CN1190212C - Medicine for treating fatty liver - Google Patents
Medicine for treating fatty liver Download PDFInfo
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- CN1190212C CN1190212C CNB021019754A CN02101975A CN1190212C CN 1190212 C CN1190212 C CN 1190212C CN B021019754 A CNB021019754 A CN B021019754A CN 02101975 A CN02101975 A CN 02101975A CN 1190212 C CN1190212 C CN 1190212C
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- medicine
- fatty liver
- bulbus allii
- liver
- potus
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Abstract
The present invention relates to Medicine for treating fatty liver. Watermelon and garlic are used as raw material, and juice is extracted to prepare potus after treatment. The present invention has the functions of reduced cholesterol, particularly triglyceride, increased high-density lipoprotein, reduced transaminase and treated fatty liver, and is made from natural vegetables, fruits, etc.; so that the present invention has no any toxic side effect, and can protect the liver and improve liver function.
Description
Technical field
The present invention relates to a kind ofly produce the preparation method of medicine with wholefood Citrullus vulgaris, Bulbus Allii, and should the application of preparation medicine aspect the treatment fatty liver.
Background technology
Fatty liver and hypercholesterolemia have become a kind of common frdquently encountered disease, and the healthy of the mankind in serious harm.Though the medicine of treatment fatty liver and hypercholesterolemia is a lot of both at home and abroad at present, mostly hepatic and renal function is had certain side effect, takes for a long time, can bring the infringement of hepatic and renal function.
In " augmentation New Compilation of Proved Recipes " volume five " tympanites doors " piece of writing, have " get one of Citrullus vulgaris; cut the top, cut out three one-tenth in flesh back and fill up and, place and cook the melon Bulbus Allii in the new marmite on the former top cover with Bulbus Allii; with soup do two, three secondary eclipses it; can control various tympanites " description, illustrate that just there is the record that utilizes Citrullus vulgaris and Bulbus Allii treatment disease in China from ancient times, but passes through to retrieve, find that it only is confined to tympanites class disease aspect, be not applied in others.
Summary of the invention
The object of the present invention is to provide a kind of new preparation process for preparing medicine by Citrullus vulgaris and Bulbus Allii.
The present invention also aims to provide the new purposes of this medicine aspect the treatment fatty liver.
The present invention utilizes fully natural green vegetable and fruit, increases the hepatocyte vigor, improves liver function, and cholesterol reducing, particularly triglyceride increase high density lipoprotein, with the treatment fatty liver and eliminate the side effect of other fat-reducing medicaments.
Medicine of the present invention is made by following component:
Citrullus vulgaris 60～94% Bulbus Alliis 6～40%
The preparation method of medicine of the present invention is:
1, dries after at first Bulbus Allii peeling being cleaned, be ground into the Bulbus Allii slurry.
2, Citrullus vulgaris is cleaned, goes to dry behind the epidermis, pulverizes pulping.
3, the Citrullus vulgaris pulp pulverized and Bulbus Allii are starched mix by described proportioning after, put into container and boil.
4, ripe slurry filters, and makes the potus medicine after removing thick thing.
Wherein, Citrullus vulgaris pulp and Bulbus Allii slurry are put into container, need to boil in 20 minutes.
After also need adding a certain amount of essence in the potus medicine that the present invention makes, just can make finished product through the degassing, homogenizing, flash pasteurization, enzyme denaturing, sealed package.
Among the present invention, the Bulbus Allii of use can be handled in deodorize, also can re-use after deodorize is handled.Concrete deodour method is: the Bulbus Allii juice that will pulverize, squeezes out is put into container, places 10 ℃ to transfer 4～5 days, adds the raw vegetable oil mixing that accounts for Bulbus Allii juice 5～10%, leaves standstill the dark Bulbus Allii liquid of collection container bottom 40 days.Also can in the Bulbus Allii juice, add 0.3～0.5% beta-schardinger dextrin-, carry out deodorize in 8～12 minutes in 65～70 ℃ of heating and handle.
Medicine of the present invention can also further be prepared into other dosage forms except that being prepared as potus.For example, potus is further concentrated, sterile filling of bottles with is made oral liquid then.The oral liquid reconcentration can also be removed moisture, add a small amount of glucose absorbent drying after, electuary is made in sterilization.In also the glue of packing into behind the oral liquid drying and dehydrating can being assisted, make glue and assist agent.
The medicine of any treatment fatty liver, the one, should reduce the cholesterol in the blood rapidly, triglyceride reducing particularly, the 2nd, should be able to improve the liver fat metabolic function, increase the hepatocyte vigor, the superabundant fats in the liver particularly triglyceride be converted into very low density lipoprotein (VLDL), and output in the blood rapidly.
By China's theory of Chinese medical science, hepatopathy is fatty liver, liver cirrhosis, hepatic ascites particularly, is mostly to be caused by damp and hot and stagnation of liver-QI, so treatment hepatopathy multiselect with regulate the flow of vital energy, invigorate blood circulation, heat clearing away, dry, spleen invigorating diuretic Chinese medicine, to reach heat clearing away spleen invigorating dehumidifying, soothing the liver reason spleen, the purpose of blood stasis-eliminating and stagnation-dissipating.
