CN118258675A - Reagent processing apparatus, method and sample analyzer - Google Patents

Abstract

The embodiment of the application provides a reagent processing device, a reagent processing method and a sample analyzer, wherein the reagent processing method comprises the following steps: an information acquisition mechanism for controlling the reagent processing device acquires reagent information corresponding to the reagent stored in the second reagent container in the second reagent storage position, and controls a reagent distribution mechanism of the reagent processing device to distribute a target solid reagent according to the information of the item to be detected of the sample analyzer and the reagent information; in a reagent dispensing period, a reagent dispensing mechanism of the reagent processing device is controlled to absorb the redissolved reagent from a first reagent container, and the redissolved reagent is discharged to a second reagent container carrying the target solid reagent so as to process the target reagent to form the target reagent.

Description

Reagent processing apparatus, method and sample analyzer

Technical Field

The application relates to the technical field of medical instruments, in particular to a reagent processing device, a reagent processing method and a sample analyzer.

Background

Since biological agents have reduced biological activity when stored at normal temperatures, the biological agents generally need to be stored and transported in a relatively severe low temperature environment, for example, in a low temperature environment of about-80 ℃ for a long period of time. Because the preservation condition of the biological agent is severe, the biological agent has the defects of high preservation cost, unfavorable long-distance transportation and the like.

In order to solve the inherent defects of high preservation cost and unfavorable long-distance transportation of biological agents, the biological agents are generally subjected to freeze drying treatment and are prepared into solid reagents such as freeze-dried preparations or dry powder preparations. The solid reagents need to be reconstituted prior to use to configure the formation of the corresponding liquid reagents. And the configured liquid reagent needs to be stored under the preset environment condition, and the storage time is limited, so that the reagent can be used in a waste way due to early reconstitution or removal from the preset environment.

In the prior art, manual reconstitution is usually adopted when solid reagents are reconstituted, however, the manual reconstitution may bring pollution, and the accuracy of sample analysis results can be affected when the polluted reagents are used for sample analysis.

Disclosure of Invention

The embodiment of the application mainly aims to provide a reagent processing device, a reagent processing method and a sample analyzer, and aims to realize accurate re-dissolution of a solid reagent so as to improve the accuracy and reliability of a sample analysis result.

In a first aspect, an embodiment of the present application provides a reagent processing apparatus, applied to a sample analyzer, including:

A reagent supply mechanism provided with a reagent placement site, the reagent placement site comprising a first reagent placement site for placing a first reagent container and a second reagent placement site for placing a second reagent container, wherein the first reagent container is used for storing a reconstituted reagent, and the second reagent container is used for storing a solid reagent;

the information acquisition mechanism is at least used for acquiring reagent information corresponding to the reagent stored in the second reagent container in the second reagent storage position;

the reagent distribution mechanism is used for distributing a target solid reagent, wherein the target solid reagent is a solid reagent to be treated;

a reagent dispensing mechanism for performing a reagent dispensing operation at least during a reagent dispensing cycle to dispense reagent to a corresponding reagent container; and

A controller for at least:

Controlling the information acquisition mechanism to acquire reagent information corresponding to a reagent stored in a second reagent container in a second reagent storage position, and controlling the reagent distribution mechanism to distribute the target solid reagent according to the information of a project to be detected of the sample analyzer and the reagent information;

During the reagent dispensing cycle, controlling the reagent dispensing mechanism to draw reconstituted reagent from the first reagent container and expel the reconstituted reagent to the second reagent container carrying the target solid reagent to process the target reagent to form a target reagent.

In a second aspect, embodiments of the present application provide a reagent processing method, the method comprising:

An information acquisition mechanism for controlling the reagent processing device acquires reagent information corresponding to the reagent stored in the second reagent container in the second reagent storage position, and controls a reagent distribution mechanism of the reagent processing device to distribute a target solid reagent according to the information of the item to be detected of the sample analyzer and the reagent information;

In a reagent dispensing cycle, a reagent dispensing mechanism of the reagent processing apparatus is controlled to draw reconstituted reagent from a first reagent container and expel the reconstituted reagent to a second reagent container carrying the target solid reagent to process the target reagent to form a target reagent.

In a third aspect, embodiments of the present application provide a sample analyzer, comprising:

reagent processing means for configuring at least a target reagent;

The separation device is used for separating a reaction liquid to obtain a sample to be detected, and the reaction liquid is formed by mixing at least the target reagent and the sample to be detected;

the detection device is used for detecting the sample to be detected to obtain a detection result; and

A controller;

Wherein the reagent processing apparatus comprises:

A reagent supply mechanism provided with a reagent placement site, the reagent placement site comprising a first reagent placement site for placing a first reagent container and a second reagent placement site for placing a second reagent container, wherein the first reagent container is used for storing a reconstituted reagent, and the second reagent container is used for storing a solid reagent;

the information acquisition mechanism is at least used for acquiring reagent information corresponding to the reagent stored in the second reagent container in the second reagent storage position;

the reagent distribution mechanism is used for distributing a target solid reagent, wherein the target solid reagent is a solid reagent to be treated;

a reagent dispensing mechanism for performing a reagent dispensing operation at least in a reagent dispensing cycle to dispense a reagent to a corresponding reagent container;

the controller is at least used for:

Controlling the information acquisition mechanism to acquire reagent information corresponding to a reagent stored in a second reagent container in a second reagent storage position, and controlling the reagent distribution mechanism to distribute the target solid reagent according to the information of a project to be detected of the sample analyzer and the reagent information;

During the reagent dispensing cycle, controlling the reagent dispensing mechanism to draw reconstituted reagent from the first reagent container and expel the reconstituted reagent to the second reagent container carrying the target solid reagent to process the target reagent to form a target reagent.

In a fourth aspect, an embodiment of the present application provides a reagent processing apparatus, including:

A reagent supply mechanism provided with a reagent placement site, the reagent placement site comprising a first reagent placement site for placing a first reagent container and a second reagent placement site for placing a second reagent container, wherein the first reagent container is used for storing a reconstituted reagent, and the second reagent container is used for storing a solid reagent;

the reagent distribution mechanism is used for distributing a target solid reagent, wherein the target solid reagent is a solid reagent to be treated;

a reagent dispensing mechanism for performing a reagent dispensing operation at least during a reagent dispensing cycle to dispense reagent to a corresponding reagent container; and

A controller for at least:

controlling the reagent dispensing mechanism to dispense a target solid reagent;

Controlling the reagent dispensing mechanism to draw reconstituted reagent from the first reagent container and expel the reconstituted reagent to the second reagent container carrying the target solid reagent during the reagent dispensing cycle to process the target reagent to form a target reagent;

And after the reagent dispensing mechanism finishes the operation of discharging the reconstituted reagent to the second reagent container, controlling the reagent dispensing mechanism to perform a uniform mixing operation on the target reagent in the second reagent container.

The embodiment of the application provides a reagent processing device, a reagent processing method and a sample analyzer, wherein in an implementation mode, the reagent processing device comprises a reagent supply mechanism and a reagent placing position, the reagent placing position comprises a first reagent placing position for placing a first reagent container and a second reagent placing position for placing a second reagent container, the first reagent container is used for storing a redissolved reagent, and the second reagent container is used for storing a solid reagent; the information acquisition mechanism is at least used for acquiring reagent information corresponding to the reagent stored in the second reagent container in the second reagent storage position; the reagent distribution mechanism is used for distributing a target solid reagent, wherein the target solid reagent is a solid reagent to be treated; a reagent dispensing mechanism for performing a reagent dispensing operation at least during a reagent dispensing cycle to dispense reagent to a corresponding reagent container; and a controller for at least: the control information acquisition mechanism acquires reagent information corresponding to the reagent stored in the second reagent container in the second reagent storage position, and controls the reagent distribution mechanism to distribute the target solid reagent according to the information of the item to be detected of the sample analyzer and the reagent information; in the reagent dispensing cycle, the reagent dispensing mechanism is controlled to draw reconstituted reagent from the first reagent container and expel reconstituted reagent to the second reagent container carrying the target solid reagent to process the target reagent to form the target reagent. According to the reagent processing device provided by the embodiment, the target solid reagent to be processed is determined according to the information of the item to be detected of the sample analyzer, in the process of re-dissolving the target solid reagent, a reagent re-dissolving mechanism is utilized to absorb a preset amount of re-dissolving reagent for re-dissolving the target solid reagent in a reagent re-dissolving period, and the re-dissolving reagent is filled into the target solid reagent, so that accurate re-dissolving of the target reagent is realized according to the requirement of the item to be detected.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for the description of the embodiments will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present application, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic block diagram of a sample analyzer according to an embodiment of the present application;

FIG. 2 is a schematic diagram showing the configuration of the cooperation of a reagent supply mechanism and an information acquisition mechanism of a reagent processing apparatus in a sample analyzer;

FIG. 3 is a schematic view showing the structure of a reagent dispensing mechanism of the reagent processing apparatus;

FIG. 4 is a schematic view showing a reagent dispensing mechanism of the reagent processing apparatus for dispensing a reagent into a reagent container;

FIG. 5 is a schematic view showing a case where a reagent dispensing mechanism of the reagent processing apparatus performs a mixing operation on a reagent in a reagent container;

FIG. 6 is a flow chart of steps of a reagent processing method according to an embodiment of the present application.

Detailed Description

The following description of the embodiments of the present application will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are some, but not all embodiments of the application. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.

In the description of the present application, unless explicitly stated and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present application will be understood in specific cases by those of ordinary skill in the art.

Some embodiments of the present application will be described in detail below with reference to the attached drawings, and the following examples and features of the examples may be combined with each other without conflict.

Referring to fig. 1, fig. 1 is a sample analyzer 100 according to an embodiment of the present application, configured to perform detection analysis on a sample to be detected to obtain a corresponding detection result, where the sample to be detected includes, but is not limited to, a nucleic acid sample and a blood sample.

As shown in fig. 1, the sample analyzer 100 includes a sample introduction device 10, a reagent processing device 20, a separation device 30, a detection device 40, and a controller 50. The reagent processing apparatus 10 is at least for performing a solid reagent reconstitution operation to reconstitute a solid reagent into a target reagent. The sample injection device 10 is used for performing a sample injection operation to supply a corresponding sample to be tested to a preset sample injection position. The separation device 30 is used for performing a sample separation operation to separate a reaction liquid formed by mixing at least a sample to be measured and a target reagent, thereby obtaining a sample to be measured. The detecting device 40 is used for performing a sample detecting operation to detect a sample to be tested, so as to obtain detection data.

The controller 50 communicates with the sample injection device 10, the reagent processing device 20, the separation device 30 and the detection device 40, and is used for controlling the corresponding devices to execute preset operation procedures respectively so as to realize respective preset functions. For example, the controller 50 controls the reagent processing apparatus 10 to perform a solid reagent reconstitution operation to reconstitute a solid reagent into a target reagent. The controller 50 controls the separation device 30 to perform a sample separation operation to separate a reaction liquid formed by mixing at least a sample to be measured and a target reagent, thereby obtaining a sample to be measured.

Alternatively, the controller 50 may be one or more, and may be integrated with or disposed in at least one of the sample injection device 10, the reagent processing device 20, the separation device 30, and the detection device 40, or may be disposed independently, which is not limited herein, and only needs that the controller 50 can control each device of the sample analyzer 100 to execute a corresponding preset operation procedure.

In some embodiments, the sample injection device 10 includes a sample sucking component and an information obtaining component, where the information obtaining component is configured to obtain information of a to-be-measured item corresponding to a to-be-measured sample carried in a sample tube, and the sample sucking component is configured to suck the to-be-measured sample from the sample tube and transfer the to-be-measured sample into a reaction tube.

For example, the sample to be tested is carried on the sample tube, and the corresponding information of the item to be tested of the sample to be tested is set on the outer wall of the sample tube through an information tag, where the information tag may be a two-dimensional code tag, a bar code tag or an RFID (Radio Frequency Identification ) tag, and is not limited herein. In the sample injection process, the information acquisition component scans the information label arranged on the sample tube, so that corresponding information of the item to be detected is obtained. Meanwhile, the sample sucking assembly can perform two-dimensional or three-dimensional movement in space, so that the sample sucking assembly can move to a sample sucking position to suck a sample to be detected loaded in a sample tube positioned at the sample sucking position, and the sample to be detected is discharged into a reaction tube, so that the sample to be detected loaded in the reaction tube reacts with a reagent to form a reaction liquid.

It will be appreciated that in some embodiments, the sample analyzer 100 may not require the sample introduction device 10, and the item information to be measured may be obtained by manually introducing sample through an input device connected to the sample analyzer 100. For example, before or after the sample is introduced, an operator inputs information of a to-be-measured item corresponding to a current to-be-measured sample to the sample analyzer 100 through an input device such as a keyboard, a mouse, a key, a touch panel, etc.

