CN1208084C - Chinese patent medicine for curing chronix virus B hepatitis and its preparation method - Google Patents
Chinese patent medicine for curing chronix virus B hepatitis and its preparation method Download PDFInfo
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Abstract
The present invention discloses Chinese patent medicine for curing chronic virus B hepatitis (schisandra conversion powder) and a preparation method thereof, and relates to Chinese medicine for treating infectious great three positive diseases of chronic virus B hepatitis or people with positive HBVDNA and ALT increase, namely Chinese patent medicine for making HBVDNA negative, converting great three positive HBeAg serum or making the great three positive HBeAg serum negative and making the ALT recover to normality, and a preparation method thereof. The present invention is medicine prepared from the following parts by weight proportions of Chinese medicinal materials: 9 to 15 of polyporus, 10 to 30 of isatis root, 10 to 30 of mushroom, 10 to 20 of salvia and 3 to 10 of prepared liquorice. The preparation method comprises: medicinal materials are quantitatively weighed; partial medicinal materials are extracted by alcohol with a prescribed concentration according to prescribed time; the partial medicinal materials are extracted by direct decoction with water and boiling; two kinds of extracting solution are combined, and temperature is limited; the two kinds of extracting solution are together concentrated into pasty articles; after being dried in vacuum at prescribed temperature, the two kinds of extracting solution are pulverized and sieved into powder or are subpackaged into a capsule to become a capsule preparation or subpackaged into water to become a pill; the powder or the capsule preparation or the pill is packed and labelled for preparing the Chinese patent medicine.
Description
Technical field
Chinese patent medicine (five tastes conversion is loose) that the present invention is a kind of to treat chronic viral hepatitis B and preparation method thereof relates to is a kind of Chinese medicine contagious department chronic viral hepatitis B great three positive or has the hepatitis B virus DNA (deoxyribonucleic acid) HBVDNA positive, the glutamate pyruvate transaminase ALT person of increasing simultaneously, make that HBVDNA turns out cloudy, the conversion of great three positive hepatitis B virus e antigen HBeAg serum or turn out cloudy, Chinese Traditional Medicines that ALT is normal again and preparation method thereof.Relate to the Chinese medicine field, in conjunction with herbal pharmacology, form the immobilised compound prescription, become compounding powder with traditional diamond-making technique in conjunction with the theoretical processes of Chemistry for Chinese Traditional Medicine again according to determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs.
Background technology
Hepatitis B is one of disease that has a strong impact on human health, and is in close relations with liver cirrhosis, hepatocarcinoma.And hepatitis B great three positive infectiousness is very strong, very easily causes popular.The home and abroad does not have satisfied Therapeutic Method and specific medicament so far as yet.Although it is modern that traditional medicine is drawn ancient opinion in theory, manage out certificate, dialectical complicated and changeable, the type folder of holding concurrently differs, and can't form unified diagnostic criteria and fixing prescription, thereby curative effect is difficult to certainly.No matter modern medicine is the molecular biosciences level of etiological diagnosis, and still high-tech imaging diagnosis means have all reached quite advanced level.Although the kind of antiviral drugs is also many, but medicine is difficult for reaching effective concentration in cell, impact effect, antiviral drugs can not thoroughly be removed one type of cccDNA original copy template of the DNA (deoxyribonucleic acid) of virus replication, have given virus to transcribe the condition of duplicating again; Virus all easily morphs, thereby forms drug resistance or lessen the curative effect; Chronic hepatitis B patients often produces immunologic tolerance and immunologic hypofunction to hepatitis B viruses (HBV), affects the treatment; HBVDNA can integrate with host cell chromosome DNA, and the HBVDNA after the integration is difficult for being removed by antiviral drugs.Add the toxic and side effects of antiviral drugs, so still there is not ideal antiviral drugs so far.
Two kinds of medical system, with regard to the clinical treatment result, curative effect all can not be satisfactory.Hepatopathy intractable, particularly chronic viral hepatitis B is intractable, has become domestic and international medical circle question of common concern.Medical expense is also very high simultaneously, and patient is difficult to bear.
Summary of the invention
The objective of the invention is at above-mentioned at present both at home and abroad, Chinese and western medical still do not have promising result to the treatment of chronic viral hepatitis B, and hepatitis B great three positive infectiousness is very strong, very easily cause popularly, this disease course of disease is long, and part patient can develop into liver cirrhosis, hepatitis gravis or hepatocarcinoma.Patient's mental burden is heavy, and medical expense height, problems such as patient is difficult to bear, a kind of Chinese patent medicine (five tastes conversion is loose) for the treatment of chronic viral hepatitis B and preparation method thereof is provided, it is a kind of Chinese medicine compound medicament for the treatment of the chronic viral hepatitis B great three positive or existing the HBVDNA positive, ALT to increase simultaneously, the present invention adopts and to meet state-promulgated pharmacopoeia and relevant provincial standard fully, meet the Chinese crude drug of prepared slices of Chinese crude drugs concocted specification fully, becomes powder, pill or capsule through certain processes.Can HBVDNA be turned out cloudy, virus is duplicated no longer in vivo, make great three positive serum be converted to small three positive simultaneously or directly turn out cloudy, weaken infectiousness greatly.Shorten the course of treatment relatively; Expense very cheap (1/8-1/5 that is equivalent to Western medicine) patient bears easily; To human body, without any side effects to liver.
Technical scheme: the spirit that the present invention combines with the doctor trained in Western medicine differential diagnosis of diseases according to Chinese medical discrimination; The method that determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs combines with specific prescription and medication.In clinical practice, form and dialectical, the corresponding fixed compound recipe prescription of differential diagnosis of diseases.Medical material is through quantitative weighing, and the part medical material extracts in required time through the ethanol of normal concentration; The part medical material is directly with water boiling and extraction, and the limit temperature is condensed into pastel altogether, and being crushed and screened into powder, capsule or water more general behind the temperature vacuum drying of regulation is pill, packs, identifies and make.The treatment chronic viral hepatitis B.
The present invention is made up of the following traditional Chinese medicines material: consumption is the weight portion proportioning
Polyporus 9-15; Radix Isatidis 10-30; Lentinus Edodes 10-30;
Radix Salviae Miltiorrhizae 10-20; Radix Glycyrrhizae Preparata 3-6.
Making invention Chinese patent drug formula optimization weight portion ratio range is:
Polyporus 9-12; Radix Isatidis 12-25; Lentinus Edodes 15-20;
Radix Salviae Miltiorrhizae 9-15; Radix Glycyrrhizae Preparata 3-6.
Above-mentioned group of each group made a kind of manufacture method for the treatment of the Chinese patent medicine of chronic viral hepatitis B respectively:
According to the medical material in the clear and definite place of production, the use position of clear and definite medical material, the clearly requirement of the processing process of preparing Chinese medicine.Proportionally weigh.According to Chemistry for Chinese Traditional Medicine and pharmacology requirement, the part medical material extracts in required time through the ethanol of normal concentration; The part medical material directly extracts with decocting in water.Admixing medical solutions limits temperature to concentrate, limit warm vacuum drying to become solid, shaped then, again crushing screening, packing, sign.
Concrete manufacture method is as follows:
1, get Polyporus earlier with twice of an amount of ethanol leaching of 45-60%: be respectively 8h (hour), 16h (hour) each once, stir once every 4h.Take out medical material: standby behind (1) immersion recovery ethanol.(2) decoct twice behind the medical material water logging 2h with above-mentioned taking-up again, boil 1/2h at every turn, discard medicinal residues, decocting liquid is standby.H is hour.
2, getting Radix Isatidis leaches twice with 45-65% ethanol: be respectively 8h, 16h respectively once, stir once every 4h.Take out medical material: standby behind (1) immersion recovery ethanol.(2) again with decocting twice behind the medical material water logging 2h that takes out, boil 1/2h at every turn, discard medicinal residues, decocting liquid is standby.
3, getting Lentinus Edodes leaches twice with 45-65% ethanol: be respectively 8h, 16h respectively once, stir once every 4h, take out medical material: standby behind (1) immersion recovery ethanol.(2) again with decocting twice behind the medical material water logging 2h that takes out, boil 1/2h at every turn, discard medicinal residues, decocting liquid is standby.
4, with behind the Radix Salviae Miltiorrhizae water logging 4h, decoct twice, boil 1/2h at every turn.Discard medicinal residues, decocting liquid is standby.
5, get Radix Glycyrrhizae Preparata earlier with twice of 45-65% ethanol leaching: be respectively 8h, 16h respectively once, stir once every 2h.Take out medical material; (1) standby behind the ethanol leaching medicinal liquid recovery ethanol.(2) again with decocting 2 times behind the medical material water logging 2h that takes out, boil 1/2h at every turn, discard medicinal residues, medicinal liquid is standby.
6, above standby medicinal liquid is merged, adopts the boiling machine of computer control temperature, limit warm 80-90 ℃ to concentrate, carry out vacuum drying again, first design temperature 80-90 ℃, be dried into semi-solid state after temperature set 65-75 ℃ for to solid.Pulverize, weigh, packing, sign, make Chinese Traditional Medicines, i.e. Chinese herbal medicine powder.Can be pill or be capsule powder is general with water the powder branch capsule of packing into.
The clinical use result of Chinese patent medicine of the present invention shows that following advantage is arranged: curative effect is remarkable especially: HBVDNA negative conversion rate 94%; Hepatitis B surface antigen HBsAg, hepatitis B virus e antigen HBeAg, the anti-HBc negative conversion rate 40% of hepatitis B core antibody; HBsAg, HBeAg, anti-HBc frequence of seroconversion 43%; The ALT normalization rate is 72%, knock-on do not occur once curing.Without any side effects, expense is cheap, taking convenience, and crude drug source is abundant.
A kind of Chinese patent medicine clinical data statistics for the treatment of chronic viral hepatitis B: five tastes conversion is loose and is treated the 30 routine chronic viral hepatitis B great three positives companion HBVDNA positives, and the case that part patient ALT increases is the adult.Wherein: male 18 examples; Woman's 12 examples; HBVDNA is quantitatively 5.7 * 10
6-8.0 * 10
3Between the copy/ml; HBsAg is between 7.8-42.3ng/ml.HbeAg is between 15.6-32.8NCu/ml.Treat through 6-11m: HBVDNA 28 people that turn out cloudy, negative conversion rate 94%; HBeAg serum is converted to anti-HBe13 people, and conversion ratio is 43%; HBeAg 12 people that turn out cloudy, negative conversion rate 40%; HBsAg 18 people that turn out cloudy, negative conversion rate 60%.The ALT normalization rate is 72%.
Chronic viral hepatitis B, the cause of disease of traditional Chinese medical science understanding is the epidemic disease caused by damp-heat pathogen poison, this epidemic disease poison has the negative and positive dual nature of noxious dampness and pyretic toxicity, basic pathogenesis is damp and hot miscellaneous QI invasion and attack, glue is difficult to resolve admittedly, decrease liver and spleen, injure negative and positive of qi and blood, and the complicated pathogenesis general layout that the good and evil prosperity and decline develops in the PD process, occurs.Struggle between vital QI and pathogen is through state of an illness overall process.Because the pathogenesis development is different, complicated clinical manifestation usually occurs, and fashion non-evident sympton, sign are arranged, and does not also have tangible pathogenic process, clinical main suit is very few, often " not having card can distinguish ".Sometimes the syndrome type is complicated and changeable, and type is held concurrently to press from both sides and differed.Therefore Wang Baixiang stresses comprehensive analysis of the data gained by the four methods of diagnosis, pays attention to Chinese medical discrimination is combined with the doctor trained in Western medicine differential diagnosis of diseases.Modern medicine thinks that antiviral and immunomodulating are two key links of chb treatment.Tcm clinical practice adopts strengthening vital QI to eliminate pathogenic factors, dispersing liver and promoting blood circulation more, the principle of the stomach function regulating of being amusing.Face in the card from organic conception, be regardless of a card one type, determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs is combined with specific prescription and medication.
The main foundation of motherland's medical science on legislation side's medicine is determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, during the research combination of Chinese and Western medicine, for the ease of repeated trials and operability.We are in research process, adhere to the rule of the marrow establishment determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs of motherland's medical science on the one hand, chb is divided into great three positive, small three positive, three main syndromes of hepatic fibrosis and prescription according to the difference of syndrome, and the spirit according to the doctor trained in Western medicine differential diagnosis of diseases is fixed up prescription simultaneously.
Five tastes conversion is loose, and is made up of Polyporus, Radix Isatidis, Lentinus Edodes, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae Preparata Chinese medicine of the five flavours material.The Polyporus promoting diuresis to eliminate damp pathogen; Radix Isatidis heat-clearing and toxic substances removing, removing heat from blood; Lentinus Edodes is set upright tonify deficiency, spleen benefiting and stimulating the appetite; Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, removing heat from blood, eliminating carbuncle; The invigorating middle warmer of Radix Glycyrrhizae Preparata QI invigorating, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Form: clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, set upright making a concerted effort of tonify deficiency, spleen benefiting and stimulating the appetite, QI invigorating invigorating middle warmer, blood circulation promoting and blood stasis dispelling.The chb great three positive still has remaining damp and hot poison unclear though be in chronic phase, so still need remove.At this moment patient's immunologic hypofunction so set upright tonify deficiency, spleen invigorating, QI invigorating, invigorating middle warmer, is the act of adjusting immunologic function; Chronic phase hepatocyte fibrosis is just in formation and development, so with blood circulation promoting and blood stasis dispelling, fibrosis forms, established fibrosis is reversed.That is the antiviral of modern medicine, adjust immunologic function, the Trinitarian therapy of anti-hepatic fibrosis.
Experimental results show that:
Radix Isatidis has stronger anti-HBV effect, and immunomodulating and effect of reducing enzyme levels are arranged simultaneously; Polyporus has significant protective effect to hepatic injury, improves clinical symptoms, can significantly promote hepatitis B surface antibody to produce, and effect of reducing enzyme levels and promotion humoral immunization, adjusting immunization are preferably arranged; Lentinus Edodes is regulated immunity of organism, induces r-interferon (IFN), promotes splenic t-cell to discharge interleukin-3 (IL-3), strengthens peritoneal macrophage and produces IL-1, and anti-hepatitis improves the T cell subsets, strengthens IL-2 expression of receptor function, removes chronic hepatitis virus infection; Radix Salviae Miltiorrhizae alleviates the inflammation necrosis of liver, thereby alleviates hepatic injury.Correct microcirculation disturbance in the liver, anti-hepatic fibrosis, prevent hepatitis interstitialis chronica; Radix Glycyrrhizae Preparata reaches antiviral effect by inducement interferon, enhancing NKT (NK) cell and macrophage function, and the protection hepatic injury descends Serum ALT, prevents that hepatocarcinoma from taking place.Regulate immunologic function, produce IL-1, disturb with r-to have cooperative effect, the generation of lymphokine is had regulating action.Has Detoxication simultaneously.
The present invention fundamentally according to the principle of tcm treatment according to syndrome differentiation, in conjunction with the science of modern medicine, through clinical long-term practice, develops determined curative effect.
The specific embodiment
Embodiment 1: take by weighing raw material (g) by following proportioning
Polyporus 9g; Radix Isatidis 10g; Lentinus Edodes 10g;
Radix Salviae Miltiorrhizae 10g; Radix Glycyrrhizae Preparata 3g.
1, get Polyporus earlier with twice of an amount of ethanol leaching of 45-60%: be respectively 8h, 16h respectively once stirs once every 4h, takes out medical material; (1) standby behind the immersion recovery ethanol.(2) again with decocting twice behind the medical material water logging 2h that takes out, boil 1/2h at every turn, discard medicinal residues, decocting liquid is standby.
2, getting Radix Isatidis leaches twice with 45-65% ethanol: be respectively 8h, 16h respectively once, stir once every 4h.Take out medical material: standby behind (1) leaching liquid recovery ethanol.(2) again the medical material that takes out is decocted twice after with water logging 2h, boil 1/2h at every turn, discard medicinal residues, decocting liquid is standby.
3, getting Lentinus Edodes leaches twice with 45-65% ethanol: be respectively 8h, 16h respectively once, stir once every 4h.Take out medical material: standby behind (1) immersion recovery ethanol.(2) again with decocting twice behind the medical material water logging 2h that takes out, boil 1/2h at every turn, discard medicinal residues, decocting liquid is standby.
4, with behind the Radix Salviae Miltiorrhizae water logging 4h, decoct twice, boil 1/2h at every turn.Discard medical material, decocting liquid is standby.
5, get Radix Glycyrrhizae Preparata earlier with twice of 45-65% ethanol leaching: be respectively 8h, 16h respectively once, stir once every 2h.Take out medical material: standby behind (1) ethanol leaching medicinal liquid recovery ethanol.(2) again with decocting 2 times behind the medical material water logging 2h that takes out, boil 1/2h at every turn, discard medicinal residues, medicinal liquid is standby;
6, above standby medicinal liquid is merged, adopts the boiling machine of computer control temperature to limit warm 80-90 ℃ to concentrate, carry out vacuum drying again, first design temperature 80-90 ℃, be dried into semi-solid state after temperature set 65-75 ℃ for to solid.Pulverize, weigh, packing, make Chinese patent medicine, i.e. Chinese herbal medicine powder.Can be pill or be capsule powder is general with water the powder branch capsule of packing into.
