CN118217256A - Yian Ning pill for treating coronary heart disease and preparation method thereof - Google Patents
Yian Ning pill for treating coronary heart disease and preparation method thereof Download PDFInfo
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention belongs to the technical field of medicine preparation, and provides Yi an Ning pills for treating coronary heart disease and a preparation method thereof. The preparation method of the Yi Anning pill comprises the following steps: (1) Pulverizing part of the materials in YIANNING pill, extracting part of the materials with water, and concentrating to obtain fluid extract; (2) taking refined honey with the water content of 10-14%; (3) Mixing the fine powder, extract, refined Mel and water, making pill, and drying. The Yianning pill has the advantages of good soft material viscosity, moderate hardness, good pill integrity, high yield, short dissolution time and higher dissolution rate in the preparation process.
Description
Technical Field
The invention belongs to the technical field of medicine preparation, and relates to Yian Ning pills for treating coronary heart disease and a preparation method thereof.
Background
The honeyed pill is prepared from honey serving as an adhesive, is a dosage form which is most widely applied in clinical application of traditional Chinese medicine, is compared with decoction, is slowly decomposed in intestinal tracts after being taken by patients, gradually releases drug effects, has lasting effect, and can be slowly absorbed by patients aiming at drugs with high toxicity or high irritation, so that adverse reactions can be effectively reduced. Although the production equipment and the process of the honeyed pill are relatively simple, the quality of the honeyed pill is difficult to control in the preparation process.
The Chinese patent CN100339111C discloses a medicine for curing coronary heart disease and a preparation method thereof, which is prepared by taking American ginseng, dendrobium, cordyceps, schisandra chinensis, chicken's gizzard-skin, tortoise plastron, turtle shell, pilose antler, saffron, pseudo-ginseng, red sage root, sea horse, ganoderma lucidum and snake gall as raw materials, has obvious curing effect on coronary heart disease and can obviously relieve or eliminate other complications. However, the medicine (Yi an Ning pill) has insufficient medicine powder viscosity, the extract amount obtained by decocting the medicine materials in water and concentrating the decoction is also small, and the pill preparation process has great difficulty, so that the yield is required to be further improved.
In the preparation of traditional Chinese medicine pill, refined honey is required to be added as adhesive when the medicine powder is not enough in viscosity. Except selecting honey, the refined honey is refined, the water content of the refined honey is controlled, so that the refined honey has moderate viscosity, and the method is a key link for preparing the traditional Chinese medicine pill. Because honey contains about 25% moisture and contains impurities such as waxes and starches. These impurities are not removed and the wax floats on the surface of the pellet, forming an extremely thin wax layer which can lead to cracking of the pellet surface after storage for a period of time. When the honey contains more starch impurities, the finished product of the pill can be dry and hard. Therefore, honey must be refined before use to remove impurities, destroy biological enzymes, kill microorganisms, and properly reduce water content to enhance adhesion. If the honey refining link is not well controlled, the finished pill products can be mildewed, dried and hard, cracked and the like during storage, and the quality of the pills is seriously affected.
The refined honey generally used in the preparation of traditional Chinese medicine pills is divided into three types of tender honey (with the water content of 18-20%), medium honey (with the water content of 14-16%) and old honey (with the water content of less than 10%) according to different refining degrees, wherein the refining degree of honey is selected according to the adhesive property of traditional Chinese medicine powder in a traditional Chinese medicine prescription, the water content of the powder, the viscosity of an extract and the proportion of the powder to the extract, and the refining temperature and time are used for refining the tender honey, the medium honey or the old honey.
In order to improve the quality and the yield of the Yi-an-ning pill, the preparation formability of the Yi-an-ning pill and the yield of the pill are evaluated and selected to select a proper honey refining scheme, and the dissolution condition of the finished product are further verified.
Disclosure of Invention
The inventor of the invention discovers that in the preparation process of Yianning pills, the prepared soft material has insufficient viscosity or too high viscosity and too high hardness by using refined honey which is commonly used at present, so that the situation that the yield of the prepared Yianning pills is low or the dissolution condition is poor occurs.
The invention provides Yi an Ning pills for treating coronary heart disease and a preparation method thereof. According to the invention, the refined honey with proper water content is obtained through the honey refining process of the honey, and is used as an adhesive to be applied to the preparation process of Yian Ning pills, so that the forming performance of the pills is improved, and the pill yield is improved; the dissolution time of the pill is also greatly shortened, and higher dissolution rate is realized.
One of the objects of the present invention is:
Provides a preparation method of Yianning pills for treating coronary heart disease, which comprises the following steps:
(1) Pulverizing part of the materials in YIANNING pill, extracting part of the materials with water, and concentrating to obtain fluid extract;
(2) Taking refined honey with the water content of 10-14%;
(3) Mixing the fine powder, extract, refined Mel and water, making pill, and drying.
Preferably, the water content of the refined honey is 12-14%.
In some embodiments of the invention, the refined honey is obtained by heating honey to boiling by steam and refining to a temperature of 115-120 ℃.
Further, the fine powder is prepared as follows:
Pulverizing radix Panacis Quinquefolii, notoginseng radix, fructus Schisandrae chinensis, saviae Miltiorrhizae radix, endothelium corneum Gigeriae Galli, herba Dendrobii 1/4 weight parts, cordyceps 1/2 weight parts, stigma croci Sativi 1/4 weight parts, and Hippocampus 1/4 weight parts.
Further, the fluid extract is prepared according to the following method:
Decocting carapax Trionycis, cornu Cervi Pantotrichum, carapax et Plastrum Testudinis, ganoderma, fel Serpentis and the rest herba Dendrobii, cordyceps, stigma croci Sativi and Hippocampus in water, and concentrating the decoction.
In some embodiments of the invention, the raw materials of turtle shell, pilose antler, tortoise plastron, lucid ganoderma, snake gall and the rest of dendrobium, cordyceps sinensis, stigma croci and sea horse are taken and decocted with water twice, 8 times of water is added for the first time, 6 times of water is added for the second time, the decoction is decocted for 2 hours respectively, the decoction is combined, and the decoction is filtered and concentrated, thus obtaining the traditional Chinese medicine.
Further, the pelleting process comprises: mixing, refining, rubbing and repairing pills.
Still further, the lump sum and drug refining process comprises: mixing the fine powder, the extract, refined honey and water, adding into a medicine-making machine, and making into medicine to obtain soft material; the medicine smelting frequency is 30.0-80.0Hz.
Still further, the refined honey is 14 to 15 weight percent of the amount of the fine powder, and the water is 13 to 14 weight percent of the amount of the fine powder.
Further, the pill rolling process comprises: adding the refined soft material into a pill making machine, setting the pushing speed of the pill cutting machine to be 25.00-60.00Hz, and performing pill rolling at the pill cutting speed of 48.00-60.00Hz to obtain coarse pills.
Further, the pellet repair process includes: adding coarse pill under the rotation frequency of 3.0-5.0Hz, setting the rotation frequency to 45.0-60.0Hz after the coarse pill is added, and repairing pill with the operation time of 15-20 min.
The second object of the invention is:
provides Yianning pills for treating coronary heart disease, which are prepared by any one of the preparation methods.
American ginseng, pseudo-ginseng, schisandra chinensis, red sage root, chicken's gizzard-skin, dendrobium, cordyceps sinensis, saffron, hippocampus, turtle shell, pilose antler, tortoise plastron (also called tortoise shell) and lucid ganoderma, all of which are in accordance with the corresponding regulations of the first part of the Chinese pharmacopoeia 2020 edition.
The medicinal material base stock, medicinal parts, nature, taste, channel tropism, efficacy and the like of the snake gall meet the corresponding regulations of 2012 edition of Fujian province Chinese herbal medicine decoction piece processing Specification.
Compared with the prior art, the invention has the following beneficial effects:
(1) According to the invention, refined honey with proper water content is obtained through a honey refining process of honey, and the refined honey is used as an adhesive in a preparation process of Yianning pills, so that the problems of poor pill forming, low yield and the like caused by insufficient viscosity of fine powder of raw materials and small amount of clear paste (caused by water decoction extraction and concentration process limitation) in the preparation process of Yianning pills are effectively solved;
(2) The dissolution time of the pill is effectively shortened and better dissolution rate is obtained by further optimizing the honey refining process of honey or the water content of honey refining;
(3) The Yianning pill of the invention has simple preparation process and high stability, and can be used for industrial mass production.
Drawings
FIG. 1 is a high performance liquid chromatogram of a blank sample;
FIG. 2 is a high performance liquid chromatogram of a mixed solution of notoginsenoside R 1 and ginsenoside Rb 1 as reference;
FIG. 3 is a high performance liquid chromatogram of a sample solution with a sampling time of 240 minutes according to example 3 of the present invention;
FIG. 4 is a high performance liquid chromatogram of a sample solution with a sampling time of 360 minutes according to example 4 of the present invention;
FIG. 5 is a graph showing the dissolution of the notoginsenoside R 1 in Yianning pills prepared with refined honey having different water contents;
fig. 6 is a dissolution profile of ginsenoside Rb 1 in Yian ning pills prepared with refined honey of varying water content.
Detailed Description
The following non-limiting examples will enable those of ordinary skill in the art to more fully understand the invention and are not intended to limit the invention in any way. The following is merely exemplary of the scope of the invention as claimed and many variations and modifications of the invention will be apparent to those skilled in the art in light of the disclosure, which are intended to be within the scope of the invention as claimed.
The reference notoginsenoside R 1 (batch No. 110745-202322; content 97.8%) and ginsenoside Rb 1 (batch No. 110704-202331; content 93.8%) are all purchased from Chinese food and drug assay institute.
Example 1
The formula of the Yi Anning pill comprises the following components: 10 parts of American ginseng, 8 parts of pseudo-ginseng, 2 parts of shizandra berry, 2 parts of red sage root, 2 parts of chicken's gizzard-skin, 6.6 parts of dendrobium, 3.2 parts of cordyceps sinensis, 3.2 parts of stigma croci Sativi, 3.2 parts of sea horse, 8 parts of turtle shell, 2.6 parts of hairy antler, 10 parts of tortoise plastron, 3.2 parts of lucid ganoderma and 2 parts of snake gall.
The preparation method comprises the following steps:
(1) Pulverizing radix Panacis Quinquefolii, notoginseng radix, fructus Schisandrae chinensis, saviae Miltiorrhizae radix, endothelium corneum Gigeriae Galli and 1.6 parts of herba Dendrobii, 1.6 parts of Cordyceps, 0.8 part of stigma croci Sativi and 0.8 part of Hippocampus, and sieving with 80 mesh sieve to obtain fine powder;
(2) Decocting carapax Trionycis, cornu Cervi Pantotrichum, carapax et Plastrum Testudinis, ganoderma, fel Serpentis, and the rest herba Dendrobii, cordyceps, stigma croci Sativi and Hippocampus in water, concentrating the decoction to obtain fluid extract with relative density of 1.21 (measured at 70deg.C);
(3) Preparing refined honey: heating 50kg of honey with steam to boiling, refining to 105 deg.C, measuring water content of refined honey to 19.2%, and stopping heating;
(4) Preparing pills:
S1, lump mixing and medicine refining: mixing the fine powder, the fluid extract, refined honey (4.3 parts) and purified water (4.2 parts) for 3 minutes by a mixer to form lump, feeding the prepared soft material into a medicine-making machine, setting the medicine-making speed frequency to be 50.0Hz, and observing and recording the softness of the soft material;
S2, pill rubbing: adding the refined soft material into a traditional Chinese medicine pill making machine, setting the material pushing speed of the pill cutting machine to 40.00Hz, and the pill cutting speed to 54.00Hz, and rubbing the pills, wherein the pill weight is controlled to be 1.700-2.000g per 10 pills. Observing and recording the pill shape condition (whether the sizes are consistent and the colors are uniform) of the prepared pills;
S3, repairing pills: adding pills into the pan turning polishing unit, and keeping the pan body continuously rotated (the frequency is controlled to be 4.0 Hz) in the process of adding pills; after the pill adding is finished, adjusting the rotation frequency of the pot body to 50.0Hz, setting the running time to 16min, and repairing the pills; repairing the pill until the appearance and the size of the pill are uniform, rounding the pill, and controlling the weight of the pill to be 1.700-2.212g per 10 pills. After the pills are rounded to meet the standard control requirement, adjusting the overturning frequency (controlled to be 5.0 Hz) and the rotating frequency (controlled to be 4.0 Hz) of the pot body, and pouring out the pills in the pot;
S4, drying: starting each program of the tunnel microwave dryer, and setting the speed 1 frequency of the conveyor belt to be 38.5Hz; the speed 2 frequency of the conveyor belt is 36.5Hz; and controlling the heating power to 75kW, uniformly spreading qualified wet pellets on a conveying belt of a tunnel type microwave dryer for drying, and adjusting the frequency of a dehumidifying motor according to the water temperature of cooling water in the drying process to ensure that the water temperature of the cooling water is not more than 30.0 ℃.
Example 2
The formulation of Yi an Ning Wan is the same as in example 1.
The preparation process differs from example 1 only in that: and (3) preparing honey, namely refining to 110 ℃ in the honey refining process, wherein the water content of the honey is 16.9% by measurement, and stopping heating.
Example 3
The formulation of Yi an Ning Wan is the same as in example 1.
The preparation process differs from example 1 only in that: and (3) preparing honey, namely refining to 115 ℃ until the water content of the honey is 14.0%, and stopping heating.
Example 4
The formulation of Yi an Ning Wan is the same as in example 1.
The preparation process differs from example 1 only in that: and (3) preparing honey, namely refining to 117 ℃ in the honey refining process, wherein the water content of the honey is measured to be 12.1%, and stopping heating.
Example 5
The formulation of Yi an Ning Wan is the same as in example 1.
The preparation process differs from example 1 only in that: and (3) preparing honey, namely refining to 120 ℃ in the honey refining process, wherein the water content of the honey is 10.0% when measured, and stopping heating.
Example 6
The formulation of Yi an Ning Wan is the same as in example 1.
The preparation process differs from example 1 only in that: and (3) preparing honey, namely refining to 122 ℃ in the honey refining process, wherein the water content of the honey is 8.2% when measured, and stopping heating.
Test case
(1) And (3) measuring the water content of the prepared refined honey: the water content of refined honey is measured according to the four 0622 refractive index measuring method of Chinese pharmacopoeia 2020 edition.
(2) Sampling at the front, middle and rear stages of blanking in the pill drying process, mixing the sampled samples to obtain a mixed sample, and detecting the dissolution time limit and dissolution rate of pills.
① And (3) measuring the dissolution time limit: the method is determined according to the dissolution time limit determination method under the four 0108 pills of the 2020 edition of Chinese pharmacopoeia, and specifically comprises the following steps: taking 6 pills of a test sample, respectively placing the pills into glass tubes of a six-tube disintegration tester, adding a baffle plate into water with the temperature of 37+/-1, and starting the six-tube disintegration tester for examination. During the operation, if the adhesion baffle of the test sample prevents the inspection, the test sample 6 pills should be taken separately for the inspection without the baffle.
② Dissolution rate measurement: measured by a cuvette method.
Preparation of a control solution: precisely weighing ginsenoside Rb 1 reference substance and Notoginseng radix saponin R 1 reference substance, adding methanol to obtain mixed solution containing ginsenoside Rb 1 0.4.4 mg and Notoginseng radix saponin R 1 0.1.1 mg per 1 mL.
