CN117942284A - Antibacterial skin-friendly wet tissue - Google Patents
Antibacterial skin-friendly wet tissue Download PDFInfo
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- CN117942284A CN117942284A CN202410074649.1A CN202410074649A CN117942284A CN 117942284 A CN117942284 A CN 117942284A CN 202410074649 A CN202410074649 A CN 202410074649A CN 117942284 A CN117942284 A CN 117942284A
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- antibacterial
- reaction
- titanium dioxide
- liquid
- nano titanium
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 76
- 239000007788 liquid Substances 0.000 claims abstract description 58
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000008367 deionised water Substances 0.000 claims abstract description 19
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 19
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 13
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000000463 material Substances 0.000 claims abstract description 8
- -1 sorbitan fatty acid ester Chemical class 0.000 claims abstract description 7
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims abstract description 6
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims abstract description 6
- KVTFEOAKFFQCCX-UHFFFAOYSA-N N-hexadecanoylglycine Chemical compound CCCCCCCCCCCCCCCC(=O)NCC(O)=O KVTFEOAKFFQCCX-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 6
- 229960003237 betaine Drugs 0.000 claims abstract description 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 6
- 229930195729 fatty acid Natural products 0.000 claims abstract description 6
- 239000000194 fatty acid Substances 0.000 claims abstract description 6
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229940075639 palmitoyl glycine Drugs 0.000 claims abstract description 6
- 239000000758 substrate Substances 0.000 claims abstract description 6
- 229940046009 vitamin E Drugs 0.000 claims abstract description 6
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 6
- 239000011709 vitamin E Substances 0.000 claims abstract description 6
- RSNFCPMTLUYXIK-UHFFFAOYSA-N [Na].[Na].CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O.NCCN Chemical compound [Na].[Na].CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O.NCCN RSNFCPMTLUYXIK-UHFFFAOYSA-N 0.000 claims abstract description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 63
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 claims description 45
- 229920002101 Chitin Polymers 0.000 claims description 43
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 claims description 38
- 239000003242 anti bacterial agent Substances 0.000 claims description 35
- 238000006243 chemical reaction Methods 0.000 claims description 35
- 150000001875 compounds Chemical class 0.000 claims description 34
- 239000000243 solution Substances 0.000 claims description 33
- 238000003756 stirring Methods 0.000 claims description 25
- 238000002360 preparation method Methods 0.000 claims description 22
- 239000000047 product Substances 0.000 claims description 20
- 229940074391 gallic acid Drugs 0.000 claims description 19
- 235000004515 gallic acid Nutrition 0.000 claims description 19
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 18
- 238000002156 mixing Methods 0.000 claims description 15
- 238000000926 separation method Methods 0.000 claims description 13
- 238000001354 calcination Methods 0.000 claims description 12
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 claims description 11
- 239000007853 buffer solution Substances 0.000 claims description 11
- 235000009024 Ceanothus sanguineus Nutrition 0.000 claims description 10
- 240000003553 Leptospermum scoparium Species 0.000 claims description 10
- 235000015459 Lycium barbarum Nutrition 0.000 claims description 10
- 239000007795 chemical reaction product Substances 0.000 claims description 10
- 238000001291 vacuum drying Methods 0.000 claims description 10
- 239000000341 volatile oil Substances 0.000 claims description 10
- 238000005406 washing Methods 0.000 claims description 10
- 230000000845 anti-microbial effect Effects 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 9
- 238000003837 high-temperature calcination Methods 0.000 claims description 9
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 claims description 7
- 239000004599 antimicrobial Substances 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- 150000001412 amines Chemical class 0.000 claims description 5
- 239000011159 matrix material Substances 0.000 claims description 5
- 238000006116 polymerization reaction Methods 0.000 claims description 5
- VILCJCGEZXAXTO-UHFFFAOYSA-N 2,2,2-tetramine Chemical compound NCCNCCNCCN VILCJCGEZXAXTO-UHFFFAOYSA-N 0.000 claims description 4
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 3
- MKNXBRLZBFVUPV-UHFFFAOYSA-L cyclopenta-1,3-diene;dichlorotitanium Chemical compound Cl[Ti]Cl.C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 MKNXBRLZBFVUPV-UHFFFAOYSA-L 0.000 claims description 3
- 239000001509 sodium citrate Substances 0.000 claims description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 3
- 239000011975 tartaric acid Substances 0.000 claims description 3