Embodiment 2: take by weighing raw material (g) by following proportioning
Polyporus 12g; Radix Isatidis 20g; Lentinus Edodes 20g;
Radix Salviae Miltiorrhizae 15g; Radix Glycyrrhizae Preparata 6g.
Manufacture method is as follows:
1, get Polyporus earlier with twice of an amount of ethanol leaching of 45-60%: be respectively 8h, 16h respectively once stirs once every 4h.Take out medical material: standby behind (1) immersion recovery ethanol.(2) again with decocting twice behind the medical material water logging 2h that takes out, boil 1/2h at every turn, discard medicinal residues, decocting liquid is standby.
2, getting Radix Isatidis leaches twice with 45-65% ethanol: be respectively 8h, 16h respectively once, stir once every 4h.Take out medical material: standby behind (1) leaching liquid recovery ethanol.(2) again the medical material that takes out is decocted twice after with water logging 2h, boil 1/2h at every turn, discard medicinal residues, decocting liquid is standby.
3, getting Lentinus Edodes leaches twice with 45-65% ethanol: be respectively 8h, 16h respectively once, stir once every 4h.Take out medical material: standby behind (1) immersion recovery ethanol.(2) again with decocting twice behind the medical material water logging 2h that takes out, boil 1/2h at every turn, discard medicinal residues, decocting liquid is standby.
4, with behind the Radix Salviae Miltiorrhizae water logging 4h, decoct twice, boil 1/2h at every turn.Discard medicinal residues, decocting liquid is standby.
5, get Radix Glycyrrhizae Preparata earlier with twice of 45-65% ethanol leaching: be respectively 8h, 16h respectively once, stir once every 2h.Take out medical material: standby behind (1) ethanol leaching medicinal liquid recovery ethanol.(2) again with decocting 2 times behind the medical material water logging 2h that takes out, boil 1/2h at every turn, discard medicinal residues, medicinal liquid is standby;
6, above standby medicinal liquid is merged, adopts the boiling machine limit temperature of computer control temperature to concentrate at 80-90 ℃,, carry out vacuum drying again, first design temperature 80-90 ℃, be dried into semi-solid state after temperature set 65-75 ℃ for to solid.Pulverize, weigh, packing, make Chinese patent medicine, i.e. Chinese herbal medicine powder.Can be pill or be capsule powder is general with water the powder branch capsule of packing into.
Embodiment 3: take by weighing raw material (g) by following proportioning
Polyporus 15g; Radix Isatidis 30g; Lentinus Edodes 30g;
Radix Salviae Miltiorrhizae 20g; Radix Glycyrrhizae Preparata 10g.
Manufacture method is as follows:
1, get Polyporus earlier with twice of an amount of ethanol leaching of 45-60%: be respectively 8h, 16h respectively once stirs once every 4h.Take out medical material: standby behind (1) immersion recovery ethanol.(2) again with decocting twice behind the medical material water logging 2h that takes out, boil 1/2h at every turn, discard medicinal residues, decocting liquid is standby.
2, getting Radix Isatidis leaches twice with 45-65% ethanol: be respectively 8h, 16h respectively once, stir once every 4h.Take out medical material: standby behind (1) leaching liquid recovery ethanol.(2) again the medical material that takes out is decocted twice after with water logging 2h, boil 1/2h at every turn, discard medicinal residues, decocting liquid is standby.
3, getting Lentinus Edodes leaches twice with 45-65% ethanol: be respectively 8h, 16h respectively once, stir once every 4h.Take out medical material: standby behind (1) immersion recovery ethanol.(2) again with decocting twice behind the medical material water logging 2h that takes out, boil 1/2h at every turn, discard medicinal residues, decocting liquid is standby.
4, with behind the Radix Salviae Miltiorrhizae water logging 4h, decoct twice, boil 1/2h at every turn, discard medicinal residues, decocting liquid is standby.
5, get Radix Glycyrrhizae Preparata earlier with twice of 45-65% ethanol leaching: be respectively 8h, 16h respectively once, stir once every 2h.Take out medical material: standby behind (1) ethanol leaching medicinal liquid recovery ethanol.(2) again with decocting 2 times behind the medical material water logging 2h that takes out, boil 1/2h at every turn, discard medicinal residues, medicinal liquid is standby;
6, above standby medicinal liquid is merged, adopts the boiling machine of computer control temperature to limit warm 80-90 ℃ to concentrate, carry out vacuum drying again, first design temperature 80-90 ℃, be dried into semi-solid state after temperature set 65-75 ℃ for to solid.Pulverize, weigh, packing, make Chinese patent medicine, i.e. Chinese herbal medicine powder.Can be pill or be capsule powder is general with water the powder branch capsule of packing into.
Claims (5)
1. Chinese patent medicine for the treatment of chronic viral hepatitis B is characterized in that it is the medicament of being made by the Chinese crude drug of following weight proportioning:
Polyporus 9-15,
Radix Isatidis 10-30,
Lentinus Edodes 10-30,
Radix Salviae Miltiorrhizae 10-20 and
Radix Glycyrrhizae Preparata 3-10.
2. a kind of treatment chronic viral hepatitis B Chinese patent medicine according to claim 1, wherein the weight proportion scope of each raw materials of traditional Chinese medicinal materials is: Polyporus 9-12, Radix Isatidis 12-25, Lentinus Edodes 15-20, Radix Salviae Miltiorrhizae 9-15 and Radix Glycyrrhizae Preparata 3-6.
3. a kind of treatment chronic viral hepatitis B Chinese patent medicine according to claim 1, the medicament that it is characterized in that indication is powder, tablet, pill or capsule.
4. the preparation method of the medicine of treatment chronic viral hepatitis B according to claim 1 is characterized in that technical process is as described below:
(1) gets Polyporus earlier with twice of an amount of ethanol leaching of 45-60%; 8h, 16h respectively once stirs once every 4h, and is standby behind taking-up medical material: a, the leaching liquid recovery ethanol; B, again with decocting twice behind the medical material water logging 2h that takes out, boil 1/2h at every turn, discard medicinal residues, decocting liquid is standby;
(2) Radix Isatidis is leached twice with 45-65% ethanol: 8h, 16h respectively once stir once every 4h, take out medical material; Standby behind a, the leaching liquid recovery ethanol; B, again the medical material that takes out is decocted twice after with water logging 2h, boil 1/2h at every turn, discard medicinal residues, decocting liquid is standby;
(3) getting Lentinus Edodes leaches twice with 45-65% ethanol: 8h, 16h respectively once stir once every 4h, and be standby behind taking-up medical material: a, the immersion recovery ethanol; B, will take out to boil behind the medical material water logging 2h and get twice again, and boil 1/2h at every turn, and remove medicinal residues, decocting liquid is standby;
(4) with behind the Radix Salviae Miltiorrhizae water logging 4h, decoct twice, boil 1/2h at every turn, discard medicinal residues, decocting liquid is standby;
(5) getting Radix Glycyrrhizae Preparata elder generation leaches twice with 45-65% ethanol: be respectively 8h, 16h respectively once, stir once every 2h, and standby behind taking-up medical material: a, the ethanol leaching medicinal liquid recovery ethanol; B, again with decocting 2 times behind the medical material water logging 2h that takes out, boil 1/2h at every turn, discard medicinal residues, medicinal liquid is standby;
(6) above standby medicinal liquid is merged, adopt the boiling machine of computer control temperature to limit warm 80-90 ℃ to concentrate, carry out vacuum drying again, 80-90 ℃ of design temperature of elder generation, be dried into semi-solid state after temperature set 65-75 ℃ for to solid, pulverize, weigh, packing, make Chinese Traditional Medicines, i.e. Chinese herbal medicine powder.
5, the preparation method of the medicine of treatment chronic viral hepatitis B according to claim 4 is characterized in that being pill or being capsule with the powder branch capsule of packing into powder is general with water.
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| CN106539864A (en) * | 2015-09-23 | 2017-03-29 | 刘从双 | It is a kind of to treat Chinese patent medicine of chronic viral hepatitis B and preparation method thereof |
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| CN106539864A (en) * | 2015-09-23 | 2017-03-29 | 刘从双 | It is a kind of to treat Chinese patent medicine of chronic viral hepatitis B and preparation method thereof |
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