In some embodiments, the reagent processing apparatus 20 includes a reagent supply mechanism 21, an information acquisition mechanism 22, a reagent dispensing mechanism 23, and a reagent dispensing mechanism 24. Wherein the reagent supply mechanism 21 is provided with a reagent placement site 211, the reagent placement site 211 comprising a first reagent placement site 2111 for placing a first reagent container for storing a reconstituted reagent and a second reagent placement site 2112 for placing a second reagent container for storing a solid reagent. For example, the reagent supply mechanism 21 includes a reagent tray, on which at least a first reagent placement site 2111 for placing a first reagent container and a second reagent placement site 2112 for placing a second reagent container are provided, and optionally, the second reagent placement sites 2112 are plural, and plural kinds of solid reagents to be reconstituted are placed in the corresponding second reagent containers, and the sample analyzer can dispense the corresponding solid reagents according to the items to be tested of the sample to be tested.

Information acquisition means 22 for acquiring reagent information corresponding to the reagent stored in the corresponding reagent container in the reagent storage position, for example, the information acquisition means 22 is at least for acquiring reagent information corresponding to the reagent stored in the second reagent container in the second reagent storage position 2112.

As shown in fig. 2, a reagent label, which may be a two-dimensional code label, a bar code label, or an RFID label, is attached to the reagent container, the reagent label stores reagent information, and the information acquiring mechanism 22 acquires the reagent information stored in the corresponding reagent container by scanning the reagent label attached to the reagent container, for example.

The sample analyzer 100 is provided with a reagent information collection site at which the information acquisition mechanism 22 performs an information collection operation. In the process of acquiring reagent information corresponding to the reagent stored in the second reagent container, the reagent supply mechanism 21 currently drives the second reagent container to be identified as a target second reagent container to rotate to a reagent information acquisition position, and then the information acquisition mechanism 22 acquires reagent information of a reagent label on the target second reagent container, thereby acquiring a reagent type corresponding to the solid reagent stored in the target second reagent container.

A reagent dispensing mechanism 23 for dispensing a target solid reagent, which is a solid reagent to be treated. Alternatively, the reagent dispensing mechanism 23 is connected to the reagent supplying mechanism 21 for driving the reagent supplying mechanism 21 to rotate in a preset direction to rotate the reagent container on the corresponding reagent placing position in the reagent supplying mechanism 21 as the target reagent container to a preset position. For example, the reagent dispensing mechanism 23 drives the reagent supply mechanism 21 to move the first reagent container placed on the first reagent station 2111 to the reconstitution position so that the reagent dispensing mechanism 24 aspirates the reconstituted reagent into the first reagent container at the reconstitution position. Or the reagent dispensing mechanism 23 drives the reagent supplying mechanism 21 to move the second reagent container placed at the second reagent position 2112 to the reconstitution position so that the reagent dispensing mechanism 24 fills the solid reagent in the second reagent container with the reconstituted reagent at the reconstitution position to achieve reconstitution of the solid reagent.

For another example, the reagent dispensing mechanism 23 drives the reagent supplying mechanism 21 to move the second reagent container placed on the second reagent station 2112 to the reagent information collecting station so that the information acquiring mechanism 22 performs an information collecting operation on the second reagent container at the reagent information collecting station, thereby acquiring reagent information stored in the corresponding second reagent container.

The reagent dispensing mechanism 24 is at least for performing a reagent dispensing operation during a reagent dispensing cycle to dispense reagent to a corresponding reagent container.

Illustratively, the sample analyzer 100 is also provided with a reconstitution site at which the reagent processing apparatus 20 performs a reagent reconstitution operation. For example, after determining a target solid reagent to be processed from among a plurality of solid reagents, the controller 50 controls the reagent dispensing mechanism 23 to rotate the reagent supplying mechanism 21 and rotate the second reagent container carrying the target solid reagent to the reconstitution position, so that the reagent dispensing mechanism 24 sucks the corresponding reconstituted reagent from the first reagent container during the reagent dispensing cycle and fills the reconstituted reagent into the corresponding second reagent container, thereby achieving reconstitution of the target solid reagent in the corresponding second reagent container to obtain the target reagent.

Referring to fig. 3, in some embodiments, reagent dispensing mechanism 24 includes a reagent needle 241 and a power assembly 240 for powering reagent needle 241 for performing a reagent dispensing operation. The power assembly 240 includes a first driving mechanism 242 and a first pipetting driving unit 243. The first driving mechanism 242 is used for supporting the reagent needle 241 and driving the reagent needle 241 to move. For example, the reagent needle 241 is spatially moved in two or three dimensions by the two or three-dimensional first driving mechanism 242, so that the reagent needle 241 can be moved to suck up the reagent carried in the corresponding reagent container and discharge the reagent to the corresponding target reagent container.

The first pipetting drive unit 243 is configured to quantitatively aspirate a reagent through the reagent needle 241, for example, the reagent needle 241 is moved under the driving of the first driving mechanism 242 to below the liquid surface carrying the reconstituted reagent container, and quantitatively aspirate the reconstituted reagent under the driving of the first pipetting drive unit 243, and discharge the aspirated reconstituted reagent into the reagent container carrying the solid reagent, thereby achieving reconstitution of the solid reagent.

Optionally, the first driving mechanism 242 includes a supporting frame 2421, the supporting frame 2421 is fixed on the supporting rod 2422, the supporting rod 2422 can move vertically and rotate, and the supporting frame 2421 is driven by the supporting rod 2422 to realize vertical movement and horizontal rotation. The reagent needle 241 is disposed on the supporting frame 2421, and can reach the target position under the driving of the supporting frame 2421. The first driving mechanism 242 further includes a driver 2423 for driving the support bar 2422 to move, for example, a stepper motor, although the present invention is not limited thereto. Optionally, the reagent needle 241 is detachably connected, or fixedly connected, to the first drive mechanism 242.

Optionally, the first pipetting driving unit 243 includes a pipe 2431 and a power unit 2433, where the pipe 2431 is used for transporting a fluid medium, one end of the pipe 2431 is communicated with the reagent needle 241, and the other end is communicated with the power unit 2433, so that the flow direction of the fluid medium in the pipe 2431 is changed under the action of the power unit 2433, so that the reagent needle 241 can transfer a reagent.

In some embodiments, the reagent dispensing mechanism 24 is further configured to dispense a target reagent into the reaction tube carrying the sample to be measured during a reagent dispensing cycle, such that the target reagent and the sample to be measured within the reaction tube form a sample solution to be measured.

