CN118979003A - 表达血清3型菌毛的鲍特菌属菌株 - Google Patents

表达血清3型菌毛的鲍特菌属菌株 Download PDF

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Publication number
CN118979003A
CN118979003A CN202411102248.9A CN202411102248A CN118979003A CN 118979003 A CN118979003 A CN 118979003A CN 202411102248 A CN202411102248 A CN 202411102248A CN 118979003 A CN118979003 A CN 118979003A
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CN
China
Prior art keywords
functional
fim3
strain
fim2
bordetella strain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202411102248.9A
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English (en)
Chinese (zh)
Inventor
阿内-索菲·德布里
多米尼克·拉兹
卡米尔·洛赫特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Pasteur de Lille
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Institut Pasteur de Lille
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Pasteur de Lille, Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Institut Pasteur de Lille
Publication of CN118979003A publication Critical patent/CN118979003A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202411102248.9A 2017-10-18 2018-10-18 表达血清3型菌毛的鲍特菌属菌株 Pending CN118979003A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762574068P 2017-10-18 2017-10-18
US62/574,068 2017-10-18
PCT/EP2018/078522 WO2019077028A1 (en) 2017-10-18 2018-10-18 BORDETELLA STRAINS EXPRESSING SERO-TYPE FIMBRIAE 3
CN201880067004.8A CN111278456B (zh) 2017-10-18 2018-10-18 表达血清3型菌毛的鲍特菌属菌株

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201880067004.8A Division CN111278456B (zh) 2017-10-18 2018-10-18 表达血清3型菌毛的鲍特菌属菌株

Publications (1)

Publication Number Publication Date
CN118979003A true CN118979003A (zh) 2024-11-19

Family

ID=64664226

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202411102248.9A Pending CN118979003A (zh) 2017-10-18 2018-10-18 表达血清3型菌毛的鲍特菌属菌株
CN201880067004.8A Active CN111278456B (zh) 2017-10-18 2018-10-18 表达血清3型菌毛的鲍特菌属菌株

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201880067004.8A Active CN111278456B (zh) 2017-10-18 2018-10-18 表达血清3型菌毛的鲍特菌属菌株

Country Status (8)

Country Link
US (2) US11446372B2 (enExample)
EP (1) EP3697439A1 (enExample)
JP (2) JP7335874B2 (enExample)
CN (2) CN118979003A (enExample)
AU (1) AU2018353409B2 (enExample)
CA (1) CA3077428A1 (enExample)
SG (1) SG11202003333WA (enExample)
WO (1) WO2019077028A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007224734C1 (en) 2006-03-10 2016-07-14 Institut National De La Sante Et De La Recherche Medicale (Inserm) Live attenuated Bordetella strains as a single dose vaccine against whooping cough
CN102448490B (zh) 2009-04-28 2015-05-13 国家健康与医学研究院 用于预防或治疗过敏原引起的气道疾病的疫苗
EP3697439A1 (en) * 2017-10-18 2020-08-26 Institut Pasteur de Lille Bordetella strains expressing serotype 3 fimbriae
JP2023550052A (ja) 2020-11-17 2023-11-30 イリアド バイオテクノロジーズ，リミテッド ライアビリティ カンパニー 神経変性疾患に関連する神経病理の治療および予防

Family Cites Families (27)

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US4883761A (en) * 1986-03-25 1989-11-28 The United States Of America As Represented By The Department Of Health And Human Services Pertussis toxin gene: cloning and expression of protective antigen
US6713072B1 (en) 1987-11-02 2004-03-30 Chiron S.R.L. Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine
IT1236971B (it) * 1989-11-03 1993-05-07 Eniricerche Spa Regione promotore dei geni codificanti le subunita' piliniche fim2, fm3 e fimx di bordetella pertussis e loro impiego per l'espressione di geni che codificano una proteina di interesse.
GB9115332D0 (en) 1991-07-16 1991-08-28 Connaught Lab Manipulation of gene copy number in bordetella
FR2718750B1 (fr) 1994-04-19 1996-06-14 Pasteur Institut Protéines recombinantes de l'hémagglutinine filamenteuse de Bordetella, notamment, B. Pertussis, production et application à la production de protéines étrangères ou de principes actifs vaccinants.
FR2754543B1 (fr) * 1996-10-11 1998-12-31 Pasteur Institut Souche de bordetella deficiente dans la production de toxine et exprimant une proteine hydride, liposomes comprenant de la fha et leurs utilisations comme vaccins, et utilisation de la fha pour stimuler les reponses immunitaires
FR2840319B1 (fr) 2002-05-30 2004-08-20 Pasteur Institut Souches de bordetella rendues deficientes par attenuation genetique
EP1617805A4 (en) 2003-04-11 2012-07-04 Medimmune Llc METHODS FOR PREVENTING OR TREATING RESPIRATORY CONDITIONS
GB0402131D0 (en) * 2004-01-30 2004-03-03 Isis Innovation Delivery method
AU2007224734C1 (en) 2006-03-10 2016-07-14 Institut National De La Sante Et De La Recherche Medicale (Inserm) Live attenuated Bordetella strains as a single dose vaccine against whooping cough
WO2008058396A1 (en) 2006-11-15 2008-05-22 Folia Biotech Inc. Papaya mosaic virus-based vaccines for influenza
WO2008118592A2 (en) 2007-02-23 2008-10-02 The Penn State Research Foundation Use of an avirulent bordetella mutant as a live vaccine vector
CN100537767C (zh) * 2007-04-29 2009-09-09 中国药品生物制品检定所 百日咳疫苗保护性抗原的重组表达及其应用
CN101790534A (zh) 2007-06-18 2010-07-28 半球生物制药公司 使用免疫活性剂的病毒感染早期干预
CN102448490B (zh) * 2009-04-28 2015-05-13 国家健康与医学研究院 用于预防或治疗过敏原引起的气道疾病的疫苗
CA2765364C (en) 2009-06-15 2015-05-26 National University Of Singapore Influenza vaccine, composition, and methods of use
DK2773371T3 (da) * 2011-11-02 2020-03-09 Nat Univ Singapore Virkning af en svækket bordetella-stamme mod allergisk sygdom
CA2879939A1 (en) * 2012-08-06 2014-02-13 Glaxosmithkline Biologicals S.A. Novel method
EP2722338A1 (en) * 2012-10-17 2014-04-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Novel recombinant Bordetella strains
US9655959B2 (en) * 2014-10-01 2017-05-23 National University Of Singapore Adenylate cyclase deficient bordetella strains
DK3436034T3 (da) 2016-03-29 2025-05-12 Pasteur Institut Muterede bordetella-stammer og fremgangsmåder til brug
US10799573B2 (en) * 2016-03-30 2020-10-13 Regents Of The University Of Minnesota Pertussis vaccines and methods of making and using
WO2018213361A1 (en) * 2017-05-15 2018-11-22 Vanderbilt University LONG-CIRCULATING ZWITTERIONIC POLYPLEXES FOR siRNA DELIVERY
JP7404226B2 (ja) * 2017-07-18 2023-12-25 セラム インスティテュート オブ インディア プライベート リミティド 向上した安定性、高度の免疫原性、及び減少した反応源性を有する免疫原性組成物、並びにその調製プロセス
EP3697439A1 (en) * 2017-10-18 2020-08-26 Institut Pasteur de Lille Bordetella strains expressing serotype 3 fimbriae
US12036405B2 (en) * 2018-03-23 2024-07-16 The Board Of Regents Of The University Of Oklahoma System and method of electric-induced acoustic tomography for electrotherapy monitoring
WO2020049133A1 (en) 2018-09-05 2020-03-12 National University Of Singapore Adenylate cyclase catalytic domain deficient bordetella strains

Also Published As

Publication number Publication date
CA3077428A1 (en) 2019-04-25
SG11202003333WA (en) 2020-05-28
CN111278456A (zh) 2020-06-12
JP7335874B2 (ja) 2023-08-30
EP3697439A1 (en) 2020-08-26
WO2019077028A1 (en) 2019-04-25
AU2018353409B2 (en) 2025-07-17
US20200297833A1 (en) 2020-09-24
CN111278456B (zh) 2024-08-09
US11446372B2 (en) 2022-09-20
US12403188B2 (en) 2025-09-02
US20220362369A1 (en) 2022-11-17
JP2021500325A (ja) 2021-01-07
WO2019077028A4 (en) 2019-06-27
AU2018353409A1 (en) 2020-04-16
JP2023109996A (ja) 2023-08-08

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