CN118067818A - Reagent package assembly and blood gas analyzer - Google Patents

Reagent package assembly and blood gas analyzer Download PDF

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Publication number
CN118067818A
CN118067818A CN202311200033.6A CN202311200033A CN118067818A CN 118067818 A CN118067818 A CN 118067818A CN 202311200033 A CN202311200033 A CN 202311200033A CN 118067818 A CN118067818 A CN 118067818A
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China
Prior art keywords
liquid
assembly
test
pipe orifice
communicated
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Chinese (zh)
Inventor
朱志华
王继华
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Edan Instruments Inc
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Edan Instruments Inc
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Application filed by Edan Instruments Inc filed Critical Edan Instruments Inc
Priority to CN202311200033.6A priority Critical patent/CN118067818A/en
Publication of CN118067818A publication Critical patent/CN118067818A/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/4163—Systems checking the operation of, or calibrating, the measuring apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The invention relates to a blood gas analyzer, which comprises a test card assembly and a reagent pack assembly, wherein the test card assembly at least comprises a test card main body provided with a calibration liquid port, the reagent pack assembly at least comprises a rotary switch assembly, a liquid storage device, an air inlet device and a sample injection device provided with a liquid inlet needle, the rotary switch assembly comprises a fixed valve body provided with a first pipe orifice communicated with the liquid storage device, a second pipe orifice communicated with the sample injection device, a third pipe orifice communicated with the air inlet device and a rotary main body provided with a communication pipeline, two ends of the liquid inlet needle are respectively communicated with the second pipe orifice and the calibration liquid port, and the rotary main body is arranged in the fixed valve body and can rotate relative to the fixed valve body to realize the communication of the first pipe orifice and the second pipe orifice, the communication of the second pipe orifice and the third pipe orifice, or the closing of the second pipe orifice. The blood gas analyzer utilizes the rotary switch assembly to realize on-off control of different pipelines, does not need to press and loosen a rubber tube, does not have hidden danger of pipeline blockage, and prevents scaling liquid from leaking.

Description

Reagent package assembly and blood gas analyzer
The application relates to a divisional application of Chinese patent with the application date of 2016, 03 and 31 and the application number of CN 201610207561.8.
Technical Field
The invention relates to the technical field of medical treatment, in particular to a blood gas analyzer.
Background
The blood gas analyzer belongs to common medical equipment, and a reagent pack is arranged in the blood gas analyzer, and is used for calibrating an electrode to be measured, wherein a calibration liquid is stored in the reagent pack. In order to ensure the stability of the components of the calibration fluid, it must be well sealed. The reagent bag in the market mainly comprises a shell, a rubber tube valve and the like. The rubber tube valve can be inserted around the assembly position of the shell, so that the clamping hook part is clamped into the clamping hole, and the shell and the rubber tube valve compress the rubber tube to realize the shutoff of the rubber tube; the clamping hook part is separated from the clamping hole, the shell and the rubber tube valve loosen the compression of the rubber tube, and the rubber tube is jacked up by the rubber tube valve by means of the elasticity of the rubber tube, so that the conduction of the rubber tube is realized. Although the on-off control of the rubber tube can be realized, the following defects exist: the reagent bag needs to press the rubber tube for a long time by the rubber tube valve to prevent the leakage of the calibration liquid in the transportation and storage process, and the rubber tube is easy to adhere together and cannot rebound in the long-time pressing state, so that the pipeline is blocked; the action of the valve pressing rubber tube is unreliable, and the hidden trouble that the section of the pipeline cannot be completely pressed to cause liquid leakage exists.
Disclosure of Invention
The invention aims to provide a blood gas analyzer which can avoid the occurrence of pipeline blockage and liquid leakage.
In order to achieve the aim of the invention, the technical scheme adopted is as follows:
The utility model provides a blood gas analyzer, including test card subassembly and reagent package subassembly, test card subassembly is including the test card main part that is equipped with the scale liquid mouth at least, reagent package subassembly is including rotary switch subassembly at least, the liquid storage device, air inlet unit and be equipped with the sampling device of feed liquor needle, rotary switch subassembly is including being equipped with the first mouth of pipe with the liquid storage device intercommunication, the second mouth of pipe with the sampling device intercommunication, the third mouth of pipe fixed valve body with the air inlet unit intercommunication, and be equipped with the rotatory main part of communicating pipe, the both ends of feed liquor needle respectively with the second mouth of pipe and scale liquid mouth intercommunication, rotatory main part sets up in the inside just relatively fixed valve body of fixed valve body rotates in order to realize first mouth of pipe and second mouth of pipe intercommunication, or second mouth of pipe and third mouth of pipe intercommunication, or close the second mouth of pipe.
When the rotary switch assembly is in a state that the first pipe orifice is communicated with the second pipe orifice, the liquid storage device is communicated with the sample injection device, and the calibration liquid can be extracted; when the rotary switch assembly is in a state that the second pipe orifice is communicated with the third pipe orifice, the sample injection device is communicated with the air inlet device, and air can be extracted; when the rotary switch assembly is in a state that the second pipe orifice is closed, namely the sample injection device is closed, so that the test card can pump test liquid. The blood gas analyzer utilizes the rotary switch assembly to realize on-off control of different pipelines, does not need to press and relax a rubber pipe, does not have hidden danger of pipeline blockage, and simultaneously, the first pipe orifice is effectively closed when the rotary switch assembly is in a third state, so that scaling liquid is prevented from leaking.
The following technical scheme is further described:
Further, the test card main body is also provided with a liquid pipeline, a sample inlet and an electrode circuit board, the liquid pipeline comprises a test liquid pipeline, a calibration liquid pipeline and an electrode pipeline connected with the electrode circuit board, one end of the test liquid pipeline is communicated with the sample inlet, the other end of the test liquid pipeline is communicated with the calibration liquid pipeline and the electrode pipeline, one end of the calibration liquid pipeline, which is far away from the test liquid pipeline, is communicated with the calibration liquid port, and the highest liquid level of the calibration liquid pipeline is higher than the liquid level of the test liquid. After the test is finished, the calibration liquid port is separated from the reagent pack assembly, the test liquid is stored in the electrode pipeline and the calibration liquid pipeline, and because the highest liquid level position of the calibration liquid pipeline is higher than the liquid level of the test liquid, the test liquid cannot flow through the highest liquid level position of the calibration liquid pipeline under the action of no external force, the liquid cannot leak from the calibration liquid port, and liquid pollution is prevented. Compared with the traditional blood gas analyzer, the calibration liquid port does not need to be provided with a sealing plug, the reagent pack component is directly communicated with the calibration liquid port, the problem of scraps generated by puncturing the sealing plug is avoided, and the hidden danger of scrapping of testing caused by scraps pollution to an electrode is eliminated.
Further, the highest liquid level of the calibration liquid pipeline is concavely provided with a leakage-proof groove with an upward opening. The leak protection groove and the scaling liquid pipeline have the cross-section difference, and the test liquid can't flow out from the leak protection groove because of self liquid tension, further prevents that liquid from revealing out from the scaling liquid mouth.
Further, the test card main body is also provided with a liquid pipeline, a sample inlet, an extraction opening and an electrode circuit board, wherein the liquid pipeline comprises a test liquid pipeline, a waste liquid cavity and an electrode pipeline connected with the electrode circuit board, two ends of the test liquid pipeline are respectively communicated with the sample inlet and the electrode pipeline, one end of the electrode pipeline, which is far away from the test liquid pipeline, is communicated with a liquid inlet of the waste liquid cavity, a liquid outlet of the waste liquid cavity is communicated with the extraction opening, and the liquid outlet is positioned above the liquid inlet. After the test is completed, the extraction opening is separated from the external device, the calibration liquid is stored in the waste liquid cavity, and because the liquid outlet of the waste liquid cavity is positioned above the liquid inlet, the calibration liquid cannot flow out from the liquid outlet under the action of no external force, and the liquid leakage can not occur to the extraction opening communicated with the liquid outlet, so that the liquid pollution is prevented. Compared with the traditional blood gas analyzer, the air extraction port does not need to be provided with the sealing plug, and the external device is directly communicated with the air extraction port, so that the problem of scraps generated by puncturing the sealing plug is avoided, and the hidden danger of scrapping of testing caused by the pollution of the electrodes by scraps is eliminated.
