CN117980457A - 变色消毒组合物和使用方法 - Google Patents
变色消毒组合物和使用方法 Download PDFInfo
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- CN117980457A CN117980457A CN202180102515.0A CN202180102515A CN117980457A CN 117980457 A CN117980457 A CN 117980457A CN 202180102515 A CN202180102515 A CN 202180102515A CN 117980457 A CN117980457 A CN 117980457A
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- sanitizing composition
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- disinfecting
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- 238000000034 method Methods 0.000 title claims abstract description 19
- 238000011012 sanitization Methods 0.000 claims abstract description 40
- 239000000758 substrate Substances 0.000 claims abstract description 34
- 239000007793 ph indicator Substances 0.000 claims abstract description 32
- 239000004599 antimicrobial Substances 0.000 claims abstract description 30
- 239000003429 antifungal agent Substances 0.000 claims abstract description 24
- 229940121375 antifungal agent Drugs 0.000 claims abstract description 24
- 239000002253 acid Substances 0.000 claims abstract description 21
- 239000002904 solvent Substances 0.000 claims abstract description 20
- 239000003443 antiviral agent Substances 0.000 claims abstract description 19
- 150000007513 acids Chemical class 0.000 claims abstract description 15
- 230000000845 anti-microbial effect Effects 0.000 claims abstract description 14
- 230000007704 transition Effects 0.000 claims abstract description 14
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- 239000000654 additive Substances 0.000 claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 33
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 18
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 13
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 5
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- LIIDWKDFORMMDQ-UHFFFAOYSA-N 2-[[4-(dipropylamino)phenyl]diazenyl]benzoic acid Chemical compound C1=CC(N(CCC)CCC)=CC=C1N=NC1=CC=CC=C1C(O)=O LIIDWKDFORMMDQ-UHFFFAOYSA-N 0.000 claims description 3
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- MGUKYHHAGPFJMC-UHFFFAOYSA-N 4-[3-(4-hydroxy-2,5-dimethylphenyl)-1,1-dioxo-2,1$l^{6}-benzoxathiol-3-yl]-2,5-dimethylphenol Chemical compound C1=C(O)C(C)=CC(C2(C3=CC=CC=C3S(=O)(=O)O2)C=2C(=CC(O)=C(C)C=2)C)=C1C MGUKYHHAGPFJMC-UHFFFAOYSA-N 0.000 claims description 3
- OLQIKGSZDTXODA-UHFFFAOYSA-N 4-[3-(4-hydroxy-2-methylphenyl)-1,1-dioxo-2,1$l^{6}-benzoxathiol-3-yl]-3-methylphenol Chemical compound CC1=CC(O)=CC=C1C1(C=2C(=CC(O)=CC=2)C)C2=CC=CC=C2S(=O)(=O)O1 OLQIKGSZDTXODA-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- A—HUMAN NECESSITIES
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- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P3/00—Fungicides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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Abstract
本发明提供了一种消毒组合物。所述消毒组合物包含0.1重量%至约10重量%的一种或多种抗微生物剂、抗真菌剂和/或抗病毒剂和0.001重量%至约10重量%的一种或多种挥发性酸或挥发性碱。所述消毒组合物包含0.0001重量%至约5重量%的颜色转变pH范围为约2至约6.5的一种或多种pH指示剂或颜色转变范围为约7.5至约12的pH指示剂。所述消毒组合物包含80重量%至约98重量%的一种或多种挥发性溶剂。任选地,所述消毒组合物包含一种或多种添加剂。本发明还提供了用所述消毒组合物预饱和的多孔柔性基材和使用方法。
Description
背景技术
有效的清洁和杀菌以减少各种病原体的感染风险对于医疗保健行业和家庭非常重要。通常,用包含抗微生物剂和/或杀菌剂的清洁溶液预润湿的清洁溶液或擦拭物被广泛用于此目的。然而,为了确保有效杀菌,根据制造商的说明,杀菌剂必须在特定杀菌剂的完整接触时间内保留在表面上。这种接触时间,也称为湿润时间,是指杀菌剂需要在表面上保持湿润以确保功效的时间。各种杀菌剂的接触时间范围为约15秒至约10分钟。因此,对于消费者来说,了解接触时间并确保在杀菌剂施加后达到适当的接触时间是一个独特的挑战。接触时间缩短可能会导致清洁效果不佳,从而无法充分杀死致病性物质。此外,消费者可能会因未在表面上施加足够的杀菌剂或者在杀菌剂完全杀死致病性微生物之前移除杀菌剂而意外缩短接触时间。
因此,需要在已经发生适当量的接触时间时提供清晰指示的改进的清洁溶液。
发明内容
整体上,本公开涉及能够在期望量的接触时间之后改变颜色的消毒组合物。提供的一个实施方案包括一种消毒组合物,所述消毒组合物包含0.1重量%至约10重量%的一种或多种抗微生物剂、抗真菌剂和/或抗病毒剂;0.001重量%至约10重量%的一种或多种挥发性酸;0.0001重量%至约5重量%的一种或多种pH指示剂,所述pH指示剂的颜色转变pH范围为约2至约6.5;80重量%至约98重量%的一种或多种挥发性溶剂;以及任选地,一种或多种添加剂。所述一种或多种挥发性酸可以包括乙酸、丙酸、丁酸、盐酸、低级脂肪酸诸如庚酸和己酸或它们的组合。所述一种或多种pH指示剂可以包括甲基红、丙基红、溴酚蓝、溴甲酚绿、溴甲酚紫、刚果红、溴百里酚蓝或它们的组合。
本发明的另一个方面提供了一种消毒组合物,所述消毒组合物包含0.1重量%至约10重量%的一种或多种抗微生物剂、抗真菌剂和/或抗病毒剂;0.001重量%至约10重量%的一种或多种挥发性碱;0.0001重量%至约5重量%的一种或多种pH指示剂,所述pH指示剂的颜色转变pH范围为约7.5至约12;80重量%至约98重量%的一种或多种挥发性溶剂;以及任选地,一种或多种添加剂。所述一种或多种挥发性碱可以包括氢氧化铵、三乙胺、乙醇胺、三乙醇胺或它们的组合。所述一种或多种pH指示剂可以包括茜素红S、茜素黄、香芹酚酞、铬橙GR、邻甲酚酞、间甲酚紫、姜黄素、二二甲酚酞、愈创木酚酞、尼罗蓝、百里酚酞、二甲酚蓝、二甲酚酞或它们的组合。
还提供了包含本文公开的消毒组合物的预饱和的多孔柔性基材以及使用所述消毒组合物或基材的方法。
本公开的其他特征和方面在下文更详细地讨论。
具体实施方式
本领域的普通技术人员应理解,本论述只是对示例性实施方案的描述,并且无意限制本公开的更广泛的方面。
如本文所用,术语“非织造”织物或纤网是指成夹层的但不是以可识别方式的(如在编织或织造织物中)各纤维或线的结构。非织造织物或纤网已通过多种工艺形成,所述工艺例如熔喷工艺、纺粘工艺、水刺、气流成网和梳理工艺。
如本文所用,术语“多孔材料”包括其中具有开放区域或间隙空间的那些材料;开放区域或间隙空间不需要延伸通过整个材料。
本文提供的消毒组合物通常在全文中可称为“组合物”和/或“制剂”。实际上,这些术语可互换使用,是指本文公开的消毒组合物。
除非上下文另有明确规定,否则单数形式“一(a)”、“一个(an)”以及“该(the)”包括复数引用。
如本文在整个说明书和权利要求书中使用的近似语言被用于修饰任何定量表示,该定量表示可允许变化,而不会导致与其相关的基本功能的变化。因此,由一个或多个术语诸如“约”、“近似”和“基本上”修饰的值不限于指定的精确值。在至少一些情况下,近似语言可以对应于用于测量值的仪器的精度或者用于构造或制造部件和/或系统的方法或机器的精度。例如,近似语言可以指在1%、2%、4%、10%、15%或20%的界限内。这些近似界限可以应用于单个值、限定数值范围的任一或两个端点、和/或端点之间范围的界限。
包括本公开的组合物(包括其组分)、基材和方法的实施方案可以包括以下、由以下组成或基本上由以下组成:本文中所述的实施方案的基本元件和限制以及本文中所述或以其他方式有用的任何附加或任选的组分或限制。
本公开涉及消毒组合物、含有本文公开的消毒组合物的预饱和的基材以及使用本文公开的消毒组合物的方法。本公开的消毒组合物包含一种或多种挥发性酸或挥发性碱以及合适的pH指示剂,当溶液在一段时间后在表面上基本上干燥时,所述pH指示剂能够改变颜色。因此,本文提供的消毒组合物可以提供何时达到适当的接触时间的指示,从而提醒使用者表面已经被充分消毒。
另外,提供了已经用如本文所述的消毒组合物预饱和的柔性基材。例如,可以将消毒溶液施加于基材上,因此基材具有原始颜色。当基材保持原始颜色时,基材含有足够量的消毒组合物,因此被认为是有效的。然而,当基材的颜色改变为第二颜色(例如,由于干燥)时,基材所含的消毒组合物不足且应当丢弃。因此,本文提供的基材可以提供消毒组合物的存在量是否足以进行有效清洁和消毒的视觉指示。
此外,如所指出,本文提供的消毒组合物包含挥发性溶剂和挥发性酸和/或碱的组合。挥发性溶剂和/或挥发性酸或挥发性碱的共蒸发可以引发组合物的颜色变化,从而同时指示干燥和时间排程。有利地,可以改变挥发性溶剂、挥发性碱和/或挥发性酸的量或类型,以便当达到期望消毒剂的适当接触时间时提供适当的颜色变化。因此,可以根据特定消毒剂的期望接触时间来调整和使用挥发性溶剂、挥发性碱和/或挥发性酸的包含。
I.消毒剂
如所指出,消毒组合物可以包含一种或多种消毒剂,所述消毒剂通常是指抗微生物剂和抗真菌剂和/或抗病毒剂中的任一者。实际上,组合物可以含有抗微生物剂、抗真菌剂和/或抗病毒剂的任何组合。例如,在某些实施方案中,组合物可以包含抗微生物剂、抗真菌剂和抗病毒剂中的每者,而在其他实施方案中,组合物包含抗微生物剂、抗真菌剂或抗病毒剂中的至少两者。一旦选择抗微生物剂、抗真菌剂和/或抗病毒剂,所述抗微生物剂、抗真菌剂和/或抗病毒剂就可以根据组合物的消毒需要以期望的重量百分比包含在内。
消毒组合物中采用的抗微生物剂、抗真菌剂或抗病毒剂的量通常可以根据组合物中存在的其他组分的相对量而变化。通常,抗微生物剂、抗真菌剂或抗病毒剂在组合物中的存在量为约0.01重量%至约10重量%,诸如约0.1重量%至约9重量%,诸如约1重量%至约8重量%,诸如约2重量%至约7重量%,诸如约3重量%至约6重量%,诸如约4重量%至约5重量%。
a.抗微生物剂
合适的抗微生物剂包括能够杀死微生物(例如,革兰氏阴性菌和/或革兰氏阳性菌)和/或抑制微生物的生长的任何抗微生物剂。任何合适的抗微生物剂均可用于本公开。在一个具体实施方案中,抗微生物剂包含至少一种具有下式的季铵化合物:
其中,
R1、R2、R3和R4独立地选自由以下各项组成的组:H、C1-C30烷基、C1-C30烯基、C1-C30烷基乙氧基、C1-C30烷基酚乙氧基等;并且A选自由以下各项组成的组:卤素(例如,氯、溴、氟等);甲基硫酸根、磷酸根等。例如,可以用于本公开的一些合适的季铵化合物包括但不限于苯扎氯铵(BZK)或其他苯扎卤铵、苄索氯铵或其他苄索卤铵、氯化十六烷基吡啶、地喹氯铵、N-肉豆蔻基-N-甲基-吗啉鎓甲基硫酸盐、聚-N-3-(二甲基铵)丙基-N-3-(乙烯氧基乙烯二甲基铵)丙基脲二盐酸盐、α-4-1-三(2-羟乙基)氯化铵-2-丁烯基-ω-三(2-羟乙基)氯化铵、聚氧乙烯(二甲基亚氨基)乙烯(二甲基亚氨基)-二氯乙烷。
在一些实施方案中,可以采用具有下式的季铵卤化物化合物:
其中,
R是C8-C18烷基;并且
A是卤素原子,诸如氯、溴、氟等。
包含这种季铵化合物的抗微生物剂的一种商购获得的实例可以商品名208M得自Lonza,Inc.,Allendale,N.J.。具体而言,/>208M含有烷基二甲基苄基氯化铵的共混物。据信,合适的季铵化合物的其他商购获得的实例包括2050和/>2080(基于二烷基(C8-C10)二甲基氯化铵);2250和/>2280(二癸基二甲基氯化铵);/>LF和LF 80(基于二辛基二甲基氯化铵);/>MB-50和/>MB-80(基于烷基二甲基苄基氯化铵);/>MX-50和/>MX-80(基于烷基二甲基苄基氯化铵);/>OJ-50和/>OJ-80(基于烷基二甲基苄基氯化铵);/>4250、/>4280、/>4250Z和4280Z(基于烷基二甲基苄基氯化铵和/或烷基二甲基乙基苄基氯化铵);以及/>MS-100(基于肉豆蔻基二甲基苄基氯化铵),它可得自Lonza,Inc.。含有此类化合物的合适的灭菌溶液也是可商购获得的,诸如/>II 128,它由Diversey,Inc.销售并且含有N-烷基二甲基苄基氯化铵、二癸基二甲基氯化铵和乙醇。共混的季铵化合物的另外其他溶液可以商品名OASISTM(例如,OASISTM146)得自Ecolab,Inc,St.Paul,Minn.。
除了季铵化合物之外,其他抗微生物剂也可以用于本公开。例如,可以采用的一些合适的抗微生物剂包括但不限于:醇,卤代二苯醚,如2,4,4'-三氯-2'-羟基二苯醚(或TCS)或2,2'-二羟基-5,5'-二溴-二苯醚;酚化合物,如苯氧基乙醇、苯氧基丙醇、苯氧基异丙醇、对氯间二甲苯酚(PCMX)等;双酚化合物,诸如2,2'-亚甲基双(4-氯苯酚)、2,2'-亚甲基双(3,4,6-三氯苯酚)、2,2'-亚甲基双(4-氯-6-溴苯酚)、双(2-羟基-3,5-二氯苯基)硫醚和双(2-羟基-5-氯苄基)硫醚;卤代碳酰苯胺,例如3,4,4'-三氯碳酰苯胺(或TOG);苯甲醇;氯己定;葡萄糖酸氯己定;和盐酸氯己定。其他合适的抗微生物剂在WO 96/06152;WO 96106153;和授予Beerse等人的美国专利6,201,695号中有所描述。此外,美国联邦法规汇编(C.F.R.)第21编第178.010条中阐述了各种其他抗微生物剂。
在某些实施方案中,抗微生物剂可以包括庆大霉素(gentamicin)。庆大霉素,也称为加拉霉素(Garamycin)、西多霉素(Cidomycin)或塞托帕(Septopa),是一种对包括革兰氏阴性菌以及革兰氏阳性菌在内的多种细菌具有活性的抗生素,所述革兰氏阴性菌诸如假单胞菌属(Pseudomonas)、变形杆菌属(Proteus)、大肠杆菌(Escherichia coli)、肺炎克雷伯氏菌(Kiebsiella pneumoniae)、产气肠杆菌(Enterobacter aerogenes)、沙雷氏菌属(Serratia),所述革兰氏阳性菌诸如葡萄球菌属(Staphylococcus)。
其他合适的抗微生物剂包括具有抗微生物性的化合物、分子和化学元素,包括但不限于抗生素、防腐剂或其他抗微生物化合物、银、银纳米颗粒、离子银、一种或多种一种银化合物的组合、其他金属诸如锌、铜、金、铂以及它们的盐或络合物例如十一碳烯酸锌、异烟肼(isoniazid)、乙胺丁醇(ethambutol)、吡嗪酰胺(pyrazinamnide)、链霉素(streptomycin)、氯法齐明(clofazimine)、利福布丁(rifabutin)、氟喹诺酮(fluoroquinolones)、氧氟沙星(ofloxacin)、司帕沙星(sparfloxacin)、利福平(rifampin)、阿奇霉素(azithromycin)、克拉霉素(clarithromycin)、氨苯砜(dapsone)、四环素(tetracycline)、红霉素(erythromycin)、环丙沙星(ciprofloxacin)、多西环素(doxycycline)、氨苄青霉素(ampicillin)、两性霉素B(amphotericin B)、酮康唑(ketoconazole)、氟康唑(fluconazole)、乙胺嘧啶(pyrimethamine)、磺胺嘧啶(sulfadiazine)、克林霉素(clindamycin)、林肯霉素(lincomycin)、喷他脒(pentamidine)、阿托伐醌(atovaquone)、巴龙霉素(paromomycin)、地克珠利(diclazaril)、阿昔洛韦(acyclovir)、三氟尿苷、膦甲酸(foscarnet)、青霉素(penicillin)、更昔洛韦(ganciclovir)、伊曲康唑(iatroconazole)、咪康唑(miconazole)、吡硫鎓锌(Zn-pyrithione)、氯己定(chlorohexidine)、聚六亚甲基双胍、聚六亚甲基双胍、三氯生(triclosan)、碘、碘-聚乙烯吡咯烷酮复合物、过氧化脲复合物、苯扎氯铵盐、基于糖精酸盐的季铵化合物诸如Onyxide(Stepan Chemical)、姜黄提取物、其他天然抗感染化合物以及它们的组合。适用于本公开的抗微生物剂的实例是可以作为细颗粒溶解或分散或者存在于惰性载体之上或之中的试剂。本公开还包括聚合物抗微生物组合物。
b.抗真菌剂
合适的抗真菌剂包括减少或抑制(例如,杀死)真菌生长的任何试剂。例如,本公开的抗真菌剂可以是“抑真菌剂”和/或“杀真菌剂”。在某些实施方案中,抗真菌剂包括减少或抑制真菌生长至少10%的那些抗真菌剂。任何合适的抗真菌剂均可用于本公开。
在某些实施方案中,抗真菌剂包括克霉唑(clotrimazole)。克霉唑是具有下式的咪唑衍生物:
一般而言,克霉唑被认为通过改变真菌细胞壁的渗透性来抑制单独的真菌细胞的生长而发挥作用。克霉唑能够与细胞膜中的磷脂结合,并且可以抑制麦角甾醇和细胞膜产生所需的其他甾醇的生物合成,从而导致真菌生长减慢和/或细胞死亡。
在某些实施方案中,抗真菌剂包括特比萘芬(terbinafine),也称为乐肤舒(Lamisil)。特比萘芬具有下式:
特比萘芬是一种合成的烯丙胺衍生物,具有抗真菌活性。特比萘芬抑制鲨烯环氧化酶,从而阻断麦角甾醇的生物合成,麦角甾醇是真菌细胞膜的重要组分。因此,特比萘芬可以防止某些真菌形成保护性外层,从而导致真菌细胞死亡。
其他抗真菌剂包括醋、硼砂、铜、2-正辛基-4-异噻唑啉-3-酮、葡萄油、葵花籽油、几丁质酶E(家族19;IV类)、葡萄柚提取物、吲哚生物碱文那亭、2-芳基-3-(1H-1,2,4-三唑-1-基)丙腈的含硅衍生物、邻碳硼烷基丙氨酸和多相CST(即,非金属、水分散性液体杀菌剂/防霉剂)。
其他示例性抗真菌剂包括氯和氯化合物(例如,次氯酸钠)、碘和碘化合物、其他卤素和卤素化合物(例如,溴)、醇(例如,IPA、ETOH、甲醇)、氧化剂(例如,过氧化氢、过乙酸)、氮化合物(例如,噻唑、巯基苯并噻唑、喹啉、酰苯胺)、季铵化合物(例如,苯扎氯铵)、酚醛树脂(羟基苯甲酸、氯二甲酚)、酸-阴离子化合物(例如,磺酸烷基芳基酯)和有机酸(例如,丙酸、苯甲酸、乳酸、柠檬酸、山梨酸)。
一些其他示例性抗真菌剂包括有机汞和无机汞、银和银化合物、其他重金属(例如,锌、铜、镍)、阳离子双胍、三氯生、异噻唑啉、氯化苯氧基、氨基甲酸酯、2-二溴-3-次氮基丙酰胺以及多种天然化合物(例如,萜烯和脂族化合物)。
c.抗病毒剂
合适的抗病毒剂包括能够杀死病毒和/或抑制病毒的生长的任何试剂或试剂组合。任何合适的抗病毒剂均可用于本公开。在某些实施方案中,抗病毒剂包括福米韦生(formivirsen)。福米韦生是一种反义寡核苷酸,特异性抑制人巨细胞病毒的复制。福米韦生通过与从病毒的主要立即早期转录单元转录的信使RNA上的互补序列结合来发挥作用。
在其他实施方案中,抗病毒组合物可以包含溴夫定(brivudine)。溴夫定是一种具有下式的核苷胸苷的类似物:
溴夫定通过阻断DNA聚合酶的作用,从而抑制病毒复制来发挥作用。
其他抗病毒剂可以包括一种或多种羧酸,诸如柠檬酸、苹果酸、琥珀酸、苯甲酸等等。一种或多种羧酸可以与表面活性剂组合使用以提供抗病毒活性。
II.挥发性酸或挥发性碱
消毒组合物可以包含一种或多种挥发性酸或一种或多种挥发性碱。例如,根据所用的化学组合物和pH指示剂,组合物通常将含有挥发性酸或挥发性碱。例如,如果采用颜色转变pH范围为约2至约6.5的pH指示剂,则可以采用一种或多种挥发性酸。然而,如果pH指示剂包括颜色转变pH范围为约7.5至约12的pH指示剂,则可以采用一种或多种挥发性碱。
当包含一种或多种挥发性酸或挥发性碱时,所述一种或多种挥发性酸或挥发性碱可以以约0.001重量%至约10重量%,诸如0.01重量%至约9.5重量%,诸如0.1重量%至约9%,诸如1重量%至约8.5重量%,诸如2重量%至约8重量%,诸如约3重量%至约7.5重量%,诸如约4重量%至约7重量%,诸如约5重量%至约6重量%的量掺入。
合适的挥发性酸包括能够快速发生气化的任何酸。这种快速气化是酸在室温处具有高蒸气压的结果。因此,挥发性酸无需加热或任何其他外力即可发生气化。合适的挥发性酸包括乙酸、丙酸、丁酸、盐酸、低级脂肪酸诸如庚酸和己酸或它们的组合。
合适的挥发性碱包括能够快速发生气化的任何碱。合适的挥发性碱包括氢氧化铵、三乙胺、乙醇胺、三乙醇胺或它们的组合。
III.pH指示剂
本文提供的消毒组合物中包含合适的pH指示剂。pH指示剂具有基于一定pH范围的特定颜色转变pH值。pH指示剂提供的颜色变化可以是从有色变为无色、从无色变为有色或从一种颜色变为另一种颜色。此外,可以组合一种或多种具有视觉上不同的颜色的pH指示剂,或者可以组合具有相同视觉颜色的pH指示剂并且将这些pH指示剂包含在本文提供的制剂中。
所包含的pH指示剂的量可以在约0.0001重量%至约2重量%,诸如约0.001重量%至约1.8重量%,诸如约0.01重量%至约1.6重量%,诸如约0.1重量%至约1.4重量%,诸如约0.5重量%至约1.2重量%之间变化,诸如约1.0重量%。所包含的pH指示剂的量可以根据总体组合物制剂和必要颜色变化的所需量而变化。
如所指出,pH指示剂具有特定颜色转变pH,其中如本文提供的pH指示剂使颜色发生改变。在某些实施方案中,pH指示剂具有的颜色转变pH范围为约2至约6.5。具有在酸性范围内的颜色转变pH的合适的pH指示剂将适合包含在包含一种或多种挥发性酸的消毒组合物中。具有在酸性范围内的颜色转变pH的合适的pH指示剂的实例包括甲基红、丙基红、溴酚蓝、溴甲酚绿、溴甲酚紫、刚果红、溴百里酚蓝或它们的组合。
在某些实施方案中,pH指示剂具有的颜色转变pH范围为约7.5至约12。具有在碱性范围内的颜色转变pH的合适的pH指示剂将适合包含在包含一种或多种挥发性碱的消毒组合物中。具有在碱性范围内的颜色转变pH的合适的pH指示剂的实例包括茜素红S、茜素黄、香芹酚酞、铬橙GR、邻甲酚酞、间甲酚紫、姜黄素、二二甲酚酞、愈创木酚酞、尼罗蓝、百里酚酞、二甲酚蓝、二甲酚酞或它们的组合。
IV.挥发性溶剂
本公开的消毒组合物可以包含一种或多种挥发性溶剂。所包含的挥发性溶剂可以是单一溶剂或溶剂的混合物。合适的溶剂包括水、乙醇、甲醇、丁醇、丙醇、异丙醇、丁酮、丙酮、四氢呋喃以及它们的组合。在制备本公开的变色组合物和基材时,组分可以全部一起溶解在溶剂中或者依次溶解以制备均质溶液。另外,消毒组合物的某些组分可以悬浮在挥发性溶剂中。
挥发性溶剂可以以约80重量%至约98重量%,诸如约82重量%至约96重量%,诸如约84重量%至约94重量%,诸如约86重量%至约92重量%,诸如约88重量%至约90重量%的量存在。
V.添加剂
消毒组合物可以包含其他添加剂,诸如香料、着色剂、发泡剂、粘度调节剂以及它们的组合。例如,多种香料可以用于本文提供的制剂中。因此,还可以采用本领域的技术人员已知的用于消毒组合物的香料。