In some embodiments, the separation device 30 employs magnetic separation techniques to extract the components of interest from the reaction solution, thereby obtaining the test sample. The basic principle is that the surface of small particles with magnetic materials is utilized to adsorb required substances through treatment, then the waste liquid is discarded after the adsorption and enrichment of the magnetic materials by a magnet, the enriched magnetic beads are cleaned to further remove impurities and other unnecessary substances, the biological substances of interest are reserved because the biological substances are adsorbed on the magnetic beads, and finally the biological substances enriched on the magnetic beads are released into a required solution system under the preset condition, so that a sample to be tested is obtained.

After the sample to be tested is obtained, the sample to be tested is detected by the detection device 40, so that a corresponding detection result is obtained.

In some embodiments, the reagent processing apparatus 20 further includes a cleaning mechanism for performing a cleaning operation on the target device, e.g., for performing a cleaning operation on the reagent dispensing mechanism 24 that completes the reagent dispensing operation.

In some embodiments, the reagent processing apparatus 20 further includes a mixing mechanism for performing a mixing operation to better mix the solutions in the respective containers.

In some embodiments, the controller 50 includes at least a processor 501, a memory 502, a communication interface (not shown), and an I/O interface (not shown). The processor 501, memory 502, communication interfaces, and I/O interfaces communicate over a bus. The Processor 501 may be a central processing unit (Central Processing Unit, CPU), which may also be other general purpose processors, digital signal processors (DIGITAL SIGNAL Processor, DSP), application SPECIFIC INTEGRATED Circuit (ASIC), field-Programmable gate array (Field-Programmable GATE ARRAY, FPGA) or other Programmable logic device, discrete gate or transistor logic device, discrete hardware components, or the like. Wherein the general purpose processor may be a microprocessor or the processor may be any conventional processor or the like.

The memory 502 contains various computer programs such as an operating system and application programs for execution by the processor 501, and data necessary for execution of the computer programs. During analysis of the sample to be tested, data stored locally may be stored in memory 502, if desired. Meanwhile, the controller 50 invokes the computer program stored in the memory 502 through the processor 501, for controlling the corresponding devices and/or mechanisms in the sample analyzer to respectively execute the preset operation procedures so as to realize the respective preset functions.

The I/O interface includes, but is not limited to, serial interfaces such as USB, IEEE1394, or RS-232C, parallel interfaces such as SCSI, IDE, or IEEE1284, and analog signal interfaces composed of D/a converters, and the like. An input device is coupled to the I/O interface, and a user may directly input data to the controller 50 using the input device, including but not limited to a keyboard, mouse, touch screen, or control buttons. The communication interface may be an interface of any communication protocol known at present, the communication interface communicates with the outside through a network, and the controller 50 may transmit data with any device connected through the network through the communication interface in a preset communication protocol.

It will be appreciated that the controller 50, and in particular the processor 501 of the controller 50, invokes a computer program stored in the memory 502 in implementing the corresponding method steps, thereby implementing the corresponding method steps.

In some embodiments, the controller 50 is configured to implement the following method steps:

The control information acquisition means 22 acquires reagent information corresponding to the reagent stored in the second reagent container in the second reagent storage position 2112, and controls the reagent dispensing means 23 to dispense the target solid reagent based on the item information to be measured of the sample analyzer 100 and the reagent information;

during the reagent dispensing cycle, the reagent dispensing mechanism 24 is controlled to draw reconstituted reagent from a first reagent container and expel reconstituted reagent into a second reagent container carrying a target solid reagent to process the target reagent to form the target reagent.

Illustratively, the first reagent placement site 2111 houses a first reagent container for holding a reconstituted reagent, which may be configured according to the solid reagent to be reconstituted, e.g., the reconstituted reagent may be a diluent, deionized water. The second reagent placement site 2112 is used to place a second reagent container into which the solid reagent to be treated is placed, including but not limited to lyophilized reagents, such as PCR (Polymerase Chain Reaction ) lyophilized reagents.

When the sample analyzer 100 needs the reagent processing apparatus 20 to perform the reagent reconstitution operation, the controller 50 controls the information acquisition mechanism 22 of the reagent processing apparatus 20 to acquire reagent information corresponding to the reagent stored in the second reagent container in the second reagent storage position 2112 of the reagent supply mechanism 21, so as to determine reagent information corresponding to the solid reagent stored in the reagent supply mechanism 21 of the current reagent processing apparatus 20, and determines a target reagent required for detecting the sample to be detected according to the reagent information and the item information to be detected of the sample to be detected, and further controls the reagent distribution mechanism 21 to distribute the target solid reagent required for configuring the target reagent.

After the target solid reagent is dispensed, the reagent dispensing mechanism 24 is controlled to perform a target reagent configuration operation, that is, to suck the reconstituted reagent from the first reagent container and discharge the reconstituted reagent to the second reagent container carrying the target solid reagent, so as to process the target reagent to form the target reagent, thereby enabling the solid reagent to realize precise reconstitution according to the requirement of the item to be tested, and simultaneously avoiding the possibility that the advanced reconstitution of the solid reagent may cause waste of the reagent use time.

For example, after determining the solid reagent required for the target reagent, the reagent dispensing mechanism 23 drives the reagent supply mechanism 21 to move the first reagent container placed on the first reagent station 2111 to the reconstitution position so that the reagent dispensing mechanism 24 aspirates the reconstituted reagent into the first reagent container at the reconstitution position.

After the completion of the reconstitution reagent suction, the reagent dispensing mechanism 23 drives the reagent supplying mechanism 21 to move the second reagent container having the target solid reagent placed on the second reagent position 2112 to the reconstitution position, so that the reagent dispensing mechanism 24 injects the reconstituted reagent into the target solid reagent in the second reagent container at the reconstitution position to achieve the reconstitution of the target solid reagent.

Alternatively, the information of the item to be measured of the sample analyzer 100 may be obtained by the sample injection device 10 or may be input by an operator manipulating an input device.

Alternatively, the information acquiring mechanism 22 may acquire the reagent information corresponding to the reagent stored in the second reagent container, in such a manner that the reagent supplying mechanism 21 rotates the second reagent sites 2112 one by one to the reagent information acquiring site, so that the information acquiring mechanism 22 acquires the reagent information corresponding to the reagent stored in the second reagent container in each of the second reagent sites 2112 at the reagent information acquiring site.

Optionally, the information obtaining mechanism 22 may be movably configured, and the manner in which the information obtaining mechanism 22 obtains the reagent information corresponding to the reagent stored in the second reagent container may be that the controller 50 controls the information obtaining mechanism 22 to move to the second reagent position 2112 where the information is to be collected, and collect the reagent information corresponding to the reagent stored in the second reagent container in the current second reagent position 2112 until the collection of the reagent information corresponding to the reagent stored in the second reagent container in all the second reagent positions 2112 is completed.

