CN119013394A - 用于治疗乙型肝炎病毒感染的组合物和方法 - Google Patents

用于治疗乙型肝炎病毒感染的组合物和方法 Download PDF

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Publication number
CN119013394A
CN119013394A CN202280077560.XA CN202280077560A CN119013394A CN 119013394 A CN119013394 A CN 119013394A CN 202280077560 A CN202280077560 A CN 202280077560A CN 119013394 A CN119013394 A CN 119013394A
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China
Prior art keywords
seq
hbv
tada
deaminase
amino acid
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Pending
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CN202280077560.XA
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English (en)
Chinese (zh)
Inventor
法比安·祖林
玛丽亚·瓜达卢佩·马丁内斯
芭芭拉·特斯托尼
埃琳娜·斯梅卡洛娃
路易斯·巴雷拉
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French National Institute Of Health And Medicine
Bim Medical Co ltd
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French National Institute Of Health And Medicine
Bim Medical Co ltd
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Publication of CN119013394A publication Critical patent/CN119013394A/zh
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
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    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN202280077560.XA 2021-09-27 2022-09-27 用于治疗乙型肝炎病毒感染的组合物和方法 Pending CN119013394A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202163248938P 2021-09-27 2021-09-27
US63/248,938 2021-09-27
US202263357623P 2022-06-30 2022-06-30
US63/357,623 2022-06-30
US202263371634P 2022-08-16 2022-08-16
US63/371,634 2022-08-16
PCT/US2022/077105 WO2023049935A1 (en) 2021-09-27 2022-09-27 Compositions and methods for treating hepatitis b virus infection

Publications (1)

Publication Number Publication Date
CN119013394A true CN119013394A (zh) 2024-11-22

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CN202280077560.XA Pending CN119013394A (zh) 2021-09-27 2022-09-27 用于治疗乙型肝炎病毒感染的组合物和方法

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US (1) US20240294914A1 (enExample)
EP (1) EP4408986A4 (enExample)
JP (1) JP2024534639A (enExample)
KR (1) KR20240111821A (enExample)
CN (1) CN119013394A (enExample)
AU (1) AU2022353130A1 (enExample)
CA (1) CA3233413A1 (enExample)
WO (1) WO2023049935A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026124637A1 (zh) * 2024-12-13 2026-06-18 益杰立科(上海)生物科技有限公司 靶向乙型肝炎病毒基因的表观编辑工具

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202503061A (zh) * 2023-06-16 2025-01-16 大陸商益杰立科（上海）生物科技有限公司 靶向ｂ型肝炎病毒基因的表觀編輯工具
WO2025126049A2 (en) * 2023-12-11 2025-06-19 Crispr Therapeutics Ag Multiplex gene editing

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2966170A1 (en) * 2014-07-10 2016-01-13 Heinrich-Pette-Institut Leibniz-Institut für experimentelle Virologie-Stiftung bürgerlichen Rechts - HBV inactivation
CA3001351A1 (en) * 2015-10-21 2017-04-27 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating hepatitis b virus
KR101842131B1 (ko) * 2016-09-05 2018-03-27 연세대학교 산학협력단 Hbv를 표적으로 하는 유전자 가위 및 이를 포함하는 hbv 감염 치료용 조성물
MA51787A (fr) * 2018-02-05 2020-12-16 Vertex Pharma Substances et méthodes de traitement d'hémoglobinopathies
JP7679309B2 (ja) * 2019-05-10 2025-05-19 ビーム セラピューティクス インク． Ｂ型肝炎を治療するための組成物及び方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026124637A1 (zh) * 2024-12-13 2026-06-18 益杰立科(上海)生物科技有限公司 靶向乙型肝炎病毒基因的表观编辑工具

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Publication number Publication date
KR20240111821A (ko) 2024-07-17
WO2023049935A1 (en) 2023-03-30
US20240294914A1 (en) 2024-09-05
CA3233413A1 (en) 2023-03-30
EP4408986A4 (en) 2026-01-21
JP2024534639A (ja) 2024-09-20
EP4408986A1 (en) 2024-08-07
AU2022353130A1 (en) 2024-04-11

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