CN120152726A - 用于处置或预防中枢神经系统损伤疾病的环状肽衍生物组合物 - Google Patents

用于处置或预防中枢神经系统损伤疾病的环状肽衍生物组合物 Download PDF

Info

Publication number
CN120152726A
CN120152726A CN202380076631.9A CN202380076631A CN120152726A CN 120152726 A CN120152726 A CN 120152726A CN 202380076631 A CN202380076631 A CN 202380076631A CN 120152726 A CN120152726 A CN 120152726A
Authority
CN
China
Prior art keywords
group
mmol
hydrogen atom
alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380076631.9A
Other languages
English (en)
Chinese (zh)
Inventor
松本恒平
大西海斗
寺上佳奈
苅田祐马
田部七大
安井航佑
正司武嗣
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DKS Co Ltd
Original Assignee
Dai Ichi Kogyo Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dai Ichi Kogyo Seiyaku Co Ltd filed Critical Dai Ichi Kogyo Seiyaku Co Ltd
Publication of CN120152726A publication Critical patent/CN120152726A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202380076631.9A 2022-11-04 2023-11-01 用于处置或预防中枢神经系统损伤疾病的环状肽衍生物组合物 Pending CN120152726A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022-177714 2022-11-04
JP2022177714 2022-11-04
PCT/JP2023/039446 WO2024096066A1 (ja) 2022-11-04 2023-11-01 中枢神経系損傷疾患を処置または予防するための環状ペプチド誘導体組成物

Publications (1)

Publication Number Publication Date
CN120152726A true CN120152726A (zh) 2025-06-13

Family

ID=90930657

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380076631.9A Pending CN120152726A (zh) 2022-11-04 2023-11-01 用于处置或预防中枢神经系统损伤疾病的环状肽衍生物组合物

Country Status (7)

Country Link
EP (1) EP4613282A1 (https=)
JP (1) JPWO2024096066A1 (https=)
KR (1) KR20250111317A (https=)
CN (1) CN120152726A (https=)
IL (1) IL320606A (https=)
TW (1) TW202525320A (https=)
WO (1) WO2024096066A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202547546A (zh) * 2024-02-07 2025-12-16 日商第一工業製藥股份有限公司 用以改善腦功能之環狀肽衍生物組成物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172896A (en) 1978-06-05 1979-10-30 Dainippon Pharmaceutical Co., Ltd. Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same
GB9217295D0 (en) 1992-08-14 1992-09-30 Wellcome Found Controlled released tablets
US5541231A (en) 1993-07-30 1996-07-30 Glaxo Wellcome Inc. Stabilized Pharmaceutical
GB9315856D0 (en) 1993-07-30 1993-09-15 Wellcome Found Stabilized pharmaceutical
US5358970A (en) 1993-08-12 1994-10-25 Burroughs Wellcome Co. Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
DE69839355T2 (de) 1997-07-29 2009-06-04 Alcon Laboratories, Inc., Fort Worth Ophthalmische Zusammensetzungen enthaltend Galaktomannanpolymere und Borat
AU2483599A (en) 1998-01-29 1999-08-16 Sepracor, Inc. Pharmaceutical uses of optically pure (-)-bupropion
US8889112B2 (en) 1999-09-16 2014-11-18 Ocularis Pharma, Llc Ophthalmic formulations including selective alpha 1 antagonists
US6933289B2 (en) 2003-07-01 2005-08-23 Allergan, Inc. Inhibition of irritating side effects associated with use of a topical ophthalmic medication
EP1654002B2 (en) 2003-08-07 2014-01-29 Allergan, Inc. Compositions for delivery of therapeutics into the eyes
US20050059744A1 (en) 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
WO2016047638A1 (ja) * 2014-09-24 2016-03-31 国立大学法人岩手大学 環状ペプチド誘導体とその製造方法および組成物
JP7486328B2 (ja) * 2020-03-05 2024-05-17 株式会社バイオコクーン研究所 神経突起伸長促進剤、神経細胞の樹状突起発現促進剤、及び神経栄養因子様作用物質
JP7695662B2 (ja) * 2020-11-02 2025-06-19 公立大学法人大阪 環状ペプチド誘導体の製造方法及び環状ペプチド化合物の製造方法

Also Published As

Publication number Publication date
JPWO2024096066A1 (https=) 2024-05-10
TW202525320A (zh) 2025-07-01
WO2024096066A1 (ja) 2024-05-10
KR20250111317A (ko) 2025-07-22
EP4613282A1 (en) 2025-09-10
IL320606A (en) 2025-07-01

Similar Documents

Publication Publication Date Title
JP6138243B2 (ja) 置換ピペリジノアセトアミドおよびその使用
JP2026016715A (ja) 狂犬病治療のための環状アミド化合物およびその方法
TW201020249A (en) Synthetic mimetics of host defense and uses thereof
CN120152726A (zh) 用于处置或预防中枢神经系统损伤疾病的环状肽衍生物组合物
US6083987A (en) Phenylenediamine derivative, radical scavenger, brain-infarction depressant, and brain-edema depressant
CN119731193A (zh) 环状肽衍生物及其制造方法和组合物
CN120187444A (zh) 用于处置或预防神经病理性疼痛和/或炎性疼痛的环状肽衍生物组合物
CN119947740A (zh) 用于处置或预防眼科疾病的环状肽衍生物组合物
HK40128045A (zh) 用於处置或预防中枢神经系统损伤疾病的环状肽衍生物组合物
WO2025169981A1 (ja) 脳機能を改善するための環状ペプチド誘導体組成物
JPH09157236A (ja) フェニレンジアミン誘導体及びラジカルスカベンジャー、脳梗塞抑制剤、脳浮腫抑制剤
HK40129190A (zh) 用於处置或预防神经病理性疼痛和/或炎性疼痛的环状肽衍生物组合物
HK40122917A (zh) 环状肽衍生物及其制造方法和组合物
WO2025169980A1 (ja) テストステロンの産生／分泌を調節するための環状ペプチド誘導体組成物
JPH08269013A (ja) ピラゾリジン誘導体及びラジカルスカベンジャー、脳梗塞抑制剤、脳浮腫抑制剤
CN108640916A (zh) 一类具有抗癌活性的硫代吲嗪类化合物及其衍生物
JP2023084946A (ja) 生理活性を有する新規化合物
JP2022091476A (ja) 新規含窒素三環性骨格化合物およびその使用
HK40088484A (zh) 抗病毒素1，3-二氧代茚化合物
JP2023084944A (ja) 生理活性を有する新規化合物
CN108864083A (zh) 一类具有抗癌活性的氨基取代吲嗪类化合物及其衍生物
JPH0967327A (ja) フェニレンジアミン誘導体及びラジカルスカベンジャー、脳梗塞抑制剤、脳浮腫抑制剤

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40128045

Country of ref document: HK