CN117959455A - 植物重组人类α-半乳糖苷酶制备治疗法布里病的药品的用途 - Google Patents
植物重组人类α-半乳糖苷酶制备治疗法布里病的药品的用途 Download PDFInfo
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- CN117959455A CN117959455A CN202410140178.XA CN202410140178A CN117959455A CN 117959455 A CN117959455 A CN 117959455A CN 202410140178 A CN202410140178 A CN 202410140178A CN 117959455 A CN117959455 A CN 117959455A
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
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- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12Y—ENZYMES
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| US201762442537P | 2017-01-05 | 2017-01-05 | |
| US62/442,537 | 2017-01-05 | ||
| PCT/IL2018/050018 WO2018127920A1 (en) | 2017-01-05 | 2018-01-05 | Therapeutic regimen for the treatment of fabry using stabilized alpha-galactosidase |
| CN201880016068.5A CN110381987A (zh) | 2017-01-05 | 2018-01-05 | 使用稳定化α-半乳糖苷酶治疗法布里病的治疗方法 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201880016068.5A Division CN110381987A (zh) | 2017-01-05 | 2018-01-05 | 使用稳定化α-半乳糖苷酶治疗法布里病的治疗方法 |
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| CN201880016068.5A Pending CN110381987A (zh) | 2017-01-05 | 2018-01-05 | 使用稳定化α-半乳糖苷酶治疗法布里病的治疗方法 |
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| EP (1) | EP3565583A4 (https=) |
| JP (2) | JP2020504131A (https=) |
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| US12020820B1 (en) * | 2017-03-03 | 2024-06-25 | Cerner Innovation, Inc. | Predicting sphingolipidoses (fabry's disease) and decision support |
| MX2021015352A (es) * | 2019-06-11 | 2022-04-06 | Amicus Therapeutics Inc | Métodos para tratar la enfermedad de fabry en pacientes que tienen insuficiencia renal. |
| US20230416714A1 (en) * | 2020-11-13 | 2023-12-28 | Hanmi Pharm. Co., Ltd | Use of therapeutic enzyme fusion protein in prevention and treatment of neuropathy caused by or accompanied by fabry disease |
| AU2021378707A1 (en) * | 2020-11-13 | 2023-06-01 | Hanmi Pharm. Co., Ltd. | Use of therapeutic enzyme fusion protein in prevention and treatment of renal diseases caused by or accompanied by Fabry disease |
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| US5766897A (en) | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| CA2052728A1 (en) | 1991-10-03 | 1993-04-04 | Guy Ampleman | Glycidyl azide polymer |
| DK1503788T3 (da) * | 2002-04-25 | 2011-10-17 | Shire Human Genetic Therapies | Behandling af alpha-galactosidase A-deficiens |
| EP1877099B1 (en) | 2005-04-06 | 2012-09-19 | Genzyme Corporation | Therapeutic conjugates comprising a lysosomal enzyme, polysialic acid and a targeting moiety |
| US9999618B2 (en) * | 2007-04-26 | 2018-06-19 | Amicus Therapeutics, Inc. | Dosing regimens for the treatment of lysosomal storage diseases using pharmacological chaperones |
| CA2696699A1 (en) | 2007-08-20 | 2009-02-26 | Protalix Ltd. | Saccharide-containing protein conjugates and uses thereof |
| US9194011B2 (en) * | 2009-11-17 | 2015-11-24 | Protalix Ltd. | Stabilized alpha-galactosidase and uses thereof |
| US20120230974A1 (en) | 2009-11-17 | 2012-09-13 | Protalix Ltd | Alkaline alpha galactosidase for the treatment of fabry disease |
| SI2865751T1 (sl) | 2010-03-02 | 2017-01-31 | Protalix Ltd. | Stabilizirana alfa-galaktozidaza in njene uporabe |
| KR101883803B1 (ko) | 2011-01-20 | 2018-07-31 | 프로탈릭스 리미티드 | 식물 및 식물 세포에서 알파-갈락토시다제의 발현용 핵산 작제물 |
| WO2014120900A1 (en) * | 2013-01-31 | 2014-08-07 | Icahn School Of Medicine At Mount Sinai | Enhanced therapeutic regimens for treating fabry disease |
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Also Published As
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| KR20190103320A (ko) | 2019-09-04 |
| EP3565583A4 (en) | 2020-12-02 |
| BR112019013920A2 (pt) | 2020-02-04 |
| NZ755725A (en) | 2023-06-30 |
| CA3048151A1 (en) | 2018-07-12 |
| CL2019001867A1 (es) | 2019-10-04 |
| CN110381987A (zh) | 2019-10-25 |
| RU2019124280A (ru) | 2021-02-06 |
| MX2019008076A (es) | 2019-08-29 |
| KR20240042110A (ko) | 2024-04-01 |
| US20250134968A1 (en) | 2025-05-01 |
| AU2018205891A1 (en) | 2019-08-15 |
| AU2018205891B2 (en) | 2024-11-07 |
| JP2023022244A (ja) | 2023-02-14 |
| IL267863A (en) | 2019-09-26 |
| WO2018127920A1 (en) | 2018-07-12 |
| US20200155654A1 (en) | 2020-05-21 |
| US12194079B2 (en) | 2025-01-14 |
| RU2019124280A3 (https=) | 2021-09-14 |
| ZA201904850B (en) | 2022-04-28 |
| JP2020504131A (ja) | 2020-02-06 |
| EP3565583A1 (en) | 2019-11-13 |
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