Further, the waste liquid chamber includes first waste liquid chamber and second waste liquid chamber that arranges side by side at least, the leakage fluid dram in intercommunication first waste liquid chamber and second waste liquid chamber, and the bottom in first waste liquid chamber is equipped with the inlet, and the top in second waste liquid chamber is equipped with the liquid outlet, and the leakage fluid dram is located one side that is close to the liquid outlet. After the test is completed, the calibration liquid is stored in the first liquid waste cavity, a liquid outlet is arranged between the first liquid waste cavity and the second liquid waste cavity, the liquid outlet is positioned on one side close to the liquid outlet and is communicated with the tops of the first liquid waste cavity and the second liquid waste cavity, a section difference exists between the liquid outlet and the liquid waste cavity, and the calibration liquid cannot flow into the second liquid waste cavity from the first liquid waste cavity due to the liquid tension of the calibration liquid, so that the liquid is further prevented from leaking out from the extraction opening.
Further, support columns are arranged in the first waste liquid cavity and the second waste liquid cavity. Through setting up the support column, prevent that the test card from being when extracting through the extraction opening, the sealing membrane on the test card from sinking into the waste liquid intracavity.
Further, the blood gas analyzer further comprises a test valve assembly provided with a pressing piece, the test card main body is further provided with a liquid pipeline, the test card assembly further comprises a sealing film for sealing the liquid pipeline, the sealing film is an elastic composite film, a valve groove is formed in the opposite surface of the liquid pipeline and the sealing film, the sealing film is located between the valve groove and the pressing piece, and the pressing piece is provided with a pressing head matched with the valve groove. When the pressing piece presses the sealing film to attach to one side of the valve groove, the test liquid pipeline is closed; the sealing film is an elastic composite film, and when the extrusion piece leaves the sealing film, the sealing film leaves the valve groove by means of self elastic deformation, and the test liquid pipeline is opened. The valve slot is arranged in the test liquid pipeline and is integrated with the test liquid pipeline, so that redundant cavities and residual bubbles are avoided, the test liquid consumption is reduced, and the test accuracy is improved; the test card main body is not required to be provided with the on-off switch rubber plug and the sealing film for covering the channel switch rubber plug, so that the air leakage problem is avoided, the number of parts is reduced, the production is convenient, and the reject ratio of products is reduced.
Further, a protrusion protruding to one side of the sealing film is provided at the bottom of the valve groove. When the sealing film is filled on the valve groove, the protruding part is inlaid in the sealing film, so that the sealing effect of the test liquid pipeline is better.
Further, the test valve assembly further comprises a first driving device for driving the pressing piece to reciprocate to one side of the valve groove.
Further, the fixed valve body is in interference fit with the rotating body. The wall surface of the rotary main body is utilized to realize the sealing of the pipeline, and the structural design is ingenious.
Further, the blood gas analyzer further comprises a reagent pack valve control assembly, and the reagent pack valve control assembly further comprises a rotary cover sleeved on the rotary main body and a second driving device for driving the rotary cover to rotate. The second driving device drives the rotary cover and the rotary main body to realize rotary motion, and the rotary switch assembly is utilized to realize on-off control of different pipelines.
Further, the test card main part still is equipped with sample inlet, extraction opening, electrode circuit board and liquid pipeline, and liquid pipeline includes test liquid pipeline, calibration liquid pipeline, waste liquid chamber and the electrode pipeline that meets with electrode circuit board, test liquid pipeline's one end and sample inlet intercommunication, the other end with calibration liquid pipeline with electrode pipeline intercommunication, calibration liquid pipeline keep away from test liquid pipeline's one end and calibration liquid mouth intercommunication, calibration liquid pipeline's the liquid level highest point is higher than the liquid level of test liquid, electrode pipeline keeps away from test liquid pipeline's one end and the feed liquor mouth intercommunication in waste liquid chamber, the liquid outlet and the extraction opening intercommunication in waste liquid chamber, the liquid outlet is located the top of feed liquor mouth. Under the action of no external force, the test liquid can not flow through the highest liquid level position of the calibration liquid pipeline, and the calibration liquid can not flow out from the liquid outlet of the waste liquid cavity, so that the liquid is prevented from flowing out from the calibration liquid outlet and the extraction opening communicated with the liquid outlet, and the liquid pollution is prevented.
Further, the blood gas analyzer also comprises a test valve assembly provided with a pressure-resisting piece, the test card main body is also provided with a sample inlet, an electrode circuit board and a liquid pipeline, the test card assembly also comprises a sealing film for sealing the liquid pipeline, a valve slot is arranged on the opposite surface of the liquid pipeline and the sealing film, the sealing film is positioned between the valve slot and the pressure-resisting piece, and the pressure-resisting piece is provided with a pressure head matched with the valve slot; the liquid pipeline comprises a test liquid pipeline, a calibration liquid pipeline and an electrode pipeline connected with the electrode circuit board, one end of the test liquid pipeline is communicated with the sample inlet, the other end of the test liquid pipeline is communicated with the calibration liquid pipeline and the electrode pipeline, one end of the calibration liquid pipeline, which is far away from the test liquid pipeline, is communicated with the calibration liquid inlet, and the highest liquid level of the calibration liquid pipeline is higher than the liquid level of the test liquid. The liquid is prevented from flowing out from the calibration liquid port, the air leakage problem is avoided, and the testing accuracy of the blood gas analyzer is improved.
Further, the blood gas analyzer also comprises a test valve assembly provided with a pressure-resisting piece, the test card main body is also provided with a sample inlet, an air extraction opening, an electrode circuit board and a liquid pipeline, the test card assembly also comprises a sealing film for sealing the liquid pipeline, the opposite surface of the liquid pipeline and the sealing film is provided with a valve slot, the sealing film is positioned between the valve slot and the pressure-resisting piece, and the pressure-resisting piece is provided with a pressure head matched with the valve slot; the liquid pipeline comprises a test liquid pipeline, a waste liquid cavity and an electrode pipeline connected with the electrode circuit board, wherein two ends of the test liquid pipeline are respectively communicated with the sample inlet and the electrode pipeline, one end of the electrode pipeline, which is far away from the test liquid pipeline, is communicated with a liquid inlet of the waste liquid cavity, a liquid outlet of the waste liquid cavity is communicated with the extraction opening, and the liquid outlet is positioned above the liquid inlet. The liquid is prevented from flowing out from the air extraction opening, the air leakage problem is avoided, and the testing accuracy of the blood gas analyzer is improved.
Further, the liquid pipeline comprises a calibration liquid pipeline, one end of the test liquid pipeline, which is communicated with the electrode pipeline, is also communicated with the calibration liquid pipeline and the electrode pipeline, one end of the calibration liquid pipeline, which is far away from the test liquid pipeline, is communicated with the calibration liquid port, and the highest liquid level of the calibration liquid pipeline is higher than the liquid level of the test liquid. The liquid is prevented from flowing out from the air extraction opening and the calibration liquid opening, the air leakage problem is avoided, and the testing accuracy of the blood gas analyzer is improved.
Further, the blood gas analyzer also comprises a piston pump assembly, the testing card main body is also provided with an extraction opening, and the piston pump assembly comprises an extraction needle, a connector, a piston and a third driving device, wherein one end of the extraction needle is communicated with the extraction opening, the connector is communicated with the extraction needle, the piston is connected with the connector, and the third driving device drives the piston to do linear reciprocating motion. In the testing process, the third driving device drives the piston to retreat, so that the liquid pipeline in the test card main body generates negative pressure, and the calibration liquid, the air or the test liquid is led to flow into the liquid pipeline, thereby completing the extraction of each medium.
Further, the blood gas analyzer further comprises a sealing piece, the sealing piece is sleeved on the liquid inlet needle and the air suction needle, and a sealing groove matched with the sealing piece in shape is formed in the outer wall of the test card body. The effect of preventing liquid leakage of messenger's blood gas analysis appearance is better, compares with traditional blood gas analysis appearance, and the sealing member seals respectively at feed liquor needle and bleed needle, and reagent package subassembly and piston pump subassembly are separated with test card main part after, under the prerequisite of guaranteeing sealedly, avoids eliminating the hidden danger that the piece pollutes the electrode and causes the test to scrap again.
Further, the blood gas analyzer further comprises a slider component, the slider component is arranged opposite to the test card body and located on one side of the test card body facing the electrode circuit board, the slider component comprises a sliding block, a first fixing seat, and first compression springs with two ends respectively propped against the sliding block and the fixing seat, the sliding block is provided with a first plug protruding towards one side of the test card body, and the test card body is provided with a first limit groove matched with the first plug. After the test card assembly is inserted into the reagent pack assembly, the first plug on the slider is inserted into the first limit groove under the action of the first compression spring by the slider, so that the positioning of the test card main body is realized.
Further, the blood gas analyzer also comprises a heating component, the test card main body is further provided with an electrode circuit board, the heating component is arranged opposite to the test card main body and is positioned on one side of the test card main body, which is opposite to the electrode circuit board, the heating component comprises a first heating body, a heating body fixing support, a fourth driving device, the first heating body fixing support is fixed on the first heating body, the fourth driving device is used for driving the heating body fixing support to reciprocate towards one side of the electrode circuit board, the heating body fixing support is provided with a second plug protruding towards one side of the test card main body, and the test card main body is provided with a second limiting groove matched with the second plug. After the test card assembly is inserted into the reagent pack assembly, the first plug on the slider is inserted into the first limit groove under the action of the first compression spring by the slider, so that the primary positioning of the test card main body is realized; the second plug moves to one side of the test card main body under the action of the fourth driving device, and the second plug is inserted into the second limit groove, so that the second positioning of the test card main body is realized, the positioning of the test card main body is more accurate and reliable, and the liquid in the test card main body is heated through the first heating body, so that the liquid reaches the specified temperature. The slide fastener component and the heating component are used for carrying out bilateral positioning on the front surface and the back surface of the test card main body, so that the test card main body is uniformly stressed and cannot deform under stress.
Further, the blood gas analyzer also comprises a bouncing component positioned under the test card main body, wherein the bouncing component comprises a second fixing seat, a pressing block and a second compression spring, the pressing block is oppositely arranged at the bottom of the test card main body, and the two ends of the second compression spring are respectively propped against the second fixing seat and the pressing block. After the test card assembly is inserted into the reagent pack assembly, the slide fastener assembly and the heating assembly fix the test card main body, the pressing piece is pressed down by the force, and the second compression spring is compressed by the force; after the test is completed, the slide fastener component and the heating component release the fixation of the test card main body, and the pressing block upwards rebounds under the action of the second compression spring, so that the test card main body can be automatically sprung.
Further, the blood gas analyzer also comprises a test assembly, the test assembly is arranged opposite to the test card main body and positioned on one side of the test card main body facing the electrode circuit board, the test assembly comprises a detection module, a second heating body arranged opposite to the electrode circuit board, a shell body fixed with the detection module and the second heating body, and a fifth driving device for driving the shell body to reciprocate towards one side of the electrode circuit board, the sliding block is positioned above the shell body, a matching rib is arranged at the bottom of the sliding block in a protruding manner towards one side of the shell body, a pushing rib is arranged at the top of the shell body in a protruding manner towards one side of the sliding block, and the pushing rib is positioned between the matching rib and the test card main body. After the test card assembly is inserted into the reagent pack assembly, the fifth driving device drives the second heating body on the shell to move to one side of the electrode circuit board, the first plug is inserted into the first limit groove, and the second plug is inserted into the second limit groove; after the test assembly is electrified, the electrode circuit board is heated to enable the liquid in the main body of the test card to reach a specified temperature, and current and voltage signals generated on the electrode circuit board are transmitted into the main body through the detection module to realize the test of the calibration liquid and the test liquid; after the test is completed, the fifth driving device of the test assembly drives the shell to retreat, and as the pushing rib is positioned between the matching rib and the test card main body, when the pushing rib on the shell contacts with the matching rib, the pushing rib retreats continuously along with the shell, the sliding block retreats along with the pushing rib, the first compression spring is compressed, and the first plug on the sliding block is separated from the first limit groove. After the test card main body is automatically sprung, the fifth driving device enables the shell to move forwards, the sliding block also moves forwards together under the action of the first compression spring, the matching rib extrudes the pushing rib, when the shell moves to the position where no stress exists between the pushing rib and the matching rib, the first plug of the sliding buckle component returns to the initial position, the next round of test is conveniently carried out, the structures of the matching rib and the pushing rib are skillfully designed, the position control of the sliding buckle component by the test component is realized, and the action is more reliable.
Further, the blood gas analyzer also comprises a reagent pack valve control assembly, a piston pump assembly, a heating assembly and a testing assembly, the testing valve assembly further comprises a first driving device for driving the pressing piece to reciprocate towards one side of the valve groove, the reagent pack valve control assembly further comprises a rotary cover sleeved on the rotary main body, a second driving device for driving the rotary cover to rotate, the piston pump assembly comprises an air pumping needle with one end communicated with the air pumping hole, a connector communicated with the air pumping needle, a piston connected with the connector and a third driving device for driving the piston to reciprocate linearly, the heating assembly comprises a first heating body, a heating body fixing support fixed with the first heating body, a fourth driving device for driving the heating body fixing support to reciprocate towards one side of the electrode circuit board, and the testing assembly comprises a detection module, a second heating body, a shell fixed with the detection module and the second heating body and a fifth driving device for driving the shell to reciprocate towards one side of the electrode circuit board. The testing valve assembly, the reagent pack valve control assembly, the piston pump assembly, the heating assembly and the testing assembly are all controlled by independent driving devices, and compared with a traditional turntable synchronous driving system of the blood gas analyzer, the control of the blood gas analyzer is more flexible, and the working period is shortened.
Further, the first driving device, the third driving device, the fourth driving device and the fifth driving device are linear stepping motors, and the second driving device is a rotary stepping motor. The first driving device, the second driving device, the third driving device, the fourth driving device and the fifth driving device are all stepping motors, compared with a turntable synchronous driving system of a traditional blood gas analyzer, the speed of the stepping motors is adjustable, the action is gentle and controllable, the noise is low, the structure is simplified, and the assembly efficiency is improved.
Further, the first driving device, the second driving device, the third driving device, the fourth driving device and the fifth driving device are all provided with reset optocouplers. The reset optocoupler plays a role in detecting the initial position of the motor shaft, and eliminates position errors after each movement, so that the control is more accurate.
Compared with the prior art, the invention has the following beneficial effects:
When the rotary switch assembly is in a state that the first pipe orifice is communicated with the second pipe orifice, the liquid storage device is communicated with the sample injection device, and the calibration liquid can be extracted; when the rotary switch assembly is in a state that the second pipe orifice is communicated with the third pipe orifice, the sample injection device is communicated with the air inlet device, and air can be extracted; when the rotary switch assembly is in a state that the second pipe orifice is closed, namely the sample injection device is closed, so that the test card can pump test liquid. The blood gas analyzer utilizes the rotary switch assembly to realize on-off control of different pipelines, does not need to press and relax a rubber pipe, does not have hidden danger of pipeline blockage, and simultaneously, the first pipe orifice is effectively closed when the rotary switch assembly is in a third state, so that scaling liquid is prevented from leaking.
Drawings
FIG. 1 is a schematic diagram of a blood gas analyzer according to an embodiment of the present invention;
FIG. 2 is an exploded view of a blood gas analyzer according to an embodiment of the present invention;
FIG. 3 is a schematic illustration of the connection of a test card assembly and a reagent pack assembly according to an embodiment of the present invention;
FIG. 4 is a schematic view of the structure of a reagent pack assembly according to an embodiment of the present invention;
FIG. 5 is an exploded view of a reagent pack assembly according to an embodiment of the present invention;
FIG. 6 is a schematic illustration of the connection of a reagent pack assembly and a reagent pack valve control assembly according to an embodiment of the present invention;
FIG. 7 is a schematic illustration of the structure of a piston pump assembly according to an embodiment of the present invention;
FIG. 8 is a schematic diagram of a test card assembly according to an embodiment of the invention;
FIG. 9 is an exploded view of a test card assembly according to an embodiment of the present invention;
FIG. 10 is a cross-sectional view taken along line A-A of FIG. 8;
FIG. 11 is an enlarged view of FIG. 10 at I;
FIG. 12 is a schematic illustration of the structure of a test valve assembly according to an embodiment of the present invention;
FIG. 13 is a schematic view of a first operating state of a test card assembly according to an embodiment of the invention;
FIG. 14 is a schematic diagram of a second operational state of the test card assembly according to an embodiment of the invention;
FIG. 15 is a schematic view of a third operational state of a test card assembly according to an embodiment of the invention;
FIG. 16 is an enlarged view of FIG. 1 at II;
FIG. 17 is an enlarged view at III of FIG. 1;
FIG. 18 is a schematic diagram of the connection of a test card assembly, a heating assembly, and a test assembly according to an embodiment of the invention;
FIG. 19 is an enlarged view at IV of FIG. 18;
FIG. 20 is a schematic view of a heating assembly according to an embodiment of the present invention;
FIG. 21 is a schematic diagram of a test assembly according to an embodiment of the present invention;
fig. 22 is an enlarged view of v in fig. 4.
Reference numerals illustrate:
10. The test card assembly, 110, the test card body, 111, the sample inlet, 112, the calibration fluid inlet, 113, the exhaust port, 114, the seal groove, 115, the electrode test groove, 116, the first limit groove, 117, the second limit groove, 120, the seal film, 121, the adhesive film, 122, the elastic silica film, 123, the PET film, 130, the electrode circuit board, 140, the liquid pipeline, 141, the test fluid pipeline, 1411, the valve groove, 142, the calibration fluid pipeline, 1421, the leakage-proof groove, 1422, the top, 143, the liquid cavity 1431, the first liquid cavity, 1432, the second liquid cavity, 1433, the liquid outlet, 1434, the liquid inlet, 1435, the liquid outlet, 144, the electrode pipeline, 145, the liquid cavity 150, the seal, 160, the support column, 170, the sample injection needle, 180, the injector, 190, the protrusion 20, the reagent package assembly, 210, the rotary switch assembly, 211, the fixed valve body, 212, 213, the connecting pipeline, 214, first orifice, 215, second orifice, 216, third orifice, 220, reservoir, 221, outlet, 230, intake, 240, sample injection, 241, inlet needle, 242, inlet, 250, outer housing, 251, front housing, 252, rear housing, 260, rotary handle, 270, support, 30, reagent pack valve control assembly, 310, rotary cover, 320, second drive, 321, first motor shaft, 330, first optocoupler, 40, piston pump assembly, 410, suction needle, 420, suction tube, 430, connector, 440, piston, 450, third drive device, 451, second motor shaft, 460, second optocoupler, 470, first mounting bracket, 480, pump body, 50, test valve assembly, 510, pressure block, 511, pressure head, 520, first drive device, 521, third motor shaft, 530, third optocoupler, 60, slider assembly, 610, slider, 611, first plug, 612. the assembly includes, by way of example, a first mounting bracket 620, 630, a first compression spring 640, a first guide shaft 70, a heating assembly 710, a first heating body 720, a heating body mounting bracket 721, a second plug 730, a fourth drive device 731, a fourth motor shaft 740, a fourth optocoupler 750, a heating body mounting cover 760, a motor mounting bracket 770, a second guide shaft 780, a snap-in position 80, a pop-up assembly 810, a second mounting bracket 820, an abutment, 830, a second compression spring 90, a test assembly 910, a detection module 911, a test probe 920, a second heating body 930, a housing 931, a push rib 940, a fifth drive device 941, a fifth motor shaft 950, and a fifth optocoupler.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to the attached drawings:
As shown in fig. 1 to 4, 9 and 22, a blood gas analyzer comprises a test card assembly 10 and a reagent pack assembly 20, wherein the test card assembly 10 comprises a test card main body 110 provided with a sample inlet 111, a calibration liquid inlet 112, an air extraction port 113 and a liquid pipeline 140, a sealing membrane 120 for sealing the liquid pipeline 140, an electrode circuit board 130 arranged on the test card main body 110, the reagent pack assembly 20 at least comprises a rotary switch assembly 210, a liquid storage device 220, an air inlet device 230 and a sample inlet device 240 provided with a liquid inlet needle 241, the rotary switch assembly 210 comprises a fixed valve body 211 and a rotary main body 212, the rotary main body 212 is arranged in the fixed valve body 211 and can rotate relative to the fixed valve body 211, a connecting pipeline 213 is arranged on the rotary main body 212, a first pipe orifice 214 communicated with the liquid storage device 220, a second pipe orifice 215 communicated with the sample inlet device 240 and a third pipe orifice 216 communicated with the air inlet device 230 are arranged on the fixed valve body 211, and two ends of the liquid inlet needle 241 are respectively communicated with the second pipe orifice 215 and the calibration liquid inlet 112; rotating the rotating body 212 may place the rotary switch assembly 210 in a first state, a second state, or a third state: the first state is that the second nozzle 215 is communicated with the first nozzle 214 through the connecting pipeline 213; the second state is that the second pipe orifice 215 is communicated with the third pipe orifice 216 through the connecting pipe 213; the third state is where both the second orifice 215 and the first orifice 214 are closed.
When the rotary switch assembly 210 is in the first state, the liquid storage device 220 is communicated with the sample injection device 240, so that the calibration liquid can be extracted; when the rotary switch assembly 210 is in the second state, the sample injection device 240 is communicated with the air inlet device 230, so that air can be extracted; when the rotary switch assembly 210 is in the third state, the second nozzle 215 is closed, i.e. the sample injection device 240 is closed, so that the test card can perform the test liquid extraction action. The blood gas analyzer utilizes the rotary switch assembly 210 to realize on-off control of different pipelines, does not need to press and loosen a rubber pipe, has no hidden danger of pipeline blockage, and simultaneously, the first pipe orifice 214 is effectively closed when the rotary switch assembly 210 is in a third state, so that scaling liquid is prevented from leaking. Preferably, the fixed valve body 211 is in interference fit with the rotary body 212, and the wall surface of the rotary body 212 is directly utilized to realize the sealing of the pipeline.
In this embodiment, as shown in fig. 4, 5 and 22, the reagent pack assembly 20 further includes a housing 250 having a placement cavity, the fixed valve body 211 is fixed in the placement cavity, the connecting pipe 213 is an L-shaped pipe, the housing 250 is provided with a rotating handle 260 connected to the rotating body 212, and the rotating handle 260 is exposed on the housing 250, and when in use, the rotating handle 260 is rotated, so that the rotating switch assembly 210 can be adjusted to different states, and the use is convenient. The connecting duct 213 may be provided in other shapes according to actual needs.
As shown in fig. 4 and 5, the liquid storage device 220 is a calibration liquid bag disposed in the placement cavity, the housing 250 has the function of protecting the calibration liquid bag, preventing the calibration liquid bag from being polluted, and the calibration liquid bag is provided with a liquid outlet pipe 221, and the liquid outlet pipe 221 is sleeved on the first pipe orifice 214. Wherein, the shell 250 includes a front shell 251 and a rear shell 252, and the front shell 251 is detachably connected with the rear shell 252, so as to facilitate the installation of the calibration liquid bag.
In this embodiment, the front casing 251 and the rear casing are fixed by screws, and a status indicator (not shown in the drawings) is provided on the casing 250 near the rotary handle 260, so that a user can know what status the rotary switch assembly 210 is currently in.
As shown in fig. 2 and 6, the blood gas analyzer further includes a reagent pack valve control assembly 30, and the reagent pack valve control assembly 30 further includes a rotary cover 310 sleeved on the rotary body 212, and a second driving device 320 for driving the rotary cover 310 to rotate. The second driving device 320 drives the rotary cover 310 and the rotary body 212 to realize rotary motion, and the rotary switch assembly 210 is utilized to realize on-off control of different pipelines.
In this embodiment, the second driving device 320 is a rotary stepper motor, which is provided with a first motor shaft 321, an optocoupler sensing wall (not shown in the drawings) is designed on the rotary cover 310, and the rotary cover 310 is fixed to the first motor shaft 321 by a screw. When the rotary stepper motor is electrified to work, the first motor shaft 321 drives the rotary cover 310 and the rotary main body 212 to realize rotary motion, so that on-off control of the sample injection liquid path and the air inlet pipeline of the reagent pack assembly 20 is realized.
The reagent pack valve control assembly 30 further comprises a first optical coupler 330, wherein the first optical coupler 330 is used for detecting and controlling the initial position of the first motor shaft 321, and eliminating the position error after each rotation.
As shown in fig. 4 and 22, the reagent pack assembly 20 further includes a support seat 270, the support seat 270 is fixed on the housing 250, the sample injection device 240 includes a liquid inlet needle 241 and a liquid inlet tube 242, the liquid inlet needle 241 is fixed on the support seat 270 and is connected with the calibration liquid port 112 of the test card, so as to provide a sample conveniently, one end of the liquid inlet tube 242 is sleeved on the liquid inlet needle 241, the other end is sleeved on the second pipe orifice 215, and the liquid inlet needle 241 is communicated with the second pipe orifice 215 through the liquid inlet tube 242. The air inlet device 230 is an air tube sleeved on the third tube orifice 216, and the air tube is communicated with the atmosphere to directly extract air from the atmosphere.
As shown in fig. 3, 4 and 7, the blood gas analyzer further includes a piston pump assembly 40, the piston pump assembly 40 includes an air suction needle 410 having one end connected to the air suction port 113, an air suction tube 420 having one end connected to the other end of the air suction needle 410, a connection head 430 connected to the other end of the air suction tube 420, a piston 440 connected to the connection head 430, and a third driving device 450 driving the piston 440 to reciprocate linearly, and the air suction needle 410 and the air suction tube 420 are fixed to the support seat 270 of the reagent pack assembly 20. In the testing process, the third driving device 450 drives the piston 440 to retract, so that the liquid pipeline 140 in the test card main body 110 generates negative pressure, and the calibration liquid, air or the test liquid is made to flow into the liquid pipeline 140, thereby completing the extraction of each medium.
In this embodiment, the third driving device 450 is a linear stepper motor provided with a second motor shaft 451, the piston pump assembly 40 further comprises a piston pump sub-assembly provided with a piston 440 and a connector 430, a second optocoupler 460 and a first fixing bracket 470, the piston pump sub-assembly further comprises a pump body 480, the piston pump sub-assembly is sleeved in the first fixing bracket 470, wherein the piston 440 is in threaded connection with the second motor shaft 451, and the third driving device 450 is fixed to the first fixing bracket 470 by screws and simultaneously fixes the piston pump sub-assembly. When the third driving device 450 is powered on, the second motor shaft 451 drives the piston 440 to reciprocate along the pump body 480, and the second optical coupler 460 serves to detect the initial position of the second motor shaft 451, so as to eliminate the position error after each reciprocation.
As shown in fig. 3, the blood gas analyzer further includes a sealing member 150, the sealing member 150 is sleeved on the liquid inlet needle 241 and the air exhaust needle 410, and the outer wall of the test card body 110 is provided with a sealing groove 114 matching the shape of the sealing member 150. The effect of preventing liquid leakage of the blood gas analyzer is better, compared with the traditional blood gas analyzer, the sealing member 150 is respectively sealed at the liquid inlet needle 241 and the air exhaust needle 410, and after the reagent pack assembly 20 and the piston pump assembly 40 are separated from the test card main body 110, the hidden trouble of testing scrapping caused by removing scraps and polluting the electrode is avoided under the premise of ensuring sealing.
As shown in fig. 8 and 9, the liquid pipeline 140 of the test card assembly 10 includes a test liquid pipeline 141, a calibration liquid pipeline 142, a waste liquid cavity 143 and an electrode pipeline 144 connected with the electrode circuit board 130, one end of the test liquid pipeline 141 is communicated with the sample inlet 111, the other end is communicated with the calibration liquid pipeline 142 and the electrode pipeline 140, one end of the calibration liquid pipeline 142 away from the test liquid pipeline 141 is communicated with the calibration liquid port 112, one end of the electrode pipeline 140 away from the test liquid pipeline 141 is communicated with a liquid inlet 1434 of the waste liquid cavity 143, a liquid outlet 1435 of the waste liquid cavity 143 is communicated with the pumping port 113, the liquid outlet 1435 is positioned above the liquid inlet 1434, and the highest liquid level of the calibration liquid pipeline 142 is higher than the liquid level of the test liquid. After the test is finished, the air extraction opening 113 and the calibration liquid opening 112 are separated from the reagent pack assembly 20, the calibration liquid is stored in the waste liquid cavity 143, the test liquid is stored in the electrode pipeline 140 and the calibration liquid pipeline 142, and as the liquid outlet 1435 of the waste liquid cavity 143 is positioned above the liquid inlet 1434, the calibration liquid cannot flow out from the liquid outlet 1435 under the action of no external force, the air extraction opening 113 communicated with the liquid outlet 1435 cannot leak liquid, and liquid pollution is prevented; and the highest liquid level of the calibration liquid pipeline 142, namely the top 1422 of the pipeline is higher than the liquid level of the test liquid, the test liquid cannot flow through the highest liquid level of the calibration liquid pipeline 142 under the action of no external force, and the liquid cannot leak from the calibration liquid port 112, so that liquid pollution is prevented. Compared with the traditional test card, the calibration liquid port 112 and the air extraction port 113 do not need to be provided with sealing plugs, and an external device is directly communicated with the calibration liquid port 112 and the air extraction port 113, so that the problem of scraps generated by puncturing the sealing plugs is solved, and the hidden danger of scrapping of the test caused by the scraps polluting the electrode is eliminated.
In this embodiment, the waste liquid chamber 143 includes a first waste liquid chamber 1431 and a second waste liquid chamber 1432 arranged side by side, a liquid outlet 1433 communicating the first waste liquid chamber 1431 and the second waste liquid chamber 1432, a liquid inlet 1434 is disposed at the bottom of the first waste liquid chamber 1431, a liquid outlet 1435 is disposed at the top of the second waste liquid chamber 1432, and the liquid outlet 1433 is located at one side close to the liquid outlet 1435. After the test is completed, the calibration liquid is stored in the first waste liquid cavity 1431, a liquid outlet 1433 is arranged between the first waste liquid cavity 1431 and the second waste liquid cavity 1432, the liquid outlet 1433 is positioned on one side close to the liquid outlet 1435 and is communicated with the tops of the first waste liquid cavity 1431 and the second waste liquid cavity 1432, a section difference exists between the liquid outlet 1433 and the waste liquid cavity 143, and the calibration liquid cannot flow into the second waste liquid cavity 1432 from the first waste liquid cavity 1431 easily due to the liquid tension of the calibration liquid, so that the liquid is further prevented from leaking out from the pumping hole 113. The waste liquid cavity 143 can be provided with more than one according to actual needs.
As shown in fig. 8, two support columns 160 are provided in both the first waste chamber 1431 and the second waste chamber 1432. By providing the support column 160, the sealing film 120 on the test card is prevented from sinking into the waste liquid chamber 143 when the test card is pumped through the pumping port 113. The first waste chamber 1431 and the second waste chamber 1432 may further be provided with more than one support column 160 according to actual needs.
As shown in fig. 8, the liquid pipe 140 further includes a waste liquid pipe 145, and the waste liquid pipe 145 is connected between the liquid outlet 1435 and the suction port 113.
As shown in fig. 8, the top 1422 of the calibration fluid channel 142 is concavely provided with an upwardly open leakage-proof groove 1421. The leak-proof groove 1421 and the calibration liquid pipeline 142 have a cross-section difference, so that the test liquid cannot flow out of the leak-proof groove 1421 due to the tension of the test liquid, and the test liquid is further prevented from leaking out of the calibration liquid port 112. The leakage preventing groove 1421 may be further provided between the top 1422 of the calibration fluid pipe 142 and the end of the calibration fluid pipe 142 connected to the test fluid pipe 141 according to actual needs.
As shown in fig. 10, the test card body 110 is further provided with an electrode test slot 115, and the bottom of the electrode duct 140 is connected to the electrode circuit board 130 through the electrode test slot 115.
As shown in fig. 8, the test card assembly 10 further includes a sample injection needle 170, and a liquid injection needle 241 is fixed to the sample injection port 111 of the test card body 110 and communicates with the syringe 180, and the test liquid is stored in the syringe 180.
As shown in fig. 2, 8, 9 and 12, the blood gas analyzer further includes a test valve assembly 50 provided with a pressing member 510, the sealing membrane 120 is an elastic composite membrane, a valve groove 1411 is provided on the opposite surface of the test liquid pipe 141 and the sealing membrane 120, the sealing membrane 120 is located between the valve groove 1411 and the pressing member 510, and the pressing member 510 is provided with a pressing head 511 matching the shape of the valve groove 1411. When the pressing piece 510 presses the sealing film 120 to be attached to one side of the valve groove 1411, the test liquid pipeline 141 is closed; the sealing film 120 is an elastic composite film, when the extrusion piece leaves the sealing film 120, the sealing film 120 leaves the valve groove 1411 by self elastic deformation, and the test liquid pipeline 141 is opened. The valve groove 1411 is arranged in the test liquid pipeline 141 and is integrated with the test liquid pipeline 141, so that redundant cavities and residual bubbles are avoided, the consumption of test liquid is reduced, and the test accuracy is improved; the on-off switch rubber plug and the sealing film 120 for covering the channel switch rubber plug are not required to be arranged on the test card main body 110, so that the air leakage problem is avoided, the number of parts is reduced, the production is convenient, and the reject ratio of products is reduced.
In this embodiment, as shown in fig. 12, the test valve assembly 50 further includes a first driving device 520 and a third optocoupler 530 for driving the pressing member 510 to reciprocate toward the valve slot 1411, the first driving device 520 is a linear stepping motor, the linear stepping motor is provided with a third motor shaft 521, the pressing member 510 is screwed onto the third motor shaft 521, and when the first driving device 520 is powered on, the third motor shaft 521 drives the pressing member 510 to reciprocate along the axial direction of the linear stepping motor. The third optocoupler 530 serves to detect and control the initial position of the third motor shaft 521, eliminating the position error of each reciprocation.
As shown in fig. 11, the bottom of the valve groove 1411 is provided with a protrusion 190 protruding toward the sealing film 120 side, and the protrusion 190 is rib-shaped. When the sealing film 120 is filled in the valve groove 1411, the protrusion 190 is inserted into the sealing film 120, so that the sealing effect of the test liquid pipe 141 is better.
In this embodiment, as shown in fig. 11, the sealing film 120 includes a glue film 121, an elastic silica gel film 122 and a PET film 123, the glue film 121 is adhered between the test card body 110 and the elastic silica gel film 122, and the PET film 123 covers a side of the elastic silica gel film 122 facing away from the valve slot 1411. The adhesive film 121 plays a role of adhering the sealing film 120 and the test card main body 110, so that each pipeline of the test card is closed; the elastic silica gel film 122 plays a sealing role, and fills the valve groove 1411 by the elasticity of the elastic silica gel film 122; the PET film 123 plays a supporting and resetting role, so that the sealing film 120 is deformed and effectively resets after external force is eliminated, and the sealing film 120 seals the liquid pipeline 140 in the whole test card in a planar and large-surface film pasting mode, so that the air leakage problem is further avoided. The sealing film 120 can also take other structural forms according to actual needs.
Test card assembly 10, test valve assembly 50, reagent pack assembly 20, reagent pack valve control assembly 30, and piston pump assembly 40 comprise the fluid extraction subsystem of a blood gas analyzer. Before testing, the test card assembly 10 is inserted into the reagent pack assembly 20, the calibration liquid port 112 of the test card main body 110 is connected with the liquid inlet needle 241 on the supporting seat 270, the air exhaust port 113 of the test card main body 110 is connected with the air exhaust needle 410 on the supporting seat 270 and is sealed by the sealing piece 150, so that the pipeline of the reagent pack assembly 20 is communicated with the pipeline of the test card assembly 10; inserting the connector 430 of the piston pump assembly 40 onto the suction tube 420 on the support base 270, the suction tube 420 communicating with the suction needle 410, thereby communicating the tubing of the piston pump assembly 40 with the tubing of the test card assembly 10; the pressing member 510 of the test valve assembly 50 is assembled at the position of the valve slot 1411 of the test liquid pipeline 141, so as to realize on-off control of the test liquid pipeline 141.
During testing, firstly extracting a calibration solution: as shown in fig. 2, 3 and 13, the second driving device 320 of the reagent pack valve control assembly 30 is powered on to work, and the first motor shaft 321 drives the rotary cover 310 and the rotary main body 212 to rotate, so that the L-shaped pipeline in the rotary main body 212 is respectively communicated with the first pipe orifice 214 and the second pipe orifice 215 of the reagent pack assembly 20, and is further communicated with the calibration liquid pipeline 142 and the electrode test groove 115 of the test card assembly 10; the first driving device 520 of the test valve assembly 50 is electrified to work, the third motor shaft 521 drives the pressing member 510 to push forwards, the sealing film 120 is pressed onto the valve groove 1411 of the test liquid pipeline 141, and the elastic silica gel film 122 of the sealing film 120 is filled onto the valve groove 1411 to seal the test liquid pipeline 141; the third driving device 450 of the piston pump assembly 40 is electrified to work, and the second motor shaft 451 drives the piston 440 to retreat, so that negative pressure is generated in the liquid pipeline 140 of the test card assembly 10; under the action of negative pressure, the calibration liquid in the liquid storage device 220 of the reagent pack assembly 20 flows into the electrode test groove 115 through the rotating main body 212, the liquid inlet pipe 242, the liquid inlet needle 241 and the calibration liquid pipeline 142 of the test card assembly 10, and the extraction action of the calibration liquid is completed.
Air is then extracted: as shown in fig. 2,3 and 14, the second driving device 320 of the reagent pack valve control assembly 30 is powered on to work, and the first motor shaft 321 drives the rotary cover 310 and the rotary main body 212 of the reagent pack assembly 20 to rotate, so that the L-shaped pipeline in the rotary main body 212 is respectively communicated with the second pipe orifice 215 and the third pipe orifice 216, and is further communicated with the calibration liquid pipeline 142 and the electrode test groove 115 of the test card assembly 10; the first driving device 520 of the test valve assembly 50 still keeps the power-on working state, and the pressing piece 510 still presses the sealing film 120 on the valve groove 1411, so that the test liquid pipeline 141 keeps a closed state; the third driving device 450 of the piston pump assembly 40 is electrified to work, and the second motor shaft 451 drives the piston 440 to continue to retreat, so that negative pressure is generated in the liquid pipeline 140 of the test card assembly 10; under the action of the negative pressure, the external air of the reagent pack assembly 20 enters the electrode test groove 115 through the third pipe orifice 216, the rotary main body 212, the second pipe orifice 215, the liquid inlet pipe 242, the liquid inlet needle 241 and the calibration liquid pipe 142 of the test card assembly 10, and the air extraction is completed.
Finally, extracting the test liquid: as shown in fig. 2,3 and 15, the second driving device 320 of the reagent pack valve control assembly 30 is powered on to work, the first motor shaft 321 drives the rotary cover 310 and the rotary main body 212 of the reagent pack assembly 20 to rotate, so that the L-shaped pipeline in the rotary main body 212 is separated from the first pipe orifice 214 and the third pipe orifice 216 respectively, that is, the liquid storage device 220 and the liquid inlet pipe 242 are sealed by the outer wall of the rotary main body 212, and the reagent pack pipeline system is closed; the first driving device 520 of the test valve assembly 50 is electrified to work, so that the pressing piece 510 is separated from the valve groove 1411 of the test liquid pipeline 141, and the sealing film 120 of the test card assembly 10 is elastically reset by the PET film 123, so that the test liquid pipeline 141 is opened; the third driving device 450 of the piston pump assembly 40 is electrified to work, and the second motor shaft 451 drives the piston 440 to continue to retreat, so that negative pressure is generated in the liquid pipeline 140 of the test card assembly 10; under the action of negative pressure, the test liquid in the injector 180 enters the electrode test groove 115 through the liquid inlet needle 241 and the test liquid pipeline 141 of the test card assembly 10, and the test liquid is extracted.
As shown in fig. 1,2 and 16, the blood gas analyzer further includes a slider assembly 60, the slider assembly 60 is disposed opposite to the test card body 110 and is located at a side of the test card body 110 facing the electrode circuit board 130, the slider assembly 60 includes a slider 610, a first fixing base 620, a first compression spring 630 with two ends respectively abutting against the slider 610 and the fixing base, and a first guide shaft 640 sleeved with the first compression spring 630, one end of the first guide shaft 640 is connected with the first fixing base 620, the other end passes through a guide hole of the slider 610, the slider 610 is provided with a first plug 611 protruding toward one side of the test card body 110, and a side wall of the test card body 110 is concavely provided with a first limit groove 116 matched with the first plug 611. After the test card assembly 10 is inserted into the reagent pack assembly 20, the first plug 611 on the slider 610 is inserted into the first limit groove 116 under the action of the first compression spring 630, so as to position the test card main body 110, and the first guide shaft 640 plays a guiding role to prevent the slider 610 from shifting in the moving process.
As shown in fig. 2 and 17 to 20, the blood gas analyzer further includes a heating unit 70, the heating unit 70 is disposed opposite to the test card body 110 and is located at a side of the test card body 110 opposite to the electrode circuit board 130, the heating unit 70 includes a first heating body 710 disposed opposite to the electrode circuit board 130, a heating body fixing support 720 fixed with the first heating body 710, and a fourth driving device 730 driving the heating body fixing support 720 to reciprocate toward the electrode circuit board 130, the heating body fixing support 720 is provided with a second plug 721 protruding toward the test card body 110, and a second limiting groove 117 matched with the second plug 721 is concavely formed on a side wall of the test card body 110. After the test card assembly 10 is inserted into the reagent pack assembly 20, the first plug 611 on the slider 610 is inserted into the first limit groove 116 under the action of the first compression spring 630 by the slider 610, so as to realize the primary positioning of the test card main body 110; the second plug 721 moves to one side of the test card body 110 under the action of the fourth driving device 730, and the second plug 721 is inserted into the second limiting groove 117, so that the second positioning of the test card body 110 is realized, the positioning of the test card body 110 is more accurate and reliable, and the liquid in the test card body 110 is heated through the first heating body 710, so that the liquid reaches a specified temperature. The slider assembly 60 and the heating assembly 70 perform bilateral positioning on the front and back sides of the test card body 110, so that the test card body 110 is uniformly stressed and cannot deform under stress.
In this embodiment, as shown in fig. 20, the fourth driving device 730 is a linear stepper motor, the linear stepper motor is provided with a fourth motor shaft 731, the heating assembly 70 further includes a fourth optocoupler 740, a heating body fixing cover 750, a motor fixing bracket 760, and a second guide shaft 770 disposed on the motor fixing bracket 760, and the heating body fixing bracket 720 and the heating body fixing cover 750 are provided with mutually matched fastening positions 780. The fourth driving device 730 is fixed to the motor fixing bracket 760 by a screw, and the heating body fixing bracket 720 is sleeved on the second guide shaft 770 of the motor fixing bracket 760 and is screw-coupled with the fourth motor shaft 731, and the first heating body 710 is fixed to the heating body fixing bracket 720 by the heating body fixing cover 750. When the fourth driving device 730 is powered on, the fourth motor shaft 731 drives the first heating body 710 to reciprocate linearly along the second guide shaft 770. Fourth optocoupler 740 serves to detect and control the initial position of fourth motor shaft 731, and to eliminate position errors after each reciprocation.
As shown in fig. 1 and 2, the blood gas analyzer further includes a pop-up assembly 80 located right under the test card main body 110, where the pop-up assembly 80 includes a second fixing base 810, a pressing block 820 opposite to the bottom of the test card main body 110, and a second compression spring 830 with two ends respectively pressing against the second fixing base 810 and the pressing block 820. After the test card assembly 10 is inserted into the reagent pack assembly 20, the slide fastener assembly 60 and the heating assembly 70 fix and position the test card main body 110, the pressing piece 510 is pressed down under the force, and the second compression spring 830 is compressed under the force; after the test is completed, after the slider assembly 60 and the heating assembly 70 release the fixing of the test card body 110, the pressing block 820 rebounds upward under the action of the second compression spring 830, so as to realize the automatic bouncing of the test card body 110.
As shown in fig. 2, 18, 19 and 21, the blood gas analyzer further includes a testing component 90, where the testing component 90 is disposed opposite to the testing card main body 110 and is located on a side of the testing card main body 110 facing the electrode circuit board 130, the testing component 90 includes a detecting module 910, a second heating body 920 disposed opposite to the electrode circuit board 130, a housing 930 fixed with the detecting module 910 and the second heating body 920, and a fifth driving device 940 driving the housing 930 to reciprocate toward the electrode circuit board 130, the slider 610 is located above the housing 930, a matching rib 612 is protruding from the bottom of the slider 610 toward the housing 930, a pushing rib 931 is protruding from the top of the housing 930 toward the slider 610, and the pushing rib 931 is located between the matching rib 612 and the testing card main body 110. After the test card assembly 10 is inserted into the reagent pack assembly 20, the fifth driving device 940 drives the second heating body 920 on the housing 930 to move toward the electrode circuit board 130, the first plug 611 is inserted into the first limiting groove 116, and the second plug 721 is inserted into the second limiting groove 117; after the test assembly 90 is electrified, the electrode circuit board 130 is heated, so that the liquid in the test card main body 110 reaches a specified temperature, and current and voltage signals generated on the electrode circuit board 130 are transmitted into the host through the detection module 910, so that the test of the calibration liquid and the test liquid is realized; after the test is completed, the fifth driving device 940 of the test assembly 90 drives the housing 930 to retract, and since the pushing rib 931 is located between the mating rib 612 and the test card body 110, when the pushing rib 931 on the housing 930 contacts the mating rib 612, the pushing rib 931 continues to retract with the housing 930, the slider 610 retracts with the pushing rib 931, the first compression spring 630 is compressed, and the first plug 611 on the slider 610 is disengaged from the first limit slot 116. After the test card main body 110 automatically bounces up, the fifth driving device 940 makes the housing 930 move forward, the slider 610 also moves forward together under the action of the first compression spring 630, the matching rib 612 extrudes the pushing rib 931, when the housing 930 moves to a position where no stress exists between the pushing rib 931 and the matching rib 612, the first plug 611 of the slider assembly 60 returns to the initial position, so that the next round of test is conveniently performed, the structures of the matching rib 612 and the pushing rib 931 are skillfully designed, the position control of the slider assembly 60 by the test assembly 90 is realized, and the action is more reliable.
In this embodiment, as shown in fig. 21, the fifth driving device 940 is a linear stepper motor, the detection module 910 is a test PCBA assembly, the test PCBA assembly is provided with a test probe 911, the linear stepper motor is provided with a fifth motor shaft 941, the housing 930 is fixed on the fifth motor shaft 941 by a screw, and the test assembly 90 further includes a fifth optocoupler 950. When the linear fifth driving device 940 is powered on, the fifth motor shaft 941 drives the housing 930 to reciprocate along the axial direction of the stepper motor, thereby realizing the testing function. The fifth optocoupler 950 serves to detect and control the initial position of the fifth motor shaft 941, eliminating position errors after each reciprocation.
The test card assembly 10, the heating assembly 70 and the test assembly 90 form a test and heating subsystem of the blood gas analyzer, the test card assembly 10 is inserted into the reagent pack assembly 20, the first heating body 710 of the heating assembly 70 is opposite to the electrode test slot 115 on the test card main body 110, and the second heating body 920 and the test probe 911 of the test assembly 90 correspond to the electrode circuit board 130 on the test card main body 110.
After the test card assembly 10 is inserted into place, the pumping subsystem of the blood gas analyzer operates to pump the calibration or test fluid into the electrode test slot 115; the fourth driving device 730 of the heating assembly 70 is electrified to work, and the fourth motor shaft 731 drives the first heating body 710 to push forwards and press the first heating body onto the sealing film 120 of the test card assembly 10; the first heating body 710 is electrified to work, and generates heat to heat the sealing film 120 and the electrode test groove 115 of the test card assembly 10, so that the liquid in the electrode test groove 115 is heated to a set temperature; the fifth driving device 940 of the test assembly 90 is powered on, and the fifth motor shaft 941 drives the whole housing 930 to push forward and press against the electrode circuit board 130 on the test card assembly 10; the second heating body 920 is energized to heat, and generates heat to heat the electrode circuit board 130, thereby indirectly heating the liquid in the electrode test groove 115, and heating the liquid in the electrode test groove 115 to a set temperature; the test probe 911 of the test assembly 90 is communicated with the output end of the electrode circuit board 130, and transmits the current and voltage signals generated on the electrode circuit board 130 to the host, so as to realize the test of the calibration liquid and the test liquid; after the test card assembly 10 completes all the processes of drawing, heating and testing, the fourth driving device 730 makes the heating assembly 70 retract, and the fifth driving device 940 makes the test assembly 90 retract, so that the test card can be taken out.
In this embodiment, the first driving device 520, the second driving device 320, the third driving device 450, the fourth driving device 730 and the fifth driving device 940 are all stepper motors, and other driving methods such as other cylinders may be used for the first driving device 520, the second driving device 320, the third driving device 450, the fourth driving device 730 and the fifth driving device 940 according to actual needs.
Compared with the traditional blood gas analyzer, the blood gas analyzer has the following advantages:
1. The test card assembly 10 does not require a steel needle piercing action, effectively solving the problem of test card debris; a secondary waste liquid cavity is designed, a liquid inlet 1434 is designed at the lower end, and a liquid outlet 1435 is designed at the upper end, so that the problem of leakage of liquid from the pumping hole 113 is solved; the highest surface of the calibration liquid pipeline 142 is higher than the test liquid pipeline 141, and a leakage-proof groove 1421 is arranged at the highest position, so that the problem of liquid leakage from the calibration liquid port 112 is solved; the valve groove 1411 is designed on the test liquid pipeline 141 and is integrated with the test liquid pipeline 141, so that the parts of a cylindrical rubber plug and a film are not needed, the number of the parts is reduced, the hidden danger of liquid leakage is reduced, and the production efficiency is improved.
