CN120435491A - 胰淀素受体激动剂 - Google Patents

胰淀素受体激动剂

Info

Publication number
CN120435491A
CN120435491A CN202380088206.1A CN202380088206A CN120435491A CN 120435491 A CN120435491 A CN 120435491A CN 202380088206 A CN202380088206 A CN 202380088206A CN 120435491 A CN120435491 A CN 120435491A
Authority
CN
China
Prior art keywords
receptor agonist
amylin receptor
amylin
peptide
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380088206.1A
Other languages
English (en)
Chinese (zh)
Inventor
C·M·乔根森
T·克鲁瑟
J·F·劳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US18/512,512 external-priority patent/US12116388B2/en
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of CN120435491A publication Critical patent/CN120435491A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CN202380088206.1A 2022-12-22 2023-12-21 胰淀素受体激动剂 Pending CN120435491A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP22215958.4 2022-12-22
EP22215958 2022-12-22
US18/512,512 2023-11-17
US18/512,512 US12116388B2 (en) 2022-12-22 2023-11-17 Amylin receptor agonists
PCT/EP2023/087353 WO2024133739A1 (en) 2022-12-22 2023-12-21 Amylin receptor agonists

Publications (1)

Publication Number Publication Date
CN120435491A true CN120435491A (zh) 2025-08-05

Family

ID=89542238

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380088206.1A Pending CN120435491A (zh) 2022-12-22 2023-12-21 胰淀素受体激动剂

Country Status (12)

Country Link
EP (1) EP4638480A1 (https=)
JP (1) JP2025542410A (https=)
KR (1) KR20250127104A (https=)
CN (1) CN120435491A (https=)
AU (1) AU2023411346A1 (https=)
CL (1) CL2025001805A1 (https=)
CO (1) CO2025008319A2 (https=)
IL (1) IL321586A (https=)
JO (1) JOP20250144A1 (https=)
MX (1) MX2025007124A (https=)
TW (1) TW202428309A (https=)
WO (1) WO2024133739A1 (https=)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994008006A1 (en) 1992-09-30 1994-04-14 Zymogenetics, Inc. Human calcitonin receptor
ES2401965T3 (es) 2009-02-19 2013-04-25 Novo Nordisk A/S Modificación de Factor VIII
JP6121992B2 (ja) 2011-06-10 2017-04-26 ノヴォ ノルディスク アー／エス ポリペプチド
AR097701A1 (es) * 2013-09-19 2016-04-13 Zealand Pharma As Análogos de amilina
JP6898518B2 (ja) 2018-02-02 2021-07-07 ノヴォ ノルディスク アー／エス Ｇｌｐ−１アゴニスト、ｎ−（８−（２−ヒドロキシベンゾイル）アミノ）カプリル酸の塩及び滑沢剤を含む固形組成物
TWI829687B (zh) 2018-05-07 2024-01-21 丹麥商諾佛 儂迪克股份有限公司 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物

Also Published As

Publication number Publication date
TW202428309A (zh) 2024-07-16
KR20250127104A (ko) 2025-08-26
EP4638480A1 (en) 2025-10-29
CO2025008319A2 (es) 2025-07-17
CL2025001805A1 (es) 2025-09-26
MX2025007124A (es) 2025-07-01
JP2025542410A (ja) 2025-12-25
IL321586A (en) 2025-08-01
AU2023411346A1 (en) 2025-07-24
WO2024133739A1 (en) 2024-06-27
JOP20250144A1 (ar) 2025-06-16

Similar Documents

Publication Publication Date Title
US12054528B2 (en) Co-agonists of the GLP-1 and amylin receptors
TWI810606B (zh) Gip/glp1共促效劑化合物
TWI707865B (zh) Gip衍生物及其用途
TWI850599B (zh) 前藥及其用途
US20170313750A1 (en) Selective pyy compounds and uses thereof
US20220125940A1 (en) Co-agonists at glp-1 and gip receptors suitable for oral delivery
US9988430B2 (en) Stable GLP-1 based GLP-1/glucagon receptor co-agonists
CN102076353A (zh) 胰岛淀粉样多肽和鲑鱼降钙素的衍生杂合肽
US12116388B2 (en) Amylin receptor agonists
CN120435491A (zh) 胰淀素受体激动剂
JP7755031B2 (ja) Ｇｌｐ－１、ｇｉｐ、およびアミリン受容体の三重作動薬
WO2026008836A1 (en) Glp-1 derivatives and uses thereof
CN121991202A (zh) Glp-1和胰淀素受体的共激动剂
CN121991249A (zh) Glp-1和胰淀素受体的共激动剂
CN121975020A (en) Co-agonists of GLP-1 and the amylin receptor
EA049130B1 (ru) Коагонисты рецепторов glp-1 и gip, подходящие для пероральной доставки

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination