CN118973615A - 用于向外周血单个核细胞递送核酸的脂质纳米粒子以及使用其向外周血单个核细胞递送核酸的方法 - Google Patents

用于向外周血单个核细胞递送核酸的脂质纳米粒子以及使用其向外周血单个核细胞递送核酸的方法 Download PDF

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Publication number
CN118973615A
CN118973615A CN202380031619.6A CN202380031619A CN118973615A CN 118973615 A CN118973615 A CN 118973615A CN 202380031619 A CN202380031619 A CN 202380031619A CN 118973615 A CN118973615 A CN 118973615A
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China
Prior art keywords
group
carbon atoms
lipid
nucleic acid
formula
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Pending
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CN202380031619.6A
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English (en)
Chinese (zh)
Inventor
中井悠太
丹下耕太
秋田英万
田中浩挥
樱井游
三山亮
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Chiba University NUC
NOF Corp
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Chiba University NUC
NOF Corp
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Publication of CN118973615A publication Critical patent/CN118973615A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN202380031619.6A 2022-03-28 2023-03-24 用于向外周血单个核细胞递送核酸的脂质纳米粒子以及使用其向外周血单个核细胞递送核酸的方法 Pending CN118973615A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022051919 2022-03-28
JP2022-051919 2022-03-28
PCT/JP2023/011848 WO2023190175A1 (ja) 2022-03-28 2023-03-24 末梢血単核細胞へ核酸を送達するための脂質ナノ粒子およびこれを用いて末梢血単核細胞へ核酸を送達する方法

Publications (1)

Publication Number Publication Date
CN118973615A true CN118973615A (zh) 2024-11-15

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ID=88201464

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CN202380031619.6A Pending CN118973615A (zh) 2022-03-28 2023-03-24 用于向外周血单个核细胞递送核酸的脂质纳米粒子以及使用其向外周血单个核细胞递送核酸的方法

Country Status (5)

Country Link
US (1) US20250195429A1 (https=)
EP (1) EP4501361A4 (https=)
JP (1) JPWO2023190175A1 (https=)
CN (1) CN118973615A (https=)
WO (1) WO2023190175A1 (https=)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6093710B2 (ja) 2011-11-18 2017-03-08 日油株式会社 細胞内動態を改善したカチオン性脂質
JP6682855B2 (ja) 2015-01-30 2020-04-15 株式会社三洋物産 遊技機
WO2019188867A1 (ja) 2018-03-27 2019-10-03 日油株式会社 細胞内動態を改善した新規カチオン性脂質
JP7700101B2 (ja) * 2019-09-06 2025-06-30 ジェネレーション バイオ カンパニー 閉端ｄｎａおよび切断可能脂質を含む脂質ナノ粒子組成物ならびにそれらの使用方法
WO2021060440A1 (ja) * 2019-09-26 2021-04-01 日油株式会社 脂質ナノ粒子の凍結乾燥組成物
IL296763B2 (en) * 2020-03-27 2026-04-01 Generation Bio Co New lipids and their nanoparticle compositions
WO2023054243A1 (ja) * 2021-09-30 2023-04-06 日油株式会社 細胞指向性を有する脂質ナノ粒子
CA3234320A1 (en) * 2021-09-30 2023-04-06 Nof Corporation Lipid nanoparticle used for delivering nucleic acid to brain tissue
WO2023054242A1 (ja) * 2021-09-30 2023-04-06 日油株式会社 核酸をリンパ管内皮細胞に送達するために用いられる脂質ナノ粒子

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Publication number Publication date
US20250195429A1 (en) 2025-06-19
EP4501361A4 (en) 2026-01-28
JPWO2023190175A1 (https=) 2023-10-05
WO2023190175A1 (ja) 2023-10-05
EP4501361A1 (en) 2025-02-05

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