CN118541381A - 产生自复制rna分子的方法 - Google Patents

产生自复制rna分子的方法 Download PDF

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Publication number
CN118541381A
CN118541381A CN202280089068.4A CN202280089068A CN118541381A CN 118541381 A CN118541381 A CN 118541381A CN 202280089068 A CN202280089068 A CN 202280089068A CN 118541381 A CN118541381 A CN 118541381A
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virus
cell
srrna
lnp
composition
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CN202280089068.4A
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Chinese (zh)
Inventor
N·S·王
S·J·米亚克-斯通纳
P·阿利亚赫马德
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Ripricote Biosciences
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Ripricote Biosciences
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141—Use of virus, viral particle or viral elements as a vector
    • C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2820/00—Vectors comprising a special origin of replication system
    • C12N2820/60—Vectors comprising a special origin of replication system from viruses

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  • Medicinal Chemistry (AREA)
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  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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CN202280089068.4A 2021-11-29 2022-11-28 产生自复制rna分子的方法 Pending CN118541381A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163283660P 2021-11-29 2021-11-29
US63/283,660 2021-11-29
PCT/US2022/080515 WO2023097317A1 (en) 2021-11-29 2022-11-28 Methods of generating self-replicating rna molecules

Publications (1)

Publication Number Publication Date
CN118541381A true CN118541381A (zh) 2024-08-23

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CN202280089068.4A Pending CN118541381A (zh) 2021-11-29 2022-11-28 产生自复制rna分子的方法

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US (1) US20250019745A1 (https=)
EP (1) EP4441075A4 (https=)
JP (1) JP2024544623A (https=)
KR (1) KR20240136943A (https=)
CN (1) CN118541381A (https=)
AU (1) AU2022396547A1 (https=)
CA (1) CA3239025A1 (https=)
IL (1) IL313199A (https=)
WO (1) WO2023097317A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120555511A (zh) * 2025-05-29 2025-08-29 杭州依思康医药科技有限公司 一种mRNA转录骨架载体及其在制备自扩增型mRNA疫苗中的应用
CN120924733B (zh) * 2025-10-14 2026-03-10 南京农业大学三亚研究院 一种用于同时检测chikv、bfv、rrv的三重荧光定量pcr检测试剂盒

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3061826A1 (en) * 2015-02-27 2016-08-31 Novartis AG Flavivirus replicons
US12083174B2 (en) * 2018-08-17 2024-09-10 Glaxosmithkline Biologicals Sa Immunogenic compositions and uses thereof
US20210363543A1 (en) * 2018-10-30 2021-11-25 Nantbio, Inc. Self Replicating RNA System
US20220054611A1 (en) * 2018-12-17 2022-02-24 Immune Design Corp. Pathogen-associated molecular pattern molecules and rna immunogenic compositions and methods of using the compositions for treating cancer
KR20230172527A (ko) * 2021-04-21 2023-12-22 레플리케이트 바이오사이언스, 인크. 범용 클로닝 어댑터를 함유하는 알파바이러스 벡터

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Publication number Publication date
EP4441075A1 (en) 2024-10-09
US20250019745A1 (en) 2025-01-16
KR20240136943A (ko) 2024-09-19
CA3239025A1 (en) 2023-06-01
JP2024544623A (ja) 2024-12-03
WO2023097317A9 (en) 2024-02-15
IL313199A (en) 2024-07-01
AU2022396547A1 (en) 2024-06-06
EP4441075A4 (en) 2026-03-18
WO2023097317A1 (en) 2023-06-01

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