Preparation of test solution: taking three parts of Yianning pills prepared in each example and respectively measuring the contents of ginsenoside Rb 1 and notoginsenoside R 1, precisely weighing 18 pills each, respectively placing the pills in three different small cups, respectively placing 18 granules in each cup, and carrying out ultrasonic degassing for 30 minutes before using the distilled water, wherein the volume of a dissolution medium is 250mL of purified water, and the temperature of the dissolution medium is as follows: the rotation speed is 100 rpm at 37 ℃. The sampling time is set to 15, 30, 60, 120, 180, 240 and 360 minutes, the sampling amount is 2mL each time, and the same temperature and the same amount of release medium are added immediately after sampling. The sample solution is centrifuged at high speed at different sampling times, the supernatant is taken and filtered by a microporous filter membrane of 0.45 microns, and the subsequent filtrate is taken as the sample solution.
Assay: respectively precisely sucking 20 μl of blank sample (purified water), reference solution and test solution, and injecting into liquid chromatograph for measurement (wherein chromatographic results of sample solution 240 and 360 min of YIANNING pill prepared in examples 3 and 4 are shown in fig. 3 and 4), wherein the liquid chromatograph conditions are: venusil XBP C18 chromatographic column (4.6X105 mm,5 μm) was used, with octadecylsilane chemically bonded silica as filler; acetonitrile as mobile phase A and water as mobile phase B, and performing gradient elution according to the procedure of table 1; the detection wavelength is 203nm; the theoretical plate number is not lower than 4000 calculated according to the peak of notoginsenoside R 1, and the ginsenoside Rb 1 peak is not lower than 5000.
TABLE 1 elution procedure
Calculating according to an external standard method to obtain the contents (mg/mL) of ginsenoside Rb1 and notoginsenoside R 1 in each 1mL of the sample solution sampled at each time point; the dissolution rate of ginsenoside Rb 1 and the dissolution rate of notoginsenoside R 1 at each time point of the Yianning pill are respectively calculated according to the following formula:
Ginsenoside Rb 1 dissolution rate= (ginsenoside Rb 1 content×250 in each 1mL of sample solution sampled at each time point) ×100/(18 pill Yi Anning pill weight×Yian ning pill ginsenoside Rb 1 content (mg/g));
The dissolution rate of notoginsenoside R 1 = (the content of notoginsenoside R 1 in each 1mL of sample solution sampled at each time point is multiplied by 250) multiplied by 100/(18 pills of Yianning pills weight multiplied by the content of notoginsenoside R 1 in Yianning pills (mg/g)).
The dissolution curve was drawn with the average value of the dissolution rates measured in triplicate as ordinate and time as abscissa.
The moisture content of the refined honey prepared in examples 1-6, and the pill-making conditions and pill quality conditions of the Yianning pills are shown in Table 2.
Table 2 results of the pelleting conditions and pellet quality measurements of the examples
As can be seen from the results in Table 2, for the preparation forming process of YI AN NING WAN, when the honey refining temperature is 115-120deg.C, that is, the water content of the refined honey is 10-14%, the key process conditions such as soft material preparation and pill rubbing are good, and the qualification rate of pill finished products is high. If the water content of the refined honey is too high, the viscosity is insufficient, the soft material is too soft, so that the extrusion is not smooth, the extrusion is easy to break, and even the extrusion cannot be performed for preparing pills; the water content of the refined honey is too low, the viscosity is increased, the viscosity and hardness of the soft material are too high, and the pill cannot be rubbed. In addition, when the water content is 10.0%, although the pill making condition meets the requirement, the dissolving time of the prepared Yianning pill is close to the upper limit of 120 minutes specified under the four-part general rule 0108 pill item of the Chinese pharmacopoeia 2020, and after the pill is stored for a period of time, the risk of unqualified dissolving time limit exists, so that in the preparation and forming process of the Yianning pill, the honey refining temperature is preferably 115-117 ℃, and the honey refining water content is preferably 12-14%.
As can also be seen from the dissolution curves of fig. 5 and 6, the produced pellets dissolve slowly when the moisture content of refined honey is 10.0%, which is related to the low moisture content of refined honey and the strong adhesiveness; the greater the viscosity of the refined honey, the greater the hardness of the prepared pill, the longer the dissolution time and the slower the dissolution speed. The water content of refined honey is high, the dissolving time is short, and the dissolution of pills is quickened.
Example 7
The formulation of Yi an Ning Wan is the same as in example 4.
The preparation process differs from example 4 only in the pelleting process:
S1, lump mixing and medicine refining: mixing the fine powder with the extract, refined honey and purified water for 3 minutes by a mixer to carry out lump formation, sending the prepared soft material into a medicine refining machine, setting the medicine refining speed frequency to be 30.0Hz, and observing and recording the softness of the refined soft material;
S2, pill rubbing: adding the refined soft material into a traditional Chinese medicine pill making machine, setting the material pushing speed of the pill cutting machine to 25.00Hz, and the pill cutting speed to 48.00Hz, and rubbing the pills, wherein the pill weight is controlled to be 1.700-2.000g per 10 pills. Observing and recording the pill shape condition (whether the sizes are consistent and the colors are uniform) of the prepared pills;
S3, repairing pills: adding pills into the pan turning polishing machine set, and keeping the pan body continuously rotating (the frequency is controlled to be 3.0 Hz) in the process of adding pills. After the pill adding is finished, adjusting the rotation frequency of the pot body to 45.0Hz, setting the running time to 15min, and repairing the pills. Repairing the pill until the appearance and the size of the pill are uniform, rounding the pill, and controlling the weight of the pill to be 1.700-2.212g per 10 pills. After the pills are rounded to meet the standard control requirement, adjusting the overturning frequency (controlled to be 2.0 Hz) and the rotating frequency (controlled to be 3.0 Hz) of the pot body, and pouring out the pills in the pot;
S4, drying: starting each program of the tunnel microwave dryer, and setting the speed 1 frequency of the conveyor belt to be 38.5Hz; the speed 2 frequency of the conveyor belt is 36.5Hz; and controlling the heating power to 75kW, uniformly spreading qualified wet pellets on a conveying belt of a tunnel type microwave dryer for drying, and adjusting the frequency of a dehumidifying motor according to the water temperature of cooling water in the drying process to ensure that the water temperature of the cooling water is not more than 30.0 ℃.
Example 8
The formulation of Yi an Ning Wan is the same as in example 4.
The preparation process differs from example 4 only in the pelleting process:
S1, lump mixing and medicine refining: mixing the fine powder with the extract, refined honey and purified water for 3 min by a mixer to carry out lump formation, feeding the prepared soft material into a medicine refining machine, setting the medicine refining speed frequency to be 80.0Hz, and observing and recording the softness of the refined soft material;
S2, pill rubbing: adding the refined soft material into a traditional Chinese medicine pill making machine, setting the material pushing speed of the pill cutting machine to be 60.00Hz, and the pill cutting speed to be 60.00Hz, and carrying out pill rubbing, wherein the pill weight is controlled to be 1.700-2.000g per 10 pills. Observing and recording the pill shape condition (whether the sizes are consistent and the colors are uniform) of the prepared pills;
S3, repairing pills: adding pills into the pan turning polishing machine set, and keeping the pan body continuously rotating (the frequency is controlled to be 5.0 Hz) in the process of adding pills. After the pill adding is finished, adjusting the rotation frequency of the pot body to 60.0Hz, setting the running time to 20min, and repairing the pills. Repairing the pill until the appearance and the size of the pill are uniform, rounding the pill, and controlling the weight of the pill to be 1.700-2.212g per 10 pills. After the pills are rounded to meet the standard control requirement, adjusting the overturning frequency (controlled to be 10.0 Hz) and the rotating frequency (controlled to be 5.0 Hz) of the pot body, and pouring out the pills in the pot;
S4, drying: starting each program of the tunnel microwave dryer, and setting the speed 1 frequency of the conveyor belt to be 38.5Hz; the speed 2 frequency of the conveyor belt is 36.5Hz; and controlling the heating power to 75kW, uniformly spreading qualified wet pellets on a conveying belt of a tunnel type microwave dryer for drying, and adjusting the frequency of a dehumidifying motor according to the water temperature of cooling water in the drying process to ensure that the water temperature of the cooling water is not more than 30.0 ℃.
The moisture content of the refined honey prepared in examples 4, 7-8, and the pill-making conditions and pill quality conditions of the Yianning pills are shown in Table 3.
Table 3 results of the pelleting conditions and pellet quality measurements of the examples
As can be seen from Table 3, when the honey refining temperature (or the water content of refined honey) is within a proper range, the parameters of the pelleting process such as drug refining, pill rubbing and pill repairing process are adjusted within a certain range, and the pelleting condition and the pill quality detection result are not affected.
Example 9
The formulation of Yi an Ning Wan is the same as in example 4.
The preparation process differs from example 4 only in that: the dosage of the refined honey is 3.7 parts; the other steps are the same as in example 4.
Example 10
The formulation of Yi an Ning Wan is the same as in example 4.
The preparation process differs from example 4 only in that: the dosage of the refined honey is 4.6 parts; the other steps are the same as in example 4.
The moisture content of the refined honey prepared in examples 4, 9 and 10, and the pill preparation conditions and the pill quality conditions of the Yianning pills are shown in Table 4.
Table 4 results of the pelleting conditions and pellet quality measurements of the examples
As can be seen from Table 4, when the amount of refined honey is too large, the soft material viscosity is too strong, the pill rubbing is not smooth, the pill formability is poor, the yield is low, and the pill dissolution time is long; when the dosage of refined honey is too small, the viscosity of soft materials is insufficient, pill rolling is not smooth, the pill formability is poor, and the yield is low.
Finally, it should be noted that the above description is only for illustrating the technical solution of the present invention, and not for limiting the scope of the present invention, and that the simple modification and equivalent substitution of the technical solution of the present invention can be made by those skilled in the art without departing from the spirit and scope of the technical solution of the present invention.
Claims (10)
1. The preparation method of the Yian Ning pill for treating coronary heart disease is characterized by comprising the following steps:
(1) Pulverizing part of the materials in YIANNING pill, extracting part of the materials with water, and concentrating to obtain fluid extract;
(2) Taking refined honey with the water content of 10-14%;
(3) Mixing the fine powder, extract, refined Mel and water, making pill, and drying.
2. The method of claim 1, wherein the refined honey has a moisture content of 12% to 14%.
3. The method of claim 1, wherein the fine powder is prepared by:
Pulverizing radix Panacis Quinquefolii, notoginseng radix, fructus Schisandrae chinensis, saviae Miltiorrhizae radix, endothelium corneum Gigeriae Galli, herba Dendrobii 1/4 weight parts, cordyceps 1/2 weight parts, stigma croci Sativi 1/4 weight parts, and Hippocampus 1/4 weight parts.
4. The preparation method according to claim 1, wherein the fluid extract is prepared by the following method:
Decocting carapax Trionycis, cornu Cervi Pantotrichum, carapax et Plastrum Testudinis, ganoderma, fel Serpentis and the rest herba Dendrobii, cordyceps, stigma croci Sativi and Hippocampus with water, filtering, and concentrating.
5. The method of claim 1, wherein the pelleting process comprises: mixing, refining, rubbing and repairing pills.
6. The method according to claim 5, wherein the lump sum and drug manufacturing process comprises: mixing the fine powder, the extract, refined honey and water, adding into a medicine-making machine, and making into medicine to obtain soft material; the medicine smelting frequency is 30.0-80.0Hz.
7. The preparation method according to claim 6, wherein the refined honey is 14-15 wt% of the fine powder, and the water is 13-14 wt% of the fine powder.
8. The method according to claim 5, wherein the process of rolling the pellets comprises: adding the refined soft material into a pill making machine, setting the pushing speed of the pill cutting machine to be 25.00-60.00Hz, and performing pill rolling at the pill cutting speed of 48.00-60.00Hz to obtain coarse pills.
9. The method of claim 5, wherein the process of repairing the bolus comprises: adding coarse pill under the rotation frequency of 3.0-5.0Hz, setting the rotation frequency to 45.0-60.0Hz after the coarse pill is added, and repairing pill with the operation time of 15-20 min.
10. The Yianning pill for treating coronary heart disease prepared by the preparation method according to any one of claims 1-9.
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