- 235000002906 tartaric acid Nutrition 0.000 claims description 3
- FAGUFWYHJQFNRV-UHFFFAOYSA-N tetraethylenepentamine Chemical compound NCCNCCNCCNCCN FAGUFWYHJQFNRV-UHFFFAOYSA-N 0.000 claims description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- 238000004321 preservation Methods 0.000 claims description 2
- 230000000052 comparative effect Effects 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 206010030113 Oedema Diseases 0.000 description 3
- LNUIUONEPHRXHM-UHFFFAOYSA-L disodium acetic acid ethane-1,2-diamine diacetate Chemical compound [Na+].[Na+].CC(O)=O.CC(O)=O.CC([O-])=O.CC([O-])=O.NCCN LNUIUONEPHRXHM-UHFFFAOYSA-L 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000011056 performance test Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 206010015150 Erythema Diseases 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000011165 3D composite Substances 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 206010051814 Eschar Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 101001018064 Homo sapiens Lysosomal-trafficking regulator Proteins 0.000 description 1
- 102100033472 Lysosomal-trafficking regulator Human genes 0.000 description 1
- 244000038561 Modiola caroliniana Species 0.000 description 1
- 235000010703 Modiola caroliniana Nutrition 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 229920001131 Pulp (paper) Polymers 0.000 description 1
- 229920000297 Rayon Polymers 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 231100000333 eschar Toxicity 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G23/00—Compounds of titanium
- C01G23/04—Oxides; Hydroxides
- C01G23/047—Titanium dioxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/30—Particle morphology extending in three dimensions
- C01P2004/32—Spheres
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Environmental & Geological Engineering (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Geology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to the technical field of wet tissues, in particular to an antibacterial skin-friendly wet tissue; the antibacterial skin-friendly wet tissue comprises antibacterial liquid and a non-woven fabric substrate loaded with the antibacterial liquid; and the mass ratio of the antibacterial liquid to the non-woven fabric base material is 2-3: 1, a step of; the antibacterial liquid consists of the following raw materials in parts by weight: 0.8 to 2.0 parts of glycerol, 0.3 to 0.8 part of palmitoylglycine, 0.2 to 0.5 part of betaine, 3 to 6 parts of sorbitan fatty acid ester, 0.6 to 1.0 part of pH regulator, 0.03 to 0.08 part of vitamin E, 5 to 8 parts of antibacterial solution, 0.3 to 0.6 part of 1, 2-diaminoethane tetraacetic acid disodium and 70 to 80 parts of deionized water; the wet tissue provided by the invention not only has good water retention performance and good touch feeling, but also has excellent antibacterial effect; effectively ensures the safety of wet tissue products and the quality thereof.
Description
Technical Field
The invention relates to the technical field of wet tissues, in particular to an antibacterial skin-friendly wet tissue.
Background
The wet towel is made by taking non-woven fabric, wood pulp composite cloth, carpenter paper and the like as carriers and adding a proper amount of raw materials such as production water, disinfectant and the like. Can be used for cleaning hand, skin and object surface. The content of the liquid medicine in the wet tissues is generally about 80 percent. The main components are water and additives. In order to avoid the reaction of water with the chemical liquid, the water used in the wet tissues must be subjected to a special treatment such as refined water, pure water, etc.
In the patent document of application number CN201710085887.2, a physical antimicrobial wet wipe is disclosed, which comprises a wet wipe body and a wet wipe liquid, wherein the wet wipe body is selected from a nonwoven fabric having an antimicrobial film or nanoparticles with positive charges, which are formed by chemical bonding; the wet tissue liquid is prepared from RO purified water, surfactant, emollient, humectant, skin conditioner and other additives, then ozone concentration of 0.1-1.0 mg/L is introduced into the wet tissue liquid, finally, the wet tissue liquid is added into the wet tissue body according to a certain weight ratio, and the wet tissue body is sealed and packaged, thus the physical antibacterial wet tissue is formed. The product belongs to wet tissues with no preservative precipitation, is soft, non-irritating and non-allergic to skin, and is especially suitable for allergic skin, tender skin and the like.
The antibacterial wet tissues provided in the patent documents have the advantages of mildness and no irritation, and meanwhile, do not contain preservatives and have certain antibacterial performance. But the antibacterial performance of the antibacterial agent is relatively insufficient, and the antibacterial agent cannot achieve the effect of powerful sterilization. This affects the safety and quality of the wet wipe to some extent. Accordingly, the present invention provides an antibacterial skin-friendly wet wipe for solving the above-mentioned technical problems.
Disclosure of Invention
The invention aims to provide an antibacterial skin-friendly wet tissue which has good water retention performance, good touch feeling and excellent antibacterial effect; effectively ensures the safety of wet tissue products and the quality thereof.
In order to achieve the above purpose, the present invention provides the following technical solutions:
An antibacterial skin-friendly wet tissue, which comprises an antibacterial liquid and a non-woven fabric substrate loaded with the antibacterial liquid; and the mass ratio of the antibacterial liquid to the non-woven fabric base material is 2-3: 1, a step of; the antibacterial liquid consists of the following raw materials in parts by weight: 0.8 to 2.0 parts of glycerol, 0.3 to 0.8 part of palmitoylglycine, 0.2 to 0.5 part of betaine, 3 to 6 parts of sorbitan fatty acid ester, 0.6 to 1.0 part of pH regulator, 0.03 to 0.08 part of vitamin E, 5 to 8 parts of antibacterial solution, 0.3 to 0.6 part of 1, 2-diaminoethane tetraacetic acid disodium and 70 to 80 parts of deionized water;
Wherein the antibacterial liquid is prepared by uniformly mixing tea tree essential oil and a compound antibacterial agent with the mass of 15-20 percent of the tea tree essential oil; the compound antibacterial agent takes spherical nano titanium dioxide as a matrix material, and the surface of the compound antibacterial agent is loaded with gallic acid and the reaction product of deacetylated chitin and 2-hydroxy-4-isopropyl-2, 4, 6-cycloheptatriene-1-ketone.
Further, the preparation method of the compound antibacterial agent comprises the following steps: ultrasonically dispersing pretreated spherical nano titanium dioxide into acetic acid solution of deacetylated chitin according to the solid-to-liquid ratio of 0.008-0.02 g/mL, then adding polymerized formaldehyde with the molar weight of 1.5-2.5 times that of the deacetylated chitin and the polymerization degree of 10-20, mixing and stirring uniformly, and stirring at the temperature of 80-90 ℃ for reaction for 30-50 min; after the reaction is finished, adding 2-hydroxy-4-isopropyl-2, 4, 6-cycloheptatriene-1-one with the molar weight being 2-3 times that of deacetylated chitin into the obtained product components, and continuing the reaction for 2-3 hours; and finally, sequentially carrying out solid-liquid separation, washing with deionized water and vacuum drying treatment to obtain a finished product of the compound antibacterial agent.
Further, the preparation method of the acetic acid solution of the deacetylated chitin comprises the following steps: adding deacetylated chitin with the mass of 0.5-0.8 times of that of the aqueous acetic acid solution with the volume concentration of 0.2-0.3%, and magnetically stirring until the obtained mixed components are clear and transparent, thus obtaining the acetic acid solution of the deacetylated chitin.
Further, the molecular weight of the deacetylated chitin is 1000-50000.
Further, the preparation method of the pretreated spherical nano titanium dioxide comprises the following steps: uniformly dispersing spherical nano titanium dioxide in Tris-HCl buffer solution with pH of 8.5 according to the solid-to-liquid ratio of 0.005-0.01 g/mL, then adding gallic acid with the mass of 0.5-1.2% of that of the Tris-HCl buffer solution into the solution, and stirring the solution at the speed of 500-700 r/min for reaction for 30-50 min; after the reaction is finished, adding organic amine with the molar weight being 2-5 times that of gallic acid into the resultant components, mixing and stirring uniformly, and then continuing to perform heat preservation reaction for 20-30 h at the temperature of 30-40 ℃; and after the reaction is finished, sequentially performing centrifugal separation, deionized water washing and vacuum drying treatment on the reaction product to obtain the pretreated spherical nano titanium dioxide.
Further, the organic amine is selected from any one of triethylenetetramine and tetraethylenepentamine.
Further, the preparation method of the spherical nano titanium dioxide comprises the following steps: adding 10-20% 1, 2-diaminoethane into 2-4 mg/mL of titanocene dichloride aqueous solution, mixing and stirring uniformly, heating to 110-130 ℃, reacting for 5-8 h at a constant temperature, and carrying out solid-liquid separation on the obtained resultant component; the obtained solid micro powder is respectively centrifugally washed for 3 to 4 times by deionized water and absolute ethyl alcohol; then transferring into calcining equipment for high-temperature calcination; finally, the spherical nano titanium dioxide is obtained.
Further, the high-temperature calcination process is as follows: heating the calcining temperature to 380-450 ℃ at a heating rate of 2-5 ℃/s, and calcining for 2-3 h at the temperature; and after the calcination is finished, cooling the solid micro powder to room temperature at a cooling rate of 2-5 ℃/s, thus completing the high-temperature calcination process.
Further, the pH regulator is any one of citric acid, sodium citrate and tartaric acid.
Compared with the prior art, the invention has the beneficial effects that:
In the invention, a spherical nano titanium dioxide with a plurality of structures is prepared by taking a dichloro titanocene aqueous solution and ethylenediamine as raw materials, then the spherical nano titanium dioxide is uniformly dispersed in a Tris-HCl buffer solution, gallic acid and organic amine are added into the spherical nano titanium dioxide, and the gallic acid is grafted on the surface of the spherical nano titanium dioxide and the inner wall of a porous structure through chemical bonds by a thermal insulation reaction to form a layer of relatively dense three-dimensional network structure, so that the pretreated spherical nano titanium dioxide is obtained. Wherein, the grafted gallic acid effectively improves the antibacterial property of the spherical nano titanium dioxide to a certain extent.
And then the pretreated spherical nano titanium dioxide is ultrasonically dispersed in an acetic acid solution of deacetylated chitin, so that the deacetylated chitin in the pretreated spherical nano titanium dioxide can be uniformly dispersed and adsorbed on the surface of the modified nano titanium dioxide and in the pores of the porous structure of the modified nano titanium dioxide. Then adding polymeric formaldehyde and 2-hydroxy-4-isopropyl-2, 4, 6-cycloheptatriene-1-ketone to enable the 2-hydroxy-4-isopropyl-2, 4, 6-cycloheptatriene-1-ketone and deacetylated chitin to react chemically to form bonds, wherein molecular chains formed by the two are alternately inserted into a gallic acid three-dimensional network envelope layer on the surface of spherical nano titanium dioxide, and finally, a three-dimensional composite antibacterial envelope layer is formed on the surface of the spherical nano titanium dioxide, so that the antibacterial performance of the compound antibacterial agent is remarkably improved. The compound antibacterial agent and the tea tree essential oil are used as raw materials of the antibacterial liquid, and the compound antibacterial agent and the tea tree essential oil are mutually synergistic and matched, so that the antibacterial performance of the wet tissue is obviously improved.
In addition, the wet tissue provided by the invention not only has good water retention performance and good touch feeling, but also has excellent antibacterial effect; effectively ensures the safety of wet tissue products and the quality thereof.
Detailed Description
The technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
An antibacterial skin-friendly wet tissue comprises antibacterial liquid and a non-woven fabric substrate loaded with the antibacterial liquid; and the mass ratio of the antibacterial liquid to the non-woven fabric base material is 2:1, a step of; the antibacterial liquid consists of the following raw materials in parts by weight: 0.8 part of glycerol, 0.3 part of palmitoylglycine, 0.2 part of betaine, 3 parts of sorbitan fatty acid ester, 0.6 part of citric acid, 0.03 part of vitamin E, 5 parts of antibacterial liquid, 0.3 part of disodium 1, 2-diaminoethane tetraacetate and 70 parts of deionized water;
Wherein the antibacterial liquid is prepared by uniformly mixing tea tree essential oil and a compound antibacterial agent with the mass of 15 percent; the compound antibacterial agent takes spherical nano titanium dioxide as a matrix material, and the surface of the compound antibacterial agent is loaded with gallic acid and the reaction product of deacetylated chitin and 2-hydroxy-4-isopropyl-2, 4, 6-cycloheptatriene-1-ketone.
The preparation method of the compound antibacterial agent comprises the following steps: ultrasonically dispersing pretreated spherical nano titanium dioxide into an acetic acid solution of deacetylated chitin according to a solid-liquid ratio of 0.008g/mL, adding polymerized formaldehyde with a molar quantity of 1.5 times that of the deacetylated chitin and a polymerization degree of 10, uniformly mixing and stirring, and stirring at a temperature of 80 ℃ for reaction for 30min; after the reaction is finished, adding 2-hydroxy-4-isopropyl-2, 4, 6-cycloheptatriene-1-one with the molar weight being 2-times that of deacetylated chitin into the obtained product components, and continuing the reaction for 2 hours; and finally, sequentially carrying out solid-liquid separation, washing with deionized water and vacuum drying treatment to obtain a finished product of the compound antibacterial agent.
The preparation method of the acetic acid solution of the deacetylated chitin comprises the following steps: adding deacetylated chitin with the mass of 0.5 times of that of the aqueous acetic acid solution with the volume concentration of 0.2%, and magnetically stirring until the obtained mixed components are clear and transparent to obtain the acetic acid solution of the deacetylated chitin; wherein the molecular weight of the deacetylated chitin is 1000.
The preparation method of the pretreated spherical nano titanium dioxide comprises the following steps: uniformly dispersing spherical nano titanium dioxide in Tris-HCl buffer solution with pH of 8.5 according to solid-to-liquid ratio of 0.005g/mL, then adding gallic acid with mass of 0.5% of that of the Tris-HCl buffer solution, and stirring at the speed of 500r/min for reaction for 30min; after the reaction is finished, triethylenetetramine with the molar weight being 2 times that of gallic acid is added into the product components, and the mixture is mixed and stirred uniformly and then is kept at the temperature of 30 ℃ for reaction for 20 hours; and after the reaction is finished, sequentially performing centrifugal separation, deionized water washing and vacuum drying treatment on the reaction product to obtain the pretreated spherical nano titanium dioxide.
The preparation method of the spherical nano titanium dioxide comprises the following steps: adding 10% 1, 2-diaminoethane into 2mg/mL of titanocene dichloride aqueous solution, mixing and stirring uniformly, heating to 110 ℃, preserving heat and reacting for 5h, and then carrying out solid-liquid separation on the obtained product components; the obtained solid micro powder is respectively centrifugally washed for 3 times by deionized water and absolute ethyl alcohol; then transferring into calcining equipment for high-temperature calcination; finally, the spherical nano titanium dioxide is obtained.
The high-temperature calcination process is as follows: heating the calcination temperature to 380 ℃ at a heating rate of 2 ℃/s, and calcining for 2 hours at the temperature; and after the calcination is finished, cooling the solid micro powder to room temperature according to the cooling rate of 2 ℃/s, thus completing the high-temperature calcination process.
Example 2
This embodiment differs from embodiment 1 in that: the specific raw material ratios of the antibacterial skin-friendly wet tissues and the specific preparation methods of the compound antibacterial agents are different, and the specific raw material ratios of the antibacterial skin-friendly wet tissues and the specific preparation methods of the compound antibacterial agents in the embodiment are as follows:
An antibacterial skin-friendly wet tissue comprises antibacterial liquid and a non-woven fabric substrate loaded with the antibacterial liquid; and the mass ratio of the antibacterial liquid to the non-woven fabric base material is 2.5:1, a step of; the antibacterial liquid consists of the following raw materials in parts by weight: 1.5 parts of glycerol, 0.5 part of palmitoylglycine, 0.4 part of betaine, 5 parts of sorbitan fatty acid ester, 0.8 part of sodium citrate, 0.05 part of vitamin E, 6 parts of antibacterial liquid, 0.5 part of disodium 1, 2-diaminoethane tetraacetate and 75 parts of deionized water;
Wherein the antibacterial liquid is prepared by uniformly mixing tea tree essential oil and a compound antibacterial agent with the mass of 18 percent; the compound antibacterial agent takes spherical nano titanium dioxide as a matrix material, and the surface of the compound antibacterial agent is loaded with gallic acid and the reaction product of deacetylated chitin and 2-hydroxy-4-isopropyl-2, 4, 6-cycloheptatriene-1-ketone.
The preparation method of the compound antibacterial agent comprises the following steps: ultrasonically dispersing pretreated spherical nano titanium dioxide into an acetic acid solution of deacetylated chitin according to a solid-to-liquid ratio of 0.01g/mL, adding polymerized formaldehyde with a molar quantity of 2.0 times that of the deacetylated chitin and a polymerization degree of 10, uniformly mixing and stirring, and stirring at a temperature of 85 ℃ for reacting for 40min; after the reaction is finished, adding 2-hydroxy-4-isopropyl-2, 4, 6-cycloheptatrien-1-one with the molar weight 3 times that of deacetylated chitin into the obtained product components, and continuing the reaction for 3 hours; and finally, sequentially carrying out solid-liquid separation, washing with deionized water and vacuum drying treatment to obtain a finished product of the compound antibacterial agent.
The preparation method of the acetic acid solution of the deacetylated chitin comprises the following steps: adding deacetylated chitin with the mass of 0.6 times of that of the aqueous acetic acid solution with the volume concentration of 0.25%, and magnetically stirring until the obtained mixed components are clear and transparent to obtain the acetic acid solution of the deacetylated chitin; wherein the molecular weight of the deacetylated chitin is 1000.
The preparation method of the pretreated spherical nano titanium dioxide comprises the following steps: uniformly dispersing spherical nano titanium dioxide in Tris-HCl buffer solution with the pH value of 8.5 according to the solid-liquid ratio of 0.008g/mL, then adding gallic acid with the mass of 1.0% of that of the Tris-HCl buffer solution into the solution, and stirring the solution at the speed of 600r/min for reaction for 40min; after the reaction is finished, tetraethylenepentamine with the molar weight 3 times of that of the gallic acid is added into the resultant components, and the mixture is mixed and stirred uniformly and then is kept at the temperature of 35 ℃ for reaction for 25 hours; and after the reaction is finished, sequentially performing centrifugal separation, deionized water washing and vacuum drying treatment on the reaction product to obtain the pretreated spherical nano titanium dioxide.
Example 3
This embodiment differs from embodiment 1 in that: the specific raw material ratios of the antibacterial skin-friendly wet tissues and the specific preparation methods of the compound antibacterial agents are different, and the specific raw material ratios of the antibacterial skin-friendly wet tissues and the specific preparation methods of the compound antibacterial agents in the embodiment are as follows:
An antibacterial skin-friendly wet tissue comprises antibacterial liquid and a non-woven fabric substrate loaded with the antibacterial liquid; and the mass ratio of the antibacterial liquid to the non-woven fabric base material is 3:1, a step of; the antibacterial liquid consists of the following raw materials in parts by weight: 2.0 parts of glycerol, 0.8 part of palmitoylglycine, 0.5 part of betaine, 6 parts of sorbitan fatty acid ester, 1.0 part of tartaric acid, 0.08 part of vitamin E, 8 parts of antibacterial liquid, 0.6 part of disodium 1, 2-diaminoethane tetraacetate and 80 parts of deionized water;
Wherein the antibacterial liquid is prepared by uniformly mixing tea tree essential oil and a compound antibacterial agent with the mass of 20 percent; the compound antibacterial agent takes spherical nano titanium dioxide as a matrix material, and the surface of the compound antibacterial agent is loaded with gallic acid and the reaction product of deacetylated chitin and 2-hydroxy-4-isopropyl-2, 4, 6-cycloheptatriene-1-ketone.
The preparation method of the compound antibacterial agent comprises the following steps: ultrasonically dispersing pretreated spherical nano titanium dioxide into an acetic acid solution of deacetylated chitin according to a solid-to-liquid ratio of 0.02g/mL, adding polymerized formaldehyde with a molar quantity of 2.5 times that of the deacetylated chitin and a polymerization degree of 20, uniformly mixing and stirring, and stirring at a temperature of 90 ℃ for reacting for 50min; after the reaction is finished, adding 2-hydroxy-4-isopropyl-2, 4, 6-cycloheptatrien-1-one with the molar weight 3 times that of deacetylated chitin into the obtained product components, and continuing the reaction for 3 hours; and finally, sequentially carrying out solid-liquid separation, washing with deionized water and vacuum drying treatment to obtain a finished product of the compound antibacterial agent.
The preparation method of the acetic acid solution of the deacetylated chitin comprises the following steps: adding deacetylated chitin with the mass of 0.8 times of that of the aqueous acetic acid solution with the volume concentration of 0.3%, and magnetically stirring until the obtained mixed components are clear and transparent to obtain the acetic acid solution of the deacetylated chitin; wherein the molecular weight of the deacetylated chitin is 50000.
The preparation method of the pretreated spherical nano titanium dioxide comprises the following steps: uniformly dispersing spherical nano titanium dioxide in Tris-HCl buffer solution with pH of 8.5 according to the solid-liquid ratio of 0.01g/mL, then adding gallic acid with the mass of 1.2% of that of the Tris-HCl buffer solution into the solution, and stirring the solution at the speed of 700r/min for reaction for 50min; after the reaction is finished, triethylenetetramine with 5 times of the molar weight of gallic acid is added into the product components, and the mixture is mixed and stirred uniformly and then is kept at the temperature of 40 ℃ for reaction for 30 hours; and after the reaction is finished, sequentially performing centrifugal separation, deionized water washing and vacuum drying treatment on the reaction product to obtain the pretreated spherical nano titanium dioxide.
Comparative example 1: the difference from example 1 is that: in the embodiment, the tea tree essential oil with the same amount is adopted to replace the antibacterial liquid;
comparative example 2: the difference from example 1 is that: in the embodiment, the equivalent pretreated spherical nano titanium dioxide is adopted to replace the compound antibacterial agent;
Comparative example 3: the difference from example 1 is that: in this example, an equivalent amount of spherical nano titanium dioxide was used instead of the compound antimicrobial.
Performance test: the antibacterial skin-friendly wet tissues provided in examples 1 to 3 and comparative examples 1 to 3 were respectively labeled as examples 1 to 3 and comparative examples 1 to 3; and the following performance tests were performed on the antibacterial skin-friendly wet tissues samples provided in 1 to 3 and comparative examples 1 to 3, respectively:
1. antibacterial performance test: staphylococcus aureus, candida albicans and escherichia coli are used as test bacteria, and the antibacterial performance of each group of wet tissue samples is tested according to the specification of GB15979-2002 disposable hygienic product hygienic standard. The evaluation criteria were: the antibacterial rate is more than or equal to 50-90%, the product has antibacterial effect, the antibacterial rate is more than or equal to 90%, the product has stronger antibacterial effect, and the obtained test results are recorded in Table 1:
2. water retention test: the mass of 100% viscose non-woven fabric was measured in advance and was designated as m 0, then the wet tissue samples provided in examples 1 to 3 and comparative examples 1 to 3 were weighed, the mass was designated as m 1, and after being placed in an environment of 25 ℃ and 40% humidity for 1 hour, the wet tissue was weighed, and the mass was designated as m 2. Calculating the water loss rate according to the following formula;
The test data obtained are recorded in table 1:
TABLE 1
3. Soft and smooth testing: the soft and smooth properties of the wet wipe samples provided in examples 1-3 and comparative examples 1-3 were evaluated at 10 minutes using a 5 person panel; the test results are shown in table 2:
4. Irritation detection: skin irritation detection was performed on wet wipes according to a complete skin irritation test in the disinfection technical Specification, and the test results are shown in Table 2: wherein, the scoring criteria are specifically as follows:
erythema formation: 0 is none, 1 is barely visible, 2 is obvious, 3 is severe, 4 is mauve erythema and eschar is present;
edema formation: 0 is absent, 1 is barely visible, 2 is skin doming, well-defined, 3 is edema doming about 1mm,4 is edema doming exceeding 1mm.
TABLE 2
As can be seen by comparing and analyzing the related data in tables 1-2, the wet tissue provided by the invention not only has good water retention performance and good touch feeling, but also has excellent antibacterial effect; effectively ensures the safety of wet tissue products and the quality thereof. Therefore, the antibacterial skin-friendly wet tissue provided by the invention has a wider market prospect and is more suitable for popularization.
In the description of the present specification, the descriptions of the terms "one embodiment," "example," "specific example," and the like, mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The preferred embodiments of the invention disclosed above are intended only to assist in the explanation of the invention. The preferred embodiments are not exhaustive or to limit the invention to the precise form disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best understand and utilize the invention. The invention is limited only by the claims and the full scope and equivalents thereof.
Claims (9)
1. The antibacterial skin-friendly wet tissue is characterized by comprising an antibacterial liquid and a non-woven fabric substrate loaded with the antibacterial liquid; and the mass ratio of the antibacterial liquid to the non-woven fabric base material is 2-3: 1, a step of; the antibacterial liquid consists of the following raw materials in parts by weight: 0.8 to 2.0 parts of glycerol, 0.3 to 0.8 part of palmitoylglycine, 0.2 to 0.5 part of betaine, 3 to 6 parts of sorbitan fatty acid ester, 0.6 to 1.0 part of pH regulator, 0.03 to 0.08 part of vitamin E, 5 to 8 parts of antibacterial solution, 0.3 to 0.6 part of 1, 2-diaminoethane tetraacetic acid disodium and 70 to 80 parts of deionized water;
Wherein the antibacterial liquid is prepared by uniformly mixing tea tree essential oil and a compound antibacterial agent with the mass of 15-20 percent of the tea tree essential oil; the compound antibacterial agent takes spherical nano titanium dioxide as a matrix material, and the surface of the compound antibacterial agent is loaded with gallic acid and the reaction product of deacetylated chitin and 2-hydroxy-4-isopropyl-2, 4, 6-cycloheptatriene-1-ketone.
2. An antimicrobial skin-friendly wet wipe according to claim 1, wherein: the preparation method of the compound antibacterial agent comprises the following steps: ultrasonically dispersing pretreated spherical nano titanium dioxide into acetic acid solution of deacetylated chitin according to the solid-to-liquid ratio of 0.008-0.02 g/mL, then adding polymerized formaldehyde with the molar weight of 1.5-2.5 times that of the deacetylated chitin and the polymerization degree of 10-20, mixing and stirring uniformly, and stirring at the temperature of 80-90 ℃ for reaction for 30-50 min; after the reaction is finished, adding 2-hydroxy-4-isopropyl-2, 4, 6-cycloheptatriene-1-one with the molar weight being 2-3 times that of deacetylated chitin into the obtained product components, and continuing the reaction for 2-3 hours; and finally, sequentially carrying out solid-liquid separation, washing with deionized water and vacuum drying treatment to obtain a finished product of the compound antibacterial agent.
3. An antimicrobial skin-friendly wet wipe according to claim 2, wherein: the preparation method of the acetic acid solution of the deacetylated chitin comprises the following steps: adding deacetylated chitin with the mass of 0.5-0.8 times of that of the aqueous acetic acid solution with the volume concentration of 0.2-0.3%, and magnetically stirring until the obtained mixed components are clear and transparent, thus obtaining the acetic acid solution of the deacetylated chitin.
4. An antimicrobial skin-friendly wet wipe according to claim 3, wherein: the molecular weight of the deacetylated chitin is 1000-50000.
5. The antibacterial skin-friendly wet tissue as claimed in claim 2, wherein the preparation method of the pretreated spherical nano titanium dioxide comprises the following steps: uniformly dispersing spherical nano titanium dioxide in Tris-HCl buffer solution with pH of 8.5 according to the solid-to-liquid ratio of 0.005-0.01 g/mL, then adding gallic acid with the mass of 0.5-1.2% of that of the Tris-HCl buffer solution into the solution, and stirring the solution at the speed of 500-700 r/min for reaction for 30-50 min; after the reaction is finished, adding organic amine with the molar weight being 2-5 times that of gallic acid into the resultant components, mixing and stirring uniformly, and then continuing to perform heat preservation reaction for 20-30 h at the temperature of 30-40 ℃; and after the reaction is finished, sequentially performing centrifugal separation, deionized water washing and vacuum drying treatment on the reaction product to obtain the pretreated spherical nano titanium dioxide.
6. An antimicrobial skin-friendly wet wipe according to claim 5, wherein: the organic amine is selected from any one of triethylenetetramine and tetraethylenepentamine.
7. The antibacterial skin-friendly wet tissue according to claim 5, wherein the preparation method of the spherical nano titanium dioxide is as follows: adding 10-20% 1, 2-diaminoethane into 2-4 mg/mL of titanocene dichloride aqueous solution, mixing and stirring uniformly, heating to 110-130 ℃, reacting for 5-8 h at a constant temperature, and carrying out solid-liquid separation on the obtained resultant component; the obtained solid micro powder is respectively centrifugally washed for 3 to 4 times by deionized water and absolute ethyl alcohol; then transferring into calcining equipment for high-temperature calcination; finally, the spherical nano titanium dioxide is obtained.
8. The antimicrobial skin-friendly wet wipe of claim 7 wherein the high temperature calcination process is: heating the calcining temperature to 380-450 ℃ at a heating rate of 2-5 ℃/s, and calcining for 2-3 h at the temperature; and after the calcination is finished, cooling the solid micro powder to room temperature at a cooling rate of 2-5 ℃/s, thus completing the high-temperature calcination process.
9. An antimicrobial skin-friendly wet wipe according to claim 1, wherein: the pH regulator is any one of citric acid, sodium citrate and tartaric acid.
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