CN1207920A - Composite sea-buckthorn oil capsule - Google Patents
Composite sea-buckthorn oil capsule Download PDFInfo
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- CN1207920A CN1207920A CN 98103550 CN98103550A CN1207920A CN 1207920 A CN1207920 A CN 1207920A CN 98103550 CN98103550 CN 98103550 CN 98103550 A CN98103550 A CN 98103550A CN 1207920 A CN1207920 A CN 1207920A
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- hippophae
- buckthorn
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- fructus hippophae
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Abstract
Composite sea-buckthorn capsule is prepared by mixing sea-buckthorn seed oil extracted by means of supercritical CO2 process in 20-50 portions, sea-buckthorn fruit residue oil in 10-30 portions, sea-buckthorn fruit oil in 10-30 portions, sea-buckthorn flavone powder in 10-30 portions, and sea-buckthorn flavone extract 10-30 portions, and capsulizing the mixture. Its main components include unsaturated fatty acid, sea-buckthorn total flavone, amino acid, vitamin E, carotin, carotenoid, sterols and trace elements,such as Ca, Fe, Zn, K and Se. It has the main functions of regulating blood lipoid, resisting angicsclerosis, restraining tumor cell, resisting radiation, strengthening immunity, nourishing skin, etc.
Description
The present invention relates to a kind of composite sea-buckthorn oil capsule, composite sea-buckthorn oil capsule is by supercritical CO
2Compound and the soft capsule made of the Oleum Hippophae of extraction and Fructus Hippophae flavone.
Oleum Hippophae is very precious medicinal plant oil, has the immunity of adjusting, radioprotective, antiinflammatory granulation promoting, the anti-ageing pharmacological action of waiting for a long time.Existing Oleum Hippophae capsule is single Fructrs Hippophae seed oil.The Fructus Hippophae flavone powder is the very precious crude drug that extracts from sea buckthorn juice, sarcocarp, is that raw material is made tablet and is used for treating coronary heart disease, angina pectoris with single Fructus Hippophae flavone powder.But this dosage form has been lost the biological activity of a lot of Fructus Hippophaes.Seabuckthorn fruit flavone oral liquid is blood lipid regulation obviously, effectively prevents and treats cardiovascular and cerebrovascular disease such as coronary heart disease, angina pectoris, premature beat.But but the deficiency that this dosage form has mouthfeel, inconvenience to carry.
Chinese patent, application number are 96104896 to disclose a kind of " Guiyuan capsule " though contain Oleum Hippophae in this capsule, and other composition is a Chinese herbal medicine.Fail to make full use of the active ingredient in the Fructus Hippophae.
Purpose of the present invention is exactly at above-mentioned the deficiencies in the prior art, the composite sea-buckthorn oil capsule that provides a kind of biological activity that makes full use of in the Fructus Hippophae to form.
The present invention is with supercritical CO
2Oleum Hippophae, Fructus Hippophae dreg oil and the Oleum Hippophae of extraction are combined with each other with Fructus Hippophae flavone powder, Fructus Hippophae flavone extractum, make composite sea-buckthorn oil capsule.Become more effectively blood lipid regulation, regulate immunity, treatment, prevention coronary heart disease, angina pectoris, cardiovascular and cerebrovascular disease such as premature beat, cerebral thrombosis, cerebral infarction, radioprotective, anti-chemicotherapy, antiinflammatory granulation promoting, antidotal health care medicine.Mouthfeel, problem such as carry also are resolved simultaneously.
Composite sea-buckthorn oil capsule, the soft capsule that can be made into every is 0.25g, 0.45g, 1g is heavy.
The component and the content of composite sea-buckthorn oil capsule are as follows
Fructrs Hippophae seed oil 20-50 part; Fructus Hippophae dreg oil 10-30 part;
Oleum Hippophae 10-30 part; Fructus Hippophae flavone powder 10-30 part;
Fructus Hippophae flavone extractum 10-30 part.
Wherein the weight proportion of each component is: 30 parts of Fructrs Hippophae seed oil, 17 parts of Fructus Hippophae dreg oils, 20 parts of Oleum Hippophaes, 15 parts in Fructus Hippophae flavone powder, 18 parts of Fructus Hippophae flavone extractum.
The preparation of composite sea-buckthorn oil capsule adopts the conventional method uniform mixing to form concrete steps: (1) is earlier with Fructus Hippophae flavone powder and Fructus Hippophae flavone extractum and a small amount of Fructrs Hippophae seed oil or Oleum Hippophae allotment uniform mixing; (2) the more uniform compositions of allotment is made capsule again with behind Fructrs Hippophae seed oil, Fructus Hippophae dreg oil, the Oleum Hippophae uniform mixing.Wherein Fructrs Hippophae seed oil, Oleum Hippophae, Fructus Hippophae flavone powder are can buy on known substance, the market.The Chinese patent patent No. is 93104942, and name is called " preparation method of Fructrs Hippophae seed oil " and also discloses its preparation method, and Chinese patent application numbers 91104383, name is called: the extracting method of the full fruit oil of platymiscium " preparation method also disclosed.Fructus Hippophae dreg oil and Fructus Hippophae flavone extract making method are as described below:
The present invention adopts supercritical CO
2The Fructus Hippophae dreg oil of extraction, its raw material is the marc after Fructus Hippophae is squeezed the juice.Its technological parameter is pressure 20-30 MPa, temperature 40-65 ℃, flow 300-600 kilogram CO
2/ hour.Supercritical CO
2Extraction Fructus Hippophae dreg oil low-temperature extraction, no solvent residue.
The present invention adopts edible ethanol to extract Fructus Hippophae flavone extractum, can be raw material with Fructus Hippophae concentrated juice, sea-buckthorn pomace, Folium Hippophae separately, also three kinds of raw materials can be pressed with equal proportion or arbitrary proportion mixed extraction.Three kinds of raw material mixed extraction are more than the biological activity that single raw material extracts the Fructus Hippophae flavone extractum that obtains.
The present invention has the following advantages:
Fructrs Hippophae seed oil is extremely precious medicinal plant oil, and Fructus Hippophae dreg oil, Oleum Hippophae are very precious medicinal plant oil equally, and they have certain difference on composition, content, and as unsaturated fatty acid, the seed oil content is just much higher than Marc oil, fruit oil; And α-V
E, non-saponifiable matter, carotene, Marc oil is just than seed oil, fruit oil height; And aminoacid, fruit oil is just than seed oil, marc innage.Above-mentioned several Oleum Hippophaes are combined with each other, and it is more complete then to be combined into the Oleum Hippophae biological activity, the Oleum Hippophae that pharmacological action is stronger.
Fructus Hippophae flavone extractum is to be the raw material extraction, to concentrate the Fructus Hippophae flavone extractum made from Fructus Hippophae concentrated juice, sea-buckthorn pomace, Folium Hippophae, and this extractum contains multiple Fructus Hippophae biological activities such as Fructus Hippophae total flavones, aminoacid, betanin, organic acid, trace element.
The present invention is combined with each other multiple Oleum Hippophae and Fructus Hippophae flavone powder, Fructus Hippophae flavone extractum, is about to Fructus Hippophae 100 multiple nutrients, biological activity and is reassembled into nutrition, health care, composite sea-buckthorn oil capsule that therapeutical effect is stronger.Product assembly rationally once more this invention is extracted Fructus Hippophae by different processing methods after, thus the Fructus Hippophae biological activity that need adapt kept to greatest extent with human body.
The Main Ingredients and Appearance of composite sea-buckthorn oil capsule:
Unsaturated fatty acid 〉=40%
Fructus Hippophae total flavones 〉=5mg/g
Aminoacid, vitamin E, carotene, carotenoid, sterols, organic acid, constant and trace element: calcium, ferrum, zinc, potassium, selenium etc.
Main effect:
Scalable blood fat, anti-angiogenic sclerosis, inhibition tumor cell, auxiliary anticancer; Radioprotective, the toxic and side effects of radiotherapy and chemotherapy of alleviating; Enhance immunity function, slow down aging; Antiinflammatory granulation promoting, promotion tissue regeneration and ulcer healing, nourishing the brain and improving intelligence, improvement memory; Moisten skin nutrition.
The invention will be further described below by embodiment, but the present invention is not limited only to these examples.
The component and the content of composite sea-buckthorn oil capsule are as follows:
Embodiment 1:
Fructrs Hippophae seed oil 20kg Fructus Hippophae dreg oil 10kg
Oleum Hippophae 30kg Fructus Hippophae flavone powder 10kg
Fructus Hippophae flavone extractum 30kg.
Embodiment 2:
Fructrs Hippophae seed oil 25kg Fructus Hippophae dreg oil 25kg
Oleum Hippophae 10kg Fructus Hippophae flavone powder 30kg
Fructus Hippophae flavone extractum 10kg.
Embodiment 3:
Fructrs Hippophae seed oil 30kg Fructus Hippophae dreg oil 17kg
Oleum Hippophae 20kg Fructus Hippophae flavone powder 15kg
Fructus Hippophae flavone extractum 18kg.
Embodiment 4:
Fructrs Hippophae seed oil 45kg Fructus Hippophae dreg oil 12kg
Oleum Hippophae 13kg Fructus Hippophae flavone powder 15kg
Fructus Hippophae flavone extractum 15kg.
Embodiment 5:
Fructrs Hippophae seed oil 50kg Fructus Hippophae dreg oil 10kg
Oleum Hippophae 15kg Fructus Hippophae flavone powder 10kg
Fructus Hippophae flavone extractum 15kg.
The manufacture method of above embodiment 1-5 is the same, and raw material is all purchased in love biotechnology development centre, Shanxi.
Adopt the conventional method uniform mixing to form.Concrete steps: (1) is earlier with Fructus Hippophae flavone powder and Fructus Hippophae flavone extractum and a small amount of Fructrs Hippophae seed oil or Oleum Hippophae allotment uniform mixing; (2) the more uniform compositions of allotment is made capsule again with behind Fructrs Hippophae seed oil, Fructus Hippophae dreg oil, the Oleum Hippophae uniform mixing.Every 1g, instructions of taking: every day 2-3 time, each 1-4 grain.
Claims (2)
1, a kind of composite sea-buckthorn oil capsule is characterized in that: its component and content are:
Fructrs Hippophae seed oil 20-50 part; Fructus Hippophae dreg oil 10-30 part;
Oleum Hippophae 10-30 part; Fructus Hippophae flavone powder 10-30 part;
Fructus Hippophae flavone extractum 10-30 part.
2, composite sea-buckthorn oil capsule according to claim 1, wherein the weight proportion of each component is: 30 parts of Fructrs Hippophae seed oil, 17 parts of Fructus Hippophae dreg oils, 20 parts of Oleum Hippophaes, 15 parts in Fructus Hippophae flavone powder, 18 parts of Fructus Hippophae flavone extractum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98103550A CN1063959C (en) | 1998-08-10 | 1998-08-10 | Composite sea-buckthorn oil capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98103550A CN1063959C (en) | 1998-08-10 | 1998-08-10 | Composite sea-buckthorn oil capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1207920A true CN1207920A (en) | 1999-02-17 |
| CN1063959C CN1063959C (en) | 2001-04-04 |
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ID=5217979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98103550A Expired - Fee Related CN1063959C (en) | 1998-08-10 | 1998-08-10 | Composite sea-buckthorn oil capsule |
Country Status (1)
| Country | Link |
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| CN (1) | CN1063959C (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001079355A1 (en) * | 2000-04-12 | 2001-10-25 | Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food | Separation of carotenoids from fruits and vegetables |
| WO2006107912A1 (en) | 2005-04-05 | 2006-10-12 | Membrane Protective Technologies, Inc. | Reproductive cell system |
| CN100435663C (en) * | 2006-12-18 | 2008-11-26 | 东北虎药业股份有限公司 | Health-care food with functions of improving immunocompetence and protecting damaged gastric mucosa and its preparing method |
| CN1730018B (en) * | 2005-08-04 | 2010-07-28 | 成都中医药大学 | Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases and preparing process and application thereof |
| CN101878914A (en) * | 2010-06-28 | 2010-11-10 | 崔晓廷 | Seabuckthorn compound oil combined health care products and preparation method thereof |
| US8173177B2 (en) | 2003-09-08 | 2012-05-08 | Genyous Biomed International Inc. | Compositions of botanical extracts for cancer therapy |
| CN103372201A (en) * | 2012-04-23 | 2013-10-30 | 王铁良 | Hard capsule formula and production method thereof |
| CN103584090A (en) * | 2013-10-22 | 2014-02-19 | 山西五台山沙棘制品有限公司 | Xiangzi soft capsule and preparation method thereof |
| CN103800635A (en) * | 2014-03-12 | 2014-05-21 | 邹琳 | Medicinal and edible two-purpose composition for preventing and treating coronary heart disease and preparation method thereof |
| CN103989171A (en) * | 2014-05-26 | 2014-08-20 | 河南科技大学第一附属医院 | Soft capsule with functions of resisting aging and maintaining beauty and keeping young and preparation process thereof |
| CN106072584A (en) * | 2016-07-13 | 2016-11-09 | 大兴安岭超越野生浆果开发有限责任公司 | A kind of lutein ester and the compound edible health care product of Oleum Hippophae |
| CN106753772A (en) * | 2017-02-23 | 2017-05-31 | 甘肃农业大学 | A kind of method and compound product of low-temperature extraction Seabuckthorm Seed Oil |
| CN108157858A (en) * | 2017-12-25 | 2018-06-15 | 大连民族大学 | A kind of compound lozenge of fructus hippophae leaf |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1031108A (en) * | 1987-08-01 | 1989-02-15 | 中国科学院山西煤炭化学研究所 | The method of supercritical extraction Oleum Hippophae |
| CN1051930C (en) * | 1994-11-21 | 2000-05-03 | 中国医学科学院西安分院医药生物技术研究所 | Medicine for regulating endocrine function of woman |
| CN1062429C (en) * | 1998-07-24 | 2001-02-28 | 北京江河沙棘(集团)公司 | Capsule health food containing powdered sea-buckthorn oil and producing method thereof |
-
1998
- 1998-08-10 CN CN98103550A patent/CN1063959C/en not_active Expired - Fee Related
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001079355A1 (en) * | 2000-04-12 | 2001-10-25 | Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food | Separation of carotenoids from fruits and vegetables |
| US8173177B2 (en) | 2003-09-08 | 2012-05-08 | Genyous Biomed International Inc. | Compositions of botanical extracts for cancer therapy |
| US20130101616A1 (en) * | 2003-09-08 | 2013-04-25 | James Dao | Compositions of botanical extracts for cancer therapy |
| WO2006107912A1 (en) | 2005-04-05 | 2006-10-12 | Membrane Protective Technologies, Inc. | Reproductive cell system |
| US8202558B2 (en) | 2005-04-05 | 2012-06-19 | Membrane Protective Technologies, Inc. | Reproductive cell function preservation system |
| CN1730018B (en) * | 2005-08-04 | 2010-07-28 | 成都中医药大学 | Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases and preparing process and application thereof |
| CN100435663C (en) * | 2006-12-18 | 2008-11-26 | 东北虎药业股份有限公司 | Health-care food with functions of improving immunocompetence and protecting damaged gastric mucosa and its preparing method |
| CN101878914A (en) * | 2010-06-28 | 2010-11-10 | 崔晓廷 | Seabuckthorn compound oil combined health care products and preparation method thereof |
| CN103372201A (en) * | 2012-04-23 | 2013-10-30 | 王铁良 | Hard capsule formula and production method thereof |
| CN103584090A (en) * | 2013-10-22 | 2014-02-19 | 山西五台山沙棘制品有限公司 | Xiangzi soft capsule and preparation method thereof |
| CN103584090B (en) * | 2013-10-22 | 2015-10-28 | 山西五台山沙棘制品有限公司 | Blood fat reducing soft capsule and preparation method thereof |
| CN103800635A (en) * | 2014-03-12 | 2014-05-21 | 邹琳 | Medicinal and edible two-purpose composition for preventing and treating coronary heart disease and preparation method thereof |
| CN103989171A (en) * | 2014-05-26 | 2014-08-20 | 河南科技大学第一附属医院 | Soft capsule with functions of resisting aging and maintaining beauty and keeping young and preparation process thereof |
| CN103989171B (en) * | 2014-05-26 | 2015-11-11 | 河南科技大学第一附属医院 | A kind of anti-aging beauty-care face-nourishing soft capsules and preparation technology thereof |
| CN106072584A (en) * | 2016-07-13 | 2016-11-09 | 大兴安岭超越野生浆果开发有限责任公司 | A kind of lutein ester and the compound edible health care product of Oleum Hippophae |
| CN106753772A (en) * | 2017-02-23 | 2017-05-31 | 甘肃农业大学 | A kind of method and compound product of low-temperature extraction Seabuckthorm Seed Oil |
| CN108157858A (en) * | 2017-12-25 | 2018-06-15 | 大连民族大学 | A kind of compound lozenge of fructus hippophae leaf |
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| Publication number | Publication date |
|---|---|
| CN1063959C (en) | 2001-04-04 |
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