CN118001462A - Artificial blood vessel woven based on high molecular yarns and preparation method thereof - Google Patents
Artificial blood vessel woven based on high molecular yarns and preparation method thereof Download PDFInfo
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- CN118001462A CN118001462A CN202410152584.8A CN202410152584A CN118001462A CN 118001462 A CN118001462 A CN 118001462A CN 202410152584 A CN202410152584 A CN 202410152584A CN 118001462 A CN118001462 A CN 118001462A
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- blood vessel
- core
- artificial blood
- yarn
- polytetrafluoroethylene
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- 210000004204 blood vessel Anatomy 0.000 title claims abstract description 126
- 239000002473 artificial blood Substances 0.000 title claims abstract description 113
- 238000002360 preparation method Methods 0.000 title abstract description 16
- -1 polytetrafluoroethylene Polymers 0.000 claims abstract description 81
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims abstract description 77
- 239000004810 polytetrafluoroethylene Substances 0.000 claims abstract description 77
- 239000002131 composite material Substances 0.000 claims abstract description 63
- 239000011258 core-shell material Substances 0.000 claims abstract description 63
- 238000000034 method Methods 0.000 claims abstract description 52
- 230000008569 process Effects 0.000 claims abstract description 32
- 239000002985 plastic film Substances 0.000 claims abstract description 24
- 229920006255 plastic film Polymers 0.000 claims abstract description 24
- 229920000642 polymer Polymers 0.000 claims abstract description 23
- 238000005461 lubrication Methods 0.000 claims abstract description 20
- 239000002344 surface layer Substances 0.000 claims abstract description 11
- 239000004744 fabric Substances 0.000 claims description 27
- 238000009940 knitting Methods 0.000 claims description 23
- 239000010410 layer Substances 0.000 claims description 15
- 238000009941 weaving Methods 0.000 claims description 15
- 239000012792 core layer Substances 0.000 claims description 12
- 229920000728 polyester Polymers 0.000 claims description 10
- 230000001105 regulatory effect Effects 0.000 claims description 7
- 238000009965 tatting Methods 0.000 claims description 7
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- 230000001276 controlling effect Effects 0.000 claims description 6
- 239000000835 fiber Substances 0.000 claims description 6
- 238000007731 hot pressing Methods 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000004743 Polypropylene Substances 0.000 claims description 3
- 229920001155 polypropylene Polymers 0.000 claims description 3
- 238000004804 winding Methods 0.000 claims description 2
- 238000000465 moulding Methods 0.000 abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 8
- 230000000740 bleeding effect Effects 0.000 abstract description 6
- 238000009954 braiding Methods 0.000 abstract description 5
- 230000015271 coagulation Effects 0.000 abstract description 5
- 238000005345 coagulation Methods 0.000 abstract description 5
- 230000012010 growth Effects 0.000 abstract description 4
- 230000000052 comparative effect Effects 0.000 description 21
- 230000006872 improvement Effects 0.000 description 10
- 239000000463 material Substances 0.000 description 10
- 230000007774 longterm Effects 0.000 description 6
- 230000002209 hydrophobic effect Effects 0.000 description 5
- 230000014759 maintenance of location Effects 0.000 description 5
- 208000019553 vascular disease Diseases 0.000 description 5
- 230000006378 damage Effects 0.000 description 4
- 239000005020 polyethylene terephthalate Substances 0.000 description 4
- 230000002792 vascular Effects 0.000 description 4
- 208000024172 Cardiovascular disease Diseases 0.000 description 3
- 229920004934 Dacron® Polymers 0.000 description 3
- 239000004812 Fluorinated ethylene propylene Substances 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 229920009441 perflouroethylene propylene Polymers 0.000 description 3
- 208000007536 Thrombosis Diseases 0.000 description 2
- 230000003373 anti-fouling effect Effects 0.000 description 2
- 230000002785 anti-thrombosis Effects 0.000 description 2
- 238000009776 industrial production Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 238000009987 spinning Methods 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- 238000010523 cascade reaction Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000005253 cladding Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920000295 expanded polytetrafluoroethylene Polymers 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
-
- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02G—CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
- D02G3/00—Yarns or threads, e.g. fancy yarns; Processes or apparatus for the production thereof, not otherwise provided for
- D02G3/02—Yarns or threads characterised by the material or by the materials from which they are made
- D02G3/04—Blended or other yarns or threads containing components made from different materials
- D02G3/045—Blended or other yarns or threads containing components made from different materials all components being made from artificial or synthetic material
-
- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02G—CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
- D02G3/00—Yarns or threads, e.g. fancy yarns; Processes or apparatus for the production thereof, not otherwise provided for
- D02G3/22—Yarns or threads characterised by constructional features, e.g. blending, filament/fibre
- D02G3/36—Cored or coated yarns or threads
-
- D—TEXTILES; PAPER
- D03—WEAVING
- D03D—WOVEN FABRICS; METHODS OF WEAVING; LOOMS
- D03D13/00—Woven fabrics characterised by the special disposition of the warp or weft threads, e.g. with curved weft threads, with discontinuous warp threads, with diagonal warp or weft
-
- D—TEXTILES; PAPER
- D03—WEAVING
- D03D—WOVEN FABRICS; METHODS OF WEAVING; LOOMS
- D03D15/00—Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used
- D03D15/20—Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the material of the fibres or filaments constituting the yarns or threads
- D03D15/283—Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the material of the fibres or filaments constituting the yarns or threads synthetic polymer-based, e.g. polyamide or polyester fibres
-
- D—TEXTILES; PAPER
- D03—WEAVING
- D03D—WOVEN FABRICS; METHODS OF WEAVING; LOOMS
- D03D15/00—Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used
- D03D15/40—Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the structure of the yarns or threads
- D03D15/47—Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the structure of the yarns or threads multicomponent, e.g. blended yarns or threads
-
- D—TEXTILES; PAPER
- D03—WEAVING
- D03D—WOVEN FABRICS; METHODS OF WEAVING; LOOMS
- D03D3/00—Woven fabrics characterised by their shape
- D03D3/02—Tubular fabrics
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04B—KNITTING
- D04B21/00—Warp knitting processes for the production of fabrics or articles not dependent on the use of particular machines; Fabrics or articles defined by such processes
- D04B21/20—Warp knitting processes for the production of fabrics or articles not dependent on the use of particular machines; Fabrics or articles defined by such processes specially adapted for knitting articles of particular configuration
- D04B21/205—Elongated tubular articles of small diameter, e.g. coverings or reinforcements for cables or hoses
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2321/00—Fibres made from polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds
- D10B2321/02—Fibres made from polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds polyolefins
- D10B2321/022—Fibres made from polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds polyolefins polypropylene
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2321/00—Fibres made from polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds
- D10B2321/04—Fibres made from polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds polymers of halogenated hydrocarbons
- D10B2321/042—Fibres made from polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds polymers of halogenated hydrocarbons polymers of fluorinated hydrocarbons, e.g. polytetrafluoroethene [PTFE]
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2331/00—Fibres made from polymers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polycondensation products
- D10B2331/04—Fibres made from polymers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polycondensation products polyesters, e.g. polyethylene terephthalate [PET]
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Textile Engineering (AREA)
- Transplantation (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Mechanical Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Vascular Medicine (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention provides an artificial blood vessel woven based on high polymer yarns and a preparation method thereof. According to the invention, polytetrafluoroethylene filaments are coated on the surface layer of a high-strength core filament to obtain a core-shell composite yarn, and a braiding molding process, a low-temperature pressure plastic film forming process and a thread molding process are matched to obtain a thread-shaped artificial blood vessel with polytetrafluoroethylene super-lubrication films on the inner and outer surfaces; the artificial blood vessel has good structural stability, high strength, good smoothness, biocompatibility and water impermeability, and can directly induce tissue cells to enter growth to form a new intima without pre-coagulation treatment; solves the problems of serious bleeding, poor compliance, poor conformality, insufficient patency rate and the like of the existing artificial blood vessel, and obtains the artificial blood vessel meeting clinical requirements.
Description
Technical Field
The invention relates to the technical field of textile biological materials, in particular to an artificial blood vessel woven based on high polymer yarns and a preparation method thereof.
Background
Cardiovascular disease is one of the common diseases endangering human health, and vascular diseases mainly comprise atherosclerosis, inflammatory vascular diseases, functional vascular diseases, traumatic vascular diseases, neoplastic vascular diseases and the like. An effective treatment means for cardiovascular diseases is vascular grafting, which is limited by the limited number of autologous blood vessels and the quality difference, and simultaneously, the pain of patients can be increased by additional operations, the appearance of artificial blood vessels is a good vascular access established for the patients with cardiovascular diseases, and the market demand of the artificial blood vessels is continuously increased along with the increase of the number of patients year by year.
The dacron braided artificial blood vessel is the earliest blood vessel material, and is successfully used for large blood vessel replacement for a long time due to higher patency rate; then, protein or gelatin is required to be smeared in the terylene-woven artificial blood vessel, so that blood permeation can be prevented in a short time; meanwhile, the inner surface of the dacron blood vessel is rough, the cascade reaction of blood coagulation is easily activated, and thrombus is formed again. Polytetrafluoroethylene has excellent biocompatibility, chemical stability, corrosion resistance and super lubricity; the artificial blood vessel made of the expanded polytetrafluoroethylene material has good biocompatibility and anticoagulation performance, but has poor compliance, and the defects are more obvious especially in the small-caliber artificial blood vessel, and the long-term patency rate is extremely poor.
The invention patent (publication number CN 110859998A) discloses a kink-resistant artificial blood vessel and a preparation method thereof, wherein the kink-resistant artificial blood vessel comprises a bulked polytetrafluoroethylene tube arranged on an inner layer, a polyethylene terephthalate fabric arranged on an outer layer, a fluorinated ethylene propylene support ring arranged between the inner layer and the outer layer, the fluorinated ethylene propylene support ring and the bulked polytetrafluoroethylene tube are coaxial, and the fluorinated ethylene propylene support ring has a spiral structure; however, the artificial blood vessel has a complex structure, and the problem of compliance of the blood vessel still cannot be solved due to the too thick blood vessel wall. In recent years, researchers have proposed using highly elastic polyurethane materials for the preparation of vascular prostheses, but they have not yet met the high standards of clinical use of vascular prostheses, and at the same time, it has been found that polyurethane materials undergo aging degradation and calcification in vivo during long-term use, and that the materials undergo cracking or even complete destruction. Therefore, the artificial blood vessel in the prior art has the problems of serious bleeding, poor elasticity, poor compliance, poor shape retention, insufficient smoothness and the like, and the production of the artificial blood vessel with various calibers meeting clinical requirements is a technical problem to be solved urgently.
In view of the above, there is a need for an improved artificial blood vessel woven based on polymer yarns and a method for preparing the same, which solve the above problems.
Disclosure of Invention
The invention aims to provide an artificial blood vessel woven based on polymer yarns and a preparation method thereof, wherein a high-strength core yarn is used as a core layer, polytetrafluoroethylene filaments are wrapped on a surface layer to obtain a core-shell composite yarn for constructing the artificial blood vessel, and a weaving molding process, a low-temperature pressure plastic film forming process and a thread molding process are matched to obtain a thread-shaped artificial blood vessel with the inner and outer surfaces being polytetrafluoroethylene super-lubricating films, so that the problems of serious bleeding, poor compliance, poor shape retention, insufficient smoothness and the like of the artificial blood vessel in the prior art are solved, and the artificial blood vessel meeting clinical requirements is prepared.
In order to achieve the above purpose, the invention provides an artificial blood vessel knitted based on polymer yarns, wherein the artificial blood vessel is a threaded tubular fabric formed by a warp knitting process, the tubular fabric is made of core-shell composite yarns, the core layer of the core-shell composite yarns is high-strength core filaments, the outer layer of the core-shell composite yarns is polytetrafluoroethylene filaments, and the polytetrafluoroethylene filaments are compounded on the surface of the high-strength core filaments in a uniformly wrapping mode.
As a further improvement of the invention, the inner and outer surfaces of the artificial blood vessel are polytetrafluoroethylene super-lubrication films, and the polytetrafluoroethylene super-lubrication films are prepared by low-temperature pressure plastic film forming of polytetrafluoroethylene filaments of the core-shell composite yarns.
As a further improvement of the present invention, the polytetrafluoroethylene super-lubricating film contains a microporous structure, and the average diameter of the microporous structure is in the range of 10-20 μm.
As a further improvement of the invention, the fineness of the high-strength core filament is 140-280D, and the fineness of the polytetrafluoroethylene filament is 50-100D.
As a further improvement of the present invention, the high strength core filaments include one or more of polyester filaments, polypropylene fibers.
As a further improvement of the invention, the high-strength core yarn is polyester filament yarn.
The invention provides a preparation method of an artificial blood vessel woven based on polymer yarns, which comprises the following steps:
s1, preparing core-shell composite yarns; uniformly wrapping polytetrafluoroethylene filaments on the surface of a high-strength core filament to obtain a core-shell composite yarn; the coating rate of the outer polytetrafluoroethylene filaments of the core-shell composite yarn on the inner core filaments is 90% -95%;
s2, weaving the core-shell composite yarn in the step S1 in a tatting or knitting mode;
s3, performing low-temperature pressure plastic film forming treatment on the tubular fabric obtained in the step S2 at 50-70 ℃ to obtain an artificial blood vessel with the inner and outer surfaces being polytetrafluoroethylene ultra-lubrication films;
And S4, performing hot pressing treatment on the artificial blood vessel obtained in the step S3 by adopting a thread forming device, wherein the temperature is 150-190 ℃, and obtaining the artificial blood vessel with the surface of the thread structure and woven based on the polymer yarns.
As a further improvement of the present invention, in step S3, the time of the low-temperature pressure plastic film forming process is 10 to 20 minutes.
As a further improvement of the invention, in the step S1, the specific preparation process of the core-shell composite yarn is to uniformly wrap polytetrafluoroethylene filaments on the surface of a high-strength core yarn by adopting a S-twist and Z-twist synergetic yarn forming process.
As a further improvement of the present invention, in step S2, the weaving by means of tatting includes the steps of: (1) After the core-shell composite yarn is used as warp yarn for warping treatment, a warp beam is arranged, and an eight-page heald frame zoned drafting method is adopted for drafting, so that the warp yarn tension is regulated; (2) The pattern is tubular structure, take 1/3 right twill as basic structure, the surface layer structure is 1/3 right twill, the inner layer structure is 1/3 right twill, the surface warp yarn and the surface weft yarn are 1:1, interweaving the surface layer yarns and the inner layer yarns through binding yarns; (3) And taking the core-shell composite yarn as weft yarn, controlling the density of warp and weft, and performing beating-up weaving until the tubular fabric with a certain warp length is obtained.
As a further improvement of the present invention, in step S2, weaving is performed by knitting, comprising the steps of: (1) On a flat knitting machine, regulating the triangular positions of a machine head to the positions meeting the requirements for knitting rib patterns, putting through the core-shell composite yarns, putting the wire ends through the middle seams of the front needle bed and the rear needle bed, winding on a frame, and pushing the machine head from right to left; (2) putting on the needle lifting plate and hanging the needle lifting plate on the needle lifting plate; (3) The tubular fabric consists of two end folding parts and a middle blood vessel part, wherein the middle blood vessel part consists of two first tissues and two second tissues with different coil lengths which are alternately arranged, and the folding parts are plain weave; (4) And (3) putting down the needle lifting triangle closed in the step (3), and pushing the machine head to weave until the tubular fabric with a certain size is obtained.
The beneficial effects of the invention are as follows:
1. According to the artificial blood vessel knitted based on the high polymer yarn and the preparation method thereof, the artificial blood vessel is a threaded tubular fabric formed by a warp knitting process, the tubular fabric is made of core-shell composite yarns, the core layer of the core-shell composite yarns is high-strength core filaments, the outer layer of the core-shell composite yarns is polytetrafluoroethylene filaments, and the polytetrafluoroethylene filaments are compounded on the surface of the high-strength core filaments in a uniform wrapping mode. The invention takes a high-strength core wire as a core layer, and the surface layer is wrapped with polytetrafluoroethylene filaments to obtain a core-shell composite yarn for constructing an artificial blood vessel, and the core-shell composite yarn is matched with a braiding molding process, a low-temperature pressure plastic film forming process and a thread molding process to obtain a thread-shaped artificial blood vessel with polytetrafluoroethylene super-lubrication films on the inner and outer surfaces; the artificial blood vessel has good structural stability, high strength, good smoothness, biocompatibility and water impermeability, and can directly induce tissue cells to enter growth to form a new intima without pre-coagulation treatment; solves the problems of serious bleeding, poor compliance, poor shape retention, insufficient smoothness and the like of the artificial blood vessel in the prior art, prepares the artificial blood vessel meeting clinical requirements, and has better market application prospect.
2. According to the invention, through regulating and controlling the filament and spinning process parameters, the core-shell composite yarn with the high-strength core filament as the core layer and the polytetrafluoroethylene filament coated on the surface is obtained, the artificial blood vessel constructed by the core-shell composite yarn is made of polytetrafluoroethylene materials with hydrophobic inner and outer surfaces and extremely strong pollution resistance, and the formed surface hydrophobic structure has long-term stability in an in-vivo blood environment, so that the artificial blood vessel has excellent antithrombotic property, can not be degraded during long-term work, and the service life of the artificial blood vessel is prolonged; and the core-shell composite yarn improves the structural stability and mechanical properties of the artificial blood vessel through the cooperative matching of the high-strength core yarn and the polytetrafluoroethylene filament, so that the artificial blood vessel has good mechanical strength, fatigue resistance and crease resistance.
3. According to the invention, the thermal movement of a polytetrafluoroethylene molecular chain is accelerated and the ductility of the polytetrafluoroethylene molecular chain is improved by a low-temperature pressure plastic film forming mode, so that a polytetrafluoroethylene super-lubrication film is constructed on the inner and outer surfaces of an artificial blood vessel, the smoothness of the artificial blood vessel is improved, and the damage of high-temperature treatment to the structure and performance of the artificial blood vessel is avoided; the polytetrafluoroethylene super-lubrication film has a micropore structure smaller than the diameter of liquid water molecules, has good water seepage resistance, and has a micropore diameter smaller than the diameter of tissue cells, so that the tissue cells can be induced to grow to form a new inner membrane, and the new inner membrane does not need to be pre-coagulated when in use. In addition, the artificial blood vessel knitted based on the high polymer yarn adopts an integrated knitting molding process, and the preparation method is simple and easy to implement and has industrial production potential.
Drawings
FIG. 1 is a macroscopic structural diagram of an artificial blood vessel woven based on high molecular yarns.
Fig. 2 shows the internal and external microstructures of the artificial blood vessel woven based on the polymer yarn according to the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in detail with reference to the accompanying drawings and specific embodiments.
It should be noted that, in order to avoid obscuring the present invention due to unnecessary details, only structures and/or processing steps closely related to aspects of the present invention are shown in the drawings, and other details not greatly related to the present invention are omitted.
In addition, it should be further noted that the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Referring to fig. 1-2, an artificial blood vessel knitted based on polymer yarns is a threaded tubular fabric formed by a warp knitting process, the tubular fabric is made of core-shell composite yarns, the core layer of the core-shell composite yarns is high-strength core filaments, the outer layer of the core-shell composite yarns is polytetrafluoroethylene filaments, and the polytetrafluoroethylene filaments are compounded on the surface of the high-strength core filaments in a uniform wrapping mode. The inner and outer surfaces of the artificial blood vessel are made of polytetrafluoroethylene super-lubrication films which are prepared by low-temperature pressure plastic film forming of polytetrafluoroethylene filaments of core-shell composite yarns.
In this way, the invention takes the high-strength core yarn as the core layer, the polytetrafluoroethylene filaments are wrapped on the surface layer to obtain the core-shell composite yarn for constructing the artificial blood vessel, and the thread-shaped artificial blood vessel with the polytetrafluoroethylene super-lubrication film on the inner and outer surfaces is obtained by combining the braiding molding process, the low-temperature pressure plastic film forming process and the thread molding process; the artificial blood vessel has good structural stability, high strength, good smoothness, biocompatibility and water impermeability, and can directly induce tissue cells to enter growth to form a new intima without pre-coagulation treatment; solves the problems of serious bleeding, poor compliance, poor shape retention, insufficient smoothness and the like of the artificial blood vessel in the prior art, prepares the artificial blood vessel meeting clinical requirements, and has better market application prospect.
Specifically, the polytetrafluoroethylene super-lubrication film contains a micropore structure, and the average diameter of the micropore structure ranges from 10 mu m to 20 mu m, so that the polytetrafluoroethylene super-lubrication film has good water seepage resistance, and can induce tissue cells to grow to form a new inner film, and the application of the polytetrafluoroethylene super-lubrication film does not need to be subjected to pre-coagulation treatment.
The fineness of the high-strength core filament is 140-280D, and the fineness of the polytetrafluoroethylene filament is 50-100D. The high-strength core yarn comprises one of polyester filaments and polypropylene fibers. Preferably, the high strength core filaments are polyester filaments.
The preparation method of the artificial blood vessel 100 based on the macromolecule yarn knitting comprises the following steps:
S1, preparing core-shell composite yarns; uniformly wrapping polytetrafluoroethylene filaments on the surface of a high-strength core filament to obtain a core-shell composite yarn; the coating rate of the outer polytetrafluoroethylene filaments of the core-shell composite yarn on the inner core filaments is 90% -95%; by the process, the polytetrafluoroethylene filaments are repeatedly wrapped on the high-strength core filaments of the core layer, and the effect of completely coating the core without leakage is achieved;
s2, weaving the core-shell composite yarn in the step S1 into tubular fabric in a tatting or knitting mode;
S3, performing low-temperature pressure plastic film forming treatment on the tubular fabric obtained in the step S2 at 50-70 ℃ to obtain an artificial blood vessel with the inner and outer surfaces being polytetrafluoroethylene ultra-lubrication films; the thermal movement of a polytetrafluoroethylene molecular chain is accelerated by a low-temperature pressure plastic film forming mode, and the ductility of the polytetrafluoroethylene molecular chain is improved, so that a polytetrafluoroethylene super-lubrication film is constructed on the inner surface and the outer surface of an artificial blood vessel, the smoothness of the artificial blood vessel is improved, and the damage of high-temperature treatment to the structure and the performance of the artificial blood vessel is avoided;
And S4, performing hot pressing treatment on the artificial blood vessel obtained in the step S3 by adopting a thread forming device, wherein the temperature is 150-190 ℃, and obtaining the artificial blood vessel with the surface of the thread structure and woven based on the polymer yarns.
