CN118150819A - On-line installation error-proofing control method for kit - Google Patents
On-line installation error-proofing control method for kit Download PDFInfo
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- CN118150819A CN118150819A CN202211549123.1A CN202211549123A CN118150819A CN 118150819 A CN118150819 A CN 118150819A CN 202211549123 A CN202211549123 A CN 202211549123A CN 118150819 A CN118150819 A CN 118150819A
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- mixing
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- 238000000034 method Methods 0.000 title claims abstract description 37
- 238000009434 installation Methods 0.000 title claims description 16
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 102
- 239000011324 bead Substances 0.000 claims abstract description 34
- 230000001360 synchronised effect Effects 0.000 claims description 11
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000000741 silica gel Substances 0.000 claims description 4
- 229910002027 silica gel Inorganic materials 0.000 claims description 4
- 230000000712 assembly Effects 0.000 claims 1
- 238000000429 assembly Methods 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 238000003018 immunoassay Methods 0.000 description 5
- 238000001514 detection method Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 238000000105 evaporative light scattering detection Methods 0.000 description 1
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Abstract
The invention discloses an on-line mounting error-proofing control method for a reagent box, wherein a fluted disc is fixedly arranged in a reagent bin, an inner mixing component comprises an inner rotating shaft rotatably arranged at the edge position of a reagent tray, an inner mixing shaft is arranged at the upper end of the inner rotating shaft, a gear is fixedly arranged at the lower end of the inner rotating shaft, and the gear is meshed with the fluted disc; the outer mixing component comprises an outer rotating shaft and a motor, and an outer mixing shaft is arranged at the upper end of the outer rotating shaft; setting the number of teeth of the gears to be even, and when the inner mixing assembly stops, the stay positions of the two inner mixing shafts are one of the even positions related to the number of teeth, so that the inner mixing shafts are ensured to stay at the position which can be pre-judged; in the process of stopping movement of the external mixing assembly, the motor slowly decelerates and stops at a certain constant position, so that the mixing rib at the bottom of the magnetic bead bottle is ensured to stop at a position which can be predicted. The beneficial effects are that: the pre-judging positions of the mixing ribs and the inner mixing shaft are staggered, so that the mixing ribs and the inner mixing shaft can be ensured to be staggered.
Description
Technical Field
The invention relates to a chemiluminescent immunoassay analyzer, in particular to an on-line installation error-proofing control method for a kit.
Background
The reagent system is one of the important components of a chemiluminescent immunoassay analyzer and functions to provide the analyzer with the reagent components and magnetic beads necessary for detection. The reagent system comprises a reagent bin, a reagent tray is rotationally arranged in the reagent bin, reagent components and magnetic beads are respectively arranged in a reagent bottle and a magnetic bead bottle, the reagent bottle and the magnetic bead bottle are integrally arranged on the reagent tray through a reagent kit, and the reagent components and the magnetic beads can be provided for the chemiluminescent immunoassay analyzer along with the rotation of the reagent tray in the reagent bin.
Currently, with the rapid increase of detection demands, chemiluminescent immunoassay analyzers are being developed toward full automation, high efficiency, and capability of meeting mass detection. In order to make the chemiluminescent immunoassay analyzer have higher detection efficiency and meet larger detection batch, the applicant is proceeding to develop a reagent system capable of realizing online replacement of the reagent kit without stopping, and the working principle is as follows: the exchange channel is formed in the top of the reagent bin, the reagent box is placed at the top of the reagent bin by manpower, and after the magnetic bead bottle is uniformly shaken by the external mixing component at the top of the reagent bin, the reagent box is automatically taken and placed from the exchange channel to the inside of the reagent bin by using the mechanical gripper, so that the online replacement without stopping is realized.
The problems of online replacement of the kit by adopting the above method are as follows: the inside reagent tray circumference of reagent storehouse distributes has interior mixing subassembly, and mechanical tongs need put the magnetic bead bottle in the kit on interior mixing subassembly. The working principle of the inner mixing assembly is the same as that of the outer mixing assembly at the top of the reagent bin, a convex mixing shaft is arranged on the mixing assembly, a mixing rib is arranged at the bottom of the magnetic bead bottle, holes formed beside the mixing rib are arranged on the mixing shaft, and then the mixing assembly rotates to drive the magnetic bead bottle to rotate through the mixing shaft, so that mixing is realized. When the outer mixing assembly stops moving, the angle of the magnetic bead bottle is random, so that when the mechanical gripper transfers the kit from the outer mixing assembly to the inner mixing assembly, the mixing ribs at the bottom of the magnetic bead bottle are likely to be opposite to the mixing shafts of the inner mixing assembly, and the kit cannot be successfully placed into the kit bin at the moment, so that the online kit replacement fails.
Therefore, there is a need to design an error-proofing control method to solve the problem that the mixing ribs and the mixing shafts are opposite and cannot be installed.
Disclosure of Invention
In view of the above, the invention provides an online mounting error-proofing control method for a kit, which can ensure that mixing ribs and mixing shafts are always arranged in a staggered manner.
In order to achieve the above purpose, the technical scheme of the invention is as follows:
the on-line mounting error-proofing control method for the reagent kit comprises a reagent system, wherein the reagent system comprises a reagent bin, an outer mixing assembly and a mechanical gripper, wherein the outer mixing assembly and the mechanical gripper are arranged at the top of the reagent bin; the outer mixing component comprises an outer rotating shaft and a motor for driving the outer rotating shaft to rotate, and the upper end of the outer rotating shaft is provided with two outer mixing shafts with the same diameter; the mechanical gripper is used for grabbing the kit at the position of the outer mixing component to the position of the inner mixing component;
the method is characterized in that the on-line installation error-proofing control method of the kit comprises the following steps:
Setting the number of teeth of the gears to be even, and when the inner mixing assembly stops, the stay positions of the two inner mixing shafts are one of the even positions related to the number of teeth, so that the inner mixing shafts are ensured to stay at the position which can be predicted;
In the process of stopping the motion of the external mixing assembly, the motor slowly decelerates and stops at a certain constant position, so as to ensure that the mixing ribs at the bottom of the magnetic bead bottle stop at a prejudicial position;
The mechanical gripper is used for transferring the kit from the outer mixing assembly to the inner mixing assembly, so that the magnetic bead bottle and the kit are prevented from rotating relatively.
Preferably, the number of teeth of the gears is 10.
Preferably, the outer mixing assembly further comprises a sensor fixed at the top of the reagent bin, a reset grating ruler matched with the sensor is fixedly installed on the outer rotating shaft, and the stop position of the outer mixing shaft is accurately controlled through the reset grating ruler and the sensor.
Preferably, the reagent tray is provided with inner clamping grooves of the reagent box in a circumferential array manner, a rotary support is fixedly arranged at a position corresponding to the outer ends of the inner clamping grooves of the reagent box, and the inner rotating shaft is rotatably arranged in the rotary support;
The top of the reagent bin is provided with a reagent box outer clamping groove, and the outer rotating shaft is rotatably arranged at the outer end position of the reagent box outer clamping groove.
Preferably, the mechanical gripper comprises two groups of clamping arms which can be mutually closed, wherein the inner side of one clamping arm is provided with a flexible silica gel pad, and the two groups of clamping arms are propped against the bottle cover of the magnetic bead bottle in the process of transferring the kit, so that the magnetic bead bottle is prevented from rotating in the transferring process.
Preferably, the lower end of the outer rotating shaft is fixedly sleeved with a first synchronous wheel, the output shaft of the motor is fixedly sleeved with a second synchronous wheel, and a synchronous belt is sleeved between the first synchronous wheel and the second synchronous wheel.
Preferably, the top of the inner shaft has a chamfer encircling along its circumference.
Preferably, the reset grating ruler is a round piece, and an identification notch is arranged on the edge of the reset grating ruler.
The beneficial effects of the invention are as follows:
By adopting the on-line installation error-proofing control method for the kit, the gears ensure that the inner mixing shaft is stopped at the position which can be predicted through the even number of teeth, and the outer mixing shaft ensures that the mixing ribs are stopped at the position which can be predicted through slow speed reduction and stopping at the constant position. In the whole system, the positions of the mixing ribs and the inner mixing shaft which can be prejudged are staggered, so that the mixing ribs and the inner mixing shaft can be ensured to be staggered, the reagent kit can be successfully installed in the reagent bin, and the reliability of the reagent system for on-line installation of the reagent kit is improved.
Drawings
FIG. 1 is a schematic diagram of the structure of a reagent system A;
Fig. 2 is a schematic structural view of the external mixing assembly 5;
Fig. 3 is a schematic diagram showing the assembly connection relationship of the fluted disc 2, the reagent tray 3 and the internal mixing component 4 inside the reagent bin 1;
FIG. 4 is a schematic view of the structure of the magnetic bead bottle 7;
fig. 5 is a schematic diagram showing the principle of staggered installation of the mixing ribs 7a and the inner mixing shaft 4 b;
Fig. 6 is a schematic view of the gripping arm 6a of the mechanical gripper 6 gripping the reagent cartridge 9.
Detailed Description
The invention is further described below with reference to examples and figures.
As shown in fig. 1 and 3, a reagent system a comprises a reagent bin 1, a fluted disc 2 is fixedly installed in the reagent bin 1, a reagent tray 3 is rotatably installed on the upper side of the fluted disc 2, reagent inner clamping grooves 3a are distributed on the reagent tray 3 in a circumferential array manner, inner mixing components 4 are arranged at the outer end positions of the reagent inner clamping grooves 3a, each inner mixing component 4 comprises a rotary support 4d fixedly installed on the outer end edge of each reagent inner clamping groove 3a, an inner rotary shaft 4a is rotatably installed in the rotary support 4d, two inner mixing shafts 4b located on the same diameter are arranged at the upper end of each inner rotary shaft 4a, a gear 4c is fixedly installed at the lower end of each inner mixing shaft, and the gears 4c are meshed with the fluted disc 2.
Referring to fig. 3, after the reagent bottle 8 and the magnetic bead bottle 7 are installed in the reagent kit 9, the reagent kit 9 is placed in the clamping groove 3a in the reagent kit, and then the corresponding reagent can be installed in the reagent bin 1. As can be seen from fig. 4, a mixing rib 7a is arranged at the bottom of the magnetic bead bottle 7, and a hole 7b is formed beside the mixing rib 7 a. The shaking principle of the inner mixing component 4 is as follows: the hole 7b at the bottom of the magnetic bead bottle 7 is sleeved on the inner mixing shaft 4b, the gear 4c and the inner rotating shaft 4a are forced to rotate in the process that the reagent tray 3 rotates relative to the fluted disc 2, the inner mixing shaft 4b acts on the side wall of the mixing rib 7a to push the magnetic bead bottle 7 to rotate in the reagent box 9, and therefore dynamic mixing of the magnetic bead bottle 7 in the reagent bin 1 is achieved.
As shown in fig. 1, the top of the reagent bin 1 is provided with a reagent box outer clamping groove 1a, the outer end position of the reagent box outer clamping groove 1a is provided with an outer mixing component 5, and as can be seen by combining fig. 2, the outer mixing component 5 comprises a motor 5b and an outer rotating shaft 5a rotatably mounted at the top of the reagent bin 1, the motor 5b is used for driving the outer rotating shaft 5a to rotate, and the upper end of the outer rotating shaft 5a is provided with two outer mixing shafts 5c positioned on the same diameter. Similarly, after the reagent kit 9 is placed in the reagent kit outer clamping groove 1a, the motor 5b drives the outer rotating shaft 5a to rotate, so that the magnetic bead bottle 7 can be uniformly mixed outside the reagent bin 1.
The reagent system A also comprises a mechanical gripper 6 arranged at the top of the reagent bin 1, the top of the reagent bin 1 is provided with an exchange channel 1b, and the mechanical gripper 6 can automatically grasp the reagent box on the reagent box outer clamping groove 1a to the position of the reagent box inner clamping groove 3a through the exchange channel 1b, namely: the kit at the location of the outer mixing assembly 5 is grasped to the location of the inner mixing assembly 4, a process called on-line mounting of the kit.
The embodiment also provides an online kit mounting error-proofing control method based on the online kit mounting structure of the reagent system A, which aims to prevent the mixing ribs 7a at the bottom of the magnetic bead bottle 7 from colliding on the inner mixing shaft 4 b. The error-proofing control method comprises the following three points:
1. Referring to fig. 5, the number of teeth of the gear 4c is set to be an even number, preferably 10 in this embodiment, and when the inner mixing assembly 4 is stopped, the stopping positions of the two inner mixing shafts 4b are positions corresponding to the 10 teeth, so that the inner mixing shafts 4b can be stopped at the positions that can be predicted.
2. In the process of stopping the motion of the outer mixing assembly 5, the motor 5b slowly decelerates and stops at a certain constant position, the slow deceleration stop can ensure that the outer mixing shaft 5c and the side wall of the mixing rib 7a of the magnetic bead bottle 7 are in a fitting state in the stopping moment, and the control is performed so that the mixing rib 7a at the bottom of the magnetic bead bottle 7 stops at a position which can be predicted at the position of the outer mixing assembly 5.
3. The mechanical gripper 6 is used for ensuring that the magnetic bead bottle 7 and the reagent kit 9 do not rotate relatively in the process of transferring the reagent kit from the outer mixing assembly 5 to the inner mixing assembly 4.
With the above error-proofing control method, as shown in fig. 5, in the whole system, the preset position where the mixing rib 7a stops on the outer mixing assembly 5 and the preset position where the inner mixing shaft 4b stops are staggered, so that the mixing rib 7a and the inner mixing shaft 4b can be staggered and installed, thereby ensuring that the reagent kit can be successfully installed in the reagent bin.
Please refer to fig. 6, the mechanical gripper 6 includes two groups of gripping arms 6a that can be closed together, wherein a flexible silica gel pad 6b is disposed on the inner side of one of the gripping arms 6a, and the flexible silica gel pad 6b abuts against the cover of the magnetic bead bottle 7 during the transferring process of the magnetic bead bottle 7, so that the magnetic bead bottle 7 is prevented from rotating during the transferring process, and the mixing rib 7a is always located at a preset position.
As shown in fig. 3, the top of the inner rotating shaft 4a is provided with a chamfer encircling along the circumferential direction, and the chamfer can lead the top of the inner rotating shaft 4a to be in a conical structure, so as to play a guiding role, avoid the possibility of positive collision between the uniformly mixed ribs 7a and the inner rotating shaft 4a, and further ensure the success rate of installation.
As shown in fig. 2, a first synchronizing wheel 5g is fixedly sleeved at the lower end of the outer rotating shaft 5a, a second synchronizing wheel 5h is fixedly sleeved on the output shaft of the motor 5b, and a synchronous belt 5f is sleeved between the first synchronizing wheel 5g and the second synchronizing wheel 5h, so that the outer rotating shaft 5a can be driven to rotate by the operation of the motor 5 b. Further, the outer mixing assembly 5 further comprises a sensor 5d fixed at the top of the reagent bin 1, a reset grating ruler 5e matched with the sensor 5d is fixedly mounted on the outer rotating shaft 5a, the reset grating ruler 5e is a round piece, an identification notch a is arranged on the edge of the reset grating ruler 5e, when the identification notch a passes through the sensor 5d, a control system immediately feeds back a stop signal, and the motor 5b immediately stops, so that the outer mixing shaft 5c is guaranteed to accurately stop at a preset position.
Finally, it should be noted that the above description is only a preferred embodiment of the present invention, and that many similar changes can be made by those skilled in the art without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (8)
1. The on-line mounting error-proofing control method for the reagent kit comprises a reagent system, wherein the reagent system comprises a reagent bin (1), and an outer mixing assembly (5) and a mechanical gripper (6) which are arranged at the top of the reagent bin (1), a fluted disc (2) is fixedly mounted in the reagent bin (1), a reagent tray (3) is rotatably mounted on the upper side of the fluted disc (2), inner mixing assemblies (4) are circumferentially distributed on the reagent tray (3), each inner mixing assembly (4) comprises an inner rotating shaft (4 a) rotatably mounted at the edge position of the reagent tray (3), two inner mixing shafts (4 b) which are positioned on the same diameter are arranged at the upper end of each inner rotating shaft (4 a), a gear (4 c) is fixedly arranged at the lower end of each inner mixing shaft, and the gear (4 c) is meshed with the fluted disc (2); the outer mixing assembly (5) comprises an outer rotating shaft (5 a) and a motor (5 b) for driving the outer rotating shaft (5 a) to rotate, and two outer mixing shafts (5 c) positioned on the same diameter are arranged at the upper end of the outer rotating shaft (5 a); the mechanical gripper (6) is used for gripping the kit at the position of the outer mixing component (5) to the position of the inner mixing component (4);
The method is characterized in that the on-line installation error-proofing control method of the kit comprises the following steps:
Setting the number of teeth of the gears (4 c) to be even, and when the inner mixing assembly (4) stops, the stay positions of the two inner mixing shafts (4 b) are one of the even positions related to the number of teeth, so that the inner mixing shafts (4 b) are ensured to stay at the position which can be predicted;
in the process of stopping the motion of the outer mixing component (5), the motor (5 b) is slowly decelerated and stopped at a certain constant position, so that the mixing rib at the bottom of the magnetic bead bottle is ensured to be stopped at a position which can be predicted;
the mechanical gripper (6) transfers the reagent kit from the outer mixing component (5) to the inner mixing component (4), so that the magnetic bead bottle and the reagent kit are prevented from rotating relatively.
2. The on-line installation error-proofing control method of the kit according to claim 1, wherein: the number of teeth of the gear (4 c) is 10 groups.
3. The on-line installation error-proofing control method of the kit according to claim 1, wherein: the outer mixing assembly (5) further comprises a sensor (5 d) fixed at the top of the reagent bin (1), a reset grating ruler (5 e) matched with the sensor (5 d) is fixedly mounted on the outer rotating shaft (5 a), and the stop position of the outer mixing shaft (5 c) is accurately controlled through the reset grating ruler (5 e) and the sensor (5 d).
4. The on-line installation error-proofing control method of the kit according to claim 1, wherein: the reagent tray (3) is provided with reagent box inner clamping grooves (3 a) in a circumferential array manner, a rotary support (4 d) is fixedly arranged at a position corresponding to the outer ends of the reagent box inner clamping grooves (3 a), and the inner rotating shaft (4 a) is rotatably arranged in the rotary support (4 d);
The top of the reagent bin (1) is provided with a reagent box outer clamping groove (1 a), and the outer rotating shaft (5 a) is rotatably arranged at the outer end position of the reagent box outer clamping groove (1 a).
5. The on-line installation error-proofing control method of the kit according to claim 1, wherein: the mechanical gripper (6) comprises two groups of clamping arms (6 a) which can be mutually closed, wherein flexible silica gel pads (6 b) are arranged on the inner side of one clamping arm (6 a), the two groups of clamping arms (6 a) are abutted against the bottle cover of the magnetic bead bottle in the process of transferring the kit, and therefore the magnetic bead bottle is prevented from rotating in the process of transferring.
6. The on-line installation error-proofing control method of the kit according to claim 1, wherein: the lower end of the outer rotating shaft (5 a) is fixedly sleeved with a first synchronous wheel (5 g), the output shaft of the motor (5 b) is fixedly sleeved with a second synchronous wheel (5 h), and a synchronous belt (5 f) is sleeved between the first synchronous wheel (5 g) and the second synchronous wheel (5 h).
7. The on-line installation error-proofing control method of the kit according to claim 1, wherein: the top of the inner shaft (4 a) has a chamfer encircling along its circumference.
8. The on-line installation error-proofing control method of the kit according to claim 3, wherein: the reset grating ruler (5 e) is a round sheet, and an identification notch (a) is arranged on the edge of the reset grating ruler.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211549123.1A CN118150819A (en) | 2022-12-05 | 2022-12-05 | On-line installation error-proofing control method for kit |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211549123.1A CN118150819A (en) | 2022-12-05 | 2022-12-05 | On-line installation error-proofing control method for kit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118150819A true CN118150819A (en) | 2024-06-07 |
Family
ID=91299598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211549123.1A Pending CN118150819A (en) | 2022-12-05 | 2022-12-05 | On-line installation error-proofing control method for kit |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN118150819A (en) |
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2022
- 2022-12-05 CN CN202211549123.1A patent/CN118150819A/en active Pending
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