CN118434417A - 环状磺酰胺核糖核苷酸还原酶(rnr)抑制剂及其用途 - Google Patents
环状磺酰胺核糖核苷酸还原酶(rnr)抑制剂及其用途 Download PDFInfo
- Publication number
- CN118434417A CN118434417A CN202280075394.XA CN202280075394A CN118434417A CN 118434417 A CN118434417 A CN 118434417A CN 202280075394 A CN202280075394 A CN 202280075394A CN 118434417 A CN118434417 A CN 118434417A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- compound
- stereoisomer
- tautomer
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163245718P | 2021-09-17 | 2021-09-17 | |
| US63/245,718 | 2021-09-17 | ||
| PCT/US2022/043660 WO2023043923A1 (en) | 2021-09-17 | 2022-09-15 | Cyclic sulfonamide ribonucleotide reductase (rnr) inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118434417A true CN118434417A (zh) | 2024-08-02 |
Family
ID=85603496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280075394.XA Pending CN118434417A (zh) | 2021-09-17 | 2022-09-15 | 环状磺酰胺核糖核苷酸还原酶(rnr)抑制剂及其用途 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20250002486A1 (https=) |
| EP (1) | EP4401728A4 (https=) |
| JP (1) | JP2024534420A (https=) |
| KR (1) | KR20240101555A (https=) |
| CN (1) | CN118434417A (https=) |
| AU (1) | AU2022345092A1 (https=) |
| CA (1) | CA3231660A1 (https=) |
| IL (1) | IL311458A (https=) |
| MX (1) | MX2024003258A (https=) |
| TW (1) | TW202328121A (https=) |
| WO (1) | WO2023043923A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2021325905A1 (en) | 2020-08-12 | 2023-04-13 | Boundless Bio, Inc. | Replication stress pathway agent compositions and methods for treating cancer |
| JP2025531147A (ja) * | 2022-09-13 | 2025-09-19 | バウンドレス バイオ，インク． | 環状スルホンアミドリボヌクレオチドレダクターゼ（ｒｎｒ）阻害剤およびその使用 |
| WO2025049814A2 (en) * | 2023-09-01 | 2025-03-06 | Boundless Bio, Inc. | Ribonucleotide reductase (rnr) compositions and methods of use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3466934T (pt) * | 2016-05-31 | 2024-04-30 | Taiho Pharmaceutical Co Ltd | Compostos de sulfonamida ou seus sais como inibidores da ribonucleótido-redutase para o tratamento de cancro |
| US20200405697A1 (en) * | 2017-11-29 | 2020-12-31 | Taiho Pharmaceutical Co., Ltd. | Antitumor Agent |
| MX2020005478A (es) * | 2017-11-29 | 2020-08-27 | Taiho Pharmaceutical Co Ltd | Compuestos de sulfonamida y usos de los mismos. |
| US20220226291A1 (en) * | 2019-05-29 | 2022-07-21 | Taiho Pharmaceutical Co., Ltd. | Combination Treatment of Cancer Using Sulfonamide Compound and Immune Regulator |
| US20240158383A1 (en) * | 2021-03-02 | 2024-05-16 | Boundless Bio, Inc. | Ribonucleotide reductase (rnr) inhibitors and uses thereof |
-
2022
- 2022-09-15 IL IL311458A patent/IL311458A/en unknown
- 2022-09-15 AU AU2022345092A patent/AU2022345092A1/en active Pending
- 2022-09-15 JP JP2024516798A patent/JP2024534420A/ja active Pending
- 2022-09-15 EP EP22870692.5A patent/EP4401728A4/en active Pending
- 2022-09-15 WO PCT/US2022/043660 patent/WO2023043923A1/en not_active Ceased
- 2022-09-15 CA CA3231660A patent/CA3231660A1/en active Pending
- 2022-09-15 US US18/692,503 patent/US20250002486A1/en active Pending
- 2022-09-15 TW TW111134951A patent/TW202328121A/zh unknown
- 2022-09-15 KR KR1020247012612A patent/KR20240101555A/ko active Pending
- 2022-09-15 CN CN202280075394.XA patent/CN118434417A/zh active Pending
- 2022-09-15 MX MX2024003258A patent/MX2024003258A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2022345092A1 (en) | 2024-04-04 |
| EP4401728A4 (en) | 2025-08-06 |
| MX2024003258A (es) | 2024-04-05 |
| EP4401728A1 (en) | 2024-07-24 |
| WO2023043923A1 (en) | 2023-03-23 |
| CA3231660A1 (en) | 2023-03-23 |
| JP2024534420A (ja) | 2024-09-20 |
| IL311458A (en) | 2024-05-01 |
| KR20240101555A (ko) | 2024-07-02 |
| TW202328121A (zh) | 2023-07-16 |
| US20250002486A1 (en) | 2025-01-02 |
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| Date | Code | Title | Description |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |