CN118079150A - Bipolar electrostatically atomized drug delivery method and device - Google Patents
Bipolar electrostatically atomized drug delivery method and device Download PDFInfo
- Publication number
- CN118079150A CN118079150A CN202410295027.1A CN202410295027A CN118079150A CN 118079150 A CN118079150 A CN 118079150A CN 202410295027 A CN202410295027 A CN 202410295027A CN 118079150 A CN118079150 A CN 118079150A
- Authority
- CN
- China
- Prior art keywords
- positive
- bipolar
- negative
- medicine
- drug delivery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000012377 drug delivery Methods 0.000 title claims description 19
- 238000000034 method Methods 0.000 title description 6
- 239000003814 drug Substances 0.000 claims abstract description 62
- 239000007788 liquid Substances 0.000 claims abstract description 48
- 239000002245 particle Substances 0.000 claims abstract description 39
- 238000000889 atomisation Methods 0.000 claims abstract description 27
- 229940079593 drug Drugs 0.000 claims abstract description 25
- 239000007924 injection Substances 0.000 claims abstract description 16
- 238000002347 injection Methods 0.000 claims abstract description 16
- 230000007935 neutral effect Effects 0.000 claims abstract description 5
- 230000009471 action Effects 0.000 claims description 6
- 230000005684 electric field Effects 0.000 claims description 4
- 239000000243 solution Substances 0.000 claims description 3
- 239000011810 insulating material Substances 0.000 claims description 2
- 238000005507 spraying Methods 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims 2
- 239000007799 cork Substances 0.000 claims 1
- 230000008021 deposition Effects 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 5
- 210000004072 lung Anatomy 0.000 abstract description 4
- 239000007921 spray Substances 0.000 abstract description 4
- 239000000427 antigen Substances 0.000 abstract description 3
- 102000036639 antigens Human genes 0.000 abstract description 3
- 108091007433 antigens Proteins 0.000 abstract description 3
- 210000002345 respiratory system Anatomy 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 2
- 238000000151 deposition Methods 0.000 description 9
- 239000003595 mist Substances 0.000 description 7
- 230000008901 benefit Effects 0.000 description 5
- 239000000443 aerosol Substances 0.000 description 4
- 238000013461 design Methods 0.000 description 3
- 230000005499 meniscus Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000002685 pulmonary effect Effects 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002664 inhalation therapy Methods 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 238000002663 nebulization Methods 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000010405 clearance mechanism Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000005686 electrostatic field Effects 0.000 description 1
- 238000007590 electrostatic spraying Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 244000052637 human pathogen Species 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 238000012383 pulmonary drug delivery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 238000002626 targeted therapy Methods 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 229940043263 traditional drug Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0066—Inhalators with dosage or measuring devices with means for varying the dose size
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Electrostatic Spraying Apparatus (AREA)
Abstract
The invention discloses a device for transporting external medicine/antigen particles to a specific area in a human body based on a double-electrode electrostatic atomization principle, so as to achieve better curative effect. Aiming at the characteristic that different medicine particle sizes act on different positions in the body, oral medicines and injection medicines cannot well act on the lower respiratory tract system; and the particle flow sprayed by the traditional electrostatic atomization device has a certain amount of charges, and can not enter the human body for treatment. Therefore, the bipolar electrostatic atomization device is adopted, electrostatic atomization of the liquid medicine in the inclined cone nozzle is realized through a double-electrode power supply, and the inclined cone nozzle can generate stable cone jet flow at lower voltage; the positive and negative charge particles generated by cone jet atomization are neutralized in the atomization chamber, so that fog drops are electrically neutral. At the same time, the optimal particle size suitable for deposition in the lung is obtained by adjusting the voltage of the spray electrode and the physical and chemical properties of the liquid.
Description
Technical Field
The invention relates to the field of electrostatic atomization, in particular to a device for transporting external medicine/antigen particles to a specific area in a human body based on a double-electrode electrostatic atomization principle.
Background
In the medical field, inhalation therapy has a long and rich history in the treatment of different respiratory diseases. Since human pathogens generally invade the human body from the mouth, nose, trachea and lungs, drugs act on the human body by nebulization to directly prevent local infection of the respiratory tract, are more advantageous than oral and injection administration, and can enter the circulation in the body efficiently and rapidly, and thus inhalation therapy based on drug nebulization has the unique advantages of smaller dosage, higher safety and effectiveness compared to other delivery systems. External drug delivery systems for specific drugs have long been a field of development accompanying medical research. The external drug delivery based on the particles can protect the drug from being degraded by enzymes, bypass a pulmonary clearance mechanism, slow down drug absorption, improve the deposition rate of the drug in a target area, and reduce side effects to the greatest extent so as to improve the efficiency of pulmonary drug delivery. Thus, microparticle-based drug delivery systems replace traditional drug delivery systems and become an innovative and promising new approach. However, studies have shown that particles greater than 5 μm in diameter preferentially accumulate in the upper respiratory tract (mouth, pharynx, larynx); when the particle diameter is in the range of 1-5 mu m, the maximum deposition corresponding to the size of the lower airway can be generated, so that the medicine can be better absorbed in the lung; when the particle diameter is smaller than 0.5 μm, the exhalation is made without deposition. Thus, controlling the size of drug particles is critical to depositing the particles in specific areas of the body.
Electrostatic atomization refers to a process in which accumulated charges are generated at an interface between liquid and ambient gas under the action of an electrostatic field, the liquid at the tail end of a meniscus is stretched under the action of an electric field force, the liquid is ejected from the top of the meniscus under the action of an electric shearing force, and the liquid is broken at the tail end of the jet, so that uniform micro-droplets are formed. The electrostatic atomization can effectively generate micro-nano particles, the movement track of fog drops and the particle size of the fog drops can be changed by adjusting experimental parameters, and even complex drug molecules and antigens can be compressed into single liquid drops. However, the particle flow sprayed by the traditional electrostatic atomization device has a certain amount of charges, and atomized particles cannot be efficiently conveyed to a target area under the influence of the electrostatic force in the electrode space, so that the treatment effect is reduced.
The invention combines the electrostatic spraying technology and the targeted drug delivery technology, develops a system which can control the size of atomized particles and simultaneously can neutralize drug particles to act on a specific targeted area in the body in a neutral manner, so as to achieve the aims of precise delivery, high-efficiency absorption, side effect reduction and the like, and provides a new thought and research and development reference for pulmonary targeted therapy and solubilization and targeted application of other indissolvable drugs.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a bipolar electrostatic atomization drug delivery device, which adopts two symmetrically placed injection electrodes with opposite polarities, is connected with a bipolar high-voltage direct current power supply, is respectively provided with an oblique cone nozzle on the two electrodes to generate electrostatic spray, respectively generates particle flows with positive charges and negative charges, and finishes neutralization of the particle flows in an atomization area to reduce the charge quantity of the particle flows. The optimal liquid medicine fog drop particle size suitable for lung deposition is obtained by adjusting the physicochemical property and the spraying voltage of the liquid.
In order to achieve the above object, a bipolar electrostatically atomizing drug delivery device designed herein adopts the following technical scheme:
a bipolar electrostatically atomizing drug delivery device comprising:
The electrode unit comprises a bipolar high-voltage direct current power supply which is connected with the anode and cathode electrodes around the nozzle through a wire.
The rotary support unit comprises an outer cylindrical shell and an inner cylinder structure, wherein the inner cylinder structure is provided with a rotary support, and the rotary support is provided with a rotary support.
The jet atomizing unit comprises an air pump, wherein the air pump is connected with two positive and negative liquid storage chambers, and the tail ends of the positive and negative liquid storage chambers are connected with positive and negative oblique cone nozzles.
Further, the bipolar high-voltage direct current power supply is 0-8kV.
Further, the outer cylindrical shell is made of insulating materials, and the tail end of the outer cylindrical shell is provided with a medicine mist suction inlet.
Further, the rotary support is connected with the inner cylinder through a bearing.
Further, the flow control range of the air pump is 0.0-5.0mL/h.
Further, the volumes of the two positive and negative liquid storage chambers are 10.0mL, and a liquid medicine injection port is arranged above the two positive and negative liquid storage chambers.
Further, the two bevel-cone nozzles have a metal model of 24G, an inner diameter of 0.30mm, an outer diameter of 0.55mm, a length of 13.00mm, and a bevel-cone chamfer of 60 degrees.
Compared with the prior art, the invention has the following advantages:
1. The invention adopts symmetrically arranged positive and negative electrode electrostatic atomization devices, positive and negative bevel nozzles are arranged on the positive and negative electrodes, and the ejected particle flow is respectively charged positively and negatively. The particle flows with opposite charges of the two belts are neutralized in the atomization chamber, so that the charge quantity of the finally generated aerosol is electrically neutral, and the generated aerosol is more stable. The method well solves the problems that the charged particle flow sprayed by a common unipolar electrostatic atomization system is unstable, deposition is easy to generate in the conveying process, and the charged particle cannot enter a human body better.
2. The oblique cone nozzle adopted by the invention has the advantage that the electric field generated by the ejected particle flow bends inwards to the axis. The starting voltage of the oblique cone nozzle is lower than that of the common nozzle and is stable. The beveled nozzle can produce a higher electric field strength and a larger effective meniscus than conventional nozzles; at the same time, the voltage generated at its tip can enhance the characteristics of the jet, more easily neutralizing the ionic wind.
3. The invention can ensure that the device generates the drug particle flow with proper particle size by changing the physicochemical property and voltage of the liquid medicine so as to ensure that the deposition rate of the drug in the target area is improved and the drug fully acts on the target area. Experiments prove that the device can generate particle flow with the size of a few microns, can reach the maximum deposition amount in the lower airway, and is very suitable for pulmonary administration.
4. The invention provides a rotating device, wherein positive and negative electrode electrostatic atomization devices are symmetrically arranged on a bracket of the rotating device. Under the rotation action, the anode and cathode oblique cone nozzles connected with the spray nozzle spray in a rotating way, so that the particle flows with opposite charges of the two sprayed belts can be fully mixed in the atomization chamber, the charge quantity neutralization rate of the finally generated aerosol is greatly improved, and the aerosol can be stably sprayed from the medicine mist suction inlet into a human body.
5. Compared with the prior device design, the device has the advantages that a plurality of driving circuits and a plurality of independently driven electrostatic atomization system sources are not needed, and the device is more suitable for practical application.
6. The invention can generate 3.0-4.0 mu m liquid drop in the voltage range of 5.0-7.5 kV, can effectively improve the conveying effect of the liquid drop and can meet the aim of high-efficiency conveying of medicines.
Drawings
Fig. 1 shows a schematic structural view of a bipolar electrostatically atomizing drug delivery device of the present invention.
FIG. 2 shows a schematic view of the structure of section A-A of FIG. 1 according to the present invention;
FIG. 3 shows the obtained droplet size versus voltage for the present patent;
in the figure, a 1-bipolar high-voltage direct current power supply 2-air pump 3-cylinder 4-rotary support 5-rotary support 6-positive electrode liquid medicine injection port 7-negative electrode liquid medicine injection port 8-positive electrode liquid storage chamber 9-negative electrode liquid storage chamber 10-positive electrode 11-negative electrode 12-positive electrode inclined cone nozzle 13-negative electrode inclined cone nozzle 14-shell 15-atomizing chamber 16-medicine mist suction inlet
Detailed Description
The present invention will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
The invention provides a bipolar electrostatically atomizing drug delivery device, which is particularly arranged as shown in figure 1. The device is cylindrical, a cylinder 3 is arranged inside, a rotary support 4 is arranged outside the cylinder 3, a rotary support 5 is arranged on the rotary support 4, and symmetrically arranged positive and negative electrostatic atomization devices are arranged on the rotary support 5. The positive and negative electrostatic atomization device comprises a positive electrode liquid storage chamber 8 and a negative electrode liquid storage chamber 9, wherein the positive electrode liquid storage chamber and the negative electrode liquid storage chamber are respectively provided with a positive electrode liquid medicine injection opening 6 and a negative electrode liquid medicine injection opening 7. The positive and negative electrode liquid storage chambers are externally connected with a positive electrode inclined cone nozzle 12 and a negative electrode inclined cone nozzle 13, and a positive electrode 10 and a negative electrode 11 are arranged around the positive and negative electrode inclined cone nozzles. The positive and negative pole liquid storage chamber is externally connected with an air pump 2. The positive and negative electrodes are externally connected with a bipolar high-voltage direct-current power supply 1 through insulated wires. A cylindrical shell 14 is arranged outside the positive and negative liquid storage chambers, an atomization chamber 15 is formed in the shell, and a medicine mist suction inlet 16 is formed at the tail end of the cylindrical shell.
Referring to fig. 2, the invention can also adopt four oppositely placed electrostatic atomization devices, the same electrodes are symmetrically placed, and opposite electrodes are adjacently placed to form a total system. The charged medicine particles flow through the four belts in the atomizing chamber 15 and are sprayed into the human body through the medicine mist suction inlet. The device has the characteristics of enabling the finally sprayed medicine mist to be mixed more uniformly and enabling the flow to be larger.
The working process of the invention is further explained below:
In the embodiment, the required liquid medicine working medium is respectively injected into the positive and negative liquid storage chambers 8 and 9 through the positive liquid medicine injection port 6 and the negative liquid medicine injection port 7 in the symmetrically placed positive and negative electrostatic atomization device; the positive and negative liquid storage chambers 8 and 9 are connected by an air pump 2, working medium enters the positive oblique cone nozzle 12 and the negative oblique cone nozzle 13 under the action of the air pump, and the flow rate of liquid medicine is controlled to be 2.0mL/h by adjusting the pressure of the air pump; meanwhile, a bipolar high-voltage direct current power supply 1 is turned on, the voltage value of the bipolar high-voltage direct current power supply is set to be 4.0kV, and the bipolar high-voltage direct current power supply is connected with a positive electrode 10 and a negative electrode 11 around the anode and cathode oblique cone nozzles through wires, so that the two electrodes respectively carry opposite charges. At this time, two drug particle streams respectively with positive charges and negative charges sprayed by the positive and negative oblique cone nozzles are mixed in the atomizing chamber 15, so that the charge quantity of the finally generated drug mist is electrically neutral, and the diameter of the working medium particles is maintained within the range of 1-5 mu m through the regulation and control of voltage and flow. Finally, the neutralized drug working substance enters the body through the drug suction inlet 16, well acts on the target area in the body, and achieves higher deposition rate.
In addition, for different medicinal working media, the voltage and the flow of the medicinal working media need to be regulated and controlled due to the different physical parameters such as conductivity, surface tension, density and the like, so that the diameter of the working media is maintained in the range of 1-5 mu m; meanwhile, the number of the nozzles can be increased on the rotary support, so that the larger flow requirement can be achieved.
The above embodiments are merely for illustrating the design concept and features of the present invention, and are intended to enable those skilled in the art to understand the content of the present invention and implement the same, the scope of the present invention is not limited to the above embodiments. Therefore, all equivalent changes or modifications according to the principles and design ideas of the present invention are within the scope of the present invention.
Claims (9)
1. The bipolar electrostatic atomization drug delivery device comprises an electrode unit, a rotary supporting unit and a jet atomization unit, and is characterized in that the electrode unit comprises a bipolar high-voltage direct current power supply, a lead and positive and negative electrodes, wherein the bipolar high-voltage direct current power supply is 4.0-8.0kV, the positive and negative electrodes are bevel nozzles with inclination angles, and the bipolar high-voltage direct current power supply is connected with the positive and negative electrodes through the lead;
the rotary support unit comprises an outer cylindrical shell, an inner cylinder structure, a rotary support and a rotary support, wherein the outer cylindrical shell is made of insulating materials, the tail end of the outer cylindrical shell is provided with a medicine fog suction inlet, the rotary support is arranged on the rotary support, the rotary support is connected with the inner cylinder through a bearing, and the inner cylinder is embedded into the outer cylindrical shell through a mortise and tenon structure;
The jet atomizing unit comprises an air pump, an anode and cathode liquid storage chamber, an anode and cathode liquid medicine injection opening and an anode and cathode inclined cone nozzle, the air pump is connected with the anode and cathode liquid storage chamber through an air duct, the anode and cathode liquid medicine injection opening is respectively arranged above the anode and cathode liquid storage chamber, and the bottom end of the anode and cathode liquid medicine injection opening is connected with the anode and cathode inclined cone nozzle;
The required liquid medicine working medium is respectively injected into the liquid storage chamber through the positive and negative liquid medicine injection ports, the voltage is controlled by adjusting the bipolar high-voltage direct current power supply, the liquid medicine flow is controlled by adjusting the air pump, finally the liquid medicine is sprayed out through the positive and negative inclined cone nozzles under the action of an electric field, the atomizing mode of liquid medicine spraying is cone jet flow, two bundles of cone jet flow form medicine particle flows with positive charges and negative charges respectively, and the medicine particle flows are mixed in the atomizing chamber inside the cylindrical shell, so that the finally generated medicine fog electric charge quantity is electrically neutral, and the particle size of the medicine particles is 3.0-5.0 mu m.
2. The bipolar electrostatically atomizing medication delivery device of claim 1 wherein said rotatable housing has four apertures therein, the apertures being the same size as the positive and negative fluid reservoirs, the positive and negative fluid reservoirs being connected to the rotatable housing by the apertures.
3. The bipolar electrostatically atomizing drug delivery device as claimed in claim 1, wherein said two beveled conical nozzles have an inner diameter of 0.30mm to 1.00mm, an outer diameter of 0.55mm to 1.5mm, a length of 13.00mm, beveled corners of 60 °, and are provided as positive and negative electrodes, respectively.
4. A bipolar electrostatically atomizing drug delivery device as claimed in claim 1 wherein said two beveled nozzles are disposed symmetrically inwardly of the beveled surfaces of said two beveled nozzles when mounted.
5. The bipolar electrostatically atomizing drug delivery device as claimed in claim 1, wherein said two positive and negative reservoirs are cylindrical with a volume of 10.0mL, and a drug solution injection port is provided above said two positive and negative reservoirs, said drug injection port being sealed by a rubber cork.
6. A bipolar electrostatically atomizing drug delivery device as set forth in claim 1 wherein said air pump flow control range is matched to the selected positive and negative beveled cone nozzles and produces stable cone jet atomization with a recommended flow control range of 0.0-5.0mL/h.
7. The bipolar electrostatically atomized drug delivery apparatus as claimed in claim 1, wherein the nozzle produces a stable cone jet of atomized drug solution and is beveled.
8. A bipolar electrostatically atomized drug delivery device as claimed in claim 1, wherein the particle size of the drug particles is controlled to be in the range of 3.0-5.0 μm.
9. The bipolar electrostatically atomized medicine conveyer as claimed in claim 2, wherein a plurality of jet atomizing units are mountable on the rotatable support, the jet atomizing units having the same polarity being symmetrically arranged.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410295027.1A CN118079150A (en) | 2024-03-14 | 2024-03-14 | Bipolar electrostatically atomized drug delivery method and device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410295027.1A CN118079150A (en) | 2024-03-14 | 2024-03-14 | Bipolar electrostatically atomized drug delivery method and device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118079150A true CN118079150A (en) | 2024-05-28 |
Family
ID=91145538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410295027.1A Pending CN118079150A (en) | 2024-03-14 | 2024-03-14 | Bipolar electrostatically atomized drug delivery method and device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN118079150A (en) |
-
2024
- 2024-03-14 CN CN202410295027.1A patent/CN118079150A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4530548B2 (en) | Efficient electrohydrodynamic aerosol sprayer for mass transfer and method for generating and delivering aerosol to a desired location | |
| CN1069557C (en) | Dispensing device | |
| JP4677102B2 (en) | Aerosol feeder and method for feeding aerosol droplets | |
| US8991722B2 (en) | Microfluidic apparatus for the atomisation of a liquid | |
| US6394086B1 (en) | Inhalation apparatus | |
| JPH09510653A (en) | Dispensing device | |
| EP2018224B1 (en) | Dissociated discharge ehd sprayer with electric field shield | |
| CN1076987C (en) | Electrostatic spraying | |
| JP2002532163A (en) | Nasal inhaler | |
| JP2004500975A (en) | High throughput particle generator and particle generation method using multiple nozzle spray operations | |
| CN111494760A (en) | Plasma active water atomizer | |
| CN118079150A (en) | Bipolar electrostatically atomized drug delivery method and device | |
| CN211301573U (en) | Medical atomizing device based on multi-micron-hole array electrostatic atomization | |
| CN110812628B (en) | Medical atomizing device based on multi-micro-pore array electrostatic atomization | |
| CN212631752U (en) | Miniaturized atomizer | |
| WO2012158033A1 (en) | System for electro-hydrodynamic atomisation | |
| CN215351311U (en) | Tubular atomizing face guard that sustainability humidification was used | |
| CN109846695B (en) | Salt treatment equipment | |
| CN213589421U (en) | Dry powder medicine inhalation device | |
| CN117399191A (en) | Electrostatic atomizing system | |
| CN117399192A (en) | Electrostatic atomizing system | |
| CN118142736A (en) | Electronic atomizing device | |
| WO2024065108A1 (en) | Electrostatic atomizing device | |
| CN117045910A (en) | Atomization therapeutic device with improved structure | |
| WO2024092468A1 (en) | Electrostatic atomization device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |