CN118374493A - 生成哺乳动物t细胞活化诱导型合成启动子(syn+pro)以改善t细胞疗法 - Google Patents

生成哺乳动物t细胞活化诱导型合成启动子(syn+pro)以改善t细胞疗法 Download PDF

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CN118374493A
CN118374493A CN202410174641.2A CN202410174641A CN118374493A CN 118374493 A CN118374493 A CN 118374493A CN 202410174641 A CN202410174641 A CN 202410174641A CN 118374493 A CN118374493 A CN 118374493A
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cells
promoter
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魏佳
迈克尔·C·延森
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Seattle Childrens Hospital
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CN202410174641.2A 2017-05-17 2018-05-15 生成哺乳动物t细胞活化诱导型合成启动子(syn+pro)以改善t细胞疗法 Pending CN118374493A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762507565P 2017-05-17 2017-05-17
US62/507,565 2017-05-17
CN201880047704.0A CN110913871B (zh) 2017-05-17 2018-05-15 生成哺乳动物t细胞活化诱导型合成启动子(syn+pro)以改善t细胞疗法
PCT/US2018/032800 WO2018213332A1 (en) 2017-05-17 2018-05-15 Generating mammalian t cell activation inducible synthetic promoters (syn+pro) to improve t cell therapy

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CN202410174641.2A Pending CN118374493A (zh) 2017-05-17 2018-05-15 生成哺乳动物t细胞活化诱导型合成启动子(syn+pro)以改善t细胞疗法
CN201880047704.0A Active CN110913871B (zh) 2017-05-17 2018-05-15 生成哺乳动物t细胞活化诱导型合成启动子(syn+pro)以改善t细胞疗法
CN202410163430.9A Pending CN118147137A (zh) 2017-05-17 2018-05-15 生成哺乳动物t细胞活化诱导型合成启动子(syn+pro)以改善t细胞疗法

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CN202410163430.9A Pending CN118147137A (zh) 2017-05-17 2018-05-15 生成哺乳动物t细胞活化诱导型合成启动子(syn+pro)以改善t细胞疗法

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US (2) US11851649B2 (https=)
EP (3) EP3624814A4 (https=)
JP (3) JP7264329B2 (https=)
CN (3) CN118374493A (https=)
AU (2) AU2018270156B2 (https=)
CA (1) CA3063695A1 (https=)
WO (1) WO2018213332A1 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4282419A1 (en) 2012-12-20 2023-11-29 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
EP3439675A4 (en) 2016-04-08 2019-12-18 Purdue Research Foundation METHOD AND COMPOSITIONS FOR CAR-T CELL THERAPY
WO2018160622A1 (en) 2017-02-28 2018-09-07 Endocyte, Inc. Compositions and methods for car t cell therapy
US20210130775A1 (en) * 2017-08-02 2021-05-06 Autolus Limited Cells expressing a chimeric antigen receptor or engineered tcr and comprising a nucleotide sequence which is selectively expressed
AU2018329741B2 (en) 2017-09-08 2025-02-20 Poseida Therapeutics, Inc. Compositions and methods for chimeric ligand receptor (CLR)-mediated conditional gene expression
US11311576B2 (en) 2018-01-22 2022-04-26 Seattle Children's Hospital Methods of use for CAR T cells
AU2019225174B2 (en) 2018-02-23 2025-11-20 Endocyte, Inc. Sequencing method for CAR T cell therapy
KR20210122814A (ko) * 2019-02-01 2021-10-12 시애틀 칠드런즈 호스피탈 디/비/에이 시애틀 칠드런즈 리서치 인스티튜트 조작된 유전자 발현을 조절하기 위한 미세환경 센서
EP3922721A4 (en) * 2019-03-12 2023-01-11 Chongqing Precision Biotech Company Limited PROMOTER REGULATED BY HYPOXIA AND ITS APPLICATION
WO2021231569A1 (en) * 2020-05-14 2021-11-18 Seattle Children's Hospital (dba Seattle Children's Research Institute) Dual promoter systems
WO2021259334A1 (zh) * 2020-06-24 2021-12-30 南京博望医药科技有限公司 自我调节型嵌合抗原受体及其在肿瘤免疫中的应用
US20240043868A1 (en) * 2020-09-21 2024-02-08 Fundación Pública Andaluza Progreso Y Salud Polynucleotide for physiological expression in t-cells
ES2901575A1 (es) * 2020-09-21 2022-03-22 Fund Publica Andaluza Progreso Y Salud Polinucleótido para expresión fisiológica en células T
KR20220113092A (ko) * 2021-02-05 2022-08-12 바이젠셀 주식회사 변형된 살해 세포, 이의 제조방법 및 이의 약제학적 용도
WO2022212879A1 (en) 2021-04-01 2022-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Il-13ra2 chimeric antigen receptors and methods of use
US20240207319A1 (en) 2021-05-06 2024-06-27 Ludwig Institute For Cancer Research Ltd Compositions and methods for immunotherapy
EP4377464A4 (en) * 2021-07-29 2025-07-09 Seattle Childrens Hospital D/B/A Seattle Childrens Res Institute SYNTHETIC NUCLEIC ACID ELEMENTS TO IMPROVE CAR-T CELL EFFICACY
US20250009802A1 (en) 2021-12-16 2025-01-09 Ludwig Institute For Cancer Research Ltd Antisense transfer vectors and methods of use thereof
CN116813794B (zh) * 2023-02-27 2024-07-12 武汉波睿达生物科技有限公司 共表达spi1的嵌合抗原受体及其应用
EP4694897A1 (en) * 2023-04-14 2026-02-18 Seattle Children's Hospital d/b/a Seattle Children's Research Institute Inducible programmed cell death-1 (pd1)-cytokine chimera for potentiated immune cell function
WO2024229126A2 (en) * 2023-05-01 2024-11-07 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Mutant interleukin 15 expressing immune cells
WO2024243460A1 (en) * 2023-05-23 2024-11-28 Abintus Bio, Inc. Vectors and methods for in vivo transduction
CN119530217A (zh) * 2023-08-30 2025-02-28 徐州医科大学 T细胞激活后特异诱导基因表达的重组启动子系统
CN120112648A (zh) * 2023-09-22 2025-06-06 京东方科技集团股份有限公司 一种免疫细胞的制备方法
WO2025076415A1 (en) * 2023-10-06 2025-04-10 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Inducible transgenes encoding intracellular molecules for modulating immune cell function
WO2025085511A1 (en) * 2023-10-18 2025-04-24 University Of Washington Systems and methods for polymer-mediated activation of engineered cells
WO2025199252A1 (en) * 2024-03-19 2025-09-25 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Inducible transcription factor expression for modulating immune cell function
WO2026025092A1 (en) * 2024-07-26 2026-01-29 Juno Therapeutics, Inc. Synthetic promoters for t cell expression

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2390399A1 (en) * 2000-12-27 2002-07-04 Geneka Biotechnology Inc. Methods for selecting and producing selective pharmaceutical compounds and compositions using an established genetically altered cell-based library responsive to transcription factors; genetic constructs and library therefor
CA2327581A1 (en) 2000-12-27 2002-06-27 Yves Blais Methods and compositions for the establishment of genetically altered cell-based library designed for monitoring transcriptional activity of compounds and molecules
WO2004031357A2 (en) * 2002-10-01 2004-04-15 Duke University Targeted tumor therapy by use of recombinant adenovirus vectors that selectively replicate in hypoxic regions of tumors
EP2046818A4 (en) * 2006-07-11 2010-03-03 Leap Biosciences Corp METHOD FOR THE SELECTIVE ENRICHMENT OF PROTEINS AND APPLICATIONS
US20110165568A1 (en) * 2009-12-31 2011-07-07 Life Technologies Corporation Sequences of e.coli 055:h7 genome
US10391126B2 (en) * 2011-11-18 2019-08-27 Board Of Regents, The University Of Texas System CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA
CA3285826A1 (en) 2012-02-22 2026-03-02 The Trustees Of The University Of Pennsylvania Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer
BR122020002986A8 (pt) * 2012-08-20 2023-04-18 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Método e composições para imunoterapia celular
DK2986311T3 (en) * 2013-04-18 2019-02-25 Tilt Biotherapeutics Oy IMPROVED ADOPTIVE CELL THERAPY
WO2015079053A2 (en) * 2013-11-29 2015-06-04 Ucb Biopharma Sprl Synthetic promoters
WO2015092024A2 (en) 2013-12-20 2015-06-25 Cellectis Method of engineering multi-input signal sensitive t cell for immunotherapy
US10611837B2 (en) * 2014-04-10 2020-04-07 Seattle Children's Hospital Transgene genetic tags and methods of use
JP6827319B2 (ja) 2014-05-08 2021-02-10 中外製薬株式会社 Ｇｐｃ３標的治療剤療法が有効である患者に投与されるｇｐｃ３標的治療剤
KR20170068504A (ko) * 2014-10-08 2017-06-19 노파르티스 아게 키메라 항원 수용체 요법에 대한 치료 반응성을 예측하는 바이오마커 및 그의 용도
WO2016100575A1 (en) * 2014-12-16 2016-06-23 Board Of Regents Of The University Of Nebraska Gene therapy for juvenile batten disease
KR102624023B1 (ko) * 2015-02-24 2024-01-11 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 결합-촉발된 전사 스위치 및 이들의 이용 방법
JP6961490B2 (ja) * 2015-04-08 2021-11-05 ノバルティス アーゲー Ｃｄ２０療法、ｃｄ２２療法、およびｃｄ１９キメラ抗原受容体（ｃａｒ）発現細胞との併用療法
EP3288568A4 (en) * 2015-04-30 2019-01-02 University of Southern California Secretory tnt car cell immunotherapy
EP3347026A4 (en) * 2015-09-09 2019-05-08 Seattle Children's Hospital (DBA Seattle Children's Research Institute) GENEMANIPULATION OF MACROPHAGES FOR IMMUNOTHERAPY

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