CN1204496A - Woundless blood sugar measuring apparatus - Google Patents

Abstract

A woundless blood sugar measuring instrument has two structures. One features that a probe that contains oxygen electrode and glucase and is connected to existing blood sugar meter is close tightly to the finger of the person to be tested and the tissue liquid exuded from finger acts on the glucase to show the blood sugar on blood sugar meter. Another features that it has a controlled laser device, infrared beam is splitted into two by raster and splitter, one of both beams goes to chopper through finger, another goes to chopper through reference pool, and the chopper sends them to infrared receiver and then to microprocessor, where data is processed to show the result on display.

Description

Woundless blood sugar measuring apparatus

The present invention relates to a kind of glucometer, particularly Woundless blood sugar measuring apparatus.

At present, measuring blood sugar concentration in the blood of human body, mainly is to adopt blood-glucose meter, and there is platinum and silver chloride--silver electrode the blood-glucose meter outside; There is single-chip microcomputer inside, and the electrode output lead is connected with single-chip microcomputer; Numerical value display and status displays are arranged on the panel.During test, extract person's to be measured blood, the blood that extracts is coated on the reagent paper in the blood-glucose meter, utilize in glucose in the blood and the blood-glucose meter glucase on the reagent paper to have an effect, promptly utilize the glucose oxidase film technology, the reagent paper of having an effect is on the electrode of blood-glucose meter, promptly by platinum and silver chloride--produce electric current on the electrode that silver is formed, after the electric current that is produced is calculated by the single-chip microcomputer in the blood-glucose meter, convert digital signal to, shown by liquid crystal display, this numeral that shows is exactly the blood sugar concentration in gauger's blood.As measuring one group of complete data, generally need in one day, measure 8 times, every measurement once will be taken out blood one time, promptly need to extract 8 blood of patient and just can finish, and the patient infection chance increases, and brings very big misery to patient simultaneously.

The objective of the invention is to provide a kind of patient's no pain, do not need to extract the Woundless blood sugar measuring apparatus that patient blood can be measured blood sugar concentration in the patient blood.

Realize first kind of version of the object of the invention: a probe is arranged, and probe is connected with air pump, and the output lead of probe and the control line of air pump are connected with single-chip microcomputer in the blood-glucose meter.

There is through hole at the center of probe, and the front end of through-hole wall has glucoseoxidase, studs with oxygen electrode on the inwall at glucoseoxidase rear portion; There is the interface that is connected with air pump at the rear portion of probe.

Oxygen electrode is by platinum and potassium chloride--and silver is formed.

Realize second kind of version of the object of the invention: an iraser is arranged, and iraser is connected with the iraser power supply, on the light path of iraser grating is arranged; Spectroscope is arranged behind the grating, spectroscope is divided into two bundle infrared beams with light path, a branch ofly point the arrival chopper by the tester, another bundle arrives three by illuminator and examines the pond, three examines the pond exports chopper to, infrared remote receiver is arranged behind the chopper, infrared remote receiver converts the infrared beam that receives to current signal and delivers to microprocessor, there is a data base to be connected with microprocessor, microprocessor and data base handle the current signal of infrared beam jointly, microprocessor has five tunnel output control signals, controls the infrared laser power supply respectively, grating, three examines the pond, chopper, printer; One tunnel shows signal is used for display result.

Described iraser power supply can be controlled the spacing frequency of iraser emission.

Described grating has a motor, connects the grating disk on the motor, on the grating disk gratings strips is arranged, and gratings strips is surperficial through laser scoring, about 200 gratings of arranging with circle, and the grating disk is rotated by micro processor controls.

Described three examines dress Glucose Liquid in the pond, and its varied in thickness is adjustable, makes its thickness and calculate concentration suitable.

Described chopper has a motor, connects a blade on the motor, and blade is the fence gate of a controlled rotation, alternately selects two bundle infrared beams to inject, and the infrared beam by chopper is received by infrared remote receiver.

Owing to adopted above-mentioned first kind of version, measure blood sugar concentration person in the blood, only need will finger finger abdomen surface be close on the probe of glucometer, at the front end of the inwall of probe glucoseoxidase is arranged, on the inwall at glucoseoxidase rear portion oxygen electrode is arranged; Also this moment, single-chip microcomputer sent the decompression of instruction control air pump, probe will be pointed being adsorbed on the probe tightly, at this moment from inside of human body in a organized way liquid ooze out, composition in this tissue fluid is almost consistent with the blood component in the blood vessel, the glucoseoxidase of a certain amount of tissue fluid and inner probe wall and macromolecular compound combined effect, formation is based on the instantaneous value electric current of concentration of glucose, transient current is passed to single-chip microcomputer in the blood-glucose meter by oxygen electrode, single-chip microcomputer is handled the back with liquid crystal display numerical value and sound count off, show various execution simultaneously, output state, can declare the correctness of each order, reach purpose of the present invention.

Owing to adopted above-mentioned second kind of version, opening power, iraser sends infrared beam under the control of Laser Power Devices, infrared beam directly enters grating, under the effect of grating, form narrower incident beam, the change of grating is associated by microcomputer control and with the change of infrared wavelength, be divided into two bundle infrared beams through spectroscopical effect, a branch ofly enter thick change adjustable three through the illuminator effect and examine the pond and enter chopper, another bundle arrives chopper by gauger's finger, two bundle infrared beams arrive chopper simultaneously, the fence gate of the controlled rotation of chopper alternately selects two bundle infrared beams to inject, and selecteed infrared beam arrives infrared remote receiver at last, infrared remote receiver converts infrared beam to current signal and sends into microprocessor, through data base's combined effect, carry out numerical calculation, at last the blood sugar concentration result is shown in display, printer prints goes out the result simultaneously, has reached purpose of the present invention.

Adopt the advantage of such scheme to be: (1) has solved when checking the blood glucose blood drawing damage to human body; (2) lowered the infection probability; (3) accuracy rate raising, time shorten; (4) check that for family blood glucose provides convenience; (5) success rate of operation and the wound healing for surgical patient provides reliable way; (6) greatly reduce the inspection cost; (7) reduced the pollution of reagent to environment.

The clinical value of such scheme: (1) has solved present blood glucose and has dynamically guarded, and takes out the drawback of 8 blood in one day; (2) solved can't monitor in the operation stress blood glucose level; (3) solved real-time and dynamic blood sugar concentration difficulty (promptly going out the result 1 second); (4) for diabetes patient's diagnosis provides extremely important means, by it, with the mode of monitoring in 24 hours, to determine insulin-dependent and two kinds of causes of disease of non-insulin-depending type; Physiological still is a pathology hemopoietic sugar; Stress type still be the endocrine regulation type; (5) instruct clinical application, for the doctor provides the medication Evaluation on effect; (6) in operation can for anaesthetist, operation teacher provide blood glucose stress parameter, can cross its understanding patient endocrine situation and assess wound healing state; (7) for the patient of diabetic ketoacidosis and stupor, rescue extremely important means are provided, saved a large amount of time; (8) to the sick needed continuous care of relevant blood glucose, improved diagnostic strength.

Elaborate in conjunction with the embodiments with reference to the accompanying drawings below.

Fig. 1 is the block diagram of first kind of version of the present invention.

The structure chart of Fig. 2 for popping one's head in first kind of version of the present invention.

Fig. 3 is the block diagram of second kind of version of the present invention.

Fig. 4 is chopper blade figure in second kind of version of the present invention.

Fig. 5 is grating pie chart in second kind of version of the present invention.

Fig. 6 is the detailed circuit diagram of second kind of version of the present invention.

Embodiment 1: among Fig. 1,2, with the finger abdomen surface that probe 1 is close to person under inspection's dry fingers, there is through hole at 1 center of popping one's head in, and the rear portion of probe 1 is connected with air pump 2 by pipeline, and 1 inwall front end posts (or scribbling) glucoseoxidase 5 popping one's head in; Plastics ventilated membrane 8 is arranged behind the glucoseoxidase 5, stud with oxygen electrode 6 on the inwall at plastics ventilated membrane 8 rear portions, oxygen electrode 6 is made up of platinum 11 and potassium chloride 13--silver 12, single-chip microcomputer 7 in blood-glucose meter this moment (blood glucose is counted commercially available known products) sends 2 decompressions of instruction control air pump, probe 1 will point being adsorbed on and popping one's head on 1 tightly, after after a while, inside of human body liquid in a organized way oozes out from 1 absorption of popping one's head in, composition in this tissue fluid is almost consistent with the blood component in the blood vessel, a certain amount of tissue fluid and the glucoseoxidase 5 and macromolecular compound and oxygen electrode 6 combineds effect that are attached to (or being coated in) probe 1 inwall, formation is based on the instantaneous value electric current of concentration of glucose, this instantaneous value electric current sends single-chip microcomputer 7 in the blood-glucose meter to by oxygen electrode 6, after single-chip microcomputer 7 is handled, the liquid crystal numerical value of blood-glucose meter shows that 3 devices show numerical value and sound count off, state shows that 4 devices show various execution simultaneously, output state can be declared the correctness of each order.

Embodiment 2: among Fig. 3,4,5,6, an iraser 14 is arranged, iraser 14 is subjected to 15 controls of iraser power supply, and iraser power supply 15 can be controlled the transmission interval frequency of iraser 14.

Grating 16 is arranged on the light path of iraser 14, grating 16 has a motor, motor is subjected to microprocessor 24 controls, the position of rotation and the positive and negative direction of microprocessor 24 control motors connect the grating disk on the motor, post gratings strips on the grating disk, gratings strips is that the surface is through laser scoring, about 200 gratings of arranging with circle, spectroscope 17 is arranged behind the grating 16,, form the narrower incidence point of wavelength through the effect of grating 16.

Tell two bundle infrared beams through the effect of spectroscope 17, a branch ofly point 19 by the tester and arrive choppers 20, this bundle infrared beam is to erythrocyte specific wavelength sensitivity, another bundle arrives three by illuminator 18 and examines pond 21, this bundle infrared beam is to the specific wavelength sensitivity of glucose, and two bundle infrared beams only have very little absorbance to other wavelength.

Three examines pond 21 exports chopper 20, three to and examines dress Glucose Liquids in the pond 21, and its varied in thickness is adjustable, makes its thickness and to calculate concentration suitable.

Chopper 20 has a motor, motor is subjected to microprocessor 24 controls, the direction of rotation and the rotating speed of microprocessor 24 control motors, connect a blade on the motor, blade is the fence gate of a controlled rotation, alternately selects two bundle infrared beams to inject, by the infrared beam of chopper 20, received by infrared remote receiver 22, infrared remote receiver 22 converts the infrared beam that receives to electric current and delivers to microprocessor 24.

There is a data base 23 to be connected outside the microprocessor 24 with microprocessor 24, microprocessors support 24, microprocessor 24 will be pointed 19 the current signal that is converted to by infrared beam and handle, draw the about 200 nanometer bandwidth of different wave length, be complex superposition spectrum, this moment microprocessor 24 maintenance data storehouses 23, carry out the least square fitting computing, glucose and blood mixture are handled as two kinds of independent reagent, thereby the concentration of calculating, obtain a result, examine pond 21 and varied in thickness by microprocessor 24 control three again, make three to examine in the pond 21 the Glucose Liquid thickness and to calculate concentration suitable, microprocessor 24 reuse subtract each other the differential method and come assay, the result is normal: promptly under the normal physiological under a certain specific wavelength, by a large amount of experiment experiences sum up and on, very little for the mixed body permeability of blood, and glucose is very big, very big with the mixed body permeability of blood, and glucose is less, this moment, result of calculation was suitable, microprocessor 24 stops search, and confirms currency; Result error: may get rid of and disturb because the pathology reason changes or injects other medicine and cause interference, and computer is searched for specific wavelength again in conjunction with database feature, uses Array Method to calculate multi-element type one time again.

Microprocessor 24 is with result output, and output has five tunnel control signals, controls iraser power supply 15 respectively, grating 16, three is examined pond 21, chopper 20, printer 26; One tunnel shows signal, control display 25 is used for display result.

Iraser 14 is measured the feasibility of blood sugar for human body, and ultimate principle is a Lambert-Beer's law, the thick proportional relation that becomes of absorbance and solution concentration and liquid layer, and the Mathematical treatment pattern is a least square curve fitting.In actual use, blood as solvent, creatinine, albumin, bilirubin, ammonia and various electrolyte etc. in the blood, common stack spectrum with hemoglobin is regarded the formed spectrum of a kind of material as, the spectrum of glucose as with above spectrographic stack, use least square curve fitting, but because in human body, various physiology, pathological change, may significantly raise by certain composition in the blood habitually in the past, or the injection all ingredients, microprocessor 24 is when analyzing above-mentioned data, must obtain data base 23 support, just can finish the work of treatment of data.

Claims (5)

1, a kind of Woundless blood sugar measuring apparatus comprises blood-glucose meter, it is characterized in that: a probe is arranged, and probe is connected with air pump, and the output lead of probe and the control line of air pump are connected with single-chip microcomputer in the blood-glucose meter.

2, require 1 described Woundless blood sugar analyzer according to power, it is characterized in that: there is through hole at the center of probe, and the front end of through-hole wall has glucoseoxidase, studs with oxygen electrode on the inwall at glucoseoxidase rear portion; There is the interface that is connected with air pump at the rear portion of probe.

3, Woundless blood sugar analyzer according to claim 2, it is characterized in that: described oxygen electrode is by platinum and potassium chloride--and silver is formed.

4, a kind of Woundless blood sugar measuring apparatus is characterized in that: an iraser is arranged, and iraser is connected with the iraser power supply, on the light path of iraser grating is arranged; Spectroscope is arranged behind the grating, spectroscope is divided into two bundle infrared beams with light path, a branch ofly point the arrival chopper by the tester, another bundle arrives three by illuminator and examines the pond, three examines the pond exports chopper to, infrared remote receiver is arranged behind the chopper, infrared remote receiver converts the infrared beam that receives to current signal and delivers to microprocessor, there is a data base to be connected with microprocessor, microprocessor and data base handle the current signal of infrared beam jointly, microprocessor has five tunnel output control signals, controls the infrared laser power supply respectively, grating, three examines the pond, chopper, printer; One tunnel shows signal is used for display result.

5, Woundless blood sugar measuring apparatus according to claim 4 is characterized in that: described iraser power supply can be controlled the spacing frequency of iraser emission; Described grating has a motor, connects the grating disk on the motor, on the grating disk gratings strips is arranged, and gratings strips is surperficial through laser scoring, about 200 gratings of arranging with circle, and the grating disk is rotated by micro processor controls; Described three examines dress Glucose Liquid in the pond, and its varied in thickness is adjustable, makes its thickness and calculate concentration suitable; Described chopper has a motor, connects a blade on the motor, and blade is the fence gate of a controlled rotation, alternately selects two bundle infrared beams to inject, and the infrared beam by chopper is received by infrared remote receiver.

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