CN118119714A - 具有异源非结构蛋白的经修饰的甲病毒 - Google Patents

具有异源非结构蛋白的经修饰的甲病毒 Download PDF

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Publication number
CN118119714A
CN118119714A CN202280070364.XA CN202280070364A CN118119714A CN 118119714 A CN118119714 A CN 118119714A CN 202280070364 A CN202280070364 A CN 202280070364A CN 118119714 A CN118119714 A CN 118119714A
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nucleic acid
cells
virus
acid construct
rna
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CN202280070364.XA
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Chinese (zh)
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N·S·王
S·J·米亚克-斯通纳
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Ripricote Biosciences
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Ripricote Biosciences
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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    • C12N2760/20011—Rhabdoviridae
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    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20111—Lyssavirus, e.g. rabies virus
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    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
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    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141—Use of virus, viral particle or viral elements as a vector
    • C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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CN202280070364.XA 2021-09-02 2022-09-01 具有异源非结构蛋白的经修饰的甲病毒 Pending CN118119714A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163240297P 2021-09-02 2021-09-02
US63/240,297 2021-09-02
PCT/US2022/075853 WO2023034927A1 (en) 2021-09-02 2022-09-01 Modified alphaviruses with heterologous nonstructural proteins

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CN118119714A true CN118119714A (zh) 2024-05-31

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CN202280070364.XA Pending CN118119714A (zh) 2021-09-02 2022-09-01 具有异源非结构蛋白的经修饰的甲病毒

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US (1) US20240400619A1 (https=)
EP (1) EP4396359A4 (https=)
JP (1) JP2024535729A (https=)
KR (1) KR20240051229A (https=)
CN (1) CN118119714A (https=)
AU (1) AU2022339954A1 (https=)
CA (1) CA3230407A1 (https=)
IL (1) IL311112A (https=)
WO (1) WO2023034927A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2024279218A1 (en) * 2023-05-26 2026-01-15 Replicate Bioscience, Inc. Compositions and methods for expression of il-1ra and il-18bp
WO2025144717A1 (en) * 2023-12-27 2025-07-03 Replicate Bioscience, Inc. Compositions and methods for inducing immune response against epstein-barr viruses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458560B1 (en) * 1996-04-05 2002-10-01 Chiron Corporation Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis
US5811407A (en) * 1997-02-19 1998-09-22 The University Of North Carolina At Chapel Hill System for the in vivo delivery and expression of heterologous genes in the bone marrow
CN111163799A (zh) * 2017-07-28 2020-05-15 扬森疫苗与预防公司 用于异源repRNA免疫接种的方法和组合物
JP7494117B2 (ja) * 2018-01-19 2024-06-03 ヤンセン ファーマシューティカルズ，インコーポレーテッド 組換えレプリコン系を使用する免疫応答の誘導および増強

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WO2023034927A1 (en) 2023-03-09
US20240400619A1 (en) 2024-12-05
JP2024535729A (ja) 2024-10-02
KR20240051229A (ko) 2024-04-19
EP4396359A1 (en) 2024-07-10
EP4396359A4 (en) 2025-09-17
IL311112A (en) 2024-04-01
AU2022339954A1 (en) 2024-03-14
CA3230407A1 (en) 2023-03-09

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