Bulbus Allii is universally acknowledged fat-reducing food, its composition more complicated, remove outside 69.8% the moisture, conventional nutritional labeling has carbohydrate, protein, reducing sugar, crude fibre and a spot of fat, micro-nutrient composition has vitamin, calcium, phosphorus, ferrum, zinc etc., particularly content of sulphur compounds is very abundant, and it is peppery new to include allicin (Allicin), alliin (Alijn) and Bulbus Allii.The function ratio of Bulbus Allii is more, mainly contains lipidemia, improves fibrinolytic activity, antiplatelet aggregative activity; Blood vessel dilating produces hypotensive effect; The liver protecting increases the hepatocyte vigor, and the blood sugar regulation level improves immunologic function, eliminates free radical, antitumor, antibiotic and anti-infection effect.Bulbus Allii mainly plays a part in the present invention to regulate the flow of vital energy, invigorates blood circulation, soothing the liver, reduce cholesterol, particularly triglyceride reducing in the blood, blood vessel dilating, promoting blood flow.Evidence of the present invention, Bulbus Allii not only can cholesterol reducing, and the effect of its antiplatelet aggregation is also favourable to rapid treatment fatty liver.
Citrullus vulgaris is known as the king of melon and fruit in summer.Studies show that, in the Citrullus vulgaris except that containing up to 96.6% the moisture content, also containing a large amount of sucrose, phosphoric acid, tannic acid, fructose, glucose, aminoacid, Lycine, licopin, carotene, saccharase, calcium, phosphorus, ferrum, vitamin etc., all is the useful component of human body.Motherland's theory of Chinese medical science is thought: Citrullus vulgaris slightly sweet flavor, cold in nature has clearing away summer-heat and dries, promoting the production of body fluid to quench thirst, functions such as diuresis.Eat Citrullus vulgaris then to have an appetizing aid digestion more, enhances metabolism, and nourishes the effect of health.The pharmaceutical characteristic of Citrullus vulgaris, many effects such as medical science ancient books and records such as Compendium of Material Medica have argumentation more, and Li Shizhen (1518-1593 A.D.) is called it to be had " disappear tired quench one's thirst the alleviating distention in middle-JIAO therapeutic method to keep the adverse QI flowing downwards, diuresis, alcoholic intoxication ".Modern medicine study proves, but the Citrullus vulgaris blood fat reducing, and vessel softening to nephritis, liver cirrhosis and cardiovascular disease and the patient of edema to occur useful, and truly has the function of hepatoprotective.The salt of glucose, sucrose and saccharase, protein and trace particularly, can form glucuronic acid at liver, in order to eliminate the illeffects of the various toxin of human body, reduce harmful toxins to liver injury, improve the hepatocyte vigor, impel the synthetic very low density lipoprotein (VLDL) of liver to output in the blood, thus realize triglyceride synthetic with transport between equilibrium function.Citrullus vulgaris effect in the present invention mainly is the heat clearing away spleen invigorating, and diuresis is dried, and hepatoprotective improves the liver cell metabolic function, and particularly lipid metabolism function improves the hepatocyte vigor, to reduce the accumulation of triglyceride in liver.In the present invention, Citrullus vulgaris has not only been strengthened the lipid-reducing function of Bulbus Allii, also by diuresis, is discharged to the very low density lipoprotein (VLDL) in the blood external by urine.
Medicine of the present invention proves to have following advantage through clinical use:
1, Citrullus vulgaris and Bulbus Allii are fully natural green vegetable and fruit, cholesterol reducing and triglyceride effectively, the treatment fatty liver is taken for a long time not only without any toxic and side effects, and can be treated effectively and take the hepatic and renal function injure that other fat-reducing medicaments bring.
2, medicine of the present invention not only can be treated hypercholesterolemia, increase high density lipoprotein, improve fatty function, other hepatic disease such as treatment fatty liver and hepatic ascites, it is swollen also to have treatment various floating (water), lipidemia and arteriosclerosis, transaminase lowering, the effect of antiplatelet aggregation, treatment thrombosis, blood vessel dilating, blood pressure lowering, also have antitumor, blood sugar regulation level, improve immunocompetence, eliminate free radical, antibiotic and anti-infection effect.
3, medicine production method of the present invention is simple, product cost is low, is easy to be accepted by consumer.
For showing the therapeutic effect of medicine of the present invention to fatty liver, the present invention has selected 30 routine patients to carry out clinical observation on the therapeutic effect, and observed result is added up.
In 30 routine patients, the lipid examination correlation data after 23 people have the preceding clothes of clothes is arranged, statistical result sees Table 1.
As can be seen from Table 1, average everyone T-CHOL reduces by 5.15% before and after taking medicine, and low density lipoprotein, LDL reduces by 2.42%, and triglyceride reduces by 36.34%, and high density lipoprotein raises 10.16%, p＜0.05.Prove medicine of the present invention hypercholesterolemia reducing effectively, low density lipoprotein, LDL and triglyceride, high density lipoprotein increasing, wherein the triglyceride reducing effect is the most remarkable.
Table 1 is taken medicine of the present invention front and back blood lipids index situation of change
| Index | Case load | Preceding mmol/L takes medicine | Back mmol/L takes medicine | Lifting (%) | T value | p |
| T-CHOL | 23 | 6.02±0.93 | 5.71±0.79 | -5.15 | 0.0931 | ＜0.05 |
| Triglyceride | 23 | 3.88±1.33 | 2.47±0.80 | -36.34 | 1.7384 | ＜0.05 |
| Low density lipoprotein, LDL | 23 | 3.30±0.74 | 3.22±0.63 | -2.42 | 0.1140 | ＜0.05 |
| High density lipoprotein | 23 | 1.28±0.28 | 1.41±0.24 | -10.16 | 1.9245 | ＜0.05 |
Among the 30 routine patients, 5 people obey back alanine aminotransferase correlation data before clothes are arranged, and the results are shown in Table 2
Table 2 is taken medicine of the present invention front and back transaminase's index situation of change
| Index | Case load | Before taking medicine (U/L) | After taking medicine (U/L) | Lifting (%) |
| The third ammonia transferring enzyme | 5 | 61.4 | 33.8 | -44.95 |
| p＜0.05 | ||||
Table 2 result shows that medicine of the present invention has tangible hepatoprotective, improves the effect of liver function, takes medicine of the present invention in cholesterol reducing, not only can not cause damage to liver, and can improve liver function.
Among the 30 routine patients, there are 17 people after ultrasound diagnosis, to be diagnosed as fatty liver, its mild or moderate fatty liver 5 people, moderate fatty liver 12 people, on average everyone takes after 46 days again through ultrasound diagnosis, with fat-free liver or normal hepatocytes is criterion of cure, and it is the remarkable result standard that the moderate fatty liver is reduced to slight fatty liver, and more not having property fatty liver is changed to the locality fatty liver, in go up the degree fatty liver reduce in degree fatty liver down, light upward degree fatty liver is reduced to the light fatty liver of degree down and is the standard of producing effect, and carries out curative effect and adds up, and the results are shown in Table 3.
Table 3 Drug therapy fatty liver of the present invention total effects statistics
| Curative effect | Cure | Produce effects | Effectively | Invalid | |
| Case load | 17 | 5 | 8 | 4 | 0 |
| Percentage rate (%) | 29.41 | 47.06 | 23.53 | 0 |
Statistical result shows, Drug therapy fatty liver of the present invention cures 29.41%, and produce effects 47.06% is effective 23.53%, and total effective rate reaches 100%.
The specific embodiment
Get clean, Citrullus vulgaris 80kg after going epidermis to dry, pulverize pulping, get the 20kg peeling again and clean the air dried Bulbus Allii in back, also pulverize pulping, put into container after the mixing and boil 20 minutes to ripe, cooled and filtered is removed thick thing, add a small amount of essence in the filtered juice, through degassing homogenizing, flash pasteurization, enzyme denaturing rear enclosed packing are made the potus finished product.
Claims (5)
1, a kind of preparation method for the treatment of the fatty liver medicine, be to be that 60～94% Citrullus vulgaris and weight proportion are that 6～40% Bulbus Allii is the method for feedstock production potus by weight proportion, it is characterized in that: dry after the Bulbus Allii peeling is cleaned, be ground into the Bulbus Allii slurry, Citrullus vulgaris is cleaned, goes to dry behind the epidermis, pulverizes pulping; With the Citrullus vulgaris pulp pulverized and Bulbus Allii starch mix by described proportioning after, put into container and boil; Ripe slurry removes by filter thick thing, behind the degassing, homogenizing, high temperature sterilize enzyme denaturing, is packaged to be potus.
2,, it is characterized in that the time of boiling of Citrullus vulgaris pulp and Bulbus Allii slurry needs 20 minutes according to the preparation method of the described treatment fatty liver of claim 1 medicine.
3, according to the preparation method of the described treatment fatty liver of claim 1 medicine, it is characterized in that described Bulbus Allii slurry can handle through deodorize, also can not deodorize directly use.
4, the application of the potus for preparing of method according to claim 1 in preparation treatment fatty liver medicine.
5, the application of the potus for preparing of method according to claim 1 in preparation blood fat reducing, the liver protecting medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021019754A CN1190212C (en) | 2002-01-21 | 2002-01-21 | Medicine for treating fatty liver |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021019754A CN1190212C (en) | 2002-01-21 | 2002-01-21 | Medicine for treating fatty liver |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1385183A CN1385183A (en) | 2002-12-18 |
| CN1190212C true CN1190212C (en) | 2005-02-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021019754A Expired - Fee Related CN1190212C (en) | 2002-01-21 | 2002-01-21 | Medicine for treating fatty liver |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1190212C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100877600B1 (en) * | 2006-11-30 | 2009-01-08 | 재단법인서울대학교산학협력재단 | Pharmaceutical composition comprising metadoxine and garlic oil for preventing and treating alcohol-induced fatty liver and steatohepatitis |
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2002
- 2002-01-21 CN CNB021019754A patent/CN1190212C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1385183A (en) | 2002-12-18 |
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