143206 CN 03143206 A CN03143206 A CN 03143206A CN 1210056 C CN1210056 C CN 1210056C
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Abstract
The present invention relates to a method using ultrafine pulverizing technology for preparing Chinese medicinal tablets, which comprises the steps of processing traditional Chinese medicines, granulating the traditional Chinese medicines, pressing the granules into tablets and coating the tablets. After the traditional Chinese medicines are crushed into the coarse granules of which the granule sizes are from 60 to 300 meshes in the operation of crushing the traditional Chinese medicines, and the coarse granules of the traditional Chinese medicines are crushed into the ultrafine traditional Chinese powder of which the granule sizes are from 1250 to 25000 meshes, a solvent is added for sufficient dissolution and filtration, and filtrated liquid is taken. The present invention solves the problem that the preparing technology in the prior art has the defects of long consuming time, low extracting rate of effective ingredients, low medical using rate, high wasting degree on the resources of the traditional Chinese medicines, etc., and has the advantages of traditional Chinese medicine source saving, high extracting rate of the effective ingredients, small tablet volume, high medical using rate, rapid effect, etc.
Description
Technical field
The present invention relates to a kind of method for preparing Chinese medicinal tablet with superfine communication technique.
Background technology
Chinese medicinal tablet is that Chinese medicine fine powder or extract add the Formulation that the compacting of Chinese medicine fine powder or adjuvant forms, and its technological process of production mainly comprises steps such as the pulverizing, lixiviate, system granule, tabletting of Chinese medicine, and the thickness that Chinese medicine is pulverized directly has influence on the drug effect of tablet.Traditional handicraft is Chinese medicine to be ground to fine powder standby, and the above-mentioned background technology has the technical process shortcomings such as extraction ratio long, active ingredient is low, utilization ratio of drug is low, natural resources of Chinese medicinal materials waste degree height that expend time in.
Summary of the invention
The object of the present invention is to provide a kind of method of Chinese medicinal tablet for preparing with superfine communication technique to overcome
The deficiency of prior art.
General idea of the present invention is:
Micronizing prepares the method for Chinese medicinal tablet, and it comprises processing, system granule, tabletting, the coating steps of Chinese medicine, and the processing of Chinese medicine is divided into following steps: A, Chinese medicine powder is broken into granularity is 60-300 purpose coarse granule; B, the Chinese medicine coarse granule pulverizing that above-mentioned steps is pulverized are 1250 orders-25000 purpose ultra micro Chinese medicine powder for particle diameter; C, adopt an amount of solvent fully to dissolve, filter the ultra micro Chinese medicine powder in the B step, get filtrate.
Of the present invention other are contemplated that:
It is 150-300 purpose coarse granule that Chinese medicine is pulverized.
Coarse granule is ground into 2500 purpose ultra micro Chinese medicine powders.
The Chinese medicine coarse granule is ground into the step of ultra micro Chinese medicine powder, be to pulverize and be the ultra micro Chinese medicine powder with pulverizing to coarse grained Chinese medicine and air after lyophilization inject super micron mill jointly, air themperature after the lyophilization is 0-10 ℃, water content≤1%, pressure is 0.8-1.5MP when injecting super micron mill, the operating pressure of super micron mill is 0.8-1.5MP, and the internal work temperature is 0 ℃-8 ℃.
Air themperature after the lyophilization is 0 ℃, and water content is 0.5%, and the pressure when injecting super micron mill is 0.8MP, super micron mill operating pressure be 1MP, the internal work temperature is 8 ℃.
The course of dissolution of ultra micro Chinese medicine powder is divided into following two steps: (1) takes out the 1/5-1/3 mixing with the ultra micro Chinese medicine powder is the former powder of Chinese medicine; (2) remaining ultra micro Chinese medicine powder in above-mentioned (1) step is soaked after-filtration, filtrate concentrating produced thick paste or dried cream.
When producing thick paste, filtrate is answered simmer down to relative density 1.2-1.3, when producing dried cream, with filtrate simmer down to relative density 1.0-1.2 after drying.
Earlier dried cream is directly pulverized before the tabletting be 20 orders-40 purpose granule after, add 95% ethanol moistening, moistening time 〉=4 hour are blended into the lubricant compression molding again.
Elder generation is with behind thick paste and the former powder mix homogeneously of Chinese medicine before the tabletting, add wetting agent or binding agent and form soft material, the soft material that makes is made wet granular and dry by 12 orders-20 purpose screen cloth, baking temperature is 60 ℃-80 ℃, the particulate water content in dry back is 3%-5%, dried granule is crossed 16-22 purpose screen cloth, after being mixed the drug particles after sieving and the former powder of Chinese medicine evenly in proportion, again with expensive thin spice, disintegrating agent, lubricant, prescription in volatile ingredient, other liquid components back compression molding that is mixed.
The technological progress that the present invention obtains is:
Advantages such as the present invention has natural resources of Chinese medicinal materials, the effective component extraction rate height of saving, tablet volume is little, utilization ratio of drug is high, rapid-action.
Description of drawings
Fig. 1 is a process chart of the present invention.
The specific embodiment
Be further described below in conjunction with 1 pair of embodiments of the invention of accompanying drawing.
Embodiment 1:
After Chinese medicine powder is broken into granularity 200 purpose coarse granules, be that 0 ℃, water content are that 0.5% lyophilization air injects super micron mill jointly with itself and temperature, adopting high velocity air to be prepared into particle diameter is 2500 purpose ultra micro Chinese medicine powders.Super micron mill is selected close friend's board jet mill for use, and product type is QYF-260, and operating pressure is 1MP, and the internal work temperature is 8 ℃, and compressed-air actuated pressure is 0.8MP.The Chinese medicine coarse granule is discharged when micronizing the subsidiary air-flow that the ultra micro Chinese medicine powder arranged after filtration, dedusting makes the ultra micro Chinese medicine powder after collecting.
It is that the former powder of Chinese medicine is standby that the ultra micro Chinese medicine powder is taken out 1/5 mixing; Adopt an amount of solvent fully to dissolve, soak after-filtration remaining ultra micro Chinese medicine powder, filtrate concentrating produced thick paste or dried cream.When producing thick paste, soak is answered simmer down to relative density 1.2, when producing dried cream, after soak simmer down to relative density 1.1, utilizes spray drying or vacuum drying method drying.Can select suitable solvent and method for use according to the character of the main effective ingredient of Chinese medicine during lixiviate, for example: contain the Chinese medicine of the composition that volatilizees, the available water vapor distillation method extracts its volatile ingredient, and residue decocts with water the back and receives cream, is used as medicine with volatile ingredient; Contain the big or bigger medical material of viscosity of water solublity effective ingredient, fibre-bearing amount, Ying Shuiqian boils and gets its effective ingredient, and boiling liquid, to receive thick paste standby; The Chinese medicine that contains the molten living effective ingredient of alcohol can select for use Different concentrations of alcohol to extract with methods such as percolation, dipping, backflows, and it is standby to make thick paste behind the recovery ethanol.
The dried cream that makes directly is ground into granule, after sieving with 20-40 purpose granulation mesh screen, adds 95% ethanol moistening 4 hours, is blended into the lubricant compression molding.
Add suitable wetting agent or binding agent behind the former powder uniform mixing of thick paste that makes and Chinese medicine, mix is even, make it to become the wetting state of scattering of pinch agglomerating, stranding, promptly form soft material, wetting agent or adhesive consumption Ying Yineng make the minimum of soft material and are advisable.Wetting agent and binding agent commonly used mainly comprise: distilled water, starch slurry (paste), ethanol, dextrin, syrup, maltose, refined honey, liquid glucose, mucialga of arabic gummy, gelatine size, sodium carboxymethyl cellulose, low substituted hydroxy-propyl fiber system, polyvinylpyrrolidone, Chinese medical concrete etc.
Above-mentioned soft material is made wet granular according to the suitable granulation screen cloth of sheet reselection procedure, and the above tablet of common 0.5 gram is selected 12-16 purpose screen cloth for use, and the following tablet of 0.4 gram is selected 14-20 purpose screen cloth for use.When preparing wet granular in a large number, can use oscillating granulator.
The wet granular that makes is at 60 ℃-80 ℃ temperature range inner drying, the medicine that contains volatility or case of thermal instability should be dry below 60 ℃, should progressively heat up when dry and form dry dura mater, thereby influence distributing of granule interior moisture in case particle surface moisture evaporates rapidly.By the scorching baking oven of the wet grain drying equipment that uses, drying room, wet granular is generally used the drip pan splendid attire, and spreading out and putting on thickness is good to be no more than 2cm, when the wet granular water content reaches 3%-5%, promptly finishes dry run.
Dried granule is crossed 16-22 purpose screen cloth, and the ratio of sieve back granule and the former powder of Chinese medicine was advisable with 1: 1.With the granule after sieving with the prescription in volatile ingredient, other liquid components, expensive thin spice, disintegrating agent, lubricant be mixed the back compression molding.Disintegrating agent commonly used is: dry starch, gas-producing disintegrant, surfactant, the Chinese medicine fine powder that crushes, microcrystalline Cellulose, modified starch, hydroxypropyl emthylcellulose, sodium alginate, kaolin etc., lubricant commonly used is: magnesium stearate, Pulvis Talci, liquid paraffin, boric acid, hydrogenated vegetable oil, sodium laurylsulfate.
Tablet machine is generally selected for use many towards rotary tablet machine, can select different model according to different needs.
Chinese medicinal tablet can also be the former powder sheet of Chinese medicine, the former powder sheet of Chinese medicine be with Chinese medicine through obtaining after the micronizing the ultra micro Chinese medicine powder and the adjuvant mix homogeneously after the direct compression molding.Adjuvant commonly used has dry adhesive, fluidizer, disintegrating agent, lubricant, dry adhesive can be selected microcrystalline Cellulose, dextrin, Icing Sugar, carboxymethyl cellulose, gel aluminum hydroxide, spraying lactose, spraying glucose powder, spraying dextrin, cane sugar powder, methyl starch for use, fluidizer can be selected micropowder silica gel (white carbon), gel aluminum hydroxide, magnesium oxide for use, and lubricant can be selected magnesium stearate, Pulvis Talci for use.
The Chinese medicinal tablet coating can be divided into sugar-coat, film-coat, enteric coating, and coating can be selected turnadle pan coating (pan coating method), air suspension coating, compression coating, coating electrostatic method, dip coating and lamination coating method for use.
Embodiment 2:
After Chinese medicine powder is broken into granularity 60 purpose coarse granules, be that 10 ℃, water content are that 1% lyophilization air injects super micron mill jointly with itself and temperature, adopting high velocity air to be prepared into particle diameter is 1250 purpose ultra micro Chinese medicine powders.Super micron mill is selected close friend's board jet mill for use, and product type is QYF-260, and operating pressure is 1.5MP, and the internal work temperature is 3 ℃, and compressed-air actuated pressure is 1MP.The Chinese medicine coarse granule is discharged when micronizing the subsidiary air-flow that the ultra micro Chinese medicine powder arranged after filtration, dedusting makes the ultra micro Chinese medicine powder after collecting.
It is that the former powder of Chinese medicine is standby that the ultra micro Chinese medicine powder is taken out 1/3 mixing; Adopt an amount of solvent fully to dissolve, soak after-filtration remaining ultra micro Chinese medicine powder, filtrate concentrating produced thick paste or dried cream.When producing thick paste, soak is answered simmer down to relative density 1.3, when producing dried cream, after soak simmer down to relative density 1.2, utilizes spray drying or vacuum drying method drying.
The dried cream that makes directly is ground into granule, after sieving with 20-40 purpose granulation mesh screen, adds 95% ethanol moistening 6 hours, is blended into the lubricant compression molding.
Other designs of present embodiment are as described in the embodiment 1.
Embodiment 3:
After Chinese medicine powder is broken into granularity 300 purpose coarse granules, be that 5 ℃, water content are that 0.1% lyophilization air injects super micron mill jointly with itself and temperature, adopting high velocity air to be prepared into particle diameter is 12500 purpose ultra micro Chinese medicine powders.Super micron mill is selected close friend's board jet mill for use, and product type is QYF-260, and operating pressure is 0.9MP, and the internal work temperature is 10 ℃, and compressed-air actuated pressure is 1.5MP.The Chinese medicine coarse granule is discharged when micronizing the subsidiary air-flow that the ultra micro Chinese medicine powder arranged after filtration, dedusting makes the ultra micro Chinese medicine powder after collecting.
It is that the former powder of Chinese medicine is standby that the ultra micro Chinese medicine powder is taken out 1/4 mixing; Adopt an amount of solvent fully to dissolve, soak after-filtration remaining ultra micro Chinese medicine powder, filtrate concentrating produced thick paste or dried cream.When producing thick paste, soak is answered simmer down to relative density 1.3, when producing dried cream, after soak simmer down to relative density 1.0, utilizes spray drying or vacuum drying method drying.
The dried cream that makes directly is ground into granule, after sieving with 20-40 purpose granulation mesh screen, adds 95% ethanol moistening 7 hours, is blended into the lubricant compression molding.
Other designs of present embodiment are as described in the embodiment 1.
Claims (10)
1, the method for preparing Chinese medicinal tablet with superfine communication technique, it comprises processing, system granule, tabletting, the coating steps of Chinese medicine, it is characterized in that the processing of Chinese medicine is divided into following steps:
A, Chinese medicine powder is broken into granularity is 60-300 purpose coarse granule;
B, the Chinese medicine coarse granule pulverizing that above-mentioned steps is pulverized are 1250 orders-25000 purpose ultra micro Chinese medicine powder for particle diameter;
C, adopt an amount of solvent fully to dissolve, filter the ultra micro Chinese medicine powder in the B step, get filtrate.
2, according to claim 1ly prepare the method for Chinese medicinal tablet, it is characterized in that Chinese medicine pulverized and be 150-300 purpose coarse granule with superfine communication technique.
3, according to claim 1ly prepare the method for Chinese medicinal tablet with superfine communication technique, it is characterized in that Chinese medicine is pulverized is 200 purpose coarse granules.
4, according to claim 1ly prepare the method for Chinese medicinal tablet, it is characterized in that coarse granule is ground into 2500 purpose ultra micro Chinese medicine powders with superfine communication technique.
5, the method for preparing Chinese medicinal tablet with superfine communication technique according to claim 1, it is characterized in that the Chinese medicine coarse granule is ground into the step of ultra micro Chinese medicine powder, be to pulverize and be the ultra micro Chinese medicine powder with pulverizing to coarse grained Chinese medicine and air after lyophilization inject super micron mill jointly, air themperature after the lyophilization is 0-10 ℃, water content≤1%, pressure is 0.8-1.5MP when injecting super micron mill, the operating pressure of super micron mill is 0.8-1.5MP, and the internal work temperature is 0 ℃-8 ℃.
6, the method for preparing Chinese medicinal tablet with superfine communication technique according to claim 5, it is characterized in that the air themperature after the lyophilization is 0 ℃, water content is 0.5%, pressure when injecting super micron mill is 0.8MP, super micron mill operating pressure be 1MP, the internal work temperature is 8 ℃.
7, according to claim 1ly prepare the method for Chinese medicinal tablet, it is characterized in that the course of dissolution of ultra micro Chinese medicine powder is divided into following two steps with superfine communication technique:
(1) the ultra micro Chinese medicine powder being taken out the 1/5-1/3 mixing is the former powder of Chinese medicine;
(2) remaining ultra micro Chinese medicine powder in above-mentioned (1) step is soaked after-filtration, filtrate concentrating produced thick paste or dried cream.
8, require 7 describedly to prepare the method for Chinese medicinal tablet with superfine communication technique according to claim, when it is characterized in that producing thick paste, filtrate is answered simmer down to relative density 1.2-1.3, when producing dried cream, with filtrate simmer down to relative density 1.0-1.2 after drying.
9, according to claim 1, the 7 or 8 described methods that prepare Chinese medicinal tablet with superfine communication technique, after it is characterized in that directly pulverizing is 20 orders-40 purpose granule with dried cream earlier before the tabletting, add 95% ethanol moistening, moistening time 〉=4 hour are blended into the lubricant compression molding again.
10, according to claim 1,7 or the 8 described methods that prepare Chinese medicinal tablet with superfine communication technique, elder generation is with behind thick paste and the former powder mix homogeneously of Chinese medicine before it is characterized in that tabletting, add wetting agent or binding agent and form soft material, the soft material that makes is made wet granular and dry by 12 orders-20 purpose screen cloth, baking temperature is 60 ℃-80 ℃, the particulate water content in dry back is 3%-5%, dried granule is crossed 16-22 purpose screen cloth, after being mixed the drug particles after sieving and the former powder of Chinese medicine evenly in proportion, again with expensive thin spice, disintegrating agent, lubricant, volatile ingredient in the prescription, compression molding after other liquid components are mixed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03143206 CN1210056C (en) | 2003-06-30 | 2003-06-30 | Method for preparing Chinese medicinal tablet by ultramicropulverization technology |
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| CN 03143206 CN1210056C (en) | 2003-06-30 | 2003-06-30 | Method for preparing Chinese medicinal tablet by ultramicropulverization technology |
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| CN1483461A CN1483461A (en) | 2004-03-24 |
| CN1210056C true CN1210056C (en) | 2005-07-13 |
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| CN 03143206 Expired - Fee Related CN1210056C (en) | 2003-06-30 | 2003-06-30 | Method for preparing Chinese medicinal tablet by ultramicropulverization technology |
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| CN106727809B (en) * | 2017-01-26 | 2018-05-25 | 中民康达药业股份有限公司 | A kind of preparation method of ginseng ultra micro pure powder tablet |
| CN106626496A (en) * | 2017-02-27 | 2017-05-10 | 天津橘井科技有限公司 | Traditional Chinese medicine fine powder compression mold forming technique |
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