2. The reagent pack assembly 20 is controlled by the rotary switch assembly 210 and the reagent pack valve control assembly 30 to open and close a liquid channel and a gas channel, the rotary switch technology is mature, the action is reliable, and the problems of blockage and liquid leakage of a reagent pack pipeline are effectively solved; the on-off of each liquid path of the liquid pumping subsystem is controlled by an independent stepping motor, so that each on-off action can be performed simultaneously, and compared with the existing original turntable system, the working period can be shortened without waiting time for turntable rotation.
3. The on-off of each liquid way of the liquid pumping subsystem is controlled by an independent stepping motor, compared with the prior gear transmission, spring compression and other structures in the original turntable system, the speed of the stepping motor is adjustable, the action is gentle and controllable, gear rotation noise and pull rod impact abnormal sound are avoided, the noise is low, parts such as gear sets, pull rods, springs and rollers are omitted, the number of parts is reduced, the structure is simplified, and the assembly efficiency is improved.
4. The test and heating subsystem adopts a stepping motor to control the compaction and loosening work of the test assembly 90 and the heating assembly 70, and has stable and controllable action, low noise and high matching precision.
5. The slider assembly 60, the test assembly 90 and the heating assembly 70 are effectively utilized to perform secondary positioning on the test card main body 110, wherein the mechanical primary positioning is realized through the elastic force of the first compression spring 630 of the slider assembly 60; the second accurate positioning is achieved by the second plug 721 of the heating assembly 70, so that the test card body 110 is reliably positioned; the front and back sides of the test card main body 110 are positioned in a bilateral manner through the test component 907 and the heating component 703 respectively, so that the test card main body 110 is uniformly stressed and cannot deform under stress; and fully utilizes the stepping motor action of the test assembly 90, skillfully designs the structures of the pushing rib 931 and the matching rib 612 to realize the position control of the test assembly 90 on the slide fastener assembly 60, and has reliable action.
The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
The above examples illustrate only a few embodiments of the invention, which are described in detail and are not to be construed as limiting the scope of the invention. It should be noted that it would be obvious to a person skilled in the art that modifications and improvements could be made without departing from the inventive concept, which would be within the scope of the present invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.

Claims (12)

1. A blood gas analyzer is characterized by comprising a test card component and a reagent pack component,
The test card assembly comprises a test card main body provided with a calibration liquid port and an air extraction port;
The reagent pack assembly comprises a sample injection device provided with a liquid inlet needle, a shell provided with a placing cavity, a supporting seat fixed on the shell, and a liquid inlet needle connected with the calibration liquid port and an air extraction needle connected with the air extraction port;
When the test card assembly is inserted into the reagent pack assembly, the calibration liquid port of the test card body is connected with the liquid inlet needle on the supporting seat, and the extraction port of the test card body is connected with the extraction needle on the supporting seat.
2. The blood gas analyzer of claim 1, wherein,
The reagent pack assembly further comprises a rotary switch assembly, a liquid storage device and an air inlet device, wherein the rotary switch assembly comprises a fixed valve body and a rotary main body, the rotary main body is arranged inside the fixed valve body and can rotate relative to the fixed valve body, a connecting pipeline is arranged on the rotary main body, a first pipe orifice communicated with the liquid storage device, a second pipe orifice communicated with the sample injection device and a third pipe orifice communicated with the air inlet device are arranged on the fixed valve body, and two ends of the liquid inlet needle are respectively communicated with the second pipe orifice and the calibration liquid orifice;
Rotating the rotating body may place the rotary switch assembly in a first state, a second state, or a third state: the first state is that the second pipe orifice is communicated with the first pipe orifice through the connecting pipeline; the second state is that the second pipe orifice is communicated with the third pipe orifice through the connecting pipeline; the third state is that the second pipe orifice and the first pipe orifice are both closed.
3. The blood gas analyzer as claimed in claim 2, wherein,
The fixed valve body is fixed in the placing cavity, the shell is provided with a rotating handle connected with the rotating main body, and the rotating handle is exposed on the shell.
4. The blood gas analyzer as claimed in claim 2, wherein,
The liquid storage device is a calibration liquid bag arranged in the placing cavity, a liquid outlet pipe is arranged on the calibration liquid bag, and the liquid outlet pipe is sleeved on the first pipe orifice.
5. The blood gas analyzer of claim 2, wherein:
The blood gas analyzer further comprises a reagent pack valve control assembly, wherein the reagent pack valve control assembly comprises a rotary cover sleeved on the rotary main body and a second driving device for driving the rotary cover to rotate, and the second driving device drives the rotary cover and the rotary main body to realize rotary motion.
6. The blood gas analyzer as claimed in claim 2, wherein,
The sample injection device further comprises a liquid inlet pipe, one end of the liquid inlet pipe is sleeved on the liquid inlet needle, the other end of the liquid inlet pipe is sleeved on the second pipe orifice, and the liquid inlet needle is communicated with the second pipe orifice through the liquid inlet pipe.
7. The blood gas analyzer as claimed in claim 2, wherein,
The air inlet device is an air pipe sleeved on the third pipe orifice, and the air pipe is communicated with the atmosphere.
8. The blood gas analyzer as claimed in claim 2, wherein,
The blood gas analyzer further comprises a piston pump assembly, the piston pump assembly comprises an exhaust pipe, a connector, a piston and a third driving device, one end of the exhaust pipe is communicated with the exhaust needle, the other end of the exhaust pipe is communicated with the connector, the piston is connected with the connector, and the third driving device drives the piston to do linear reciprocating motion.
9. The blood gas analyzer of claim 1, wherein,
The test card main body further comprises a liquid pipeline and a sealing film for sealing the liquid pipeline, wherein the liquid pipeline comprises a test liquid pipeline, and a valve slot is formed in the opposite surface of the test liquid pipeline and the sealing film;
The blood gas analyzer further comprises a test valve assembly provided with a pressure-resisting piece, and the sealing membrane is positioned between the valve groove and the pressure-resisting piece.
10. The blood gas analyzer of claim 9, wherein the blood gas analyzer comprises a blood gas analyzer,
The test valve assembly further comprises a first driving device for driving the pressing piece to reciprocate to one side of the valve groove.
11. A kit assembly, the kit assembly comprising:
A sample injection device provided with a liquid inlet needle,
A housing having a placement cavity is provided,
The support seat is fixed on the shell, and the liquid inlet needle connected with the calibration liquid port in the test card assembly and the air exhaust needle connected with the air exhaust port in the test card assembly are fixed on the support seat;
when the test card assembly is inserted into the reagent pack assembly, the calibration liquid port is connected with the liquid inlet needle on the supporting seat, and the extraction port is connected with the extraction needle on the supporting seat.
12. A kit assembly, the kit assembly comprising:
A sample injection device provided with a liquid inlet needle,
A housing having a placement cavity is provided,
The support seat is fixed on the shell, and the liquid inlet needle connected with the calibration liquid port in the test card assembly and the air exhaust needle connected with the air exhaust port in the test card assembly are fixed on the support seat;
The reagent pack assembly further comprises a rotary switch assembly, a liquid storage device and an air inlet device, wherein the rotary switch assembly comprises a fixed valve body and a rotary main body, the rotary main body is arranged inside the fixed valve body and can rotate relative to the fixed valve body, a connecting pipeline is arranged on the rotary main body, a first pipe orifice communicated with the liquid storage device, a second pipe orifice communicated with the sample injection device and a third pipe orifice communicated with the air inlet device are arranged on the fixed valve body, and two ends of the liquid inlet needle are respectively communicated with the second pipe orifice and the calibration liquid orifice;
Rotating the rotating body may place the rotary switch assembly in a first state, a second state, or a third state: the first state is that the second pipe orifice is communicated with the first pipe orifice through the connecting pipeline; the second state is that the second pipe orifice is communicated with the third pipe orifice through the connecting pipeline; the third state is that the second pipe orifice and the first pipe orifice are both closed.
CN202311200033.6A 2016-03-31 2016-03-31 Reagent package assembly and blood gas analyzer Pending CN118067818A (en)

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CN202311196442.3A Pending CN117470935A (en) 2016-03-31 2016-03-31 Blood gas analyzer
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CN202311200033.6A Pending CN118067818A (en) 2016-03-31 2016-03-31 Reagent package assembly and blood gas analyzer
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CN106483181B (en) 2023-08-15
CN117470935A (en) 2024-01-30

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