CN119731310A - 预测产生有用物质的克隆的产生稳定性的方法、信息处理装置、程序及预测模型生成方法 - Google Patents

预测产生有用物质的克隆的产生稳定性的方法、信息处理装置、程序及预测模型生成方法 Download PDF

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CN119731310A
CN119731310A CN202380059794.6A CN202380059794A CN119731310A CN 119731310 A CN119731310 A CN 119731310A CN 202380059794 A CN202380059794 A CN 202380059794A CN 119731310 A CN119731310 A CN 119731310A
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data
clones
prediction
stability
clone
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梅川正夫
铃木贵文
佐藤政宽
长濑雅也
松浦达也
村上裕太
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Fujifilm Corp
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    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN202380059794.6A 2022-08-31 2023-07-07 预测产生有用物质的克隆的产生稳定性的方法、信息处理装置、程序及预测模型生成方法 Pending CN119731310A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022-138789 2022-08-31
JP2022138789 2022-08-31
PCT/JP2023/025263 WO2024048079A1 (ja) 2022-08-31 2023-07-07 有用物質を産生するクローンの産生安定性を予測する方法、情報処理装置、プログラムおよび予測モデル生成方法

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CN119731310A true CN119731310A (zh) 2025-03-28

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US (1) US20250191688A1 (https=)
EP (1) EP4582536A4 (https=)
JP (1) JPWO2024048079A1 (https=)
CN (1) CN119731310A (https=)
WO (1) WO2024048079A1 (https=)

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CN121569343A (zh) * 2023-07-31 2026-02-24 富士胶片株式会社 细胞特性预测装置、细胞特性预测装置的运行方法及细胞特性预测装置的运行程序

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US7858323B2 (en) * 2004-06-09 2010-12-28 The Regents Of The University Of Michigan Phage microarray profiling of the humoral response to disease
WO2008094871A2 (en) * 2007-02-01 2008-08-07 Centocor, Inc. Selection of high-producing cell lines
US20170017891A1 (en) * 2014-01-30 2017-01-19 Valitacell Limited A method of predicting relative fed batch production titer of a panel of clonally-derived producer cells
EP3218514B1 (en) * 2014-11-12 2019-07-24 LEK Pharmaceuticals d.d. Predicting genetically stable recombinant protein production in early cell line development
CA3083124A1 (en) * 2017-11-20 2019-05-23 Lonza Ltd. Process and system for propagating cell cultures while preventing lactate accumulation
EP3844505A1 (en) * 2018-08-27 2021-07-07 F. Hoffmann-La Roche AG Method for verifying cultivation device performance
JP7562563B2 (ja) * 2019-04-30 2024-10-07 アムジエン・インコーポレーテツド バイオ医薬品生産における細胞株選択のためのデータ駆動予測モデリング
EP4034637A1 (en) * 2019-09-27 2022-08-03 GlaxoSmithKline Intellectual Property Development Limited Method of predicting production stability of clonal cell lines
CN120210094A (zh) * 2020-02-19 2025-06-27 富士胶片株式会社 细胞培养工艺搜索方法、细胞培养工艺搜索装置及已学习模型

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JPWO2024048079A1 (https=) 2024-03-07
WO2024048079A1 (ja) 2024-03-07
EP4582536A1 (en) 2025-07-09
US20250191688A1 (en) 2025-06-12
EP4582536A4 (en) 2025-12-03

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