CN118557730A - 抑制ras的方法 - Google Patents

抑制ras的方法 Download PDF

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Publication number
CN118557730A
CN118557730A CN202410561373.XA CN202410561373A CN118557730A CN 118557730 A CN118557730 A CN 118557730A CN 202410561373 A CN202410561373 A CN 202410561373A CN 118557730 A CN118557730 A CN 118557730A
Authority
CN
China
Prior art keywords
optionally substituted
membered
alkyl
hydrogen
ras
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202410561373.XA
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English (en)
Chinese (zh)
Inventor
K·西蒙
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ruixin Pharmaceutical Co
Original Assignee
Ruixin Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ruixin Pharmaceutical Co filed Critical Ruixin Pharmaceutical Co
Publication of CN118557730A publication Critical patent/CN118557730A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05Dipeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07Tetrapeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN202410561373.XA 2021-05-25 2022-05-25 抑制ras的方法 Pending CN118557730A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202163192837P 2021-05-25 2021-05-25
US63/192837 2021-05-25
CN202280050079.1A CN117715658A (zh) 2021-05-25 2022-05-25 抑制ras的方法
PCT/US2022/030823 WO2022251292A1 (en) 2021-05-25 2022-05-25 Methods for inhibiting ras

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN202280050079.1A Division CN117715658A (zh) 2021-05-25 2022-05-25 抑制ras的方法

Publications (1)

Publication Number Publication Date
CN118557730A true CN118557730A (zh) 2024-08-30

Family

ID=82115695

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202410561373.XA Pending CN118557730A (zh) 2021-05-25 2022-05-25 抑制ras的方法
CN202280050079.1A Pending CN117715658A (zh) 2021-05-25 2022-05-25 抑制ras的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202280050079.1A Pending CN117715658A (zh) 2021-05-25 2022-05-25 抑制ras的方法

Country Status (11)

Country Link
US (1) US20240277796A1 (https=)
EP (1) EP4346898A1 (https=)
JP (1) JP2024521774A (https=)
KR (1) KR20240026526A (https=)
CN (2) CN118557730A (https=)
AU (1) AU2022281343A1 (https=)
CA (1) CA3219533A1 (https=)
IL (1) IL308771A (https=)
MX (1) MX2023013912A (https=)
TW (1) TW202313631A (https=)
WO (1) WO2022251292A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2022005359A (es) 2019-11-04 2022-06-02 Revolution Medicines Inc Inhibidores de ras.
MX2023003060A (es) 2020-09-15 2023-04-05 Revolution Medicines Inc Derivados indolicos como inhibidores de ras en el tratamiento del cancer.
AU2022268962A1 (en) 2021-05-05 2023-12-14 Revolution Medicines, Inc. Ras inhibitors for the treatment of cancer
AR127308A1 (es) * 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
CN118922423A (zh) * 2022-01-10 2024-11-08 锐新医药公司 Ras抑制剂
CN119301132A (zh) * 2022-06-01 2025-01-10 豪夫迈·罗氏有限公司 用于治疗癌症的卤代吲哚大环化合物
CN119522225A (zh) 2022-09-29 2025-02-25 广州嘉越医药科技有限公司 大环衍生物及其应用
CR20250329A (es) 2023-02-14 2025-09-12 Hoffmann La Roche Compuestos tricíclicos para el tratamiento del cáncer
EP4687905A1 (en) * 2023-03-30 2026-02-11 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof
TW202446387A (zh) * 2023-04-06 2024-12-01 瑞士商赫孚孟拉羅股份公司 用於治療癌症之三環化合物
AU2024265078A1 (en) 2023-05-04 2025-12-11 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
WO2025019318A2 (en) * 2023-07-14 2025-01-23 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2025162395A1 (zh) * 2024-02-01 2025-08-07 山东先声生物制药有限公司 吲哚衍生物作为ras抑制剂及其应用
CN119431325A (zh) * 2024-10-31 2025-02-14 诚达药业股份有限公司 一种3-(1h-吡唑-1-基)氮杂环丁烷类化合物及其合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210116479A (ko) 2018-12-21 2021-09-27 레볼루션 메디슨즈, 인크. 공동 결합에 참여하는 화합물 및 그의 용도
DE102019122206B4 (de) 2019-08-19 2021-07-08 Webasto SE Dachmodul zur Bildung eines Fahrzeugdachs mit Umfeldsensor
MX2022005359A (es) 2019-11-04 2022-06-02 Revolution Medicines Inc Inhibidores de ras.
CN120699039A (zh) 2019-11-04 2025-09-26 锐新医药公司 Ras抑制剂
WO2021091956A1 (en) 2019-11-04 2021-05-14 Revolution Medicines, Inc. Ras inhibitors
MX2023003060A (es) 2020-09-15 2023-04-05 Revolution Medicines Inc Derivados indolicos como inhibidores de ras en el tratamiento del cancer.

Also Published As

Publication number Publication date
CN117715658A (zh) 2024-03-15
TW202313631A (zh) 2023-04-01
JP2024521774A (ja) 2024-06-04
MX2023013912A (es) 2024-02-12
US20240277796A1 (en) 2024-08-22
IL308771A (en) 2024-01-01
CA3219533A1 (en) 2022-12-01
WO2022251292A1 (en) 2022-12-01
EP4346898A1 (en) 2024-04-10
KR20240026526A (ko) 2024-02-28
AU2022281343A1 (en) 2023-11-30

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