In some embodiments, the controller 50 performs, in controlling the reagent dispensing mechanism 21 to aspirate the reconstituted reagent from the first reagent container and expel the reconstituted reagent to the second reagent container carrying the solid reagent of interest:

The reagent dispensing mechanism 21 is controlled to aspirate the reconstituted reagent from the first reagent container and to discharge the reconstituted reagent into the container wall of the second reagent container carrying the target solid reagent so that the reconstituted reagent flows along the container wall into the second reagent container.

Referring to fig. 4, for example, if there are more bubbles in the target reagent, the accuracy of reagent sucking may be affected, so that the reliability and accuracy of the later detection data are affected, so, in order to reduce the amount of bubbles generated in the process of re-dissolving the solid reagent, the reagent dispensing mechanism 21 drives the reagent needle 241 to move down to a position at a preset distance H from the bottom of the second reagent container after sucking the re-dissolved reagent from the first reagent container, and discharges liquid to the container wall of the second reagent container, so that the discharged re-dissolved reagent flows along the tube wall to the target solid reagent, and further reduces the amount of bubbles generated by mutual impact of the re-dissolved reagent and the solid reagent.

In some embodiments, after the reagent dispensing mechanism 24 completes the operation of expelling the reconstituted reagent to the second reagent container, the controller 50 is further configured to:

During a reagent dispensing cycle, the reagent dispensing mechanism 24 is controlled to perform a mixing operation on the target reagent in the second reagent container.

Alternatively, the reagent dispensing mechanism 24 performs a mixing operation and a target reagent dispensing operation, respectively, during different reagent dispensing cycles, wherein the target reagent dispensing operation includes aspirating reconstituted reagent from a first reagent container and expelling reconstituted reagent to a second reagent container carrying a target solid reagent to process the target reagent to form the target reagent.

Illustratively, after the target solid reagent is re-dissolved, the re-dissolved target reagent is further subjected to a mixing operation by the reagent dispensing mechanism 24, so that the mixing effect of the target solid reagent and the re-dissolved reagent is better, and the mixing operation is performed by the multiplexing reagent dispensing mechanism 24, so that a mixing mechanism for mixing the target reagent is not required to be independently arranged, thereby being beneficial to the miniaturization of equipment and saving the manufacturing cost of the equipment.

The reagent dispensing mechanism 24 performs a mixing operation on the target reagent, and may be that the reagent dispensing mechanism 24 blows gas to the target reagent to impact the target reagent to achieve mixing of the target reagent, or that the reagent dispensing mechanism 24 sucks and discharges the target reagent to achieve mixing of the target reagent.

In some embodiments, the reagent dispensing mechanism 24 includes a reagent needle 241 and a power assembly 240 coupled to the reagent needle 241 for powering the reagent needle 241 for performing a reagent dispensing operation;

the controller 50 performs, during the process of controlling the reagent dispensing mechanism 24 to perform the mixing operation on the target reagent in the second reagent container:

The power assembly 240 is controlled to drive the needlepoint of the reagent needle 241 to descend to a first position below the liquid level of the target reagent in the second reagent container, and the power assembly 240 is controlled to drive the reagent needle 241 to perform a sucking and spitting mixing operation on the target reagent so as to mix the target reagent.

In the process of sucking, spitting and mixing, the reagent needle 241 of the reagent dispensing mechanism 24 sucks the target reagent in the second reagent container, and discharges at least part of the sucked target reagent to the second reagent container, so that the target reagent in the second reagent container is impacted by the discharged target reagent, and mixing of the target reagent is realized.

Alternatively, the reagent dispensing mechanism 24 always has the tip of the reagent needle 241 below the liquid surface of the target reagent in the second reagent container during the execution of the pipetting mixing operation. Alternatively, the reagent dispensing mechanism 24 may be in the process of performing the pipetting mixing operation in which the tip of the reagent needle 241 is lowered to the first position below the liquid surface of the target reagent in the second reagent container, or in the process of the tip of the reagent needle 241 contacting the liquid surface of the target reagent and being lowered to the first position below the liquid surface of the target reagent in the second reagent container.

In some embodiments, the controller 50 performs, during controlling the power assembly 240 to drive the reagent needle 241 to perform the operation of mixing the target reagent by suction and discharge:

Controlling the power assembly 240 to drive the reagent needle 241 to perform at least one sucking and spitting mixing operation, wherein the reagent needle 241 sucks a first amount of the target reagent from the second reagent container and discharges at least a second amount of the target reagent to the second reagent container in each sucking and spitting mixing operation;

referring to fig. 5, in an exemplary process of mixing the target reagent, the power assembly 240 drives the reagent needle 241 to a first position below the liquid surface of the target reagent in the second reagent container, where a distance H1 exists between the tip of the reagent needle 241 and the bottom of the second reagent container, and the liquid surface of the target reagent in the second reagent container is H2, and the change of the liquid surface due to the entering of the reagent needle below the liquid surface is less affected, so that the change of the liquid surface due to the entering of the reagent needle below the liquid surface of the target reagent is ignored.

After the reagent needle 241 is below the level of the target reagent, the power assembly 240 drives the reagent needle 241 to aspirate a first amount of the target reagent, at which point the level of the second reagent container is H3.

After the first amount of target reagent is sucked, a second amount of target reagent is discharged to the second reagent container, and at this time, the liquid level of the second reagent container is H4, and the discharged target reagent impacts the target reagent loaded in the second reagent container, so that the target reagent is uniformly mixed. Optionally, the first amount is greater than or equal to the second amount, i.e. H2 > H3 > H4, e.g. the second amount is 0.4 to 0.9 times the first amount.

Alternatively, the controller 50 controls the power unit 240 to drive the reagent needle 241 to perform the suction and spit mixing operation at least 2 times below the liquid surface of the target reagent, and the target reagent amount discharged by the last suction and spit mixing operation of the reagent needle 241 is substantially equal to the sucked target reagent amount.

For example, the reagent needle 241 needs to perform M+1 mixing operations on the target reagent, M is greater than or equal to 2, and after performing M times of sucking and spitting mixing operations, in the M+1th mixing operation, after the reagent needle 241 is below the liquid surface of the target reagent, the power assembly 240 drives the reagent needle 241 to suck the first amount of the target reagent, and at this time, the liquid surface height of the second reagent container is H3. After the suction of the target reagent is completed, the power unit 240 drives the reagent needle 241 to discharge the first amount of the target reagent to the second reagent container, and at this time, the liquid level of the second reagent container is H4.

In some embodiments, the controller 50 is further configured to, prior to the tip of the reagent needle 241 being lowered into contact with the liquid level of the target reagent within the second reagent container:

The power assembly 240 is controlled to drive the reagent needle 241 to perform a protective medium sucking operation to suck a third amount of protective medium. Optionally, the protective medium is air, optionally, the third amount is greater than the first amount.

Illustratively, the target agent is isolated by inhalation of a protective medium to effectively protect the target agent from environmental factors.

In some embodiments, the reagent dispensing cycle includes a first actuation sub-cycle, the controller 50 further configured to:

in a first action sub-cycle in the kth reagent dispensing cycle, controlling the reagent dispensing mechanism 24 to aspirate reconstituted reagent from the first reagent container and discharge the reconstituted reagent to the second reagent container carrying the target solid reagent;

In the first action sub-period in the k+n-th reagent dispensing period, the reagent dispensing mechanism 24 is controlled to perform a mixing operation on the target reagent in the second reagent container, wherein N is not less than 1, preferably N is not less than 3. Alternatively, K.gtoreq.1, preferably K.gtoreq.4.

Illustratively, the reagent dispensing mechanism 24 performs the target reagent dispensing operation and the mixing operation, respectively, in different reagent dispensing cycles, and the reagent dispensing mechanism 24 performs the mixing operation in a corresponding reagent dispensing cycle after the target reagent dispensing operation is completed. By performing the configuration operation of the target reagent and the blending operation of the target reagent in different reagent dispensing cycles, it is unnecessary to increase the blending time sequence by changing the time sequence of the whole machine during the blending operation of the reagent dispensing mechanism 24, thereby ensuring the sample analysis performance of the sample analyzer without affecting the time sequence operation of the whole machine and the subsystem of the sample analyzer.

For example, the reagent dispensing cycle includes a first action sub-cycle, and the reagent dispensing mechanism 24 performs a target reagent disposing operation in the first action sub-cycle of the kth reagent dispensing cycle to reconstitute the target solid reagent into the target reagent. And after the target reagent is configured, uniformly mixing the target reagent in the first action sub-period of the K+1th reagent dispensing period so as to fully mix the target reagent.

In some embodiments, the controller is further configured to: prior to using at least 1 of the reagent dispensing cycles of the target reagent, the reagent dispensing mechanism 24 is controlled to aspirate reconstituted reagent from the first reagent container and expel the reconstituted reagent into the second reagent container carrying the target solid reagent.

Illustratively, the configuration of the target reagent will be completed before the target reagent is required to be used, thereby effectively saving the total time required for sample analysis.

In some embodiments, the reagent processing apparatus 20 further comprises a washing mechanism, and the controller 50 is further configured to: after the reagent dispensing mechanism 24 completes the operation of discharging the reconstituted reagent to the second reagent container, controlling the washing mechanism to perform a washing operation on the reagent dispensing mechanism 24;

and/or, after the reagent dispensing mechanism 24 performs the mixing operation, controlling the cleaning mechanism to perform a cleaning operation on the reagent dispensing mechanism 24.

Illustratively, the cleaning mechanism is at least used for cleaning the reagent needle 241 of the reagent dispensing mechanism 24, and the reagent dispensing cycle further includes a second sub-cycle of operation, in which the reagent dispensing mechanism 24 is used for performing a dispensing operation of other reagents, in order to reduce the probability of contamination of the reagent used for sample analysis by the reagent needle 241, and after the reagent dispensing mechanism 24 finishes the operation of discharging the reconstituted reagent into the second reagent container, the cleaning mechanism is controlled to perform a cleaning operation on the reagent needle 241 of the reagent dispensing mechanism 24, and/or after the reagent dispensing mechanism 24 finishes the mixing operation, the cleaning mechanism is controlled to perform a cleaning operation on the reagent needle 241 of the reagent dispensing mechanism 24.

In some embodiments, the reagent processing apparatus 20 further comprises a mixing mechanism, and the controller 50 is further configured to, after the reagent dispensing mechanism 24 completes the operation of discharging the reconstituted reagent to the second reagent container:

And controlling the mixing mechanism to perform mixing operation on the target reagent in the second reagent container.

The reagent processing apparatus 20 is illustratively provided with a mixing mechanism by which the configured target reagent is mixed, wherein the mixing mechanism includes, but is not limited to, a vibration mixing mechanism, as long as the mixing of the target reagent can be achieved.

In some embodiments, the controller 50 is further configured to:

controlling the reagent dispensing mechanism 23 to dispense a target solid reagent;

During the reagent dispensing cycle, controlling the reagent dispensing mechanism 24 to draw reconstituted reagent from the first reagent container and expel the reconstituted reagent to the second reagent container carrying the target solid reagent to process the target reagent to form a target reagent;

After the reagent dispensing mechanism finishes the operation of discharging the reconstituted reagent into the second reagent container, the reagent dispensing mechanism 24 is controlled to perform a mixing operation on the target reagent in the second reagent container.

Illustratively, the controller 50, upon receiving a reagent dispensing instruction, controls the reagent dispensing mechanism 23 to dispense a target solid reagent in response to the reagent dispensing instruction, controls the reagent dispensing mechanism 24 to aspirate the reconstituted reagent from a first reagent container carrying the reconstituted and the second reagent container carrying the target solid reagent during a reagent dispensing cycle, and discharges the reconstituted reagent to process the target reagent to form the target reagent; after the reagent dispensing mechanism finishes the operation of discharging the reconstituted reagent into the second reagent container, the reagent dispensing mechanism 24 is controlled to perform a mixing operation on the target reagent in the second reagent container to mix the target reagent.

Alternatively, the reagent dispensing instruction may be an instruction that an operator sends to the reagent processing apparatus 20 through an input device, or the controller 50 generates according to the item information to be measured after receiving the item information to be measured acquired by the sample injection apparatus 10.

The reagent processing method according to the embodiment of the present application will be described below with reference to the principle of operation of the reagent processing apparatus 20.

Referring to fig. 6, the embodiment of the application further provides a reagent processing method applied to the reagent processing apparatus 20 or the sample analyzer 100, and the reagent processing method includes steps S101 to S103.

Step S101: an information acquisition mechanism for controlling the reagent processing device acquires reagent information corresponding to the reagent stored in the second reagent container in the second reagent storage position;

Step S102: controlling a reagent distributing mechanism of the reagent processing device to distribute a target solid reagent according to the information of the item to be detected of the sample analyzer and the reagent information;

Step S103: in a reagent dispensing cycle, a reagent dispensing mechanism of the reagent processing apparatus is controlled to draw reconstituted reagent from a first reagent container and expel the reconstituted reagent to a second reagent container carrying the target solid reagent to process the target reagent to form a target reagent.

In some embodiments, after the reagent dispensing mechanism completes the operation of expelling the reconstituted reagent to the second reagent container, the method further comprises:

and in the reagent dispensing period, controlling the reagent dispensing mechanism to perform uniform mixing operation on the target reagent in the second reagent container.

In some embodiments, the reagent dispensing mechanism includes a reagent needle and a power assembly coupled to the reagent needle and configured to power the reagent needle to perform a reagent dispensing operation;

the controlling the reagent dispensing mechanism to perform a mixing operation on the target reagent in the second reagent container includes:

And controlling the power assembly to drive the needle tip of the reagent needle to descend to a first position below the liquid level of the target reagent in the second reagent container, and controlling the power assembly to drive the reagent to perform sucking and spitting uniform mixing operation on the target reagent so as to uniformly mix the target reagent.

In some embodiments, the controlling the power assembly to drive the reagent to perform an imbibition and homogenization operation with respect to the target reagent comprises:

And controlling the power assembly to drive the reagent needle to perform at least one sucking and spitting mixing operation, wherein in each sucking and spitting mixing operation, the reagent needle sucks a first amount of the target reagent from the second reagent container and discharges at least a second amount of the target reagent to the second reagent container.

Optionally, the first amount is greater than or equal to the second amount. Optionally, the second amount is 0.4 to 0.9 times the first amount.

In some embodiments, the power assembly drives the reagent needle at least 2 times to perform the pipetting mixing operation below the level of the target reagent.

In some embodiments, before the tip of the reagent needle descends into contact with the liquid level of the target reagent within the second reagent container, the method further comprises:

Controlling the power assembly to drive the reagent needle to perform a protective medium sucking operation to suck a third amount of protective medium.

In some embodiments, the protective medium is air and the third amount is greater than the first amount.

In some embodiments, the reagent dispensing cycle includes a first action sub-cycle, the method further comprising:

in a first action sub-cycle in the kth reagent dispensing cycle, controlling the reagent dispensing mechanism to aspirate reconstituted reagent from the first reagent container and expel the reconstituted reagent to the second reagent container carrying the target solid reagent;

And in the first action sub-period in the K+N reagent dispensing period, controlling the reagent dispensing mechanism to perform uniform mixing operation on the target reagent in the second reagent container, wherein N is more than or equal to 1.

In some embodiments, the method further comprises: prior to using at least 1 of the reagent dispensing cycles of the target reagent, controlling the reagent dispensing mechanism to aspirate reconstituted reagent from the first reagent container and expel the reconstituted reagent into the second reagent container carrying the target solid reagent.

In some embodiments, the reagent processing apparatus further comprises a washing mechanism, the method further comprising: after the reagent dispensing mechanism finishes the operation of discharging the reconstituted reagent to the second reagent container, controlling the cleaning mechanism to perform a cleaning operation on the reagent dispensing mechanism;

and/or after the reagent dispensing mechanism performs the mixing operation, controlling the cleaning mechanism to perform a cleaning operation on the reagent dispensing mechanism.

In some embodiments, the reagent processing apparatus further comprises a mixing mechanism, the method further comprising, after the reagent dispensing mechanism completes the operation of discharging the reconstituted reagent to the second reagent container:

And controlling the mixing mechanism to perform mixing operation on the target reagent in the second reagent container.

It should be noted that, for convenience and brevity of description, specific working procedures of the reagent processing method described above may refer to corresponding working procedures of the reagent processing apparatus or the sample analyzer, and will not be described in detail herein.

It is to be understood that the terminology used in the description of the application herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used in this specification and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.

It should also be understood that the term "and/or" as used in the present specification and the appended claims refers to any and all possible combinations of one or more of the associated listed items, and includes such combinations. It should be noted that, in this document, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or system that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or system. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or system that comprises the element.

The foregoing embodiment numbers of the present application are merely for the purpose of description, and do not represent the advantages or disadvantages of the embodiments. While the application has been described with reference to certain preferred embodiments, it will be understood by those skilled in the art that various changes and substitutions of equivalents may be made and equivalents will be apparent to those skilled in the art without departing from the scope of the application. Therefore, the protection scope of the application is subject to the protection scope of the claims.

Claims (16)

1. A reagent processing apparatus for use in a sample analyzer, comprising:

A reagent supply mechanism provided with a reagent placement site, the reagent placement site comprising a first reagent placement site for placing a first reagent container and a second reagent placement site for placing a second reagent container, wherein the first reagent container is used for storing a reconstituted reagent, and the second reagent container is used for storing a solid reagent;

the information acquisition mechanism is at least used for acquiring reagent information corresponding to the reagent stored in the second reagent container in the second reagent storage position;

the reagent distribution mechanism is used for distributing a target solid reagent, wherein the target solid reagent is a solid reagent to be treated;

a reagent dispensing mechanism for performing a reagent dispensing operation at least during a reagent dispensing cycle to dispense reagent to a corresponding reagent container; and

A controller for at least:

Controlling the information acquisition mechanism to acquire reagent information corresponding to a reagent stored in a second reagent container in a second reagent storage position, and controlling the reagent distribution mechanism to distribute the target solid reagent according to the information of a project to be detected of the sample analyzer and the reagent information;

During the reagent dispensing cycle, controlling the reagent dispensing mechanism to draw reconstituted reagent from the first reagent container and expel the reconstituted reagent to the second reagent container carrying the target solid reagent to process the target reagent to form a target reagent.

2. The reagent processing apparatus of claim 1, wherein after the reagent dispensing mechanism completes the operation of discharging the reconstituted reagent to the second reagent container, the controller is further configured to:

and in the reagent dispensing period, controlling the reagent dispensing mechanism to perform uniform mixing operation on the target reagent in the second reagent container.

3. The reagent processing apparatus of claim 2, wherein the reagent dispensing mechanism comprises a reagent needle and a power assembly coupled to the reagent needle for powering the reagent needle to perform a reagent dispensing operation;

The controller performs the following steps in the process of controlling the reagent dispensing mechanism to perform the mixing operation on the target reagent in the second reagent container:

And controlling the power assembly to drive the needle tip of the reagent needle to descend to a first position below the liquid level of the target reagent in the second reagent container, and controlling the power assembly to drive the reagent to perform sucking and spitting uniform mixing operation on the target reagent so as to uniformly mix the target reagent.

4. A reagent processing apparatus according to claim 3, wherein the controller, in controlling the power assembly to drive the reagent to perform the suction and discharge mixing operation with respect to the target reagent, performs:

And controlling the power assembly to drive the reagent needle to perform at least one sucking and spitting mixing operation, wherein in each sucking and spitting mixing operation, the reagent needle sucks a first amount of the target reagent from the second reagent container and discharges at least a second amount of the target reagent to the second reagent container, and the first amount is larger than the second amount.

5. The reagent processing apparatus according to claim 4, wherein the second amount is 0.4 to 0.9 times the first amount.

6. The reagent processing apparatus of claim 4, wherein the controller controls the power assembly to drive the reagent needle at least 2 times to perform the pipetting mixing operation below the liquid level of the target reagent.

7. A reagent processing apparatus according to claim 3, wherein the controller is further adapted to, before the tip of the reagent needle is lowered into contact with the liquid surface of the target reagent in the second reagent container:

Controlling the power assembly to drive the reagent needle to perform a protective medium sucking operation to suck a third amount of protective medium.

8. The reagent processing apparatus of claim 7, wherein the protective medium is air and the third amount is greater than the first amount.

9. The reagent processing apparatus of any one of claims 2 to 8, wherein the reagent dispensing cycle comprises a first actuation sub-cycle, the controller further being configured to:

in a first action sub-cycle in the kth reagent dispensing cycle, controlling the reagent dispensing mechanism to aspirate reconstituted reagent from the first reagent container and expel the reconstituted reagent to the second reagent container carrying the target solid reagent;

And in the first action sub-period in the K+N reagent dispensing period, controlling the reagent dispensing mechanism to perform uniform mixing operation on the target reagent in the second reagent container, wherein N is more than or equal to 1.

10. The reagent processing apparatus according to claim 1, wherein the controller performs, in controlling the reagent dispensing mechanism to aspirate a reconstituted reagent from the first reagent container and to discharge the reconstituted reagent to the second reagent container carrying the target solid reagent:

Controlling the reagent dispensing mechanism to draw reconstituted reagent from the first reagent container and expel the reconstituted reagent into a container wall of the second reagent container carrying the target solid reagent such that the reconstituted reagent flows along the container wall into the second reagent container.

11. The reagent processing apparatus of claim 1, wherein the controller is further configured to:

Prior to using at least 1 of the reagent dispensing cycles of the target reagent, controlling the reagent dispensing mechanism to aspirate reconstituted reagent from the first reagent container and expel the reconstituted reagent into the second reagent container carrying the target solid reagent.

12. The reagent processing apparatus of claim 2, further comprising a washing mechanism, the controller further configured to:

after the reagent dispensing mechanism finishes the operation of discharging the reconstituted reagent to the second reagent container, controlling the cleaning mechanism to perform a cleaning operation on the reagent dispensing mechanism;

and/or after the reagent dispensing mechanism performs the mixing operation, controlling the cleaning mechanism to perform a cleaning operation on the reagent dispensing mechanism.

13. The reagent processing apparatus of claim 1, further comprising a mixing mechanism, wherein the controller is further configured to, after the reagent dispensing mechanism completes the discharging of the reconstituted reagent to the second reagent container:

And controlling the mixing mechanism to perform mixing operation on the target reagent in the second reagent container.

14. A method of reagent treatment, the method comprising:

An information acquisition mechanism for controlling the reagent processing device acquires reagent information corresponding to the reagent stored in the second reagent container in the second reagent storage position, and controls a reagent distribution mechanism of the reagent processing device to distribute a target solid reagent according to the information of the item to be detected of the sample analyzer and the reagent information;

In a reagent dispensing cycle, a reagent dispensing mechanism of the reagent processing apparatus is controlled to draw reconstituted reagent from a first reagent container and expel the reconstituted reagent to a second reagent container carrying the target solid reagent to process the target reagent to form a target reagent.

15. A sample analyzer, comprising:

reagent processing means for configuring at least a target reagent;

The separation device is used for separating a reaction liquid to obtain a sample to be detected, and the reaction liquid is formed by mixing at least the target reagent and the sample to be detected;

the detection device is used for detecting the sample to be detected to obtain a detection result; and

A controller;

Wherein the reagent processing apparatus comprises:

A reagent supply mechanism provided with a reagent placement site, the reagent placement site comprising a first reagent placement site for placing a first reagent container and a second reagent placement site for placing a second reagent container, wherein the first reagent container is used for storing a reconstituted reagent, and the second reagent container is used for storing a solid reagent;

the information acquisition mechanism is at least used for acquiring reagent information corresponding to the reagent stored in the second reagent container in the second reagent storage position;

the reagent distribution mechanism is used for distributing a target solid reagent, wherein the target solid reagent is a solid reagent to be treated;

a reagent dispensing mechanism for performing a reagent dispensing operation at least in a reagent dispensing cycle to dispense a reagent to a corresponding reagent container;

the controller is at least used for:

Controlling the information acquisition mechanism to acquire reagent information corresponding to a reagent stored in a second reagent container in a second reagent storage position, and controlling the reagent distribution mechanism to distribute the target solid reagent according to the information of a project to be detected of the sample analyzer and the reagent information;

During the reagent dispensing cycle, controlling the reagent dispensing mechanism to draw reconstituted reagent from the first reagent container and expel the reconstituted reagent to the second reagent container carrying the target solid reagent to process the target reagent to form a target reagent.

16. A reagent processing apparatus, comprising:

A reagent supply mechanism provided with a reagent placement site, the reagent placement site comprising a first reagent placement site for placing a first reagent container and a second reagent placement site for placing a second reagent container, wherein the first reagent container is used for storing a reconstituted reagent, and the second reagent container is used for storing a solid reagent;

the reagent distribution mechanism is used for distributing a target solid reagent, wherein the target solid reagent is a solid reagent to be treated;

a reagent dispensing mechanism for performing a reagent dispensing operation at least during a reagent dispensing cycle to dispense reagent to a corresponding reagent container; and

A controller for at least:

controlling the reagent dispensing mechanism to dispense a target solid reagent;

Controlling the reagent dispensing mechanism to draw reconstituted reagent from the first reagent container and expel the reconstituted reagent to the second reagent container carrying the target solid reagent during the reagent dispensing cycle to process the target reagent to form a target reagent;

And after the reagent dispensing mechanism finishes the operation of discharging the reconstituted reagent to the second reagent container, controlling the reagent dispensing mechanism to perform a uniform mixing operation on the target reagent in the second reagent container.