CN1179647C - Male sterile mouse killing agent and its preparing method - Google Patents

Abstract

The present invention discloses a male sterile mouse killing agent which is characterized in that the mouse killing agent is prepared from the components of the percentage by weight of 0.2 to 1% of gossypol, 0.1 to 0.3% of triptolide and 99 to 99.7% of mouse attracting bait in the form of irregular granules, wherein the mouse attracting bait is prepared from the components of the percentage by weight of 10 to 25% of bean cake meal or maize meal, 40 to 60% of wheat bran, 10 to 25% of peanut meal or sesame meal and 10 to 25% of fish meal. The present invention has obviously medicinal effects on the testicular damage of male mice. After freely eating the mouse killing agent, the weight of the male mice begins to decrease, the end part of the epididymis is atrophied, sperms are decreased, the volume of contorted seminiferous tubule and testicles is obviously atrophied, and the sperms of the male mice begin to die nearly for 7 days so as to obtain sterile effects. The mouse killing agent has the advantages of no environmental pollution and no secondary poisoning phenomenon, and belongs to a green safe mouse killing agent.

Description

Male sterile mouse killing agent and preparation method thereof

The present invention relates to technical field of rodenticide, specifically a kind of sterile rat-bane that reduces muroid quantity of male mouse that utilizes.

The kind of muroid is many, quantity big, it is wide to distribute, and muroid all causes tremendous loss to agricultural, livestock breeding, industry and capital construction, and muroid is also propagated multiple disease, and human beings'health is had very big harm, and killing mouse is the key subjects that the whole world faces.Aspect rodenticide deratization, what the present routine of China was used still is the chemical deratization medicine.First generation severe toxicity rodent poison bait is because of existing serious secondary poisoning phenomenon, forbidden by national explicit order, though the toxicity of second generation anticoagulation rodent poison bait is littler, but still there is the phenomenon of secondary poisoning, and the latent period of accidental poisoning is long, be difficult for realizing, the treatment difficulty is big, because chemistry is killed muroid fast and can be caused many " population vacuum " environment, stimulates residual mouse to breed rapidly, recover even surpass previous level, cause some regional plagues of rats not only not alleviated, all the more serious on the contrary, there are factors such as serious secondary poisoning and environmental pollution in chemical rodenticide in addition, impels people to remove to seek the mouse killing medicine of new mouse killing technology, adopt gossypol feed male mouse through looking into newly once to have abroad, day clothes dosage 20mg/kg body weight can cause sterile report in 62 days, but because the gossypol scent of, mouse be unwilling to eat, can not make rat-bane and kill mouse on a large scale, and need regular taking, the time of taking length just has sterile effect.

The object of the present invention is to provide a kind of male sterile mouse killing agent and preparation method thereof, the pillar rat-bane can not produce the secondary poisoning phenomenon, and has good deratization effect.

Technical scheme of the present invention is achieved in that male sterile mouse killing agent, it is characterized in that: described rat-bane is the gossypol of 0.2-1% by percentage by weight, the Triptolide of 0.1-0.3%, the irregular particle that lures the mouse feed to form of 99-99.7%, the percentage by weight that wherein lures the mouse feed to form is soybean cake powder or corn flour 10-25%, wheat bran 40-60%, groundnut meal or sesame meal 10-25%, fish meal 10-25%.

The preparation method of male sterile mouse killing agent is characterized in that:

A, get percentage by weight and be, soybean cake powder or corn flour 10-25%, wheat bran 40-60%, groundnut meal or sesame meal 10-25%, fish meal 10-25% place blender to rotate stirring and evenly mixing and make and lure the mouse feed standby;

B, the 2-20% that lures the mouse feed that will make place grinder, the gossypol that it is 5-50% that adding accounts for this percentage by weight that lures the mouse feed, and it is standby to grind mixing;

C, the 2-20% that lures the mouse feed that will make place grinder, the Triptolide that it is 2-15% that adding accounts for this percentage by weight that lures the mouse feed, and it is standby to grind mixing;

D, the mouse feed that lures that contains gossypol and Triptolide that will prepare mix, and all the other that will make lure the mouse feed to pour stirring and evenly mixing in the blender together into again;

E, the mixture of above stirring and evenly mixing is put into the cuber compacting, become block;

F,, adopt crushing mill to smash the irregular particle that becomes the 0.1-1.0 cubic centimetre block of compacting;

G, particle is put into the dry 1-3 of baking oven hour of 60-80 degree Celsius, cooling back packing, warehouse-in.

The present invention has following advantage compared with prior art:

1, the present invention is obvious to the damaging action drug effect of male mouse testis, after male mouse is freely selected food, body weight begins to descend, the atrophy of epididymis end portion, oligospermia, convoluted seminiferous tubule and testicular volume be obviously atrophy all, obviously suppress spermatogonium through experiment confirm the present invention, LDH-C4 in the spermoblast, electric border confirms in the convoluted tubule of testis disintegration that comes off of all kinds of spermatids, testicular spermatogenic epithelium serious degradation;

2, among the present invention used apholate except that gossypol, also has Triptolide, thunder godvine in Chinese medicine as anti-inflammatory and immunodepressant, after having added Triptolide, improved drug effect, reduced toxic and side effect, its therapeutic index is 8.1, safety index is 5.65, all is better than single effect with gossypol;

3, among the present invention owing to adopt the medicine of gossypol and two kinds of compositions of Triptolide, can reduce to 10-15mg/kg by single 25-30mg/kg with gossypol, greatly reduce the usage amount of gossypol, even wrongly taken, can the effect of fertility not take place to suppress to people and draught animal, so people and draught animal are belonged to nontoxic product yet;

4, through taking 15mg/kg every day on probation, the sperm of male mouse begins death about 7 days, can reach sterile effect, various compositions among the present invention can be added and subtracted according to the mouse kind of different regions, make the rat-bane of several different models, to adapt to the feeding habits of different regions muroid, lure mouse and the effect that kills mouse with enhancing;

5, the present invention is made by the pure natural plant raw material, and is free from environmental pollution, can not produce the phenomenon of secondary poisoning, belongs to the green safety rat-bane.

Below the invention will be further described and provide embodiment.

The present invention is a kind of male sterile mouse killing agent, it is characterized in that: described rat-bane is the gossypol of 0.2-1% by percentage by weight, the Triptolide of 0.1-0.3%, the irregular particle that lures the mouse feed to form of 99-99.7%, the percentage by weight that wherein lures the mouse feed to form is soybean cake powder or corn flour 10-25%, wheat bran 40-60%, groundnut meal or sesame meal 10-25%, fish meal 10-25%.The equipment for preparing this rat-bane needs is, pulvis blender, grinder, platform scale, cuber, crushing mill, baking oven, aluminium plastic packaging bag, packing carton, extranal packing box, and the preparation method of this rat-bane, it is different from prior art and is:

A, get percentage by weight and be, soybean cake powder or corn flour 10-25%, wheat bran 40-60%, groundnut meal or sesame meal 10-25%, fish meal 10-25% place blender to rotate stirring and evenly mixing and make and lure the mouse feed standby;

B, the 2-20% that lures the mouse feed that will make place grinder, the gossypol that it is 5-50% that adding accounts for this percentage by weight that lures the mouse feed, and it is standby to grind mixing;

C, the 2-20% that lures the mouse feed that will make place grinder, the Triptolide that it is 2-15% that adding accounts for this percentage by weight that lures the mouse feed, and it is standby to grind mixing;

D, the mouse feed that lures that contains gossypol and Triptolide that will prepare mix, and all the other that will make lure the mouse feed to pour stirring and evenly mixing in the blender together into again;

E, the mixture of above stirring and evenly mixing is put into the cuber compacting, become block;

F,, adopt crushing mill to smash the irregular particle that becomes the 0.1-1.0 cubic centimetre block of compacting;

G, particle is put into the dry 1-3 of baking oven hour of 60-80 degree Celsius, cooling back packing, warehouse-in.

Embodiment 1

1, getting percentage by weight is 11% corn flour, and wheat bran 58%, groundnut meal 11%, fish meal 19% place blender to rotate stirring and evenly mixing and make and lure the mouse feed standby;

2,10% of the mouse feed that lures that will make places grinder, adds that to account for this percentage by weight that lures the mouse feed be 7% gossypol, and it is standby to grind mixing;

3,10% of the mouse feed that lures that will make places grinder, adds that to account for this percentage by weight that lures the mouse feed be 3% Triptolide, and it is standby to grind mixing;

The mouse feed that lures that contains gossypol and Triptolide that 4, will prepare mixes, and all the other that will make lure the mouse feed to pour stirring and evenly mixing in the blender together into again;

5, the mixture of above stirring and evenly mixing is put into the cuber compacting, become block;

6, the block with compacting adopts crushing mill to smash the irregular particle that becomes the 0.1-1.0 cubic centimetre;

7, particle was put into Celsius 80 baking ovens of spending dry 1 hour, in the lighttight aluminium plastic bag of cooling back elder generation's inclosure, every bag of net content 100 grams refill box, and 10 bags in every box refills the case warehouse-in.

Embodiment 2

Get soybean cake powder 1.5kg, wheat bran 6.0kg, sesame meal 1.5kg, rough fish meal 1.0kg place blender to rotate stirring and evenly mixing and make after 20 minutes and lure the mouse feed standby;

The 500g that lures the mouse feed that 2, will make places grinder, adds gossypol 50g, and it is standby to grind mixing;

The 500g that lures the mouse feed that 3, will make places grinder, adds Triptolide 3g, and it is standby to grind mixing;

The mouse feed that lures that contains gossypol and Triptolide that 4, will prepare mixes, and all the other that will make lure the mouse feed to pour stirring and evenly mixing in the blender together into again;

5, the mixture of above stirring and evenly mixing is put into the cuber compacting, become block;

6, the block with compacting adopts crushing mill to smash the irregular particle that becomes the 0.1-1.0 cubic centimetre;

7, particle was put into Celsius 70 baking ovens of spending dry 2 hours, in the lighttight aluminium plastic bag of cooling back elder generation's inclosure, every bag of net content 100 grams refill box, and 10 bags in every box refills the case warehouse-in.

Embodiment 3

Preparation method is identical with embodiment 1, and the percentage by weight of the rat-bane of making is 0.9% gossypol, 0.1% Triptolide, corn flour 20%, wheat bran 43%, groundnut meal 25%, fish meal 11%.

Embodiment 4

Preparation method is identical with embodiment 1, and the percentage by weight of the rat-bane of making is 0.7% gossypol, 0.3% Triptolide, soybean cake powder 10%, wheat bran 55%, sesame meal 23%, fish meal 11%.

Embodiment 5

Preparation method is identical with embodiment 1, and the percentage by weight of the rat-bane of making is 0.4% gossypol, 0.2% Triptolide, corn flour 20%, wheat bran 50%, sesame meal 18.6%, fish meal 11%.

Claims (2)

1, male sterile mouse killing agent, it is characterized in that: described rat-bane is the gossypol of 0.2-0.9% by percentage by weight, the Triptolide of 0.1-0.3%, the irregular particle that lures the mouse feed to form of 99-99.7%, the percentage by weight that wherein lures the mouse feed to form is soybean cake powder or corn flour 10-25%, wheat bran 40-60%, groundnut meal or sesame meal 10-25%, fish meal 10-25%.

2, by the preparation method of the described male sterile mouse killing agent of claim 1, it is characterized in that:

A, get percentage by weight and be, soybean cake powder or corn flour 10-25%, wheat bran 40-60%, groundnut meal or sesame meal 10-25%, fish meal 10-25% place blender to rotate stirring and evenly mixing and make and lure the mouse feed standby;

B, the 2-20% that lures the mouse feed that will make place grinder, the gossypol that it is 5-50% that adding accounts for this percentage by weight that lures the mouse feed, and it is standby to grind mixing;

C, the 2-20% that lures the mouse feed that will make place grinder, the Triptolide that it is 2-15% that adding accounts for this percentage by weight that lures the mouse feed, and it is standby to grind mixing;

D, the mouse feed that lures that contains gossypol and Triptolide that will prepare mix, and all the other that will make lure the mouse feed to pour stirring and evenly mixing in the blender together into again;

E, the mixture of above stirring and evenly mixing is put into the cuber compacting, become block;

F,, adopt crushing mill to smash the irregular particle that becomes the 0.1-1.0 cubic centimetre block of compacting;

G, particle is put into the dry 1-3 of baking oven hour of 60-80 degree Celsius, cooling back packing, warehouse-in.