香料可以包括一种或多种芳香味化合物并且可以任选地与惰性载体混合。芳香味化合物通常包括被描述为具有前调、中调和/或后调的化合物。前调化合物的耐热性最差,通常在暴露于高温时会快速闪蒸或挥发。中调化合物,也称为醛提剂,更稳定且更持久,但是在相对较短的时间内或反复暴露于高温时仍然容易消散。后调化合物是通常特征在于具有“浓重”香气的那些化合物,并且最难随时间推移而消散,且能长时间保留。一类后调化合物包括精油。一般而言,香料可以由约5%至约50%的芳香味化合物制备。通常,香料可以包含约50%至约95%的惰性载体化合物。合适的惰性载体化合物可以包括二丙二醇。
优选地,香料包含至少两种芳香味化合物。更优选地,香料包含至少两种芳香味化合物,每种芳香味化合物具有热稳定温度高达至少约75℃的至少一种后调。最优选地,至少一种芳香味化合物是精油。合适的精油包括依兰、芫荽、葡萄柚、薰衣草、白百里香、柑橘油、晚香玉、茉莉、醒目薰衣草、白松香、丁香叶、桉树和香叶醇。适用于本公开的其他精油包括檀香木、麝香、香菖根、茉莉、玫瑰、铃兰、香柠檬、兰花、姜、肉豆蔻、柠檬草、姜黄、迷迭香、丁香、洋甘菊、蓍草、圣罗勒(thulasi)和雪松。另外,还可以使用本领域已知的其他精油。可以使用的其他香料包括柠檬烯、蒎烯、薄荷醇、樟脑以及它们的混合物。
如所指出,在某些实施方案中,组合物可以包含合适的发泡剂。例如,当使用例如合适的泵或喷洒分配器将组合物与空气组合时,发泡剂能够使组合物发泡。虽然消毒组合物可以从气溶胶容器中分配,但是不需要气溶胶来使组合物发泡。还有一个特别的优点是,消毒组合物是可发泡的,而不必包含氟化的表面活性剂。各种不同的衍生化的聚二甲基硅氧烷发泡剂可以用于本公开的组合物中。例如,衍生化的聚二甲基硅氧烷可以包括聚二甲基硅氧烷共聚醇,诸如乙氧基化的聚二甲基硅氧烷。在一个实施方案中,衍生化的聚二甲基硅氧烷是直链的,但是也可以使用支链的聚二甲基硅氧烷。
可以使用的聚二甲基硅氧烷共聚醇的具体实例包括含有约5至约20摩尔聚氧乙二醇的聚氧乙二醇聚二甲基硅氧烷。衍生化的聚二甲基硅氧烷可以是例如PEG-10聚二甲基硅氧烷、PEG-12聚二甲基硅氧烷或它们的混合物。在一个实施方案中,衍生化的聚二甲基硅氧烷可以包括聚二甲基硅氧烷共聚醇酯。例如,聚二甲基硅氧烷共聚醇酯的实例是聚二甲基硅氧烷PEG-7椰油酸酯。衍生化的聚二甲基硅氧烷可以以足以在与空气组合时使组合物发泡的量存在于消毒组合物中。
另外,可以将粘度调节剂(例如,增稠剂)添加至本文提供的组合物中,以赋予组合物期望的特征。可以采用的粘度调节剂的实例包括各种改性纤维素。例如,粘度调节剂可以包括乙基纤维素、羟丙基纤维素、羧甲基纤维素、羟丙基甲基纤维素、羟乙基甲基纤维素以及它们的组合。其他粘度调节剂包括天然树胶,诸如瓜尔胶、角叉菜胶、阿拉伯胶、刺槐豆胶、黄原胶以及它们的混合物。可以使用的其他各种聚合物粘度调节剂包括羟乙基纤维素、聚醚丙酸TMX共聚物或丙烯酸酯聚合物,诸如在烷基链中含有约10个碳原子至约30个碳原子的丙烯酸烷基酯交联聚合物。
VI.消毒组合物的使用
所描述的消毒组合物可以储存于合适的分配容器中并且可以从所述容器中分配。如所指出,可以将消毒组合物施加于表面。例如,可以将消毒组合物喷洒到需要消毒和/或杀菌的硬表面上。一般而言,消毒组合物一旦施加就可以在硬表面上保持湿润。在表面上的消毒组合物改变颜色之后,可以擦拭表面以移除上面留下的残留材料和/或消毒组合物。实际上,等到颜色发生变化后再擦拭表面,可以确保表面和消毒剂之间有适量的接触时间,从而确保适当的杀菌。
可以将消毒组合物施加于任何合适的表面以进行消毒和/或杀菌。例如,在某些实施方案中,可以将一层(例如,薄层)消毒组合物喷洒到所需表面上,而在其他实施方案中,可以将一层消毒组合物擦拭到所需表面上。
如所指出,在某些实施方案中,消毒组合物可以预饱和在多孔柔性基材上。例如,任何合适的基于非织造物的擦拭物、棉质擦拭物或织造织物擦拭物均可以用消毒组合物来预饱和,并且被用于将消毒组合物施加于表面。如所指出,可以将消毒组合物施加于多孔柔性基材上,以形成清洁制品(例如,清洁擦拭物)。
示例性多孔材料包括但不限于非织造纤网、多层层合物、开孔泡沫、织造和针织材料等等。多孔材料可以包括单独的开口或间隙空间,所述开口或间隙空间经由邻近的互连空间或开口共同地形成穿过所述材料的厚度的路径。期望的是,将消毒组合物施加于多孔材料上,以预润湿或浸透多孔材料的外部部分和内部部分两者。此外,期望的是,多孔材料是在整个织物中具有许多间隙空间的纤维片材。在另一个方面,本文公开的消毒组合物还适合于在由疏水性材料形成和/或包含疏水性材料的多孔材料内使用。如本文所用,术语“疏水性”包括具有大于45度的接触角的那些材料。
然而,适用于本公开的很多疏水性材料可以具有约60度或更大的接触角,并且更期望的是,可以具有约90度或更大的接触角。合适的疏水性材料包括但不限于由聚烯烃、聚酯、聚酰胺和类似的聚合物形成的那些疏水性材料。作为一个实例,多孔材料可以包含丙烯聚合物。示例性非织造织物可以通过多种工艺形成,所述工艺例如熔喷工艺、纺粘工艺、水刺工艺、气流成网工艺、粘结梳理纤网工艺等等。此外,多孔材料可以包括一种或多种不同材料的多层层合物。仅举例来说,适合与本公开一起使用的材料包括但不限于以下专利中描述的那些:授予Anderson等人的美国专利4,100,324号;授予Meitner的美国专利4,298,649号;授予Hotchkiss等人的美国专利4,463,780号;授予Lamers等人的美国专利4,659,609号;授予Abba等人的美国专利4,853,281号;授予Win等人的美国专利4,833,003号;授予Pike等人的美国专利5,382,400号;授予Sasse等人的美国专利5,895,710号;授予Pike等人的美国专利5,605,749号;授予Fitting的美国专利5,858,504号;授予Pike等人的美国专利5,759,926号,授予Marmon等人的美国专利申请09/760,962号和授予Keck等人的美国专利申请09/531,300号;前述参考文献中的每篇的全部内容均以引用的方式并入本文。多孔材料的尺寸和形状可以根据需要而变化,并且通常根据待清洁表面的性质来选择多孔材料的尺寸和形状。
一旦施加于所需的基材上,基材就可以堆叠并储存较长的时间。因此,堆叠的材料可以被预润湿,然后储存于密封容器中直到需要为止。就此而言,从堆叠中取出的擦拭物或片材每片均含有本文提供的消毒组合物。此外,期望的是,整个堆叠中含有的擦拭物包含基本上相同量的消毒组合物。就此而言,期望的是,片材的堆叠随时间推移经历不显著的液体迁移,具体而言,避免其中堆叠的上部部分含有的液体显著少于堆叠的下部部分中的液体量的迁移。因此,密封容器可以保持预润湿的片材,以使得即使在经历长时间储存和/或运输时,堆叠的片材从上到下每片均均匀地含有有效量的消毒组合物。
如本文所用,术语“堆叠”被广泛地用于包括其中存在多个表面对表面界面的擦拭物或片材的任何集合。这不仅包括单独的片材的垂直堆叠集合,而且还包括单独的片材的水平堆叠集合以及连续片材材料的卷起或折叠集合。就水平堆叠而言,其中单独的片材是直立的,期望的是,清洁组合物的浓度从每个单独的片材的顶部到底部以及从片材到片材维持基本上相等。期望的是,包括连续片材的卷起或折叠产品具有穿孔或过度粘合的弱化线,所述弱化线允许分离成具有期望形状和尺寸的更小的单独片材。值得注意的是,当卷绕成卷时,擦拭物或片材的卷内的清洁组合物的浓度平衡至基本上相等的浓度,而无论容器内的卷的取向如何。
此外,如果容器的堆叠内含有的一个或多个基材(例如,擦拭物)随时间推移而变干,则pH指示剂将改变基材本身的颜色,表明所选的基材不包含足够的消毒组合物并且应被丢弃。有利地,无论基材的堆叠布置方式如何,预饱和在其上的消毒组合物都能够向最终使用者指示基材何时不再适合使用。
此外,应当注意,如本文所用的“施加”或“处理”表面以广义使用,包括但不限于对表面进行擦拭、抛光、抹擦、清洁、洗涤、杀菌、擦洗、洗刷、消毒和/或施加活性剂。本公开的消毒组合物或预润湿的基材还能够从各种表面移除异物。作为非限制性实例,异物包括诸如油、润滑脂、油墨、油漆、焦油、填缝和密封化合物、粘合剂和胶水、煤粉、沥青、清漆等等的物质。此外,仅举例来说,消毒组合物和预饱和的基材非常适合处理硬表面,例如柜台、桌子、家具、工作站、窗户、实验室顶部、设备、机械、地板、墙壁等等。合适的硬表面包括金属、玻璃、木材、石头、塑料等等。
本公开可以通过以下实施例来进一步说明,这些实施例不应被解释为以任何方式对本公开的范围施加限制。相反,应当清楚地理解,本领域的技术人员在阅读本文的描述之后,可以受到以下启发:在不偏离本公开的精神和/或所附权利要求的范围的情况下,可以寻求各种其他实施方案、修改以及它们的等效方案。
实施例
除非另外说明,否则本文公开的实施例中提供的组分的百分比是指重量百分比。
实施例1
制剂1包含以下组分:1%苯扎氯铵、0.02%溴甲酚绿、0.06%的乙酸、30%乙醇和69%水。溶液呈黄色。当将黄色溶液喷洒在白色陶瓷表面或白色纸板表面上时,这些表面上的制剂保持几乎无色或微黄色。在干燥后表面变成蓝色。
实施例2
制剂2包含以下组分:2%苯扎氯铵、0.03%溴酚蓝、0.1%乙酸、30%乙醇和67.9%水。溶液呈黄色。当将黄色溶液喷洒在白色陶瓷表面或白色纸板表面上时,这些表面上的制剂保持几乎无色或微黄色。在干燥后表面变成蓝色。
实施例3
制剂3包含以下组分:2.5%苯扎氯铵、0.05%甲基红、0.1%乙酸、70%乙醇和27.4%水。溶液呈红色。当将红色溶液喷洒在白色陶瓷表面或白色纸板表面上时,这些表面上的制剂保持红色。在干燥后表面变成淡黄色。
实施例4
制剂4包含以下组分:1.7%(重量)苯扎氯铵、0.067%对二甲酚酞、0.67%三乙醇胺、6.7%乙醇和91%水。溶液呈蓝色。当将蓝色溶液喷洒在白色陶瓷表面或白色纸板表面上时,这些表面上的制剂保持蓝色。在干燥后表面变成无色。
实施例5
制剂5包含以下组分:2.5%(重量)苯扎氯铵、0.09%百里酚酞、1%三乙醇胺、8%乙醇和88.4%水。溶液呈蓝色。当将蓝色溶液喷洒在白色陶瓷表面或白色纸板表面上时,这些表面上的制剂保持蓝色。在干燥后表面变成无色。
实施例6
制剂6包含以下组分:2.5%(重量)苯扎氯铵、0.09%百里酚酞、1%乙醇胺、8%乙醇和88.4%水。溶液呈蓝色。当将蓝色溶液喷洒在白色陶瓷表面或白色纸板表面上时,这些表面上的制剂保持蓝色。在干燥后表面变成无色。
实施例7
制剂7包含以下组分:2%(重量)苯扎氯铵、0.1%酚酞、1%三乙醇胺、6%乙醇和90.9%水。溶液呈粉红色。当将粉红色溶液喷洒在白色陶瓷表面或白色纸板表面上时,这些表面上的制剂保持粉红色。在干燥后表面变成无色。
实施例8
将一块6cm×6cm的熔喷或Hydroknit非织造材料用2ml制剂1溶液浸泡至呈现淡黄色。当基材变得基本上干燥时逐渐从黄色变为蓝色。
实施例9
将一块6cm×6cm的熔喷或Hydroknit非织造材料用2ml制剂4溶液浸泡至呈现蓝色。当基材变得基本上干燥时逐渐从蓝色变为无色。
实施例10
将一块6cm×6cm的熔喷或Hydroknit非织造材料用2ml制剂1溶液浸泡至呈现淡黄色。该擦拭物被用于擦拭白色陶瓷表面或白色纸板表面。当溶液变得基本上干燥时,表面从几乎无色显示出蓝色。
实施例11
将一块6cm×6cm的熔喷或Hydroknit非织造材料用2ml制剂4溶液浸泡至呈现蓝色。该擦拭物被用于擦拭白色陶瓷表面或白色纸板表面。当溶液变得基本上干燥时,制剂4的最初蓝色变为无色。
在不脱离本公开的精神和范围的情况下,本公开的这些和其他修改和变型可以由本领域的普通技术人员实践,在所附权利要求中对此更具体地描述。此外,应当理解各种实施方案的方面可整体或部分互换。此外,本领域的普通技术人员将会知道,上述描述仅仅是举例,并非意图限制此类所附权利要求书中进一步描述的本公开。
Claims (23)
1.一种消毒组合物,其包含:
0.1重量%至约10重量%的一种或多种抗微生物剂、抗真菌剂和/或抗病毒剂;
0.001重量%至约10重量%的一种或多种挥发性酸;
0.0001重量%至约5重量%的一种或多种pH指示剂,所述pH指示剂具有的颜色转变pH范围为约2至约6.5;
80重量%至约98重量%的一种或多种挥发性溶剂;以及
任选地,一种或多种添加剂。
2.如权利要求1所述的消毒组合物,其中所述抗微生物剂包含一种或多种季铵化合物、二葡萄糖酸氯己定或过氧化氢或它们的组合,所述季铵化合物包括苄索氯铵、苯扎氯铵。
3.如权利要求1所述的消毒组合物,其中所述抗微生物剂包括庆大霉素。
4.如权利要求1所述的消毒组合物,其中所述一种或多种s抗真菌剂包括克霉唑、特比萘芬或它们的组合。
5.如权利要求1所述的消毒组合物,其中所述抗病毒剂包括福米韦生、溴夫定或它们的组合。
6.如权利要求1所述的消毒组合物,其中所述一种或多种挥发性酸包括乙酸、丙酸、丁酸、盐酸或它们的组合。
7.如权利要求1所述的消毒组合物,其中所述一种或多种pH指示剂包括甲基红、丙基红、溴酚蓝、溴甲酚绿、溴甲酚紫、刚果红、溴百里酚蓝或它们的组合。
8.如权利要求1所述的消毒组合物,其中所述一种或多种挥发性溶剂包括水、乙醇、丙醇、异丙醇、丙酮、丁酮或它们的组合。
9.如权利要求1所述的消毒组合物,其中所述一种或多种添加剂包括香料、着色剂、发泡剂、粘度调节剂或它们的组合。
10.一种消毒组合物,其包含:
0.1重量%至约10重量%的一种或多种抗微生物剂、抗真菌剂和/或抗病毒剂;
0.001重量%至约10重量%的一种或多种挥发性碱;
0.0001重量%至约5重量%的一种或多种pH指示剂,所述pH指示剂具有的颜色转变pH范围为约7.5至约12;
80重量%至约98重量%的一种或多种挥发性溶剂;以及
任选地,一种或多种添加剂。
11.如权利要求10所述的消毒组合物,其中所述抗微生物剂包含一种或多种季铵化合物或它们的组合,所述季铵化合物包括苄索氯铵、苯扎氯铵。
12.如权利要求10所述的消毒组合物,其中所述抗微生物剂包括庆大霉素。
13.如权利要求10所述的消毒组合物,其中所述一种或多种抗真菌剂包括克霉唑、特比萘芬或它们的组合。
14.如权利要求10所述的消毒组合物,其中所述抗病毒剂包括福米韦生、溴夫定或它们的组合。
15.如权利要求10所述的消毒组合物,其中所述一种或多种挥发性碱包括氢氧化铵、三乙胺、乙醇胺、三乙醇胺或它们的组合。
16.如权利要求10所述的消毒组合物,其中所述一种或多种pH指示剂包括茜素红S、茜素黄、香芹酚酞、铬橙GR、邻甲酚酞、间甲酚紫、姜黄素、二二甲酚酞、愈创木酚酞、尼罗蓝、百里酚酞、二甲酚蓝、二甲酚酞或它们的组合。
17.如权利要求10所述的消毒组合物,其中所述一种或多种挥发性溶剂包括水、乙醇、丙醇、异丙醇、丙酮、丁酮或它们的组合。
18.如权利要求10所述的消毒组合物,其中所述一种或多种添加剂包括香料、着色剂、发泡剂、粘度调节剂或它们的组合。
19.一种预饱和的多孔柔性基材,其用如前述权利要求中任一项所述的消毒组合物来预饱和。
20.如权利要求19所述的预饱和的多孔柔性基材,其中所述基材包括基于非织造物的擦拭物、棉质擦拭物或织造织物擦拭物。
21.如权利要求20所述的基材,其中所述基材的颜色从第一颜色变为第二颜色时指示不应使用所述基材。
22.一种使用如权利要求1至18中任一项所述的消毒组合物的方法,其包括:
将所述消毒组合物施加于表面;以及
在所述表面上的所述消毒组合物改变颜色之后,擦拭所述表面以移除上面留下的任何残留材料和/或消毒组合物。
23.一种使用如权利要求20至21中任一项所述的预饱和的多孔柔性基材的方法,其包括用所述预饱和的多孔柔性基材来擦拭表面,以使所述表面覆盖有预加载到所述擦拭物上的一层所述消毒组合物;以及
在所述表面上的所述消毒组合物改变颜色之后,擦拭所述表面以移除上面留下的任何残留材料和/或消毒组合物。
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