CN1186448A - Injection dart system - Google Patents

Injection dart system Download PDF

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Publication number
CN1186448A
CN1186448A CN96194345A CN96194345A CN1186448A CN 1186448 A CN1186448 A CN 1186448A CN 96194345 A CN96194345 A CN 96194345A CN 96194345 A CN96194345 A CN 96194345A CN 1186448 A CN1186448 A CN 1186448A
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CN
China
Prior art keywords
administrator
implant
head
animal
hole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN96194345A
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Chinese (zh)
Inventor
凯瑟·F·伍德鲁夫
戴维·A·彼特森
肯德拉·B·埃加
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/473,346 external-priority patent/US5868699A/en
Priority claimed from US08/473,347 external-priority patent/US5725497A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of CN1186448A publication Critical patent/CN1186448A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069Devices for implanting pellets, e.g. markers or solid medicaments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61DVETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Reverberation, Karaoke And Other Acoustics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Manufacture Of Iron (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Prostheses (AREA)

Abstract

An implant dart has a head of solid material and a tubular body that contains one or more drug delivery implant packages. The head has a blade at its front end with a chisel-type point with a beveled end and a scooped face extending rearwardly to the body. The body is formed as a helical coil that makes the body tubular, and permits the coil turns to be compressed and engage to make the body relatively rigid when the dart is injected into the subject. A passage from the head to the interior of the body provides fluid communication between the subject's body fluids and the implant packages. The complete system comprises at least one dart, an injection mechanism which retains a subject's body part on a platen, and feeds darts into the body part generally parallel to the platen.

Description

Injection dart system
Invention field
The present invention relates to a kind of comprise be used to insert in the object, the administrator of the intravital drug delivery implant of for example animal, and the system that is used for administrator is injected animal body.
Background of invention
For a long time, all be to adopt subcutaneous administration device that sedative or other medicines are expelled in animal, especially the wild animal body by rifle or similar device emission.This administrator makes can be injected in the animal skin and at ballistic its entrained medicine that discharges simultaneously.For fear of infecting or animal being caused other injury, should unload administrator on one's body from animal immediately after the use.
On the other hand, often need carry out one section lasting Drug therapy to animal.And this medicine may be the growth hormones medicine, if then may be decomposed by the digestive system of animal by the words of feeding supply.Authorize the medicine that suggestion need be supplied with in people's such as Kuzma the U.S. Patent No. 5,266,325 on November 30th, 1993 and place the drug delivery implant of sustainable release in a persistent period, this implant can be subcutaneously injected in the active mass of animal.According to people's such as Kuzma patent, implant is that the intubate by the apparatus of large-scale hypodermic needle/hypodermic syringe and so on imports in the animal body, and this apparatus can be immediately from the animal body removal after having injected implant.Yet the method for this importing medicine is unsafty treatment jumpbogroup animal.For example, when treatment cattle or pig in the pasture, for hypodermic needle is carried out disinfection or an animal just very inconvenient during with a new entry needle.So there is the danger that can influence a whole rout by an animal infected entry needle.
Adopt another defective of implant to be that they may deviation position.Even possible words, detect an animal body whether received an implant also be very the difficulty.People such as Kuzma are proposed in implant and adopt active material so that detect.Yet this still is not a gratifying solution in the pasture.
Generally speaking, one object of the present invention is to provide a kind of implant that is used for continuing discharging to import the system of animal body, and this system can avoid the defective of existing this type systematic.Special this system can import implant in large numbers of animal bodies, and does not exist in the danger of propagating infection or disease therebetween.
Another object of the present invention is that the medicine that is contained in the implant that imports in the animal body can keep a period of time constantly in animal body, although drug depletion, exist or they import in fact but be easy to detect their, and needn't use complicated instrument.
Another purpose of the present invention is that the implant that will one or more medicines be housed is expelled in the subject animal body, and does not need with same instrument many animals to be carried out the puncture of invasive.
A further object of the present invention is to provide a kind of system and device that is used for the implant of powder charge thing is imported subject animal body, and this system and device use simple, convenient and reliable, and structure is more cheap.
According to the present invention, a kind of administrator that the drug delivery implant is housed is provided, it can import and implant a given position of subject animal body easily, and for example the pig ear is subcutaneous, and needn't use the apparatus that can encroach on subject animal body.
According to a preferred embodiment of the present invention, this administrator is a hollow circular cylinder and a solid head that is made of plastics, and this head is also cylindrical haply.The surface of administrator head is spill and edge surface that it exposes has a fillet, and this fillet begins and downward-sloping and from hollow body forward from administration body top edge.This forms long narrow blade in the head bottom, its front forms a sharp chisel edge and controlled animal body so that administrator pierces through.
On each limit of administrator head, has the stable gentle wing.The stable gentle wing outwards opens and towards hollow cylinder backward, and the effect of playing a latch fitting or barb is drawn out after being controlled animal body to prevent that administrator from entering.
The hollow body of administrator preferably is made of the serpentine pipe of a plurality of coil coileds.This can make body have to a certain degree flexibility so that the administrator shape change to adapt with the position that is launched into of being controlled animal body.This coil also can make the administration body provide certain rigid when being controlled animal body to enter by compression under the administrator pressurized at length direction.One or more implants that same medicine or different pharmaceutical are housed are positioned at hollow body.Between administrator head and body, have a passage with controlled animal body fluid and be communicated with implant fluid ground.One end cap frictionally is assemblied on the opening at body rear portion.The administrator of injecting whether exist can with the naked eye detect or touch controlled animal body be launched into position (for example ear).
Characteristics of the present invention have provided the administrator that a kind of energy sees through body fluid, and this administrator has carried the implant that one or more medicines are housed, and administrator itself directly implantation controlled in the animal body, as pig.
Another characteristics of the present invention are that the administrator that is used to carry one or more implants can see through body fluid and comprise a head, and this head has the blade of band sharp tip and controlled animal body to thrust.The administration body is equipped with one or more carrying will be discharged into the implant of being controlled the intravital medicine of animal, be controlled in the animal body and while portability implant so that administrator is easy to inject.
Another characteristics of the present invention are to be used for one or more implants are taken to being controlled the intravital administrator of animal and seeing through body fluid, and has a body, this body can be hard and inflexible in animal body is controlled in insertion the time, and its length direction is inflatable has flexibility after in animal body is controlled in insertion.
Another characteristics of the present invention are whether the administrator of having injected that the drug delivery implant is housed exists to be controlled and can with the naked eye record easily in the animal body or record by this part health that animal is controlled in touch.
The summary of accompanying drawing
Can understand other purpose of the present invention and advantage more with reference to the following description, wherein:
Fig. 1 is the vertical view of administrator preferred embodiment of the present invention;
Fig. 2 is the side view of administrator shown in Figure 1;
Fig. 3 is along Fig. 2 center line 3-3 and along the being seen sectional view of the direction of arrow;
Fig. 4 is the front view of administrator among Fig. 2;
Fig. 5 is the local diagrammatic sketch of the amplification of an administrator part among Fig. 1, shows the coil of body by compression;
Fig. 6 is an overall top perspective view, shows the toughness of administrator body and the compression of the administrator wing;
Fig. 7 is and the similarly overall side isometric view of Fig. 6;
Fig. 8 is the vertical view according to administrator injecting systems of the present invention or administrator applicator;
Fig. 9 is the left side view of the injecting systems of Fig. 8, and part is cutd open the further internal structure that shows this system with showing;
Figure 10 is the ear of the being controlled animal partial section of tailing edge line 9-9 shown in Figure 8 gained of having bored a hole, and the situation when showing administrator and beginning to insert; And
Figure 11 is and the similar view of Fig. 9, shows the situation that administrator inserts fully.
The detailed description of invention
Referring to Fig. 1-7, administrator 10 comprises a roughly cylindrical generally solid head 20 and a hollow tube 30.This administrator be preferably make by the suitable plastic material of biofacies, for example Merlon.Integral type is preferably made and be preferably to this administrator 10 by injection moulding.Administrator head 20 is solid member, has an end face 22, and this end face is to be bowed downward to a spoonful shape from the rear end 23 that body 30 front ends begin.What rear end 23 began from the head is a surface, and this surface is a recessed round portion 24 and extends to a more shallow inclined surface 26.This surface stops with an elongated narrow blade 27 that stretches out, and this blade has the sharp cutting limit 28 with downward oblique angle 29.The bottom surface of blade 27 is crooked.One plow-shape part 25 forms from the changeover portion of narrow blade 27 (see figure 1)s to cylindrical administration body 30, and serves one hereinafter with the purpose of describing in detail.
The pair of flexible wing 40 is formed on the outer surface of head 20, and begins at inclined surface 26 places.All sweepback and the front end that be stacked in body 30 of the wing 40.The wing 40 has a tip edge 41 and is in the horizontal plane, and shown in Fig. 2-4, it is along the longitudinal centre line of administrator body 30 and is parallel to and plane that body bottom is tangent, as shown in Figure 2.As can be seen from Fig. 1, each wing 40 has a compensating groove 42, and its relative body slopes inwardly and the terminal rounded basically end 44 that ends at.This groove 42 can make the wing curve inwardly.This can prevent the wing 40 stress that bending is produced when animal body is controlled in the administrator insertion.
Body 30 be one by the wire turn 32 of a plurality of coilings in a spiral manner form to form a hollow pipe.Each wire turn 32 of this coil has the relative retainer of tab-like 34.This tab portion 34 has the curved shape identical with each circle of coil and preferably separates 90 ° around each side of each coil turn.The retainer 34 of a coil turn is in the face of the retainer of the adjacent windings circle that is close to, and controlled in insertion at body 30 and to constrain in together when length direction is compressed in the intravital process of animal, as shown in Figure 5.
One or more implantation packing 50 (Fig. 1 and 3) are arranged in body 30 and nutrition class or medicine class supplement or its both mixture of the required dosage of arbitrary kind are housed.This packing 50 all is to fill in the body 30 by the body opening away from head 20.Hemispherical end cap 54 borrows frictional force to be assembled to that end away from the body 30 of head.
Hole 60 can provide one from the head 20 end faces 22 to the communication passage of body 30 inside.So, when administrator inserts when being controlled animal body, between the packing 50 in the body fluid of being controlled animal body and the implant, have being communicated with of liquid so that the content in packing is discharged into is controlled in the animal body.
Fig. 6 and 7 illustrates the flexibility of body 30 under all directions.This can make administrator and be controlled animal body and adapt, and that part of health of band administrator can proper motion with avoid being controlled owing to administrator makes that animal body does not feel well, irriate or repulsion.In Fig. 6, the pressured state of the wing 40 shown in broken lines.
Fig. 8 is the plane graph that adopts the preferred embodiment of an implant administrator applicator of the present invention or insertion system 90, and Fig. 9 is that the side view that shows of partial cutaway is to illustrate the further structure of applicator system under the user mode.System 90 comprises a main body 91 substantially, and this main body comprises that one is used to hold the chamber (not shown) of an administrator 10.At an end of main body 91, a platen 92 is arranged, this platen keeps pivoting with relative main body 91 by a hinge member 98.Also comprise a propulsive mechanism (not shown) with platen 92 rightabout main bodys 91, this propulsive mechanism can start, provide a propulsive force by the administrator 10 of a push rod 59 in main body 91, and administrator is quickened to platen 92.This propulsive mechanism can be the mechanism of any traditional type, but is preferably the device of a spring-operated, and it can adopt a starter to load release then.Preferably referring to Fig. 8-10, main body 91 comprises a top 93, and this top has a hole 97, and administrator 10 quickens to platen 92 therein.By hinge member 98, platen 92 can main body 91 pivots be to hold the ear (E) of being controlled animal relatively easily, and administrator 10 inserts wherein.Ear (E) is kept being flattened on platen 92 end faces by arm 99 then, and arm 99 is pasting ear, and ear is 90 ° of bendings in outlet (in the projection periphery) the place ahead in hole 97.Under this state, ear is fastened solid between platen 92 and supporting leg 95.
To introduce the use of administrator 10 now.Though be described in conjunction with administrator is inserted pig ear, administrator can be applicable to other position of animal body or other animal, comprises cattle, sheep, goat or other domestic animal, and performing animal or wild animal.In Fig. 9 and 10, landing slab 92 is relative with the supporting leg 95 that stretch downwards at top 93.Pig ear (E) fastened solid platen 92 and supporting leg 95 between, and keep a plan-position and be 90 ° of bendings in table top.
In use, platen 92 preferably suitably is biased in the below in hole 97, and this hole so that credulous bone parallel with platen aligns with 97 bottoms, hole basically or be lower than bottom, hole (promptly outside the projection periphery in hole).
Administrator 97 is injected the end face that ear (E) exposes from the hole.Because the bottom surface of edge bends is parallel with platen 92 basically with the wing 40, and administrator is advanced to pierce through ear with an enough big speed by propulsive mechanism 94.The skin of ear (E) was cut on narrow, the sharp chisel limit 28 of administrator with the resistance of minimum.Run-off the straight slightly when the transdermal of administrator front portion.When administrator is advanced further under skin, but recessed round portion 24 and bottom plow-shape part 25 compensations are so that the downward power that neutralizes.Suffered resistance raises administrator on the top margin 23, and makes it to pass the upper surface of cartilage.Recessed round portion 24 and the wing 40 drew cartilage with administrator, and prevented that blade 27 from passing cartilage.Below will introduce the structure in these different institutions in more detail.
Shallow rake 26 of the inner of narrow blade 27 and recessed round portion 24 form an obstacle and rising chisel limit 28.Because its shape, plow-shape part 25 further make cutting edge 28 raise and prevent that it from penetrating cartilage.Oblique angle 29 continues to make cartilage downward bias, and cutting edge 28 continues to cut tissue in the administrator insertion process simultaneously.Slip over along cartilage surface when as a result, administrator advances.The wing 40 can make administrator direction and slow-roll stabilization when inserting.They also have an interlock feature in case animal body is controlled in the administrator insertion.In the administrator insertion process, the wing 40 is all to invagination (as shown in phantom in Figure 6).After inserting ear, the wing its external position (shown in the solid line among Fig. 6) that turns back again.The wing can make administrator keep stable after being controlled animal body entering.This can make administrator keep suitable rectilinearity and make resistance minimum when entering.The relief angle 46 (Fig. 6) of the wing 40 retrains the wing and bodily tissue and opens when the administrator adverse movement, thereby produces interlock feature.
In the administrator insertion process, the coil 32 of body constrains in together (as shown in Figure 3) along body length direction pressurized until stopper section 34, and this is because the high acceleration that produced of propulsive mechanism 94 acts on administrator causes.This can make administrator flatten so that becoming a rigid body when being controlled animal body near entering.Because administrator is in ear, controlled the body fluid of animal, for example blood and be communicated with by head channel 60 between the implantation in the body 30 packs 50.This can be convenient to the implant content and be discharged into and controlled animal body.
After entering, in case administrator is oriented when being controlled the outer any motion of animal body, because the effect of locking wings can prevent that administrator breaks away from animal body fully.The coil turn of body can be separated when ear is movable to a certain extent, and the administration body can be consistent with ear better like this.This also can make implants packing 50 and is controlled animal body fluid other being communicated with arranged.
Constraint ball portion 57 (Figure 10) the forward location of the spheroidal of body end cap 54 and the push rod of filling gun 59.This may command direction and prevent that end cap 54 from lateral sliding taking place when administrator is finished its motion that enters ear.
The existence of administrator 10 can be detected or be detected by being launched into the position by touch by naked eyes in being subjected to animal body.Additional measure is that administrator can comprise a little metal or magnetics so that detect with metal or magnetic tester or analogous instrument.This administrator can comprise that also a simple electrode is to assist to detect and know thing.
The size of administrator 10 certainly is taken at many factors, comprise the size and the quantity of contained implant, the kind of being controlled animal, administrator insertion depth, pierce through and controlled zoodermic required insertion force etc.When for example acting on pig ear, shown in Fig. 8 and 9, administrator 10 total lengths are about 45 millimeters, and external diameter is about 7 millimeters.
Though for ease of explanation, below in conjunction with preferred embodiment the present invention is described, but for skilled person in the art, only otherwise break away from, also can make a lot of modification, variation and substitute by determined scope of the present invention of appended claims and design.For example, if not necessity, administrator 10 need not quickened enter to be controlled in the animal body by propulsive mechanism.The substitute is, can in being controlled animal body, cut a little otch and administrator is injected in the animal body under low speed, for example artificially action advances bar 59.

Claims (24)

1. implant administrator that is used to insert animal body comprises:
One has the head of device of the animal body tissue that is used to puncture so that whole administrator enters animal body basically.
Body with the chamber that is used to hold at least one drug delivery implant; Described body can make the intravital fluid of described animal see through so that fluid enters in the described chamber.
2. implant administrator as claimed in claim 1 is characterized in that described head comprises a front end, works out body and comprises a rear end, and described front end is enough sharp to pierce through bodily tissue.
3. implant administrator as claimed in claim 2 is characterized in that described head has an outer surface, is crooked shape and comprises a concave surface.
4. implant administrator as claimed in claim 3 is characterized in that, the front end of described head is an elongated blade, has the scalpriform top of a band to inner bevel.
5. implant administrator as claimed in claim 4 is characterized in that, described head surface has recessed round portion that begins from the blade rear end and the arch circle portion of stretching to the head rear end from described recessed round portion.
6. implant administrator as claimed in claim 2 is characterized in that described body is flexible.
7. implant administrator as claimed in claim 6 is characterized in that, there is an opening body end that also is included in away from head, inserts described body to allow any implant.
8. implant administrator as claimed in claim 1 is characterized in that, also comprises the passage that leads to described body inside from described head.
9. implant administrator as claimed in claim 1 is characterized in that, comprises that also at least one stretches to the stabilizer of described body from the described head back side.
10. implant administrator as claimed in claim 9 is characterized in that, has a pair of coplanar basically stabilizer at described head opposite side.
11. implant administrator as claimed in claim 10 is characterized in that, each described wing has a groove that begins in its rear rim, and parallel with the body the longitudinal axis basically so that wing of this groove is inwardly towards the body bending.
12. implant administrator as claimed in claim 1 is characterized in that, comprises that also one is used to seal the blocking away from the described body rear end of described head.
13. implant administrator as claimed in claim 1 is characterized in that, comprising:
The head that has front-end and back-end and an elongated blade is arranged at its front end;
The one gentle body that is made of coil method is arranged in described head rear end;
At least one implant is arranged in described body; And
Run through described head have a passage with described body internal communication.
14. implant administrator as claimed in claim 1 is characterized in that, comprising:
One head comprises the front end of described administrator and has and is used to pierce through systemic device so that whole administrator enters in the health basically;
One flexible pipe body comprises the rear end of described administrator and has the chamber that is used to hold at least one drug delivery implantation container;
One from the passage of described head to described body inside, thinks that the intravital fluid of described animal enters described chamber passage is provided; And
Insert described body at opening to allow an implant away from the body end of head.
15. the intermixture that will continue to discharge is implanted the intravital method of animal, described method is by finishing as claim 1 or 13 or 14 described implant administrators, and this method may further comprise the steps:
The drug delivery implant that described lasting release intermixture is housed is introduced described chamber; And
With the inside that described implant administrator inserts a part of described animal body, administrator just entirely is arranged in described body part like this.
16. method as claimed in claim 15 is characterized in that, described body part is the ear of an animal, and described inserting step comprises:
Fixing described ear, selected part is extended along the progress path of described administrator on it like this, and the adjacent part lateral extensometer is crossed described passage, thereby described ear is curved be exposed at described administrator at an angle before; And
Described administrator is advanced towards described ear, and it enters angled part and advances along selected part like this.
17. a system that is used for an implant administrator is injected a position of animal body, this position is that one deck soft tissue on skeleton or cartilage constitutes, and comprising:
One housing has an elongated hole and can hold administrator and stopping in described housing in open front;
Be used for and keep the platen device of body part;
Be used to make the localized device of the described relatively housing of described platen device, body part is positioned in described opening the place ahead like this, and its cartilage or skeleton are in the projection peripheral outer in hole; And
The device that is communicated with described hole, close described housing rear portion is to act on acceleration forward on the administrator that is contained in the described hole.
18. system as claimed in claim 17, it is characterized in that, also the length direction with described hole is vertical basically also to comprise first containment surfaces that is formed on the described housing, one is formed on the second relative containment surfaces on the described platen device, describedly is used for localized device and acts on described housing and above solid between described first and second containment surfaces so that body part is fastened.
19. system as claimed in claim 18, it is characterized in that, also comprise the 3rd containment surfaces that is formed on the described platen device with described second containment surfaces of perpendicular, described platen device is positioned to described the 3rd containment surfaces and retrains described body part and hold it in the projection periphery in described hole.
20. a system that is used for the implant administrator of claim 1 or 13 or 14 is injected the animal body part that is made of the soft tissue layer of covering on skeleton or cartilage comprises:
One housing has and is used for holding administrator and in the intravital elongated hole that stops to open front of described shell;
Be used to hold and keep the platen device of body part;
Be used to make the localized device of the described relatively housing of described platen device, described like this health portion is positioned at described opening the place ahead, and its cartilage or skeleton are positioned at outside the projection periphery in described hole; And
The device that is communicated with the described hole at close described housing rear portion is to act on acceleration forward on the administrator that is contained in the described hole.
21. one kind is used for medicine is implanted the intravital method of animal, this said method comprising the steps of with being finished by the described system of claim 17:
Make the described relatively housing of described platen device location, health portion remains on the described platen device and is in described opening the place ahead like this, and its cartilage or skeleton are in outside the projection periphery in hole;
In described hole, put into an implant that described medicine is housed; And
Adopt described to the described administrator application of force, quicken to make it to break away from described open front.
22. one kind is used for medicine is implanted the intravital method of animal, this method is finished by the system of the implant administrator that is used to inject claim 1 or 13 or 14, the animal body part is one deck soft tissue on skeleton or the cartilage, described system comprises the housing with an elongated hole, this elongated hole is used for holding administrator and stops in the intravital open front of shell, be used to hold and keep the platen device of body part, the device that is used for making the described platen device localized device of described relatively housing and is communicated with hole near described housing rear portion applies forward an acceleration with the administrator to described hole, said method comprising the steps of:
Make the described relatively housing of described platen device location, body part just remains on the described platen device and is in described opening the place ahead like this, and it owes bone or skeleton outside the projection periphery in hole;
One implant that described medicine is housed is put in the described hole; And
Adopt described device to the described administrator application of force, quicken to make it towards described open front and to break away from it.
23. the method for finishing by a system as claimed in claim 21, it is characterized in that also comprising that first containment surfaces that is formed on the described housing is also vertical with described hole length direction basically, and second a relative containment surfaces that is formed on described platen device, described body part is an animal ear, described positioning step also comprises locatees described platen device and housing mutually the first of described ear is fastened admittedly between described first and second containment surfaces, is stating formation one bent angle on the ear near described open front place like this.
24. the method for finishing by a system as claimed in claim 23, it is characterized in that, comprise that also one is formed on the 3rd containment surfaces on the described platen device with vertical with described second containment surfaces basically, described positioning step also comprises the second portion that makes the described relatively housing of described platen device location, described like this 3rd containment surfaces retrain described ear and the selection area of described ear is remained in the projection periphery in described hole.
CN96194345A 1995-06-07 1996-06-05 Injection dart system Pending CN1186448A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/473,346 1995-06-07
US08/473,346 US5868699A (en) 1995-06-07 1995-06-07 Injection dart system
US08/473,347 1995-06-07
US08/473,347 US5725497A (en) 1995-06-07 1995-06-07 Injection dart system

Publications (1)

Publication Number Publication Date
CN1186448A true CN1186448A (en) 1998-07-01

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Application Number Title Priority Date Filing Date
CN96194345A Pending CN1186448A (en) 1995-06-07 1996-06-05 Injection dart system

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EP (1) EP0956079A4 (en)
JP (1) JPH11506668A (en)
KR (1) KR19990022725A (en)
CN (1) CN1186448A (en)
AU (1) AU712482B2 (en)
BG (1) BG63001B1 (en)
BR (1) BR9609406A (en)
CA (1) CA2221329A1 (en)
HU (1) HUP9900855A3 (en)
IL (1) IL122465A0 (en)
MX (1) MX9709307A (en)
NZ (1) NZ310689A (en)
PL (1) PL323721A1 (en)
TW (1) TW305765B (en)
WO (1) WO1996040351A1 (en)

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US7615234B2 (en) 2001-09-11 2009-11-10 Glide Pharmaceutical Technologies Limited Drug delivery technology
GB2379390B (en) * 2001-09-11 2005-01-26 Caretek Medical Ltd A novel drug delivery technology
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NZ310689A (en) 1999-11-29
EP0956079A1 (en) 1999-11-17
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MX9709307A (en) 1998-02-28
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HUP9900855A2 (en) 1999-06-28
AU6152096A (en) 1996-12-30
BG63001B1 (en) 2001-01-31
EP0956079A4 (en) 2001-04-25
TW305765B (en) 1997-05-21
HUP9900855A3 (en) 2000-09-28
WO1996040351A1 (en) 1996-12-19
BR9609406A (en) 1999-05-11
JPH11506668A (en) 1999-06-15
CA2221329A1 (en) 1996-12-19
PL323721A1 (en) 1998-04-14
IL122465A0 (en) 1998-06-15
KR19990022725A (en) 1999-03-25

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