CN119156213A - 用于治疗产后抑郁的5-甲氧基-n,n-二甲基色胺 - Google Patents

用于治疗产后抑郁的5-甲氧基-n,n-二甲基色胺 Download PDF

Info

Publication number
CN119156213A
CN119156213A CN202380037486.3A CN202380037486A CN119156213A CN 119156213 A CN119156213 A CN 119156213A CN 202380037486 A CN202380037486 A CN 202380037486A CN 119156213 A CN119156213 A CN 119156213A
Authority
CN
China
Prior art keywords
dmt
meo
pharmaceutically acceptable
acceptable salt
score
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380037486.3A
Other languages
English (en)
Chinese (zh)
Inventor
泰斯·特维
康纳·伯克
纳奥伊斯·加夫尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GH Research Ireland Ltd
Original Assignee
GH Research Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GH Research Ireland Ltd filed Critical GH Research Ireland Ltd
Priority claimed from PCT/EP2023/057874 external-priority patent/WO2023186827A1/en
Publication of CN119156213A publication Critical patent/CN119156213A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202380037486.3A 2022-03-27 2023-03-27 用于治疗产后抑郁的5-甲氧基-n,n-二甲基色胺 Pending CN119156213A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP22000085 2022-03-27
EP22000084.8 2022-03-27
EP22000085.5 2022-03-27
EP22000084 2022-03-27
EP23154014.7 2023-01-30
EP23153996 2023-01-30
EP23154014 2023-01-30
EP23153996.6 2023-01-30
PCT/EP2023/057874 WO2023186827A1 (en) 2022-03-27 2023-03-27 5-methoxy-n,n-dimethyltryptamine for the treatment of postpartum depression

Publications (1)

Publication Number Publication Date
CN119156213A true CN119156213A (zh) 2024-12-17

Family

ID=93292078

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380037486.3A Pending CN119156213A (zh) 2022-03-27 2023-03-27 用于治疗产后抑郁的5-甲氧基-n,n-二甲基色胺

Country Status (8)

Country Link
US (1) US20250205200A1 (https=)
EP (1) EP4499080A1 (https=)
JP (1) JP2025510915A (https=)
KR (1) KR20240167886A (https=)
CN (1) CN119156213A (https=)
AU (1) AU2023242438A1 (https=)
CA (1) CA3255671A1 (https=)
IL (1) IL315894A (https=)

Also Published As

Publication number Publication date
KR20240167886A (ko) 2024-11-28
AU2023242438A1 (en) 2024-11-07
EP4499080A1 (en) 2025-02-05
US20250205200A1 (en) 2025-06-26
JP2025510915A (ja) 2025-04-15
CA3255671A1 (en) 2023-10-05
IL315894A (en) 2024-11-01

Similar Documents

Publication Publication Date Title
CN120813347A (zh) 用于治疗产后抑郁的5-meo-dmt
WO2023186827A1 (en) 5-methoxy-n,n-dimethyltryptamine for the treatment of postpartum depression
WO2023186826A1 (en) 5-meo-dmt for use in the treatment of postpartum depression
CN120813348A (zh) 用于治疗产后抑郁的5-甲氧基-n,n-二甲基色胺
CN119156213A (zh) 用于治疗产后抑郁的5-甲氧基-n,n-二甲基色胺
CN118946354A (zh) 用于治疗产后抑郁的5-MeO-DMT
AU2023246547A1 (en) 5-meo-dmt for use in the treatment of postpartum depression
EP4499086A1 (en) Treatment of mental disorders
CN118946353A (zh) 用于治疗精神运动迟缓的5-甲氧基-n,n-二甲基色胺
CN118946355A (zh) 用于治疗精神运动迟缓的5-甲氧基-n,n-二甲基色胺
CN118973568A (zh) 精神障碍的治疗

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination