CN120383683A - Enpp1多肽及其使用方法 - Google Patents

Enpp1多肽及其使用方法

Info

Publication number
CN120383683A
CN120383683A CN202510521331.8A CN202510521331A CN120383683A CN 120383683 A CN120383683 A CN 120383683A CN 202510521331 A CN202510521331 A CN 202510521331A CN 120383683 A CN120383683 A CN 120383683A
Authority
CN
China
Prior art keywords
enpp1
polypeptide
subject
seq
certain embodiments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202510521331.8A
Other languages
English (en)
Chinese (zh)
Inventor
P·斯塔巴赫
D·布拉多克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Original Assignee
Yale University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yale University filed Critical Yale University
Publication of CN120383683A publication Critical patent/CN120383683A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/01—Hydrolases acting on acid anhydrides (3.6) in phosphorus-containing anhydrides (3.6.1)
    • C12Y306/01009—Nucleotide diphosphatase (3.6.1.9), i.e. nucleotide-pyrophosphatase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202510521331.8A 2018-08-31 2019-08-31 Enpp1多肽及其使用方法 Pending CN120383683A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862725607P 2018-08-31 2018-08-31
US62/725,607 2018-08-31
US201962830247P 2019-04-05 2019-04-05
US62/830,247 2019-04-05
CN201980070064.XA CN112930397B (zh) 2018-08-31 2019-08-31 Enpp1多肽及其使用方法
PCT/US2019/049243 WO2020047520A1 (en) 2018-08-31 2019-08-31 Enpp1 polypeptides and methods of using same

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201980070064.XA Division CN112930397B (zh) 2018-08-31 2019-08-31 Enpp1多肽及其使用方法

Publications (1)

Publication Number Publication Date
CN120383683A true CN120383683A (zh) 2025-07-29

Family

ID=69643272

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202510521331.8A Pending CN120383683A (zh) 2018-08-31 2019-08-31 Enpp1多肽及其使用方法
CN201980070064.XA Active CN112930397B (zh) 2018-08-31 2019-08-31 Enpp1多肽及其使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201980070064.XA Active CN112930397B (zh) 2018-08-31 2019-08-31 Enpp1多肽及其使用方法

Country Status (7)

Country Link
US (2) US12344868B2 (https=)
EP (1) EP3844280A4 (https=)
JP (2) JP2021535153A (https=)
CN (2) CN120383683A (https=)
AU (1) AU2019327572B2 (https=)
CA (1) CA3110498A1 (https=)
WO (1) WO2020047520A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3126839A1 (en) * 2019-01-18 2020-07-23 Inozyme Pharma, Inc. Treatment of diseases involving deficiency of enpp1 or enpp3
KR20230047334A (ko) * 2020-05-27 2023-04-07 이노자임 파마, 인코포레이티드 혈관 평활근 세포 증식을 억제하기 위한 조성물 및 방법
WO2021252549A1 (en) * 2020-06-09 2021-12-16 Inozyme Pharma, Inc. Soluble enpp1 or enpp3 proteins and uses thereof
CA3246877A1 (en) * 2022-03-30 2023-10-05 Yale University METHOD AND COMPOSITIONS FOR THE TREATMENT, ALLEVIATION AND/OR PREVENTION OF DIFFUSE IDIOPATHIC SKELETAL HYPEROSTOSIS (DISH)
CN116769718A (zh) * 2023-04-21 2023-09-19 南京逸微健华生物科技有限公司 一种工程化细胞外囊泡及用途

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JP5199077B2 (ja) 2005-06-10 2013-05-15 アルタス ファーマシューティカルズ インコーポレイテッド シュウ酸オキシダーゼ結晶の投与による、シュウ酸塩濃度を低下させるための方法
WO2008105911A2 (en) 2006-08-02 2008-09-04 Altus Pharmaceuticals Inc. Crystallized oxalate decarboxylase and methods of use
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EP3377105A4 (en) 2015-11-20 2019-04-24 Yale University COMPOSITIONS FOR THE TREATMENT OF ECTOPIC CALIBRATION DISORDERS AND METHODS THEREWITH
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Also Published As

Publication number Publication date
AU2019327572B2 (en) 2025-11-13
JP2025000736A (ja) 2025-01-07
CN112930397A (zh) 2021-06-08
EP3844280A4 (en) 2022-09-14
CA3110498A1 (en) 2020-03-05
EP3844280A1 (en) 2021-07-07
WO2020047520A1 (en) 2020-03-05
US12344868B2 (en) 2025-07-01
US20220119782A1 (en) 2022-04-21
JP2021535153A (ja) 2021-12-16
CN112930397B (zh) 2025-05-09
US20260049294A1 (en) 2026-02-19
AU2019327572A1 (en) 2021-03-18

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