The core-shell composite yarn with the high-strength core yarn as the core layer and the polytetrafluoroethylene filaments coated on the surface is obtained by regulating and controlling the filament and spinning process parameters, the artificial blood vessel constructed by the core-shell composite yarn is made of polytetrafluoroethylene materials with hydrophobic inner and outer surfaces and extremely strong pollution resistance, and the formed surface hydrophobic structure has long-term stability in an in-vivo blood environment, so that the artificial blood vessel has excellent antithrombotic property, can not be degraded during long-term work, and the service life of the artificial blood vessel is prolonged; and the core-shell composite yarn improves the structural stability and mechanical properties of the artificial blood vessel through the cooperative matching of the high-strength core yarn and the polytetrafluoroethylene filament, so that the artificial blood vessel has good mechanical strength, fatigue resistance and crease resistance.
In the step S3, the time of the low-temperature pressure plastic film forming treatment is 10-20 min. The expansion degree of the polytetrafluoroethylene material is controlled by controlling the low-temperature pressure plastic film forming treatment time, and the diameter of the micropore structure is regulated and controlled, so that the polytetrafluoroethylene super-lubrication film with good water seepage resistance and capability of inducing tissue cell growth is obtained.
Specifically, in step S2, when weaving is performed by a tatting method, the method includes the following steps: (1) After warping treatment by taking the core-shell composite yarn as warp yarn, feeding a warp beam, drafting by adopting an eight-page heald frame zoned drafting method, and adjusting the warp tension; (2) The pattern is tubular structure, take 1/3 right twill as basic structure, the surface layer structure is 1/3 right twill, the inner layer structure is 1/3 right twill, the surface warp yarn and the surface weft yarn are 1:1, interweaving the surface layer yarns and the inner layer yarns through binding yarns; (3) Taking the core-shell composite yarn as weft yarn, controlling the density of warp and weft, and performing beating-up weaving until the tubular fabric with a certain warp length is obtained.
When knitting is adopted for weaving, the method comprises the following steps: (1) On a flat knitting machine, the triangular positions of a machine head are adjusted to the positions meeting the requirements for knitting rib patterns, core-shell composite yarns are penetrated, the wire ends penetrate through center joints of front and rear needle beds and are wound on a frame, and the machine head is pushed from right to left; (2) putting on the needle lifting plate and hanging the needle lifting plate on the needle lifting plate; (3) The tubular fabric consists of two end folding parts and a middle blood vessel part, wherein the middle blood vessel part consists of two first tissues and two second tissues with different coil lengths which are alternately arranged, and the folding parts are plain weave; (4) And (3) putting down the needle lifting triangle closed in the step (3), and pushing the machine head to weave until the tubular fabric with a certain size is obtained.
In some specific embodiments, in step S1, the core-shell composite yarn is prepared by uniformly wrapping polytetrafluoroethylene filaments on the surface of a high-strength core yarn by using a co-yarn forming process of S-twisting and Z-twisting. The method comprises the following steps: the core-shell composite yarn is spun by adopting a hollow spindle cladding machine and two groups of hollow spindles, high-strength core filaments penetrate along the upper hollow spindle and the lower hollow spindle, the arrangement of the wrapping twisting direction is divided into the same direction or opposite direction (crossing), the twisting direction of the lower spindle is selected to be S twisting, and the upper spindle is respectively arranged in the two directions of S twisting and Z twisting, so that the polytetrafluoroethylene filaments are bidirectionally clad around the high-strength core filaments.
The artificial blood vessel knitted based on the high polymer yarn adopts an integrated knitting molding process, the preparation method is simple and easy to implement, and the artificial blood vessel has excellent industrial production potential.
Example 1
The embodiment provides a preparation method of an artificial blood vessel woven based on high polymer yarns, which comprises the following steps:
S1, preparing core-shell composite yarns; uniformly wrapping polytetrafluoroethylene filaments on the surface of polyester core filaments by adopting a S-twisting and Z-twisting synergetic yarn forming process to obtain core-shell composite yarns; wherein, the coating rate of the outer polytetrafluoroethylene filaments of the core-shell composite yarn on the inner core filaments is 92%, the fineness of the polyester core filaments is 200D, and the fineness of the polytetrafluoroethylene filaments is 80D
S2, weaving the core-shell composite yarn in the step S1 into tubular fabric in a tatting mode;
S3, performing low-temperature pressure plastic film forming treatment on the tubular fabric obtained in the step S2 at 50 ℃ for 15min to obtain an artificial blood vessel with the inner and outer surfaces being polytetrafluoroethylene ultra-lubrication films;
And S4, performing hot pressing treatment on the artificial blood vessel obtained in the step S3 by adopting a thread forming device, wherein the temperature is 150 ℃, and obtaining the artificial blood vessel with the surface of the thread structure and based on polymer yarn braiding.
Example 2
The difference between the preparation method of the artificial blood vessel based on the polymer yarn knitting provided in this embodiment is that in the step S2, the tubular fabric is knitted, and the rest is substantially the same as in embodiment 1, and is not described here.
Comparative example 1
Comparative example 1 provides a method for preparing an artificial blood vessel, which is different from example 1 in that polyester fiber is used to weave instead of core-shell composite yarn, and the rest is substantially the same as example 1, and is not repeated here.
Comparative example 2
Comparative example 2 provides a method for preparing an artificial blood vessel, which is different from example 1 in that polytetrafluoroethylene filaments are used for weaving instead of core-shell composite yarns, and the rest is substantially the same as example 1, and is not described herein.
Comparative example 3
Comparative example 3 provides a method for preparing an artificial blood vessel, which is different from example 1 in that polyester fiber is used for weaving and molding the artificial blood vessel instead of core-shell composite yarn, and then polytetrafluoroethylene coating is carried out on the inner and outer surfaces of the artificial blood vessel, so as to obtain the artificial blood vessel material.
Comparative example 4
Comparative example 4 provides a method for producing an artificial blood vessel, which is different from example 1 in that in step S3, the low-temperature pressure plastic film forming process is not performed, and the rest is substantially the same as example 1, and a detailed description thereof is omitted.
Comparative example 5
Comparative example 5 provides a method for preparing an artificial blood vessel, which is different from example 1 in that in step S3, high temperature hot pressing is used instead of low temperature pressure plastic film forming treatment, the temperature is 150 ℃, and the rest is substantially the same as example 1, and will not be described here.
Comparative example 6
Comparative example 6 provides a method for preparing an artificial blood vessel, which is different from example 1 in that the time for the low-temperature pressure plastic film forming treatment in step S3 is 5min, and the rest is substantially the same as example 1, and is not repeated here.
Comparative example 7
Comparative example 7 provides a method for preparing an artificial blood vessel, which is different from example 1 in that the time for the low-temperature pressure plastic film forming treatment in step S3 is 30min, and the rest is substantially the same as example 1, and is not repeated here.
The artificial blood vessel materials prepared in examples 1-2 and comparative examples 1-7 were tested for mechanical properties, permeability, compliance, and other properties; the braided artificial blood vessel prepared in the embodiment 1 and the embodiment 2 has better mechanical property, structural stability, compliance and permeation resistance, and the hydrophobic structure on the inner surface and the outer surface has strong anti-fouling capability and high smoothness. The dacron artificial blood vessel prepared in comparative example 1 has good mechanical properties but poor permeation resistance and thrombus resistance. The polytetrafluoroethylene artificial blood vessel prepared in comparative example 2 has good antifouling property, but poor mechanical property and short service life. In the comparative example 3, polyester fiber is adopted to weave artificial blood vessels, and polytetrafluoroethylene is coated on the inner surface and the outer surface, so that the structural stability and the compliance are poor. In comparative example 4, the artificial blood vessel obtained by not performing the low-temperature pressure plastic film forming treatment was poor in the anti-seepage performance. The thermal pressing treatment adopted in comparative example 5 damages the structural stability of the artificial blood vessel, and is unfavorable for the mechanical properties of the blood vessel. As can be seen from comparative examples 6 and 7, the film forming degree of polytetrafluoroethylene is poor when the low-temperature pressure plastic film forming treatment is too short, the improvement of the permeation resistance of the artificial blood vessel is not facilitated, and the film forming degree is high when the time is too long, so that the mechanical property and the flexibility of the artificial blood vessel are poor.
In summary, according to the artificial blood vessel knitted based on the polymer yarn and the preparation method thereof provided by the invention, the artificial blood vessel is a threaded tubular fabric formed by a warp knitting process, the tubular fabric is made of a core-shell composite yarn, the core layer of the core-shell composite yarn is a high-strength core yarn, the outer layer of the core-shell composite yarn is polytetrafluoroethylene filaments, and the polytetrafluoroethylene filaments are compounded on the surface of the high-strength core yarn in a uniform wrapping manner. The invention takes a high-strength core wire as a core layer, and the surface layer is wrapped with polytetrafluoroethylene filaments to obtain a core-shell composite yarn for constructing an artificial blood vessel, and the core-shell composite yarn is matched with a braiding molding process, a low-temperature pressure plastic film forming process and a thread molding process to obtain a thread-shaped artificial blood vessel with polytetrafluoroethylene super-lubrication films on the inner and outer surfaces; the artificial blood vessel has good structural stability, high strength, good smoothness, biocompatibility and water impermeability, and can directly induce tissue cells to enter growth to form a new intima without pre-coagulation treatment; solves the problems of serious bleeding, poor compliance, poor shape retention, insufficient smoothness and the like of the artificial blood vessel in the prior art, prepares the artificial blood vessel meeting clinical requirements, and has better market application prospect.
The above embodiments are only for illustrating the technical solution of the present invention and not for limiting the same, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications and equivalents may be made thereto without departing from the spirit and scope of the technical solution of the present invention.
Claims (10)
1. The artificial blood vessel is a threaded tubular fabric formed by a warp knitting process, the tubular fabric is made of core-shell composite yarns, the core layer of the core-shell composite yarns is high-strength core filaments, the outer layer of the core-shell composite yarns is polytetrafluoroethylene filaments, and the polytetrafluoroethylene filaments are compounded on the surface of the high-strength core filaments in a uniformly wrapping mode.
2. The artificial blood vessel knitted based on high molecular yarns according to claim 1, wherein the inner and outer surfaces of the artificial blood vessel are polytetrafluoroethylene super-lubrication films, and the polytetrafluoroethylene super-lubrication films are prepared by low-temperature pressure plastic film forming of polytetrafluoroethylene filaments of the core-shell composite yarns.
3. The artificial blood vessel knitted based on polymer yarns according to claim 2, wherein the polytetrafluoroethylene super-lubricating film contains a microporous structure having an average diameter ranging from 10 to 20 μm.
4. The artificial blood vessel knitted based on polymer yarns according to claim 1, wherein the fineness of the high-strength core yarn is 140 to 280D and the fineness of the polytetrafluoroethylene filament is 50 to 100D.
5. The polymeric yarn-based braided prosthesis of claim 1 wherein the high strength core filaments comprise one of polyester filaments and polypropylene fibers.
6. A method for producing an artificial blood vessel knitted based on a polymer yarn according to any one of claims 1 to 5, comprising the steps of:
s1, preparing core-shell composite yarns; uniformly wrapping polytetrafluoroethylene filaments on the surface of a high-strength core filament to obtain a core-shell composite yarn; the coating rate of the outer polytetrafluoroethylene filaments of the core-shell composite yarn on the inner core filaments is 90% -95%;
s2, weaving the core-shell composite yarn in the step S1 in a tatting or knitting mode;
s3, performing low-temperature pressure plastic film forming treatment on the tubular fabric obtained in the step S2 at 50-70 ℃ to obtain an artificial blood vessel with the inner and outer surfaces being polytetrafluoroethylene ultra-lubrication films;
And S4, performing hot pressing treatment on the artificial blood vessel obtained in the step S3 by adopting a thread forming device, wherein the temperature is 150-190 ℃, and obtaining the artificial blood vessel with the surface of the thread structure and woven based on the polymer yarns.
7. The method according to claim 6, wherein the low-temperature pressure plastic film forming process is performed for 10 to 20 minutes in step S3.
8. The method according to claim 6, wherein in the step S1, the core-shell composite yarn is prepared by uniformly wrapping polytetrafluoroethylene filaments on the surface of a high-strength core yarn by a co-yarn forming process of S-twisting and Z-twisting.
9. The method for preparing an artificial blood vessel based on polymer yarn knitting according to claim 6, wherein in step S2, the weaving is performed by a tatting method, comprising the steps of: (1) After the core-shell composite yarn is used as warp yarn for warping treatment, a warp beam is arranged, and an eight-page heald frame zoned drafting method is adopted for drafting, so that the warp yarn tension is regulated; (2) The pattern is tubular structure, take 1/3 right twill as basic structure, the surface layer structure is 1/3 right twill, the inner layer structure is 1/3 right twill, the surface warp yarn and the surface weft yarn are 1:1, interweaving the surface layer yarns and the inner layer yarns through binding yarns; (3) And taking the core-shell composite yarn as weft yarn, controlling the density of warp and weft, and performing beating-up weaving until the tubular fabric with a certain warp length is obtained.
10. The method for producing an artificial blood vessel knitted based on a polymer yarn according to claim 6, wherein in step S2, knitting is performed by knitting, comprising the steps of: (1) On a flat knitting machine, regulating the triangular positions of a machine head to the positions meeting the requirements for knitting rib patterns, putting through the core-shell composite yarns, putting the wire ends through the middle seams of the front needle bed and the rear needle bed, winding on a frame, and pushing the machine head from right to left; (2) putting on the needle lifting plate and hanging the needle lifting plate on the needle lifting plate; (3) The tubular fabric consists of two end folding parts and a middle blood vessel part, wherein the middle blood vessel part consists of two first tissues and two second tissues with different coil lengths which are alternately arranged, and the folding parts are plain weave; (4) And (3) putting down the needle lifting triangle closed in the step (3), and pushing the machine head to weave until the tubular fabric with a certain size is obtained.
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