CN1200369A - Method for extraction of fish-oil polyene unsaturated fatty acid ester by rectifying - Google Patents
Method for extraction of fish-oil polyene unsaturated fatty acid ester by rectifying Download PDFInfo
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- CN1200369A CN1200369A CN 97106973 CN97106973A CN1200369A CN 1200369 A CN1200369 A CN 1200369A CN 97106973 CN97106973 CN 97106973 CN 97106973 A CN97106973 A CN 97106973A CN 1200369 A CN1200369 A CN 1200369A
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Abstract
The invented rectifying extraction method of fish oil polyene unsaturated fatty acid ester uses DHA and EPA containing fish oil polyene fatty acid ester as raw material through rectifying technology treatment, the rectifying condition is: temp. is controlled within 80 to 280 deg.C, and vacuum is controlled at 2-1000 Pa, the upper part of the rectifying tower has DHA fraction outlet and EPA fraction outlet. The ratio of the fractions can be arbitrarily adjusted, so that the value of products can be raised and more economic benefit can be obtd.
Description
The present invention relates to a kind of from organism the method for purification medical insurance material, relate in particular to the method for making Max EPA fat.
Max EPA fat is mainly unsaturated fatty acid ester, composition is docosahexenoic acid formicester and second fat (C23H3402), timnodonic acid formicester and second fat (C21H3202), be so-called DHA and EPA, DHA and EPA extract from the fish oil of abyssal pelagic fishes (as sardines, black scraper fish, squid, cod, Qing Chuan fish etc.).As everyone knows, Max EPA fat mainly contains DHA and EPA, DHA is a kind of typical brain nutritive substance, selectively kill the effect of tumour cell, produce effect for the brain tonic and the memory aspect utmost point, and the health care of EPA and curative effect characteristics and DHA are different, its major function is blood fat reducing, especially reduces glycerine tricarboxylic acid fat (TG) in the serum, reduce the viscosity of blood, strengthen erythrocytic plasticity-, suppress hematoblastic gathering, the formation of anti-hemostasis suppository, the oxygen-supplying amount of internal organs such as increase heart, prevention of brain apoplexy and myocardial infarction.Further research shows that also EPA can remove the cholesterol on the vessel wall, and nontoxicity, is better than other blood lipid-lowering medicine, is expected pharmaceutically be widely used.
Existing Max EPA fat is to be raw material by thick fish oil, through esterification, concentrate refining and add stablizer and make, its main technique is: crude fish oil-add alkali depickling-washing-3-5 hour-carclazyte of vacuum high-temperature dehydration deodorization according to the height of acid number to filter decolouring-esterification-enrichment under catalytic condition-washing-make with extra care filtration, according to existing technology, can obtain containing DHA and EPA total amount and be the Max EPA fat below 70%, the production and the interpolation that are used for healthcare products and food are enough.But DHA and EPA pharmacological property with act on the machine-processed different of human body, the product of mixed DHA and EPA may not be that market needs most, for the women of children, pregnant woman and hello breast, DHA is best healthcare products, but EPA is at blood fat reducing, especially reduce glycerine tricarboxylic acid fat (TG) in the serum, reduce the viscosity of blood, on the medicinal uses such as prevention of brain apoplexy and myocardial infarction better application is arranged, this is that existing technology is insurmountable.In addition, existing Max EPA fat prod on color and luster outward appearance and taste not as external like product, dark excessively as color, smell too raw meat.Be difficult to satisfy the requirement of making high-quality healthcare products and medicine.And the ratio of existing DHA and EPA determines basically, generally at 40-60%: 60-40%.
The objective of the invention is, qualities such as the content of raising Max EPA fat, color and luster are segmented DHA and EPA, satisfy the separately needs of market to DHA and EPA, increase value-added content of product, and other purpose of the present invention is listed in specification sheets in addition.
The object of the present invention is achieved like this: with the Max EPA fat that mainly contains DHA and EPA is raw material, art breading through rectifying, the processing condition of rectifying are as follows, temperature is controlled at 80-280 ℃, vacuum degree control is at 2-1000Pa, and in being provided with the rectifying tower of structured packing, carry out, be provided with the outlet of two cuts of DHA and EPA at least on the top of tower.
But the processing condition of the rectifying of optimizing are as follows, and temperature is controlled at 150-180 ℃, and vacuum degree control is at 300-500Pa.
The fish oil that rectifying under above processing condition will mainly contain DHA and EPA further segments, though DHA and EPA reach pure product on purity, but the total content of two cuts has been much higher than 70%, total content can reach 90-95% under optimized process conditions, the content of the single cut of EPA can reach 70-90% (measuring the peak area normalization method of the not correction up factor with gas chromatography).Color and luster is obviously thin out, and fishy smell also alleviates greatly.Product through technology of the present invention can satisfy the requirement of making high-quality healthcare products and medicine, reaches and surpass the quality of external like product.The high-content of the single cut of EPA can satisfy the requirement of medical aspect, and for example purer EPA is extremely effective in reducing blood-fat, removing cholesterol, and nontoxicity, is expected to make injection liquid.In addition, owing to segmented cut, therefore two cut content ratio can be adjusted arbitrarily, have promoted the value of product greatly, can obtain better economic benefit.
The invention will be further described by the following examples:
Embodiment 1, raw material is for mainly containing the Max EPA fat of DHA and EPA total amount 50%, art breading through rectifying, the processing condition of rectifying are as follows, and temperature is controlled at 120 ℃, and vacuum degree control is at 0.5KPa, and in being provided with the rectifying tower of structured packing, carry out, at least be provided with the outlet of two cuts of DHA and EPA on the top of tower, the outlet of DHA cut up, the vaporization temperature of two cuts differs 20-40 ℃.The design of tower can be referring to CN96231087.5, to guarantee to have mass transfer and heat transfer efficiency preferably.The total content of two cuts is 80%, and the content of DHA is 70%.
Embodiment 2, with the Max EPA fat that contains DHA and EPA is raw material, total content 70%, through the art breading of rectifying, the processing condition of rectifying are as follows, and temperature is controlled at 200 ℃, vacuum degree control is at 0.8KPa, and in rectifying tower, carry out, the result is that the total content of two cuts is 85%, the content of DHA is 73%.
Embodiment 3, are that 65% Max EPA fat is raw material with the total content of DHA and EPA, through the art breading of rectifying, the processing condition of rectifying: temperature is at 180 ℃, and vacuum degree control is at 0.3KPa, and carries out in rectifying tower, the total content of two cuts is 90%, and the content of DHA is 85%.
Embodiment 4, are that 50% Max EPA fat is raw material with the total content of DHA and EPA, and through the art breading of rectifying, temperature is 240 ℃, and vacuum degree control is at 0.3KPa, and carry out in rectifying tower.Consequently the total content of two cuts is 80%, and the content of DHA is 75%.
Embodiment 5, are raw material with the Max EPA fat that contains DHA and EPA 60%, and through the art breading of rectifying, temperature is controlled at 150 ℃, and vacuum degree control is at 0.4KPa, and the result is that the total content of two cuts is 75%, and the content of DHA is 70%.
Embodiment 6, are raw material with the Max EPA fat that contains DHA and EPA 60%, and the processing condition of rectifying are as follows: 260 ℃ of temperature, vacuum degree control is at 0.2KPa.The result is that the total content of two cuts is 80%, and the content of DHA is 71%.
Embodiment 7, are that 50% Max EPA fat is raw material with the total content of DHA and EPA, through the art breading of rectifying, the processing condition of rectifying: temperature is at 190 ℃, and vacuum degree control is at 50Pa, and carries out in rectifying tower, the total content of two cuts is 90%, and the content of DHA is 85%.In a word, vacuum tightness can also be higher, but energy consumption increases and work efficiency can reduce.
Claims (2)
1. method of making Max EPA fat, it is characterized in that with the Max EPA fat that mainly contains DHA and EPA be raw material, art breading through rectifying, the processing condition of rectifying are as follows, temperature is controlled at 80-280 ℃, vacuum degree control is at 2-1000Pa, and carries out in being provided with the rectifying tower of structured packing, is provided with the outlet of two cuts of DHA and EPA at least on the top of tower.
2. by the method for the described manufacturing Max EPA of claim 1 fat, it is characterized in that the processing condition of rectifying are as follows, temperature is controlled at 150-180 ℃, and vacuum degree control is at 300-500Pa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97106973 CN1200369A (en) | 1997-05-22 | 1997-05-22 | Method for extraction of fish-oil polyene unsaturated fatty acid ester by rectifying |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97106973 CN1200369A (en) | 1997-05-22 | 1997-05-22 | Method for extraction of fish-oil polyene unsaturated fatty acid ester by rectifying |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1200369A true CN1200369A (en) | 1998-12-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 97106973 Pending CN1200369A (en) | 1997-05-22 | 1997-05-22 | Method for extraction of fish-oil polyene unsaturated fatty acid ester by rectifying |
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| CN (1) | CN1200369A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100532519C (en) * | 2003-11-19 | 2009-08-26 | 普洛阿帕茨-投资咨询有限公司 | Process for the preparation of a composition comprising unsaturated compounds |
| CN103751781A (en) * | 2006-02-07 | 2014-04-30 | 持田制药株式会社 | Composition for preventing recurrence of stroke |
| CN107216252A (en) * | 2016-03-22 | 2017-09-29 | 浙江医药股份有限公司新昌制药厂 | A kind of preparation method of high content Omega-3 fatty-acid ethyl esters |
| CN109593606A (en) * | 2019-01-31 | 2019-04-09 | 福建师范大学 | A kind of deep sea fish oil and its processing technology of high DHA content |
| CN110257446A (en) * | 2019-07-08 | 2019-09-20 | 青岛和合汇途工程技术有限公司 | A kind of preparation method of high-purity EPA glyceride and DHA glyceride |
-
1997
- 1997-05-22 CN CN 97106973 patent/CN1200369A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100532519C (en) * | 2003-11-19 | 2009-08-26 | 普洛阿帕茨-投资咨询有限公司 | Process for the preparation of a composition comprising unsaturated compounds |
| CN103751781A (en) * | 2006-02-07 | 2014-04-30 | 持田制药株式会社 | Composition for preventing recurrence of stroke |
| CN102743755B (en) * | 2006-02-07 | 2015-01-14 | 持田制药株式会社 | Composition for preventing recurrence of stroke |
| CN107216252A (en) * | 2016-03-22 | 2017-09-29 | 浙江医药股份有限公司新昌制药厂 | A kind of preparation method of high content Omega-3 fatty-acid ethyl esters |
| CN109593606A (en) * | 2019-01-31 | 2019-04-09 | 福建师范大学 | A kind of deep sea fish oil and its processing technology of high DHA content |
| CN109593606B (en) * | 2019-01-31 | 2022-07-08 | 福建师范大学 | Deep sea fish oil with high DHA content and processing technology thereof |
| CN110257446A (en) * | 2019-07-08 | 2019-09-20 | 青岛和合汇途工程技术有限公司 | A kind of preparation method of high-purity EPA glyceride and DHA glyceride |
| CN110257446B (en) * | 2019-07-08 | 2023-01-13 | 青岛和合汇途工程技术有限公司 | Preparation method of high-purity EPA glyceride and DHA glyceride |
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