CN1190598A - Apparatus for supporting life - Google Patents

Apparatus for supporting life Download PDF

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CN1190598A
CN1190598A CN97107699A CN97107699A CN1190598A CN 1190598 A CN1190598 A CN 1190598A CN 97107699 A CN97107699 A CN 97107699A CN 97107699 A CN97107699 A CN 97107699A CN 1190598 A CN1190598 A CN 1190598A
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blood
plasma
dialysis solution
dialysis
pump
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CN1121879C (en
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彭罗民
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Abstract

The present invention relates to a kind of multifunctional life supporting apparatus used for first aid of renal failure, hepatic failure, multiple organs failure, poisoning by poison (organic phosphorous farm chemical, zinc phosphide rat poison, heroin poisoning). It is composed of multifunction blood decontaminating system, biological artificial liver extracorporeal blood circulation, plasma circulation and plasma replacement system, and biological artificial kidney extracorporeal blood circulation, plasma separating circulating replacement system. Said invention features simple design, extensive source of making material, cheap price, and simple productive process.

Description

Apparatus for supporting life
The present invention relates to a kind of armarium, particularly a kind of apparatus for supporting life.The present invention is fit to medical institutions at different levels and is used to give treatment to acute hepatic failure, acute and chronic renal failure, each phase uremia, multiple organ failure, MOF and liver, renal failure, drug intoxication (sedative hypnotics, psychosis, rat poison, organophosphorus pesticide etc.), alcoholism, heroin, horse coffee are poisoned heroin addiction etc.
At present, the mortality rate of hepatitis gravis is still up to 80-90%, and the liver failure that the conventional medicine therapy causes hepatitis gravis seems powerless.Up to now, still do not have a kind of comparatively perfect artificial liver device, more do not have the complete compound life support unit of the Liver and kidney with biological function.Still there are many shortcomings in existing conventional artificial kidney machine: 1, cost an arm and a leg; 2, volume heaviness can not be moved the sick bed side at any time to according to patient's the state of an illness and give treatment to; 3, rely on water source, power supply; 4, the disposable use of dialysis solution promptly dumps waste without crossing abundant exchange; 5, side reaction is big, is prone to unbalanced syndrome in the treatment, hypotension, even shock.Conventional import hemo system makes the following medical institutions in general county and county be difficult to bear because of costing an arm and a leg, and influences the penetration and promotion of blood purification technology, makes a lot of patients that need give treatment to can not get treatment, is not suitable for the national conditions of present stage of china.At present, do not see as yet that both at home and abroad multi-functional apparatus for supporting life comes out, especially do not have the treatment device instrument of compound bioartificial liver, kidney and blood purification associating to come out.
The liver function of humans and animals has: synthetic, and metabolism, detoxifcation, functions such as drainage.Bioartificial liver's research has: the animal liver perfusion, intersect and circulate, absorption perfusion, efficient dialysis, plasmapheresis.Bioartificial liver's present situation is at present: hepatocyte system (abdominal cavity, renal cortex, lung, spleen) hepatocyte transplantation in the body.Nearest progress has: microcarrier adheres to, and needs anti-the repulsion; The microcapsule parcel need not resist repulsion.External hepatocyte system: the hepatocyte dialysis, liver cell reactor, with calcium alginate gel as material, the perfusion of microcapsule parcel hepatocyte hepatocyte.Need perfect following target: primary hepatocyte or hepatic cell line are cultivated and need be reached more than the 108/ml; The a large amount of storages of human liver cell are standby, and it is perfect that artificial liver support system (ALSS) is installed.The compound extracorporeal circulation of blood device product of domestic present inanimate object artificial liver-artificial kidney-blood purification is sold.The Hong-Kong is good for and is equipped with " the saturating machine of artificial liver " by the exploitation of Hemo-cleanes company that limit company is released, and its technical spirit is: extracorporeal circulation of blood produces negative pressure and malleation by the piston pump of design, acts on active carbon dialysis solution suspension.When the active carbon dialysis solution suspension one side generation negative pressure at the dialyser semipermeable membrane, when acting on active carbon dialysis solution suspension one side, blood flows out to blood one side of dialyser from tremulous pulse one end of extracorporeal circulation conduit; When active carbon dialysis solution suspension one side at the dialyser semipermeable membrane produces malleation, the blood pressurized of dialyser semipermeable membrane blood one side, blood flows back in the body by the extracorporeal circulation of blood conduit.Motion and so forth promotes blood circulation.The feature of this technology has: (1) dialysis solution has made active carbon dialysis solution suspension into; (2) circulation pump has made vacuum pump (back and forth positive negative pressure pump) into by impeller pump; (3) other technology all be round above-mentioned 2 and the design the attached support prior art that helps.The major defect of this technical products (the saturating machine of The BioLo-gic System artificial liver) has: (1) design is complicated, has increased manufacturing cost; (2) function ratio is more single; (3) can not utilize the ingredient of biological activity cell, so the inanimate object active function as this equipment; (4) this technical products can only be as the treatment of general drug intoxication, the treatment of liver failure is equivalent to add in the conventional dialysis liquid use active carbon, can not carry out separating plasma and plasmapheresis, hemofiltration etc., and function singleness, effect is calmly difficult.
Purpose of the present invention is exactly a kind of apparatus for supporting life that designs at above deficiency.This apparatus for supporting life is blood purification technology (blood dialysis ultrafiltration, hemoperfusion, the separating plasma displacement, dual separating plasma displacement, hemofiltration perfusion, hemodiafiltration, hemodialysis perfusion etc.) with liver, kidney bioreactor (by using the medical high polymer polysulfone membrane, the polyacrylonitrile film, the similar hemodialyzer sample that the contour biocompatible membrane hollow fibre of poly (ether sulfone) film pipe is made and/or the device of transfusion filters spline structure are moving blood at the tube chamber of hollow fibre pipe; Tube chamber external series gap at the hollow fibre pipe inserting/or moving former generation liver, nephrocyte suspension or liver, kidney cell line is cultivated suspension, or with biotechnology liver, the nephrocyte of living, fill, be pasted and fixed in the outer wall gap of above-mentioned medical bio macromolecule hollow fibre pipe constitute) combine.The hollow fibre pipe of bioreactor can be with special bioreactor manufacture; Available high-quality plasma separator of electricity or high performance transfusion filters replace temporarily." automatic hemo-dialyser " patented technology, number of patent application are adopted in the dialysis solution circulation; " 95103196.1 " and " portable artificial kidney " patented technology, number of patent application: " 92101842.8 ".So, no matter be acute and chronic renal failure, each phase uremia, still acute and chronic liver failure, hepatic coma, medicine, toxic poisoning, heroin poisoning, heroin addiction all can use the treatment of this product.Make numerous medical institutions all can use this product, especially carry out the medical institutions of specific treatment.Product of the present invention is fit to hospitals at different levels, and product has very strong adaptability, is with Chinese characteristics, and has the intellectual property of oneself, has Development and Production future and application prospect on a large scale.This product will be numerous renal failures, each uremia phase, liver failure, and multiple organ dysfunction syndrome, drug intoxication, toxic poisoning, pesticide intoxication and heroin, opium, morphinism, the patient of addiction brings glad tidings.Purpose of the present invention will be made own due contribution for blood purification and the life-support system of creating distinct Chinese characteristics.
The present invention is achieved in that a blood purification technology that is characterized in, bioartificial liver's extracorporeal circulation technology and biology artificial kidney extracorporeal circulation of blood technology three combine together, are designed to brand-new apparatus for supporting life.This design makes an equipment have the function of three equipment.The present invention is by ductus arteriosus (1), roller pump (2), plasma separator (3), blood connecting conduit (4), hemodialyzer (5), venous duct (6), bubble trap and sonac (6a), exhaustor (6b), vein pressure pipe (6c), blood plasma drainage tube (7), blood plasma pump line and feedback blood plasma pipe (8), plasma perfusion pump (9), plasma perfusion arterial end pipe (10), blood plasma feeds back pump (11), plasma perfusion device (12), plasma circulation connecting conduit (13), liver, nephrocyte bioreactor (14), plasma perfusion vein end pipe (15), blood plasma memory (16), blood plasma memory exhaustor (17), dialysis solution circulation fairlead (18a, 18b, 18c), dialysis solution circulating pump and dialysis solution circulation pipe (19a), dialysis liquid pump (19b), dialysis solution is heated and thermostat inlet tube (20), dialysis solution is heated and thermostat outlet and dialyser inlet tube (21), dialysis solution circulation pipe (22), dialyser outlet (23), dialysis solution circulation inlet tube (24a, 24b, 24c), dialysis fluid container (25a, 25c, 25b), dialysis solution and blood plasma memory are heated, thermostat and medium (26), dialysis fluid container platform (27), dialysis fluid container monitoring sensor (28), dialysis fluid container pick off supporting platform (29), casing (30), movable wheel (31), 1 district (nephropathy treatment monitoring section) (32), 2 districts (liver declines and gives treatment to monitoring section) (33), zone of alarm (34), total computer monitoring district (35), venous pressure table (36), the apparatus for supporting life that venous duct loop vascular clamp (37) is constituted is characterized in that: the present invention is the blood purification technology; Bioartificial liver's extracorporeal circulation technology and biology artificial kidney extracorporeal circulation technology three combine together, make the present invention have multiple life support function; Dialysis solution blood circulation of the present invention relies on dialysis liquid pump (19a or 19b), from dialysis solution circulation fairlead (18a, 18b, 18c) drive, draw dialysis solution, from dialysis fluid container (25a, 25b, 25c) heat and thermostat inlet tube (20) to dialysis solution, through heating, dialysis solution after the weighing apparatus temperature, from dialysis solution heat and thermostat outlet (21) to dialysis solution circulation pipe (22), deliver to the vein end of dialyser (5), again from the arterial end dialysis solution outlet of dialyser (5) and dialysis solution circulation pipe (23) respectively through dialysis solution circulation inlet tube (24a, 24b, 24c) be back to dialysis fluid container (25a, 25b, 25c); By dialysis fluid container monitoring sensor (28), experience the weight of dialysis fluid container (25a, 25b, 25c), converse the variation of dialysis solution capacity in the dialysis fluid container by weight and volumetric ratio, in treatment, monitor continuously with 1 district (nephropathy treatment monitoring section) (32); Blood circulation of the present invention is by ductus arteriosus (1), the lead body inner blood, by roller pump (2), drive the arterial end that blood arrives plasma separator (3a), by blood connecting conduit (4), blood is introduced into the arterial end of dialyser (5) from the vein end of plasma separator (3a), again by venous duct (6), blood is introduced bubble trap (6a) from the vein end of dialyser (5), link to each other with venous pressure table (36) by vein pressure pipe (6c), pressure is imported into to venous pressure table (36), variation by 1 district (nephropathy treatment monitoring section) (32) monitoring venous pressure, when venous pressure surpasses the high limit of valve definite value or lower bound, the capital starts vein loop vascular clamp (37), and occlude blood refluxes, simultaneously blood pump (2) stall, when venous pressure was recovered normal range, the blood that flows down from bubble trap (6a) continued to move ahead, flow back in patient's body; Plasma circulation of the present invention system is the blood plasma of separating from plasma separator (3a), be introduced into blood plasma memory (16) by blood plasma drainage tube (7), by the plasma perfusion circulation conduit (10) that communicates with blood plasma memory (16), pass through plasma perfusion pump (9) from the bottom of blood plasma memory (16), blood plasma is drawn and is circulated to the arrival end of plasma perfusion device (12), at the port of export of plasma perfusion device (12) by plasma circulation connecting conduit (13) and liver, the arrival end of nephrocyte bioreactor (14) links to each other, liver, the port of export of nephrocyte bioreactor (14) is drawn blood plasma by plasma perfusion circulation conduit (15) and is back to blood plasma memory (16), feed back pump (11) and blood plasma feedback pipe (8) by blood plasma, in the blood plasma memory (16) through perfusion repeatedly, purified and and liver, blood plasma after cell kidney bioreactor is had an effect, deliver to venous duct (6) with tee T, feed back and give the patient, being controlled at automatically in the treatment of plasma circulation system carried out by 2 districts (liver declines and gives treatment to monitoring section) (33); The heat thermostat and the warm medium (26) of heating, weigh of dialysis solution of the present invention and blood plasma memory are to medium heat, weigh temperature and be subjected to the monitoring of total monitoring section computer (35) by the electrical equipment heating member; Total monitoring section of the present invention (35), in treatment to kidney, liver multiple organ failure, MOF when depletion is given treatment to simultaneously or separately, 1 district (32) and 2 districts (33) are carried out synchronous monitoring, when any part breaks down at work, alarm signal is sent by zone of alarm (34) in the capital, and processing method is provided, after treated recovery is normal, report to the police promptly to automatically terminate to reset to and treat alarm condition, shown in Fig. 1 a, 1b.
The present invention realizes like this, it is by ductus arteriosus (1), roller pump (2), plasma separator (3a, 3b), blood connecting conduit (4), hemodialyzer (5), venous duct (6), bubble trap and sonac (6a), exhaustor (6b), vein pressure pipe (6c), blood plasma drainage tube (7a, 7) b, blood plasma pump line and feedback blood plasma pipe (8), plasma perfusion pump (9), plasma perfusion arterial end pipe (10), blood plasma feeds back pump (11), plasma perfusion device (12), plasma circulation connecting conduit (13), liver, nephrocyte bioreactor (14), plasma perfusion vein end pipe (15), blood plasma memory (16), blood plasma memory exhaustor (17), dialysis solution circulation fairlead (18a, 18b, 18c), dialysis solution circulating pump and dialysis solution circulation pipe (19a), dialysis liquid pump (19b), dialysis solution is heated and thermostat inlet tube (20), and dialysis solution is heated and thermostat outlet and dialyser inlet tube (21), dialysis solution circulation pipe (22), dialyser outlet (23), dialysis solution circulation inlet tube (24a, 24b, 24c), dialysis fluid container (25a, 25c, 25b), dialysis solution and blood plasma memory are heated, thermostat and medium (26), dialysis fluid container platform (27), dialysis fluid container monitoring sensor (28), dialysis fluid container pick off supporting platform (29), casing (30), movable wheel (31), 1 district (nephropathy treatment monitoring section) (32), 2 districts (liver declines and gives treatment to monitoring section) (33), zone of alarm (34), total computer monitoring district (35), venous pressure table (36), venous duct loop vascular clamp (37) constitutes.The blood circulation of this technical scheme is the blood flow of coming from ductus arteriosus (1), drive the arterial end that proceeds to plasma separator (3a) by blood pump (2), flow out the back to blood connecting conduit (4) from the vein end of plasma separator (3a), introduce the arterial end of dialyser (5) from blood connecting conduit (4), introduce bubble trap (6a) from the vein end transvenous catheter (6) of dialyser (5), continuing to move ahead passes back in patient's body; The plasma circulation system of this technical scheme be from the blood plasma drainage tube (7b) of the arterial end blood plasma tap of plasma separator (3a), introduce the arrival end of plasma separator (3b), introduce blood plasma memory (16) from the port of export of plasma separator (3b) through blood plasma drainage tube (7a) again, by plasma perfusion arterial end pipe (10), circular flow is to the arrival end of plasma perfusion device (12) under the driving of plasma perfusion pump (9), the port of export at plasma perfusion device (12) is connected with plasma circulation connecting conduit (13), the blood plasma that comes from plasma perfusion device (12) continues to move ahead, enter liver, the arrival end of nephrocyte bioreactor (14), from liver, the effusive blood plasma of nephrocyte bioreactor (14) port of export, draw through blood plasma perfusion vein end pipe (15) and to be back to blood plasma memory (16), in the blood plasma memory (16) if too much air arranged, then get rid of through blood plasma memory exhaustor (17), through circulation repeatedly, perfusion, with the blood plasma after the generation biological agent in liver or nephrocyte bioreactor (14), deliver to venous duct (6) by blood plasma pump line and feedback blood plasma pipe (8) by tee T and also feed back to the patient; The dialysis solution blood circulation of this technical scheme is by dialysis liquid pump (19a) or (19b) to drive dialysis solution from the dialysis solution fairlead (18a that circulates, 18b, 18c) dialysis solution is drawn the back and enter by the dialysis liquid pump that dialysis solution is heated and thermostat inlet tube (20), heat and thermostat outlet and dialyser inlet tube (21) to dialysis solution circulation pipe (22) and the vein end dialysis solution that enters dialyser (5) goes into to portal from dialysis solution through the dialysis solution of the temperature of heating and weigh, dialysis solution from the arterial end dialysis solution of dialyser (5) is gone into to portal and discharged circulates to dialysis solution circulation inlet tube (24a by dialyser outlet (23), 24b, 24c) also backflow enters dialysis fluid container (25a, 25b, 25c); Dialysis solution and blood plasma memory are heated, thermostat and medium (26), blood pump (2), and dialysis liquid pump (19a) and (19b), venous pressure table (36), venous duct loop vascular clamp (37) is monitored by 1 district (nephropathy treatment monitoring section) (32); When dialysis solution and medium too high or too low for temperature surpasses threshold value, stop automatically heating or heating automatically; When venous pressure is too high or too low when surpassing threshold value, deliver a letter breath to 1 district (nephropathy treatment monitoring section) (32) and send alarm signal of venous pressure table (36); When the amount of air in the bubble trap (6a) of blood circulation venous duct (6) surpasses the plane that limits, external ultrasound detector sensor at bubble trap reaches 1 district (nephropathy monitoring section) (32) to information, by computer domination electromagnetic valve push-and-pull vein loop vascular clamp (37) blocking blood flow, blood pump (2) stops operating, and prevents that alveolate blood from entering in patient's body; Plasma perfusion pump (9) can be the different segment of same roller pump roller with dialysis liquid pump (19a), and under the situation of this design, working procedure is subjected to 1 district (nephropathy treatment district) (32) monitoring; Blood plasma is accepted the monitoring in 2 districts (liver decline treatment district) (33) with the work of defeated pump (11), blood plasma feedback pump (11) and plasma perfusion pump (9) but also independent control duty, shown in Fig. 2 a, 2b.
The present invention realizes like this, it is by ductus arteriosus (1), roller pump (2), the filter side (3) of dialysis filter, the dialyser side (5) of dialysis filter, venous duct (6), bubble trap and sonac (6a), exhaustor (6b), vein pressure pipe (6c), filtered solution drainage tube (7), filtered solution feeds back pipe (8), filtered solution infusion pump (9), filtered solution perfusion circulation pipe (10), filtered solution feeds back pump (11), filtered solution perfusion device (12), filtered solution circulation connecting conduit (13), liver, kidney bioreactor (14), filtered solution perfusion circulation conduit (15), filtered solution memory (16), exhaustor (17), dialysis solution circulation fairlead (18a, 18c, 18c), dialysis liquid pump (19a, 19b), the dialysis solution thermostat inlet tube (20) of heating, the dialysis solution thermostat fairlead (21) of heating, dialysis filter dialyser side dialysis solution arrival end conduit (22), dialysis filter dialyser port of export conduit (23), dialysis solution circulation inlet tube (24a, 24b, 24c), dialysis fluid container (25a, 25b, 25c), dialysis solution heat thermostat and medium (26), dialysis solution weight detecting platform (27), pressure transducer (28), dialysis fluid container is supported detection platform (29), casing (30), universal caster wheel (31), 1 district (nephropathy treatment monitoring section) (32), 2 districts (liver declines and gives treatment to monitoring section survey district) (33), zone of alarm (34), total monitoring section (35), venous pressure table (36), the another apparatus for supporting life of venous duct loop vascular clamp (37) formation system, be primarily characterized in that: blood circulation is to drive the filter side (3) that arrives dialysis filter from the blood that ductus arteriosus (1) comes through roller pump (2), and to dialyser one side (5) of dialysis filter, transvenous catheter (6) enters bubble trap (6a) again,, be back at last in patient's body again to the far-end of venous duct from bubble trap (6a); The filtered solution of discharging from the filtered solution tap of dialysis filter, drain into filtered solution memory (16) through filtered solution drainage tube (7), under the driving of filtered solution infusion pump (9), by with the filtered solution perfusion circulation pipe (10) of filtered solution memory (16) bottom connection, the guiding filtered solution is to filtered solution perfusion device (12), arrive liver by filtered solution circulation connecting conduit (13), kidney bioreactor (14), again through filtered solution perfusion circulation conduit (15), be back to filtered solution memory (16), through circulation and liver repeatedly, filtered solution after the kidney bioreactor reacts, feed back pipe (8) by the nearly liquid of filter, feed back at filtered solution under the driving of pump (11), afferent veins conduit (6) is defeated by the patient together by venous duct (6); Dialysis fluid container (25a, 25b, dialysis solution 25c), through dialysis solution circulation fairlead (18a, 18b, 18c), under the driving of dialysis liquid pump (19a or 19b), be recycled to the dialysis solution thermostat inlet tube (20) of heating, the dialysis solution of weighing apparatus after the temperature enters dialysis filter from dialysis solution thermostat fairlead (21) to the dialyser side dialysis solution arrival end conduit (22) of dialysis filter of heating through heating, continue to move ahead from the dialyser side dialysis solution port of export conduit (23) of dialysis filter, through dialysis solution circulation inlet tube (24a, 24b, 24c) enter dialysis fluid container; By 1 district (32), 2 districts (33) and total monitoring section (35) respectively to extracorporeal blood circulation system, filtered solution perfusion blood circulation, the dialysis solution blood circulation, dialysis solution heat the weighing apparatus warm system, the venous pressure monitoring system, extracorporeal circulation of blood air monitering safety control system is monitored, is controlled, shown in Fig. 3 a, 3b.
The present invention realizes like this, it is by ductus arteriosus (1), roller pump (2), plasma separator (3), venous duct (6), bubble trap and sonac (6a), exhaustor (6b), vein pressure pipe (6c), blood plasma drainage tube (7), blood plasma pump line reach with plasma transfusion pipe (8), plasma perfusion pump (9), plasma perfusion arterial end pipe (10), blood plasma feeds back pump (11), plasma perfusion device (12), plasma circulation connecting conduit (13), liver, nephrocyte bioreactor (14), plasma perfusion vein end pipe (15), blood plasma memory (16), exhaustor (17), dialysis solution and blood plasma memory heat thermostat and medium (26), 1 district (nephropathy monitoring section) (32), 2 districts (liver decline treatment monitoring section) (33), zone of alarm (34), total monitoring section (35), venous pressure table (36), the another life-support system that vein loop vascular clamp (37) constitutes; Arterial blood moves ahead under the driving of roller pump (2) through ductus arteriosus (1), arrive the arterial end of plasma separator (3), the vein end and the venous duct (6) that arrive plasma separator behind the blood plasma separator link, and blood flow continues to move ahead behind bubble trap (6a), is back in patient's body; The blood plasma of separating from plasma separator (3), through blood plasma drainage tube (7) drain to blood plasma memory (16), through blood plasma perfusion arterial end pipe (10), under the driving of plasma perfusion pump (9), arrive plasma perfusion device (12), by plasma circulation connecting conduit (13), arrive liver, nephrocyte bioreactor (14), blood plasma from liver, nephrocyte bioreactor (14) discharge, flow back to blood plasma memory (16) through blood plasma perfusion vein end pipe (15), be back in patient's body from continuing to move ahead to venous duct (6) through blood plasma pump pipe and feedback blood plasma pipe (8); The heat weighing apparatus temperature monitoring of heating of thermostat and medium (26) of dialysis solution and blood plasma memory, the monitoring of the high and low threshold value of venous pressure and warning, closing automatically of venous blood pipe clamp (37), the monitoring of bubble trap (6a) is subjected to the monitoring of total monitoring section computer (35) by 1 district (nephropathy treatment monitoring section) monitoring; Shown in Fig. 4 a, 4b.
The present invention realizes like this, it is by ductus arteriosus (1), blood pump (or blood plasma feedback pump) (11), blood (or blood plasma) perfusion device (12), blood plasma (or blood) circulation connecting conduit (13), liver, nephrocyte bioreactor (14), venous duct (6), bubble trap and sonac (6a), exhaustor (6b), vein pressure pipe (6c), 1 district (32), 2 districts (33), zone of alarm (34), total monitoring section (35), venous pressure table (36), vein loop vascular clamp (37) constitutes another life-support system; The blood of drawing in patient's body, under the driving of blood pump (or blood plasma feedback pump) (11), arrive blood (or blood plasma) perfusion device (12) through ductus arteriosus (1), the blood of discharging from blood (or blood plasma) perfusion device arrives liver, nephrocyte bioreactor (14) through blood plasma (or blood) circulation connecting conduit (13), the blood of discharging from liver, nephrocyte bioreactor (14) arrives bubble trap (6a) from venous duct (6), and blood continues to move ahead and is back in patient's body; When venous pressure is too high or too low when surpassing threshold value, import venous pressure table (36) into by vein pressure pipe (6c), (nephropathy treatment monitoring section) (32) analyzing and processing through 1 district, and report total monitoring section computer (35), and promptly giving warning, blood pump suspends, after treated recovery was normal, blood pump restarted running; When the air in the bubble trap (6a) too much or in the blood has bubble, when surpassing the threshold definite value, after finding out by the ultrasonic detector at bubble trap place, signal is reached 1 district (32), report to the chief inspector and then distinguish (35), automatically closed by total monitoring section computer instruction vein loop vascular clamp (37), blocking-up has the blood of air to flow in patient's body; Shown in Fig. 5 a, 5b.
The present invention realizes like this, it is by ductus arteriosus (1), blood pump (2), dialyser (5), venous duct (6), bubble trap and sonac (6a), exhaustor (6b), vein pressure pipe (6c), dialysis solution circulation fairlead (18a, 18b, 18c), dialysis liquid pump and dialysis solution circulation pipe (19a), dialysis liquid pump (19b), dialysis solution is heated and thermostat inlet tube (20), dialysis solution is heated and thermostat outlet (21), dialysis solution circulation pipe (22), dialyser outlet (23), dialysis solution circulation inlet tube (24a, 24b, 24b), dialysis fluid container (25a, 25b, 25c), dialysis solution and blood plasma memory heat thermostat and medium (26), dialysis fluid container platform (27), dialysis fluid container monitoring sensor (28), dialysis fluid container pick off supporting platform (29), casing (30), movable wheel (31), 1 district (nephropathy treatment monitoring section) (32), zone of alarm (34), the another apparatus for supporting life system that total monitoring section (35), venous pressure table (36), venous duct loop vascular clamp (37) constitute; After patient's blood is drawn in the body, through ductus arteriosus (1) arrival dialyser (5) under the driving of blood pump (2), blood is discharged the laggard vein conduit (6) of going into from the vein end of dialyser (5), and continuing to move ahead arrives bubble trap (6a), moves ahead and gets back in patient's the body; From dialysis solution circulation fairlead (18a, 18b, the dialysis solution of 18c) drawing respectively, under the attraction of dialysis liquid pump (19a or 19b) drives, arriving dialysis solution heats and thermostat inlet tube (20), after the weighing apparatus temperature of heating, discharge from the dialysis solution thermostat outlet (21) of heating, proceed to dialysis solution circulation pipe (22), an end that moves ahead again with dialyser (5) joins, dialysis solution circulates the other end through dialyser and joins with dialysis solution circulation pipe (23) after the other end of dialyser (5) is discharged, arrival dialysis solution circulation inlet tube (24a continues to move ahead, 24b, 24c) flow into dialysis fluid container (25a respectively, 25b, 25c), after circulation reaches regular hour and number of times repeatedly, more change dialysis fluid container (25a, 25b, 25c), continue circulation with fresh dialysis solution, up to finishing dialysis ultrafiltration treatment; In the process of dialysis ultrafiltration treatment, dialysis fluid container monitoring sensor (28) is monitored the weight of dialysis fluid container continuously, and information is sent to 1 district (32), when the weight (volume) of dialysis fluid container surpasses predetermined threshold value and when too high or too low, the chief inspector then distinguishes computer (35) and promptly points out demonstration and warning, after making corresponding processing recovery normally, alarm condition is promptly removed; When venous pressure is too high or too low when surpassing threshold value, 1 district promptly gives warning, handle recover normally after, alarm condition automatically terminates; When the bubbles volume in the bubble trap surpasses the threshold level line, sonac at the bubble trap place promptly reaches 1 district (32) to information, close the venous duct vascular clamp (37) of going the same way immediately, roller pump (2) stops operating, when the blood levels face in the bubble trap being improved or having extracted the air in the bubble trap out, vein loop vascular clamp (37) is open automatically, and roller pump (2) recovers to rotate, and vein loop vascular clamp returns to the normal position; When dialysis solution and blood plasma memory heat that the temperature of thermostat and medium (26) surpasses the threshold value of predetermined temperature and when too high or too low, 1 district (32) promptly stop to heat or heating, and make dialysate temperature remain on the normal range that it is fixed that one is weighed; Shown in Fig. 6 a, 6b.
Below in conjunction with accompanying drawing the present invention is described in further detail:
Fig. 1 a, Fig. 1 b are a kind of duty principle of the present invention and primary structure and office of the main portion of the Appearance Panel sketch map.1-ductus arteriosus among the figure, the 2-roller pump, the 3-plasma separator, 4-blood connecting conduit, the 5-hemodialyzer, the 6-venous duct, 6a-bubble trap and sonac, the 6b-exhaustor, 6c-vein pressure pipe, 7-blood plasma drainage tube, 8-blood plasma pump line and feedback blood plasma pipe, 9-plasma perfusion pump, 10-plasma perfusion arterial end pipe, 11-blood plasma feeds back pump, 12-plasma perfusion device, 13-plasma circulation connecting conduit, the 14-liver, the nephrocyte bioreactor, 15-plasma perfusion vein end pipe, 16-blood plasma memory, 17-blood plasma memory exhaustor, 18a, 18b, 18c-dialysis solution circulation fairlead, the 19a-liquid pump of dialysing, the 19b-liquid pump of dialysing, the 20-dialysis solution is heated and the thermostat inlet tube, and the 21-dialysis solution is heated and the thermostat outlet, 22-dialysis solution circulation pipe and dialyser connection tube, 23-dialyser outlet, 24a, 24b, 24c-dialysis solution circulation inlet tube, 25a, 25b, the 25c-dialysis fluid container, 26-dialysis solution and blood plasma memory are heated, thermostat and medium, 27-dialysis solution platform, 28-dialysis fluid container monitoring sensor, 29-dialysis fluid container pick off supporting platform, 30-casing, the movable wheel of 31-, 32-1 district (nephropathy treatment monitoring section), 33-2 district (liver declines and gives treatment to monitoring section), 34-zone of alarm, the total computer monitoring of 35-district, 36-venous pressure table, 37-venous duct loop vascular clamp, more than each critical piece constitute separating plasma+plasma perfusion of the present invention+bioreactor+blood dialysis ultrafiltration or hemodiafiltration+or pure hemofiltration or simple blood ultrafiltration system; With angiographic neeclle or vascular catheterization patient's blood is drawn in body, drain into the 3-plasma separator again through 1-ductus arteriosus drain to 2-blood pump, after the vein end outflow of plasma separator, drain into 5-dialyser or filter by 4-blood connecting conduit, introduce 6a-bubble trap and sonac from the blood of dialyser or filter discharge by the 6-venous duct, draw by transvenous catheter behind the bubble trap and get back in patient's body; The blood plasma of separating from the 3-plasma separator, enter 16-blood plasma memory through 7-blood plasma drainage tube, under the driving of 9-plasma perfusion pump, arrive 12-plasma perfusion pump by 10-plasma perfusion arterial end pipe guiding blood plasma, after going out the blood plasma infusion pump, arrive the 14-liver through 13-plasma circulation connecting conduit, the nephrocyte bioreactor, from liver, after the nephrocyte bioreactor is discharged, be back to 16-blood plasma memory through 15-plasma perfusion vein end pipe, through circulation repeatedly, fully plasma perfusion and have an effect with liver or the biological anti-device of nephrocyte after blood plasma, feed back to the 6-venous duct by 8-blood plasma pump line and feedback blood plasma pipe, be back to afterwards in patient's body; The blood circulation dynamic pressure that venous pressure table 36 is being monitored from bubble trap changes, the air plane of blood plane in the bubble trap and the bubble in the blood in bubble trap and sonac 6a continuous monitoring, the temperature of filtered solution in dialysis solution and blood plasma or the filtered solution memory or blood plasma in heat thermostat and medium 26 continuous monitorings of dialysis solution, the variation that dialysis fluid container weight (volume) in 28 continuous monitorings of dialysis fluid container monitoring sensor, above-mentioned four continuous monitor systems are in case threshold value occurs surpassing, pick off passes to 1 district (nephropathy treatment monitoring section) 32 to information immediately, and reach total monitoring section computer 35, respectively venous pressure is monitored by total monitoring section computer 35, dialysis solution is heated and is weighed temperature, air monitering, dialysis fluid container weight surpass the variation of threshold value and send following indication and action.Venous pressure is too high or too low: report to the police immediately (1); (2) roller pump stall; (3) the dialysis solution thermostat of heating stops to heat or heating.When the horizontal plane that has bubble to arrive sonac in bubble or the bubble trap blood was arranged in the bubble trap: reported to the police immediately (1); (2) vein loop bloody path vascular clamp 37 is closed immediately; (3) roller pump stall immediately.When dialysate temperature was too high or too low above threshold value: reported to the police immediately (1); (2) dialysis liquid pump 19a or 19b stop operating immediately, end the dialysis solution circulation.When the dialysis solution capacity surpassed threshold value: reported to the police immediately (1); (2) point out the treatment measures that to take.
Fig. 2 a, Fig. 2 b are another duty principle of the present invention and primary structure and the main partial schematic diagram of the Appearance Panel.1-ductus arteriosus among the figure, the 2-roller pump, 3a, the 3b-plasma separator, 4-blood connecting conduit, the 5-hemodialyzer, the 6-venous duct, 6a-bubble trap and sonac, the 6b-exhaustor, 6c-vein pressure pipe, 7a, 7b-blood plasma drainage tube, 8-blood plasma pump line and feedback blood plasma pipe, 9-plasma perfusion pump, 10-plasma perfusion arterial end pipe, 11-blood plasma feeds back pump, 12-plasma perfusion device, 13-plasma circulation connecting conduit, the 14-liver, the nephrocyte bioreactor, 15-plasma perfusion vein end pipe, 16-blood plasma memory, 17-blood plasma memory exhaustor, 18a, 18b, 18c-dialysis solution circulation fairlead, 19a-dialysis solution circulating pump and dialysis solution circulation pipe, the 19b-liquid pump of dialysing, the 20-dialysis solution is heated and the thermostat inlet tube, and the 21-dialysis solution is heated and thermostat outlet and dialyser inlet tube, 22-dialysis solution circulation pipe, 23-dialyser outlet, 24a, 24b, 24c-dialysis solution circulation inlet tube, 25a, 25b, the 25c-dialysis fluid container, 26-dialysis solution and blood plasma memory are heated, thermostat and medium, 27-dialysis fluid container platform, 28-dialysis fluid container monitoring sensor, 29-dialysis fluid container pick off supporting platform, 30-casing, the movable wheel of 31-, 32-1 district (nephropathy treatment monitoring section), 33-2 district (liver declines and gives treatment to monitoring section), 34-zone of alarm, the total computer monitoring of 35-district, 36-venous pressure table, 37-venous duct loop vascular clamp, more than each critical piece constitute a separating plasma of the present invention+secondary separating plasma+plasma perfusion+liver, nephrocyte bioreactor+blood dialysis ultrafiltration or hemodiafiltration+pure hemofiltration or simple blood ultrafiltration system; Adopt angiographic neeclle or vascular catheterization that patient's blood is drawn in body, through the drain of 1-ductus arteriosus to the 2-roller pump, under the driving of roller pump, arrive plasma separator of 3a-, through 4-blood connecting conduit blood drainage is arrived 5-dialyser or filter, introduce 6a-bubble trap and sonac from the blood that dialyser or filter are discharged by the 6-venous duct, the blood by bubble trap and sonac draws through the 6-venous duct again to be got back in patient's body; The blood plasma of separating from plasma separator of 3a-, guide to 3b-secondary plasma separator through 7b-blood plasma drainage tube, by the unsegregated blood plasma of 3b-secondary plasma separator by the drain of 7a-blood plasma drainage tube to 16-blood plasma memory, enter the blood plasma of blood plasma memory, guide to 9-plasma perfusion pump and be driven arrival 12-plasma perfusion device through 10-plasma perfusion arterial end pipe, through the blood plasma of plasma perfusion device by the drain of 13-plasma circulation connecting conduit to the 14-liver, the nephrocyte bioreactor, by the 14-liver, blood plasma behind the nephrocyte bioreactor, draw by 15-plasma perfusion vein end pipe and to be back to 16-blood plasma memory, through circulating repeatedly and liver, blood plasma after the nephrocyte bioreactor fully acts on is fed back to the patient through the 6-venous duct by 8-blood plasma pump line and feedback blood plasma pipe; By the blood plasma that 3b-secondary plasma separator is separated, directly introduce the 6-venous duct by drainage tube, feed back and give the patient.The blood circulation dynamic pressure that venous pressure table 36 is being monitored from bubble trap changes, the air plane of blood plane in the bubble trap and the bubble in the blood in bubble trap and sonac 6a continuous monitoring, temperature in dialysis solution or filtered solution or the blood plasma memory in heat thermostat and medium 26 continuous monitorings of dialysis solution, the variation that dialysis fluid container weight (volume) in 28 continuous monitorings of dialysis fluid container monitoring sensor, above-mentioned four continuous monitor systems are in case threshold value occurs surpassing, pick off passes to 1 district (nephropathy treatment monitoring section) 32 to information immediately, and reach total monitoring section computer 35, respectively venous pressure is monitored by total monitoring section computer 35, dialysis solution is heated and is weighed temperature, air monitering, dialysis fluid container weight surpass the variation of threshold value and send following indication and action.Venous pressure is too high or too low: report to the police immediately (1); (2) roller pump stall; (3) the dialysis solution thermostat of heating stops to heat or heating.When the horizontal plane that has bubble to arrive sonac in bubble or the bubble trap blood was arranged in the bubble trap: reported to the police immediately (1); (2) vein loop bloody path vascular clamp 37 is closed immediately; (3) roller pump stall immediately.When dialysate temperature was too high or too low above threshold value: reported to the police immediately (1); (2) dialysis liquid pump 19a or 19b stop operating immediately, end the dialysis solution circulation.When the dialysis solution capacity surpassed threshold value: reported to the police immediately (1); (2) point out the treatment measures that to take.
Fig. 3 a, Fig. 3 b are another duty principle of the present invention and primary structure and office of the main portion of the Appearance Panel sketch map.1-ductus arteriosus among the figure, the 2-roller pump, the 3-filter, the 5-dialyser, the 6-venous duct, the 6a-bubble trap, the 6b-exhaustor, 6c-vein pressure pipe, 7-filtered solution drainage tube, the 8-filtered solution feeds back pipe, 9-filtered solution infusion pump, 10-filtered solution perfusion circulation pipe, the 11-filtered solution feeds back pump, 12-filtered solution perfusion device, 13-filtered solution circulation connecting conduit, 14-liver, the kidney bioreactor, 15-filtered solution perfusion circulation conduit, 16-filtered solution memory, 17-exhaustor, 18a, 18b, 18c-dialysis solution circulation fairlead, 19a, the 19b-liquid pump of dialysing, the 20-dialysis solution thermostat inlet tube of heating, the 21-dialysis solution thermostat fairlead of heating, 22-dialysis filter dialyser side dialysis solution arrival end conduit, 23-dialysis filter dialyser port of export conduit, 24a, 24b, 24c-dialysis solution circulation inlet tube, 25a, 25b, 25c-dialysis fluid container, 26-dialysis solution heat thermostat and medium, 27-dialysis solution weight monitoring platform, the 28-pressure transducer, the 29-dialysis fluid container is supported monitoring platform, 30-casing, the 31-universal caster wheel, 32-1 district (nephropathy treatment monitoring section), 33-2 district (liver declines and gives treatment to monitoring section), 34-zone of alarm, the total monitoring section of 35-, 36-venous pressure table, 37-venous duct loop vascular clamp more than constitutes hemofiltration+blood dialysis ultrafiltration of the present invention+filtered solution perfusion+liver, the kidney bioreactor is another life-support system; Adopt angiographic neeclle or puncture conduit, lead to patient's blood external, arrive roller pump 2 through ductus arteriosus 1, under the driving of roller pump 2, arrive filter 3, arrive dialyser 5 through filter 3, the blood transvenous catheter 6 of drawing from dialyser 5 arrives bubble trap 6a, by 6a, blood is sent back in patient's body from venous duct 6; From filter 3 filtered solutions caught on a filter, drain into filtered solution memory 16 through filtered solution drainage tube 7, be arranged in the filtered solution of filtered solution memory 16, through filtered solution perfusion circulation conduit 10, filtered solution is drawn, under the driving of filtered solution infusion pump 9, arrive filtered solution perfusion device 12, arrive liver through filtered solution circulation connecting conduit 13, kidney bioreactor 14, by filtered solution perfusion circulation conduit 15 filtered solution is sent back to the filtered solution memory again, through perfusion repeatedly and and liver, filtered solution after the kidney bioreactor is had an effect feeds back pipe 8 by filtered solution, under the driving of filtered solution feedback pump 11, deliver to venous duct 6, feed back and give the patient; Dialysis solution is respectively from dialysis fluid container 25a, 25b, 25c is through dialysis solution circulation fairlead 18a, 18b, 18c draws, at dialysis solution driving pump 19a, under the driving of 19b, through 18a, 18b, 18c guides to dialysis Wen Jiawen thermostat inlet tube 20, from the dialysis solution dialysis solution that thermostat fairlead 21 draws of heating, proceed to dialysis filter dialyser side dialysis solution arrival end conduit 22, dialysis solution from dialyser 5 discharges, deliver to dialysis solution circulation inlet tube 24a by dialysis filter dialyser port of export conduit 23 again, 24b, 24c returns dialysis fluid container 25a, 25b, 25c; The blood circulation dynamic pressure that venous pressure table 36 is being monitored from bubble trap changes, the air plane of blood plane in the bubble trap and the bubble in the blood in bubble trap and sonac 6a continuous monitoring, the temperature of filtered solution in dialysis solution and the filtered solution memory in heat thermostat and medium 26 continuous monitorings of dialysis solution, the variation that dialysis fluid container weight (volume) in 28 continuous monitorings of dialysis fluid container monitoring sensor, above-mentioned four continuous monitor systems are in case threshold value occurs surpassing, pick off passes to 1 district (nephropathy treatment monitoring section) 32 to information immediately, and reach total monitoring section computer 35, respectively venous pressure is monitored by total monitoring section computer 35, dialysis solution is heated and is weighed temperature, air monitering, dialysis fluid container weight surpass the variation of threshold value and send following indication and action.Venous pressure is too high or too low: report to the police immediately (1); (2) roller pump stall; (3) the dialysis solution thermostat of heating stops to heat or heating.When the horizontal plane that has bubble to arrive sonac in bubble or the bubble trap blood was arranged in the bubble trap: reported to the police immediately (1); (2) venous duct loop vascular clamp 37 is closed immediately; (3) roller pump 2 stall immediately.When dialysate temperature was too high or too low above threshold value: reported to the police immediately (1); (2) dialysis liquid pump 19a or 19b stop operating immediately, end the dialysis solution circulation.When the dialysis solution capacity surpassed threshold value: reported to the police immediately (1); (2) point out the treatment measures that to take.
Fig. 4 a, Fig. 4 b is another working state schematic representation of the present invention, 1-ductus arteriosus among the figure, 2-roller pump, the 3-plasma separator, 6-venous duct, 6a-bubble trap and sonac, the 6b-exhaustor, 6c-vein pressure pipe, 7-blood plasma drainage tube, 8-blood plasma pump line and blood plasma feed back pipe, 9-plasma perfusion pump, 10-plasma circulation arterial end pipe, 11-blood plasma feeds back pump, 12-plasma perfusion device, 13-plasma circulation connecting conduit, the 14-liver, the nephrocyte bioreactor, 15-plasma perfusion vein end pipe, 16-blood plasma memory, the 17-exhaustor, 26-dialysis solution and blood plasma memory are heated, thermostat and medium, 36-venous pressure table, 37-vein loop vascular clamp; More than constitute separating plasma+plasma perfusion of the present invention+liver, nephrocyte bioreactor system; Patient's blood is drawn in patient's body with puncture needle or intubate, arrive roller pump 2 through ductus arteriosus 1, under the driving of roller pump 2, arrive the arterial end of plasma separator 3, after blood is discharged from the vein end of plasma separator 3, by quiet catheter guidance to bubble trap and sonac 6a, behind 6a, continue to move ahead, transvenous catheter 6 sends back to blood in patient's body; The blood plasma of separating from plasma separator 3, introduce blood plasma memory 16 through blood plasma drainage tube 7, by plasma circulation arterial end pipe 10 blood plasma is drawn from the blood plasma memory, under the driving of plasma perfusion pump 9, arrive blood perfusion device 12, behind the plasma perfusion device, through blood plasma circulation connecting conduit 13, blood plasma is introduced liver, nephrocyte bioreactor 14,, send back to blood plasma memory 16 through blood plasma perfusion vein end pipe 15 by the blood plasma behind liver, the kidney bioreactor 14; Through the blood plasma after the effect of perfusion, liver or nephrocyte bioreactor repeatedly, feed back pipe 8 by blood plasma pump line and blood plasma, feed back at blood plasma under the driving of pump 11, deliver to venous duct 6, feed back at last and give the patient.Dialysis solution and blood plasma memory are heated, thermostat 26 is continuously being supervised then the temperature of blood plasma memory, venous pressure table 36 is continuously being monitored the venous pressure of vein end blood circuit, bubble trap and sonac 6a are continuously monitoring the bubble in the blood plane and blood in the bubble trap, in case it is too high or too low that the temperature of blood plasma memory 16 surpasses threshold value, it is too high or too low that venous pressure surpasses threshold value, in decline of bubble trap blood plane or the blood bubble is arranged, there are three kinds of information to reach the 33-2 district respectively and pass to the total monitoring section computer of 35-, send three kinds of indications respectively by 35 total monitoring section computers: (1) blood plasma memory is too high or too low for temperature, instructs 26 dialysis solution and blood plasma memory to heat, thermostat stops to heat or heating; (2) venous pressure is too high or too low, and instruction roller pump 2, plasma perfusion pump 9, blood plasma feed back pump 11 stalls; (3) in the too low or blood of blood plane bubble is arranged in the bubble trap, instruction vein loop vascular clamp 37 is closed roller pump 2 stalls simultaneously immediately, blood plasma feeds back pump 11 stalls, 9 stalls of plasma perfusion pump, when after exhaustor is extracted the gas among the bubble trap 6a out, the running that promptly recovers above-mentioned three pumps.
Fig. 5 a, Fig. 5 b are another duties of the present invention, 1-ductus arteriosus among the figure, 11-plasma perfusion pump, 12 blood perfusion devices, 13-blood circulation connecting conduit, 14-liver, nephrocyte bioreactor, 6-venous duct, 6a-bubble trap and sonac, the 6b-exhaustor, 6c-vein pressure pipe, 33-2 district (liver declines and gives treatment to the district), 34-zone of alarm, the total monitoring section of 35-, 36-venous pressure table, 37-vein loop vascular clamp, more than each parts structure the design's hemoperfusion+liver or nephrocyte bioreactor system; Patient's blood is drawn in patient's body with puncture needle or intubate, by ductus arteriosus 1, under the driving of hemoperfusion pump 11, arrive blood perfusion device 12, by blood circulation connecting conduit 13, to liver or nephrocyte bioreactor 14, the blood transvenous catheter 6 of discharging from liver or nephrocyte bioreactor 14 is back in patient's body blood drainage; Venous pressure table 36, bubble trap and sonac 6a are carrying out continuous monitoring, and at any time institute's data monitored is passed to 2 district's computers 33 and total monitoring section computer 35, in case venous pressure is too high or too low, in blood plane excessive descent in the bubble trap or the blood bubble is arranged, there are two kinds of information to reach 33-2 district (liver declines and gives treatment to the district) respectively, and pass to the total monitoring section computer of 35-, send two kinds of instructions respectively by 35 total monitoring section computers: (1) venous pressure is too high or too low, instruction plasma perfusion pump 11 or roller pump 2 stalls, 34 zone of alarm are reported to the police simultaneously; (2) in the too low or blood of blood plane bubble is arranged in the bubble trap, instruction vein loop vascular clamp 37 is closed immediately, and plasma perfusion pump 11 or roller pump 2 stop operating simultaneously, and this moment, 34 zone of alarm were reported to the police.After suitable processing recovers normally, the elimination of reporting to the police, roller pump 2 or plasma perfusion pump 11 recover to rotate, and vein loop vascular clamp 37 is opened automatically, the state when returning to the preparation warning.
Fig. 6 a, Fig. 6 b is another operation principle of the present invention and configuration state, 1-ductus arteriosus among the figure, the 2-roller pump, the 5-dialyser, filter, blood perfusion device+dialyser, dialyser+filter, the 6-venous duct, 6a-bubble trap and sonac, the 6b-exhaustor, 6a-vein pressure pipe, 18a, 18b, 18c-dialysis solution circulation fairlead, 19a-dialysis liquid pump and dialysis solution circulation pipe, the 19b-liquid pump of dialysing, the 20-dialysis solution is heated and the thermostat inlet tube, the 21-dialysis solution is heated and the thermostat outlet, 22-dialysis solution circulation pipe, 23-dialyser outlet, 24a, 24b, 24c-dialysis solution circulation inlet tube, 25a, 25b, the 25c-dialysis fluid container, 26-dialysis solution and blood plasma memory heat thermostat and medium, 27-dialysis fluid container platform, 28-dialysis fluid container monitoring sensor, 29-dialysis fluid container pick off supporting platform, the 30-casing, the movable wheel of 31-, 32-1 district (nephropathy treatment monitoring section), 34-zone of alarm, the total monitoring section of 35-, 36-venous pressure table, 37-vein loop vascular clamp more than constitutes blood dialysis ultrafiltration of the present invention, hemodiafiltration, simple blood ultrafiltration, pure hemofiltration, hemodialysis perfusion, hemodialysis and pure hemofiltration carry out simultaneously, the another operation principle that hemodialysis and simple blood ultrafiltration carry out simultaneously and the critical piece of configuration state; Be blood dialysis ultrafiltration at part 5 places with dialyser merely; 5 places are hemodiafiltration with filter merely at part; At part 5 places merely with dialyser or filter and be simple blood ultrafiltration or pure hemofiltration without dialysis solution; 5 places are the hemodialysis perfusion with dialyser and blood perfusion device simultaneously at part; 5 places use hemodialyzer and transfusion filters simultaneously at part, and transfusion filters does not circulate, and dialysis solution is hemodialysis and pure hemofiltration carries out simultaneously; Use two hemodialyzers simultaneously at part 5 places, circulation dialysis solution and another ring circulation dialysis solution, promptly becoming hemodialysis and simple blood ultrafiltration carries out simultaneously; Adopt angiographic neeclle or intubate, patient's blood is led to ductus arteriosus 1 in body, under the driving guiding of roller pump 2, arrive dialyser 5, after blood flows out from 5, arrive venous duct 6, continuing to move ahead arrives bubble trap 6a, by being back in patient's body from venous duct 6 behind the bubble trap 6a; Dialysis solution among dialysis fluid container 25a, 25b, the 25c, under dialysis solution circulation fairlead 18a, 18b, 18c attraction driving at dialysis liquid pump 19a or 19b, guide to that dialysis solution is heated and thermostat inlet tube 20, through heating and weighing temperature, heat and thermostat outlet 21 is discharged after dialysis solution circulation pipe 22 arrives dialyser arterial end dialysate holes from dialysis solution, behind dialyser, discharge from the vein end dialysate hole of dialyser, drain into dialysis solution circulation inlet tube 24a, 24b, 24c through dialyser outlet 23, enter dialysis fluid container 25a, 25b, 25c; Dialysis solution and the blood plasma memory thermostat 26 of heating is carrying out adding the monitoring of gentle weighing apparatus temperature continuously, dialysis fluid container monitor 28 is carrying out the monitoring of dialysis solution capacity or weight continuously, bubble trap and ultrasonic air monitor 6a are carrying out bubble monitoring in blood plane and the blood continuously, venous pressure table 36 is carrying out the venous pressure monitoring continuously, more than four monitoring systems in case when occurring surpassing the situation of threshold value, report to total monitoring section computer 35 by 1 district (nephropathy treatment monitoring section) 32, after total monitoring section computer 35 obtains information, send immediately with 1 district that gives an order and handle automatically: when dialysate temperature is too high or too low: report to the police immediately (1); (2) the indication dialysis solution thermostat 26 of heating stops to heat or heating; (3) indication dialysis liquid pump 19a or 19b suspend rotation, and when dialysate temperature reached applicable threshold range, dialysis liquid pump 19a or 19b recovered running.When venous pressure was too high or too low: reported to the police immediately (1); (2) indication roller pump 2 suspends running, when venous pressure returns in the scope of prescribed threshold, recovers roller pump 2 runnings.When having air or blood plane to descend obviously above threshold value among the bubble trap 6a: report to the police immediately (1); (2) roller pump suspends running immediately; (3) vein loop vascular clamp 37 is closed immediately, behind the air in having got rid of bubble trap 6a, removes and reports to the police, and roller pump recovers to rotate, and vein loop vascular clamp is open automatically.When the weight of dialysis fluid container or capacity surpassed or be lower than the threshold definite value: reported to the police immediately (1); (2) suggestion content and treating method.
Figure 7 shows that the main program schematic diagram of computer operation of the present invention, after starting power supply, then start total monitoring section computer (35), according to treatment needs selective actuation 1 districts (32) and/or 2 districts (33), the working procedure of Xuan Zeing is simultaneously: after power supply and total monitoring section (35) start, then start 1 district (32), start roller pump (2), blood drives blood circulation, start the dialysis solution thermostat (26) of heating and promptly begin dialysis solution and blood plasma memory are heated, after the dialysis solution temperature reaches instructions for use, can start dialysis liquid pump (19a or 19b), after starting the dialysis liquid pump, then start dialysis fluid container monitor (28), monitoring the variation of dialysis solution capacity at any time, the capacity in the dialysis fluid container is too much or very few when exceeding the threshold definite value, report to the police immediately, and prompting corresponding contents and processing method; Monitoring the variation of venous pressure simultaneously,, reporting to the police immediately and close blood pump (2) if venous pressure is undesired and too high or too low when exceeding the threshold definite value, venous pressure recover normal after, blood pump (2) recovers rotation; After the treatment beginning, monitoring treatment time always,, reporting to the police immediately and point out treatment time to arrive if treatment time arrives predetermined value; After starting roller pump (2), promptly start bubble trap and sonac (6a) and carrying out air monitering continuously, if the decline of air plane is arranged in bubble trap or in the blood of bubble trap, bubble is arranged, report to the police immediately, close blood pump (2) simultaneously, close vein loop vascular clamp (37), close blood plasma and feed back pump (11) and point out corresponding contents and processing method; After starting power supply, the dialysis solution thermostat (26) of heating is promptly carrying out dialysate temperature monitoring continuously, when being lower than the threshold definite value slightly, dialysate temperature heats at once, if dialysate temperature is higher than the threshold definite value and promptly suspends and heat, dialysate temperature is too high or too low all reports to the police and shows corresponding contents and processing method; After starting power supply, optionally start plasma perfusion pump (9) and blood plasma feedback pump (11) according to the treatment type, when having bubble or blood plane too low in the blood of the too high or too low and bubble trap of venous pressure, computer all instructs blood pump (2), plasma perfusion pump (9), blood plasma feeds back pump (11), and vein loop vascular clamp (37) is closed simultaneously, and alarm corresponding contents and processing method immediately.Treatment time, then reporting to the police immediately and pointing out was the selection that finishes treatment or extended treatment time.
The present invention compares with present various types of artificial kidney machines and has the following advantages or good effect: (1) its function is many, can be used as the bicarbonate hemodialysis, capacity monitoring, high-sodium dialysis, low sodium dialysis, blood dialysis ultrafiltration, hemodiafiltration, pure hemofiltration, simple blood ultrafiltration, the hemodialysis perfusion, hemoperfusion, blood dialysis ultrafiltration and simple filtration carry out simultaneously, blood dialysis ultrafiltration and isolated ultrafiltration carry out simultaneously, separating plasma, a separating plasma displacement, dual separating plasma displacement, bioartificial liver's extracorporeal circulation of blood, the external plasma circulation of bioartificial liver, biology artificial kidney extracorporeal circulation of blood, the external plasma circulation of biology artificial kidney.(2) volume is small and exquisite, is convenient to move use, and is not given treatment to the place and limits, and rescue can be used for paying a home visit.(3) low price, the function of this apparatus for supporting life one table apparatus is equivalent to three therapy apparatuss, and real price also has only present conventional hemo system to add about 10% of water treatment machine, low cost, high-tech, high added value.(4) do not rely on the water source, power supply is not had specific (special) requirements, do not resemble the conventional hemo system of import and all want indispensable regulated power supply, increased user's input expense.(5) dialysis solution is done the repeated use of certain number of times in the effective time, and the consumption of at every turn treating dialysis solution has only 1/4 of conventional hemo system, has both saved the energy, does not reduce therapeutic effect again.(6) dialysis solution can be prepared voluntarily by prescription by medical institutions, and is easy to use.(7) the manufactured materials wide material sources of the basic element of character, manufacturing process is simple, implements easily.(8) the application of result practical experience in the present invention existing 8 years early stages has directly to help the reference when implementing of the model machine implemented.
Embodiment:
Press accompanying drawing 1a, Fig. 1 b; Fig. 2 a, Fig. 2 b; Fig. 3 a, Fig. 3 b; Fig. 4 a, Fig. 4 b; Fig. 5 a, Fig. 5 b; Prepare the parts and the equipment of each several part shown in Fig. 6 a, Fig. 6 b, it is shown in Figure 6 to press accompanying drawing 1-, makes critical piece with machined and/or mould, comprising: roller pump (2); Dialysis liquid pump (19a, 19b); Plasma perfusion pump (9); Dialysis liquid pump (19a) and plasma perfusion pump (9) as adopt " convex " roller then the roller of two pumps be two sections with one, i.e. the thick section roller that part is plasma perfusion pump (9) of roller, the thin segment of roller partly are the roller of liquid pump (19a) of dialysing; Blood plasma feeds back pump (11); Blood plasma memory (16) and dialysis solution and the blood plasma memory thermostat (26) of heating; Dialysis fluid container (25); Casing (31) etc.Concrete implementation step suggestion:
1, adopts two of non-" protruding " shape roller pumps, one of " protruding " shape roller pump, arterio-venous catheter three covers, dialysis solution circulation pipe one cover, three of dialysis fluid containers, one of blood plasma memory, one of dialyser, one of filter, one of perfusion device, plasma separator one to two, each one of the biological liver cell reactor of polysulfone membrane or poly (ether sulfone) film, biological nephrocyte reactor, dialysis solution capacity (volume) are measured weighing apparatus system one cover, one of computer 386 or 486 mainboard, manufacture casing with mould or machined, press shown in Fig. 1 a-Fig. 6 b, carrying out overall package respectively can become.
2, the blood plasma memory can adopt the disposable materials useds of macromolecule such as glass or medical plastic with Mould Machining, makes.The capacity 500-1500ml/ of blood plasma memory, shape can be circle.
3, dialysis fluid container can be with medical macromolecular materials manufacturings such as plastics, capacity 3000-10000ml/, may with 5000ml/ comparatively appropriate, volume is little, is convenient to nursing staff's operation.
4, venous pressure monitoring system, vein loop vascular clamp and actuating device, dialyser, liver, nephrocyte bioreactor hold the support device, finish with methods such as machineds respectively and make.
5, press the basic design of Fig. 7, finish 1 district (32), 2 districts (33) manufacture and design with the computer command system of total monitoring section (35), and each system is organically connected.

Claims (6)

1. one kind by ductus arteriosus (1), roller pump (2), plasma separator (3a, 3b), blood connecting conduit (4), hemodialyzer (5), venous duct (6), bubble trap and sonac (6a), exhaustor (6b), vein pressure pipe (6c), blood plasma drainage tube (7a, 7) b, blood plasma pump line and feedback blood plasma pipe (8), plasma perfusion pump (9), plasma perfusion arterial end pipe (10), blood plasma feeds back pump (11), plasma perfusion device (12), plasma circulation connecting conduit (13), liver, nephrocyte bioreactor (14), plasma perfusion vein end pipe (15), blood plasma memory (16), blood plasma memory exhaustor (17), dialysis solution circulation fairlead (18a, 18b, 18c), dialysis solution circulating pump and dialysis solution circulation pipe (19a), dialysis liquid pump (19b), dialysis solution is heated and thermostat inlet tube (20), and dialysis solution is heated and thermostat outlet and dialyser inlet tube (21), dialysis solution circulation pipe (22), dialyser outlet (23), dialysis solution circulation inlet tube (24a, 24b, 24c), dialysis fluid container (25a, 25c, 25b), dialysis solution and blood plasma memory are heated, thermostat and medium (26), dialysis fluid container platform (27), dialysis fluid container monitoring sensor (28), dialysis fluid container pick off supporting platform (29), casing (30), movable wheel (31), 1 district (nephropathy treatment monitoring section) (32), 2 districts (liver declines and gives treatment to monitoring section) (33), zone of alarm (34), total computer monitoring district (35), venous pressure table (36), the venous duct apparatus for supporting life that vascular clamp (37) is constituted of going the same way, it is characterized in that: the present invention is the blood purification technology; Bioartificial liver's extracorporeal circulation technology and biology artificial kidney extracorporeal circulation technology three combine together, make the present invention have multiple life support function; Dialysis solution blood circulation of the present invention relies on dialysis liquid pump (19a or 19b), from dialysis solution circulation fairlead (18a, 18b, 18c) drive, draw dialysis solution, from dialysis fluid container (25a, 25b, 25c) heat and thermostat inlet tube (20) to dialysis solution, through heating, dialysis solution after the weighing apparatus temperature, from dialysis solution heat and thermostat outlet (21) to dialysis solution circulation pipe (22), deliver to the vein end of dialyser (5), again from the arterial end dialysis solution outlet of dialyser (5) and dialysis solution circulation pipe (23) respectively through dialysis solution circulation inlet tube (24a, 24b, 24c) be back to dialysis fluid container (25a, 25b, 25c); By dialysis fluid container monitoring sensor (28), experience the weight of dialysis fluid container (25a, 25b, 25c), converse the variation of dialysis solution capacity in the dialysis fluid container by weight and volumetric ratio, in treatment, monitor continuously with 1 district (nephropathy treatment monitoring section) (32); Blood circulation of the present invention is by ductus arteriosus (1), the lead body inner blood, by roller pump (2), drive the arterial end that blood arrives plasma separator (3a), by blood connecting conduit (4), blood is introduced into the arterial end of dialyser (5) from the vein end of plasma separator (3a), again by venous duct (6), blood is introduced bubble trap (6a) from the vein end of dialyser (5), link to each other with venous pressure table (36) by vein pressure pipe (6c), pressure is imported into to venous pressure table (36), variation by 1 district (nephropathy treatment monitoring section) (32) monitoring venous pressure, when venous pressure surpasses the high limit of valve definite value or lower bound, all can start vein loop vascular clamp (37), occlude blood refluxes, blood pump (2) stall simultaneously, when venous pressure was recovered normal range, the blood that flows down from bubble trap (6a) continued to move ahead, and flows back in patient's body; Plasma circulation of the present invention system is the blood plasma of separating from plasma separator (3a), be introduced into blood plasma memory (16) by blood plasma drainage tube (7), by the plasma perfusion circulation conduit (10) that communicates with blood plasma memory (16), pass through plasma perfusion pump (9) from the bottom of blood plasma memory (16), blood plasma is drawn and is circulated to the arrival end of plasma perfusion device (12), at the port of export of plasma perfusion device (12) by plasma circulation connecting conduit (13) and liver, the arrival end of nephrocyte bioreactor (14) links to each other, liver, the port of export of nephrocyte bioreactor (14) is drawn blood plasma by plasma perfusion circulation conduit (15) and is back to blood plasma memory (16), feed back pump (11) and blood plasma feedback pipe (8) by blood plasma, in the blood plasma memory (16) through perfusion repeatedly, purified and and liver, blood plasma after the nephrocyte bioreactor is had an effect, deliver to venous duct (6) with tee T, feed back and give the patient, being controlled at automatically in the treatment of plasma circulation system carried out by 2 districts (liver declines and gives treatment to monitoring section) (33); The heat thermostat and the warm medium (26) of heating, weigh of dialysis solution of the present invention and blood plasma memory are to medium heat, weigh temperature and be subjected to the monitoring of total monitoring section computer by the electrical equipment heating member; Total monitoring section of the present invention (35), in treatment to kidney, liver multiple organ failure, MOF when depletion is given treatment to simultaneously or separately, 1 district (32) and 2 districts (33) are supervised then synchronously, when any part breaks down at work, alarm signal is sent by zone of alarm (34) in the capital, processing method is provided, and after treated recovery was normal, reporting to the police promptly automatically reset to treating alarm condition.
2. apparatus for supporting life according to claim 1, its feature also is: heat thermostat and medium (26) of dialysis solution and blood plasma memory is to be made of water or other liquid that can conduct heat or consubstantiality material, the heat that heating element produced, arrive dialysis solution by heat transfer medium and add gentle weighing apparatus temperature pipe, dialysis solution adds gentle thermostat tube inlet and when adding gentle thermostat pipe, dialysis solution obtains adding gentle weighing apparatus temperature when the dialysis solution that comes from dialysis fluid container (25a, 25b, 25c) enters to; Dialysis solution and the blood plasma memory thermostat of heating has unique power control system, and accept monitoring, the regulation and control of total monitoring section computer, heat behind the thermostat when opening dialysis solution and blood plasma memory, promptly connect and accept monitoring with total monitoring section computer (35), when dialysis solution and blood plasma memory are heated the temperature of thermostat when being elevated to threshold value, total monitoring section computer (35) is promptly temporary transient to interrupt heating, when temperature drops to threshold value, total monitoring section computer (35) promptly instructs heats, and holding temperature is in the scope of job demand.
3. apparatus for supporting life according to claim 1, its feature also is: blood plasma memory (16) is the container of being made by transparent glass or disposable medical macromolecular materials, its peristome takes medical grade silicon rubber or medical macromolecular materials to make the gag of a band periphery, central part design at gag has blood plasma drainage tube and exhaustor, the capacity of blood plasma memory (16) is 500-1500ml, the manufactured materials of blood plasma memory (16) is all high temperature-resistant disinfected or be disposable medical macromolecular materials, helps reusing or disposable use.
4. apparatus for supporting life according to claim 1, its feature also is: dialysis liquid pump (19a) can be " protruding " shape roller pump, by the thin segment of " protruding " shape roller pump roller, spreading dialysis solution pump line drives the dialysis solution circulation; By thick section of " protruding " shape roller pump roller, spreading plasma perfusion pump line makes plasma perfusion device (12) regulating liver-QI or nephrocyte bioreactor (14) carry out plasma circulation synchronously.
5. apparatus for supporting life according to claim 1, its feature also is: dialysis liquid pump (19b) can be a centrifugal pump, and the pump head portion manufactured materials of centrifugal pump can be a rustless steel, nylon, plastics, silicone rubber or other macromolecular material, the pump head part of centrifugal pump can life-time service.
6. apparatus for supporting life according to claim 1, its feature also is: the manufactured materials of liver, nephrocyte bioreactor (14) can be a polysulfone membrane, polyacrylonitrile film, macromolecular materials such as poly (ether sulfone) film; Liver, the used biological cell of nephrocyte bioreactor (14) can be the alive liver cells of former generation animal (pig), and the kidney living cells also can be liver, the nephrocyte through cultivating; Can be former generation liver, nephrocyte suspension, also can be liver, the nephrocyte suspension through cultivating; Also can be to adopt the liver of former generation of living or cultivation, nephrocyte medical biological cell alite paste to adhere to the pipe outer wall of the medical high polymer hollow fibre pipe of bioreactor, make the alive liver cell that is fixed in hollow fibre pipe outer wall, nephrocyte alive, the biological action of performance hepatocyte, nephrocyte.
CN 97107699 1997-09-30 1997-09-30 Apparatus for supporting life Expired - Fee Related CN1121879C (en)

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CN 97107699 CN1121879C (en) 1997-09-30 1997-09-30 Apparatus for supporting life

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CN1121879C CN1121879C (en) 2003-09-24

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CN100486651C (en) * 2007-04-27 2009-05-13 高光勇 Multiple organ dysfunction support system
CN102210889A (en) * 2010-04-02 2011-10-12 瑞德肝脏疾病研究(上海)有限公司 In-vitro biomaterial for artificial liver dialysis and preparation method thereof
CN102458503A (en) * 2009-06-09 2012-05-16 德国弗雷泽纽斯医疗保健股份有限公司 Method and device for monitoring a fluid system of an extracorporeal blood treatment device
CN105169507A (en) * 2009-08-04 2015-12-23 弗雷塞尼斯医疗保健控股公司 Dialysis systems, components, and methods
CN105288768A (en) * 2008-05-29 2016-02-03 索林集团德国有限公司 Life support system
CN105561414A (en) * 2015-12-10 2016-05-11 威海威高血液净化制品有限公司 Portable blood purification apparatus
CN105879137A (en) * 2014-09-15 2016-08-24 彭罗民 A life activation instrument
CN108653844A (en) * 2018-05-16 2018-10-16 潍坊护理职业学院 A kind of portable uremic patient hemodialysis machine

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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100486651C (en) * 2007-04-27 2009-05-13 高光勇 Multiple organ dysfunction support system
CN105288768A (en) * 2008-05-29 2016-02-03 索林集团德国有限公司 Life support system
CN105288768B (en) * 2008-05-29 2018-11-27 索林集团德国有限公司 Life-support system
CN102458503A (en) * 2009-06-09 2012-05-16 德国弗雷泽纽斯医疗保健股份有限公司 Method and device for monitoring a fluid system of an extracorporeal blood treatment device
CN102458503B (en) * 2009-06-09 2015-07-15 德国弗雷泽纽斯医疗保健股份有限公司 Method and device for monitoring a fluid system of an extracorporeal blood treatment device
CN105169507B (en) * 2009-08-04 2018-04-06 弗雷塞尼斯医疗保健控股公司 Dialysis system, part and method
US9919091B2 (en) 2009-08-04 2018-03-20 Fresenius Medical Care Holdings, Inc. Dialysis systems, components, and methods
CN105169507A (en) * 2009-08-04 2015-12-23 弗雷塞尼斯医疗保健控股公司 Dialysis systems, components, and methods
US10080831B2 (en) 2009-08-04 2018-09-25 Fresenius Medical Care Holdings, Inc. Dialysis systems, components, and methods
CN102210889A (en) * 2010-04-02 2011-10-12 瑞德肝脏疾病研究(上海)有限公司 In-vitro biomaterial for artificial liver dialysis and preparation method thereof
CN105879137A (en) * 2014-09-15 2016-08-24 彭罗民 A life activation instrument
CN105561414A (en) * 2015-12-10 2016-05-11 威海威高血液净化制品有限公司 Portable blood purification apparatus
CN108653844A (en) * 2018-05-16 2018-10-16 潍坊护理职业学院 A kind of portable uremic patient hemodialysis machine
CN108653844B (en) * 2018-05-16 2021-01-01 李萌生 Portable uremia patient hemodialysis machine

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