CN118488942A - 用于制备半胱胺酒石酸氢盐的方法和由此获得的产物 - Google Patents
用于制备半胱胺酒石酸氢盐的方法和由此获得的产物 Download PDFInfo
- Publication number
- CN118488942A CN118488942A CN202280085685.7A CN202280085685A CN118488942A CN 118488942 A CN118488942 A CN 118488942A CN 202280085685 A CN202280085685 A CN 202280085685A CN 118488942 A CN118488942 A CN 118488942A
- Authority
- CN
- China
- Prior art keywords
- cysteamine
- cysteamine bitartrate
- crude
- bitartrate
- crystalline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C07C319/06—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols from sulfides, hydropolysulfides or polysulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/255—Tartaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163266021P | 2021-12-27 | 2021-12-27 | |
| US63/266,021 | 2021-12-27 | ||
| PCT/EP2022/087828 WO2023126376A2 (en) | 2021-12-27 | 2022-12-23 | Process for the preparation of cysteamine bitartrate and product so obtained |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118488942A true CN118488942A (zh) | 2024-08-13 |
Family
ID=84981754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280085685.7A Pending CN118488942A (zh) | 2021-12-27 | 2022-12-23 | 用于制备半胱胺酒石酸氢盐的方法和由此获得的产物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20230202975A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP4457210A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2025500525A (cg-RX-API-DMAC7.html) |
| CN (1) | CN118488942A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2023126376A2 (cg-RX-API-DMAC7.html) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4011233A (en) | 1973-06-28 | 1977-03-08 | Givaudan Corporation | 2-methyl-2-(4-methyl-3-pentene-1-yl) thiazolidine |
| IE49614B1 (en) | 1979-07-04 | 1985-10-30 | Sogo Pharm | Process for preparing mineral acid salt of cysteamines |
| ATE15668T1 (de) | 1980-12-12 | 1985-10-15 | Fine Organics Ltd | Verfahren zur herstellung von thiazolidinderivaten. |
| DE3742265A1 (de) | 1987-12-12 | 1989-06-22 | Basf Ag | Verfahren zur herstellung von cysteamin-saeureadditionssalzen |
| CN106146427A (zh) * | 2015-04-13 | 2016-11-23 | 安徽兴东化工有限公司 | 一种制备2,2-二甲基四氢噻唑的方法 |
| IT201600106709A1 (it) | 2016-10-24 | 2018-04-24 | Chemelectiva S R L | Procedimento per la preparazione di un’ammina solforata |
| US10251850B2 (en) * | 2017-01-11 | 2019-04-09 | Lupin Limited | Process for preparation of cysteamine bitartrate |
| IT201900025186A1 (it) | 2019-12-23 | 2021-06-23 | Farmabios Spa | Metodo per la purificazione di cisteammina |
-
2022
- 2022-12-23 EP EP22844174.7A patent/EP4457210A2/en active Pending
- 2022-12-23 JP JP2024538482A patent/JP2025500525A/ja active Pending
- 2022-12-23 US US18/087,969 patent/US20230202975A1/en active Pending
- 2022-12-23 WO PCT/EP2022/087828 patent/WO2023126376A2/en not_active Ceased
- 2022-12-23 CN CN202280085685.7A patent/CN118488942A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2025500525A (ja) | 2025-01-09 |
| US20230202975A1 (en) | 2023-06-29 |
| WO2023126376A3 (en) | 2023-09-14 |
| EP4457210A2 (en) | 2024-11-06 |
| WO2023126376A2 (en) | 2023-07-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |